| scholarly article | Q13442814 |
| P50 | author | Namandjé N. Bumpus | Q60194158 |
| P2093 | author name string | Allyson N Hamlin | |
| Carley J S Heck | |||
| P2860 | cites work | Presence of the CYP2B6 516G> T polymorphism, increased plasma Efavirenz concentrations and early neuropsychiatric side effects in South African HIV-infected patients | Q21245026 |
| Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1 | Q22011167 | ||
| XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor | Q24292102 | ||
| Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma | Q24600346 | ||
| IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response | Q24672592 | ||
| Bax Inhibitor-1 protects from Non-Alcoholic Steatohepatitis by limiting IRE1α signaling | Q49850608 | ||
| Role of the pregnane X receptor in binge ethanol-induced steatosis and hepatotoxicity | Q50066652 | ||
| Probing ligand structure-activity relationships in pregnane X receptor (PXR): efavirenz and 8-hydroxyefavirenz exhibit divergence in activation. | Q50070843 | ||
| Formation of 8-hydroxyguanine moiety in cellular DNA by agents producing oxygen radicals and evidence for its repair | Q50202507 | ||
| Successful efavirenz dose reduction guided by therapeutic drug monitoring. | Q51584401 | ||
| Lipid peroxidation and biogenic aldehydes: from the identification of 4-hydroxynonenal to further achievements in biopathology. | Q53569658 | ||
| High plasma efavirenz level and CYP2B6*6 are associated with efavirenz-based HAART-induced liver injury in the treatment of naïve HIV patients from Ethiopia: a prospective cohort study | Q56829831 | ||
| A current structural perspective on PXR and CAR in drug metabolism. | Q64900450 | ||
| Oxidative stress induces the endoplasmic reticulum stress and facilitates inclusion formation in cultured cells | Q80158585 | ||
| Structure of the Dual Enzyme Ire1 Reveals the Basis for Catalysis and Regulation in Nonconventional RNA Splicing | Q27649529 | ||
| The unfolded protein response signals through high-order assembly of Ire1 | Q27653139 | ||
| Insights into CYP2B6-mediated drug-drug interactions | Q28078857 | ||
| Long-term efavirenz autoinduction and its effect on plasma exposure in HIV patients | Q28294491 | ||
| Regulation of hepatic lipogenesis by the transcription factor XBP1 | Q28507784 | ||
| XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response | Q28585314 | ||
| Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response | Q29547299 | ||
| Constitutive role for IRE1α-XBP1 signaling pathway in the insulin-mediated hepatic lipogenic program | Q30426645 | ||
| Efavirenz plasma levels can predict treatment failure and central nervous system side effects in HIV-1-infected patients | Q31977562 | ||
| Proteomics investigations of drug-induced hepatotoxicity in HepG2 cells | Q33773197 | ||
| Involvement of endoplasmic reticulum stress on neuronal cell death in the lateral geniculate nucleus in the monkey glaucoma model | Q33799757 | ||
| Prevention of HIV protease inhibitor-induced dysregulation of hepatic lipid metabolism by raltegravir via endoplasmic reticulum stress signaling pathways | Q34035275 | ||
| HIV and HAART-Associated Dyslipidemia | Q35020217 | ||
| Hepatic gene expression in protoporphyic Fech mice is associated with cholestatic injury but not a marked depletion of the heme regulatory pool | Q35083817 | ||
| The IL-6- and lipopolysaccharide-induced transcription of hepcidin in HFE-, transferrin receptor 2-, and beta 2-microglobulin-deficient hepatocytes | Q35316703 | ||
| IRE1α activation protects mice against acetaminophen-induced hepatotoxicity | Q35760821 | ||
| XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum. | Q36322684 | ||
| PXR and CAR single nucleotide polymorphisms influence plasma efavirenz levels in South African HIV/AIDS patients | Q36468872 | ||
| Compartmentalization and antiviral effect of efavirenz metabolites in blood plasma, seminal plasma, and cerebrospinal fluid | Q36573340 | ||
| PXR ablation alleviates diet-induced and genetic obesity and insulin resistance in mice | Q36867493 | ||
| The Role of IRE-XBP1 Pathway in Regulation of Retinal Pigment Epithelium Tight Junctions | Q37319994 | ||
| Adverse events associated with nevirapine and efavirenz-based first-line antiretroviral therapy: a systematic review and meta-analysis | Q38076265 | ||
| XBP1s Is an Anti-lipogenic Protein | Q38291938 | ||
| Targeting the IRE1α-XBP1 branch of the unfolded protein response in human diseases | Q38489729 | ||
| Cell death induced by endoplasmic reticulum stress. | Q38639996 | ||
| ER stress in human hepatic cells treated with Efavirenz: mitochondria again | Q39135882 | ||
| The integrated stress response and proteotoxicity in cancer therapy | Q39141019 | ||
| Agonism of human pregnane X receptor by rilpivirine and etravirine: comparison with first generation non-nucleoside reverse transcriptase inhibitors | Q39167130 | ||
| Efavirenz biotransformation as an up-stream event of mood changes in HIV-infected patients. | Q39471850 | ||
| The IRE1alpha-XBP1 pathway of the unfolded protein response is required for adipogenesis | Q39843795 | ||
| The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosis | Q41904044 | ||
| Structure-Activity Studies Reveal the Oxazinone Ring Is a Determinant of Cytochrome P450 2B6 Activity Toward Efavirenz | Q42260918 | ||
| Efavirenz and 8-hydroxyefavirenz induce cell death via a JNK- and BimEL-dependent mechanism in primary human hepatocytes | Q42726500 | ||
| Inhibition of clinically relevant mutant variants of HIV-1 by quinazolinone non-nucleoside reverse transcriptase inhibitors | Q43503366 | ||
| The cytochrome P450 2B6 (CYP2B6) is the main catalyst of efavirenz primary and secondary metabolism: implication for HIV/AIDS therapy and utility of efavirenz as a substrate marker of CYP2B6 catalytic activity | Q44391267 | ||
| CHOP is a critical regulator of acetaminophen-induced hepatotoxicity. | Q44693987 | ||
| Single Heteroatom Substitutions in the Efavirenz Oxazinone Ring Impact Metabolism by CYP2B6. | Q49215469 | ||
| P4510 | describes a project that uses | ImageJ | Q1659584 |
| P433 | issue | 2 | |
| P921 | main subject | Macaca | Q177601 |
| efavirenz | Q422645 | ||
| P304 | page(s) | 183-195 | |
| P577 | publication date | 2018-11-15 | |
| P1433 | published in | Molecular Pharmacology | Q1943386 |
| P1476 | title | Efavirenz and Efavirenz-like Compounds Activate Human, Murine, and Macaque Hepatic IRE1α-XBP1 | |
| P478 | volume | 95 |
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