The XBP1 Arm of the Unfolded Protein Response Induces Fibrogenic Activity in Hepatic Stellate Cells Through Autophagy

scientific article published on 20 December 2016

The XBP1 Arm of the Unfolded Protein Response Induces Fibrogenic Activity in Hepatic Stellate Cells Through Autophagy is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/SREP39342
P932PMC publication ID5172197
P698PubMed publication ID27996033

P50authorBryan C FuchsQ78377620
Varinder AthwalQ87379778
P2093author name stringDaisuke Hasegawa
Dipankar Bhattacharya
Scott L Friedman
Yujin Hoshida
Christopher L Robinson
David Y Zhang
Nicolas Goossens
Xiaochen Sun
Youngmin Lee
Rosa S Kim
Takuma Tsuchida
Hsin-I Chou
P2860cites workGlobal and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010Q21534928
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Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
The unfolded protein response: from stress pathway to homeostatic regulationQ29547396
Autophagy regulates lipid metabolismQ29547421
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Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liverQ29616840
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Molecularly defined unfolded protein response subclasses have distinct correlations with fatty liver disease in zebrafishQ33814245
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Functional linkage of cirrhosis-predictive single nucleotide polymorphisms of Toll-like receptor 4 to hepatic stellate cell responses.Q33938566
UPR, autophagy, and mitochondria crosstalk underlies the ER stress responseQ35122358
Epithelial Xbp1 is required for cellular proliferation and differentiation during mammary gland developmentQ35288559
Autophagy releases lipid that promotes fibrogenesis by activated hepatic stellate cells in mice and in human tissues.Q36227227
Hepatocyte X-box binding protein 1 deficiency increases liver injury in mice fed a high-fat/sugar dietQ36382065
ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growthQ36497999
XBP-1u suppresses autophagy by promoting the degradation of FoxO1 in cancer cellsQ36739979
Endoplasmic reticulum stress induces fibrogenic activity in hepatic stellate cells through autophagyQ36941185
PHLDA3 overexpression in hepatocytes by endoplasmic reticulum stress via IRE1-Xbp1s pathway expedites liver injury.Q37156352
Autophagy regulates adipose mass and differentiation in miceQ37403082
Evolving challenges in hepatic fibrosisQ37768335
METABOLISM. S-Nitrosylation links obesity-associated inflammation to endoplasmic reticulum dysfunction.Q38297313
Gene expression profiles during hepatic stellate cell activation in culture and in vivoQ38302031
Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis.Q38333252
Unfolded proteins are Ire1-activating ligands that directly induce the unfolded protein responseQ38845249
Establishment of an immortalized human hepatic stellate cell line to develop antifibrotic therapiesQ40638123
Endoplasmic Reticulum Stress in Hepatic Stellate Cells Promotes Liver Fibrosis via PERK-Mediated Degradation of HNRNPA1 and Up-regulation of SMAD2.Q40966919
A hepatic stellate cell gene expression signature associated with outcomes in hepatitis C cirrhosis and hepatocellular carcinoma after curative resectionQ41642597
Endoplasmic reticulum stress enhances fibrosis through IRE1α-mediated degradation of miR-150 and XBP-1 splicing.Q41811106
Amplification and molecular cloning of the hamster tunicamycin-sensitive N-acetylglucosamine-1-phosphate transferase gene. The hamster and yeast enzymes share a common peptide sequenceQ48308374
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectautophagyQ288322
P304page(s)39342
P577publication date2016-12-20
P1433published inScientific ReportsQ2261792
P1476titleThe XBP1 Arm of the Unfolded Protein Response Induces Fibrogenic Activity in Hepatic Stellate Cells Through Autophagy
P478volume6

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cites work (P2860)
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Q61799897Unfolded protein response is an early, non-critical event during hepatic stellate cell activation

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