Bax Inhibitor-1 protects from Non-Alcoholic Steatohepatitis by limiting IRE1α signaling

scientific article published on 19 February 2018

Bax Inhibitor-1 protects from Non-Alcoholic Steatohepatitis by limiting IRE1α signaling is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/HEP.29847
P698PubMed publication ID29457838

P50authorGuido KroemerQ19508945
Philippe GualQ43082600
Carmelo LuciQ57586696
Cynthia LebeaupinQ59676716
Frédéric LucianoQ30419950
P2093author name stringSandra Lacas-Gervais
Albert Tran
Rodolphe Anty
Stéphanie Bonnafous
Béatrice Bailly-Maitre
Antonio Iannelli
Déborah Rousseau
Stéphanie Patouraux
Gilbert Adam
Sandrine Marchetti
Déborah Vallée
P2860cites workRoles of CHOP/GADD153 in endoplasmic reticulum stressQ24302185
BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alphaQ24310536
Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myelomaQ24600346
Endoplasmic reticulum stress and the inflammatory basis of metabolic diseaseQ24633352
The economic and clinical burden of nonalcoholic fatty liver disease in the United States and EuropeQ39471203
Overexpression of TCL1 activates the endoplasmic reticulum stress response: a novel mechanism of leukemic progression in mice.Q41786115
UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators.Q42041480
Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver diseaseQ44934521
Involvement of endoplasmic reticulum stress in insulin resistance and diabetesQ45127777
NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice.Q46228637
Mice Lacking bi-1 Gene Show Accelerated Liver RegenerationQ60877266
Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosisQ81441036
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Decoding cell death signals in liver inflammationQ26823299
The cell biology of inflammasomes: Mechanisms of inflammasome activation and regulationQ28079360
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNAQ28214814
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetesQ28575190
Increased hepatic cell proliferation and lung abnormalities in mice deficient in CCAAT/enhancer binding protein alphaQ28591694
BI-1 regulates an apoptosis pathway linked to endoplasmic reticulum stressQ28592598
The unfolded protein response: from stress pathway to homeostatic regulationQ29547396
The unfolded protein response: controlling cell fate decisions under ER stress and beyondQ29615499
Nonalcoholic fatty liver diseaseQ29619354
Hepatic Bax inhibitor-1 inhibits IRE1alpha and protects from obesity-associated insulin resistance and glucose intoleranceQ33673551
Osteopontin deficiency aggravates hepatic injury induced by ischemia-reperfusion in miceQ33720224
Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cellsQ34152594
Cytoprotective gene bi-1 is required for intrinsic protection from endoplasmic reticulum stress and ischemia-reperfusion injuryQ34479417
Dysregulation of the unfolded protein response in db/db mice with diet-induced steatohepatitisQ35490178
Tumor necrosis factor-induced reversal of adipocytic phenotype of 3T3-L1 cells is preceded by a loss of nuclear CCAAT/enhancer binding protein (C/EBP).Q35596558
Endoplasmic reticulum stress in liver diseaseQ36031838
ER stress induces NLRP3 inflammasome activation and hepatocyte death.Q36293033
Silencing of lipid metabolism genes through IRE1α-mediated mRNA decay lowers plasma lipids in mice.Q36330343
Endoplasmic reticulum stress induces fibrogenic activity in hepatic stellate cells through autophagyQ36941185
Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight lossQ37105351
Increased hepatic myeloperoxidase activity in obese subjects with nonalcoholic steatohepatitisQ37362066
Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity.Q37382279
The XBP1 Arm of the Unfolded Protein Response Induces Fibrogenic Activity in Hepatic Stellate Cells Through AutophagyQ37519318
Targeting IRE1 with small molecules counteracts progression of atherosclerosisQ37682288
Getting RIDD of RNA: IRE1 in cell fate regulationQ38198370
NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice.Q39164863
BI-1 regulates endoplasmic reticulum Ca2+ homeostasis downstream of Bcl-2 family proteinsQ39261543
IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress.Q39299575
P407language of work or nameEnglishQ1860
P921main subjectsteatohepatitisQ2335423
non-alcoholic steatohepatitisQ28692677
P577publication date2018-02-19
P1433published inHepatologyQ15724398
P1476titleBax Inhibitor-1 protects from Non-Alcoholic Steatohepatitis by limiting IRE1α signaling

Reverse relations

cites work (P2860)
Q93159480Efavirenz and Efavirenz-like Compounds Activate Human, Murine, and Macaque Hepatic IRE1α-XBP1
Q55456504Endoplasmic Reticulum Stress in Metabolic Disorders.
Q64057135Endoplasmic Reticulum Stress in Metabolic Liver Diseases and Hepatic Fibrosis
Q97522970Endoplasmic reticulum stress and liver diseases
Q102220441Hepatocyte-specific deletion of XBP1 sensitizes mice to liver injury through hyperactivation of IRE1α
Q59807301Inositol-Requiring Enzyme 1 Alpha Endoribonuclease Specific Inhibitor STF-083010 Alleviates Carbon Tetrachloride Induced Liver Injury and Liver Fibrosis in Mice
Q90484369MicroRNAs: Unfolding the Link Between Inositol-Requiring Enzyme 1α and Fatty Liver
Q90526429Relieving ER stress to target NASH-driven hepatocellular carcinoma
Q64052546Right place, right time: localisation and assembly of the NLRP3 inflammasome

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