| review article | Q7318358 |
| scholarly article | Q13442814 |
| P50 | author | Albert C. Koong | Q55221705 |
| P2093 | author name string | Maho Niwa | |
| Dadi Jiang | |||
| P2860 | cites work | Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1 | Q22011167 |
| Plasma cell differentiation requires the transcription factor XBP-1 | Q24291453 | ||
| XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor | Q24292102 | ||
| ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats | Q24298956 | ||
| A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein response | Q24305069 | ||
| A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells | Q24309442 | ||
| Protective effect against Parkinson's disease-related insults through the activation of XBP1 | Q24314837 | ||
| The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule | Q24596804 | ||
| The ER stress factor XBP1s prevents amyloid-beta neurotoxicity | Q24598012 | ||
| Blockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myeloma | Q24598483 | ||
| Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma | Q24600346 | ||
| Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors | Q24606387 | ||
| Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicing | Q24627782 | ||
| Potent and selective inhibitors of the inositol-requiring enzyme 1 endoribonuclease | Q24628936 | ||
| An integrated genomic analysis of human glioblastoma multiforme | Q24648860 | ||
| XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy | Q24655821 | ||
| Endoplasmic reticulum stress in malignancy | Q27006434 | ||
| The role of endoplasmic reticulum in hepatic lipid homeostasis and stress signaling | Q27008029 | ||
| Structure and mechanism of action of the hydroxy–aryl–aldehyde class of IRE1 endoribonuclease inhibitors | Q27640568 | ||
| Structure of the Dual Enzyme Ire1 Reveals the Basis for Catalysis and Regulation in Nonconventional RNA Splicing | Q27649529 | ||
| The unfolded protein response signals through high-order assembly of Ire1 | Q27653139 | ||
| Flavonol Activation Defines an Unanticipated Ligand-Binding Site in the Kinase-RNase Domain of IRE1 | Q27660827 | ||
| Cofactor-mediated conformational control in the bifunctional kinase/RNase Ire1 | Q27670678 | ||
| Two regulatory steps of ER-stress sensor Ire1 involving its cluster formation and interaction with unfolded proteins | Q27932183 | ||
| The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response | Q27933479 | ||
| Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase | Q27938837 | ||
| tRNA ligase is required for regulated mRNA splicing in the unfolded protein response | Q27940124 | ||
| Increased sensitivity to dextran sodium sulfate colitis in IRE1beta-deficient mice | Q28359871 | ||
| Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1 | Q28507338 | ||
| Regulation of hepatic lipogenesis by the transcription factor XBP1 | Q28507784 | ||
| The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation | Q28510062 | ||
| The transcription factor XBP-1 is essential for the development and survival of dendritic cells | Q28512302 | ||
| Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes | Q28575190 | ||
| Regulation of glucose homeostasis through a XBP-1-FoxO1 interaction | Q28592129 | ||
| Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response | Q29547299 | ||
| The unfolded protein response: from stress pathway to homeostatic regulation | Q29547396 | ||
| An integrated stress response regulates amino acid metabolism and resistance to oxidative stress | Q29547441 | ||
| Patterns of somatic mutation in human cancer genomes | Q29547841 | ||
| Induction of the unfolded protein response and cell death pathway in Alzheimer's disease, but not in aged Tg2576 mice | Q30494698 | ||
| Inositol-requiring enzyme 1alpha is a key regulator of angiogenesis and invasion in malignant glioma | Q30496396 | ||
| BiP binding to the ER-stress sensor Ire1 tunes the homeostatic behavior of the unfolded protein response | Q33631257 | ||
| Mechanism of non-spliceosomal mRNA splicing in the unfolded protein response pathway | Q33891036 | ||
| XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway | Q33926690 | ||
| IRE1 and efferent signaling from the endoplasmic reticulum. | Q34062577 | ||
| On the mechanism of sensing unfolded protein in the endoplasmic reticulum | Q34230593 | ||
| The mammalian tRNA ligase complex mediates splicing of XBP1 mRNA and controls antibody secretion in plasma cells | Q34807567 | ||
| Messenger RNA targeting to endoplasmic reticulum stress signalling sites. | Q34903088 | ||
| The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response | Q35029280 | ||
| TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages. | Q35041384 | ||
| IRE1α activation protects mice against acetaminophen-induced hepatotoxicity | Q35760821 | ||
| The differentiation and stress response factor XBP-1 drives multiple myeloma pathogenesis | Q35830099 | ||
| Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy | Q35909430 | ||
| Silencing of lipid metabolism genes through IRE1α-mediated mRNA decay lowers plasma lipids in mice. | Q36330343 | ||
| Transcription factor B cell lineage-specific activator protein regulates the gene for human X-box binding protein 1 | Q36366273 | ||
| Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis. | Q36393034 | ||
| ATF4 is an oxidative stress-inducible, prodeath transcription factor in neurons in vitro and in vivo | Q36640055 | ||
| The unfolded protein response is activated in pretangle neurons in Alzheimer's disease hippocampus | Q37164517 | ||
| Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma | Q37284612 | ||
| Regulated Ire1-dependent decay of messenger RNAs in mammalian cells | Q37309146 | ||
| The role of X-box binding protein-1 in tumorigenicity. | Q37553966 | ||
| Targeting the unfolded protein response in disease. | Q38132652 | ||
| Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response. | Q38311676 | ||
| Induction of CHOP expression by amino acid limitation requires both ATF4 expression and ATF2 phosphorylation | Q38347783 | ||
| Unfolded proteins are Ire1-activating ligands that directly induce the unfolded protein response | Q38845249 | ||
| Virus-tumor interactome screen reveals ER stress response can reprogram resistant cancers for oncolytic virus-triggered caspase-2 cell death. | Q39455351 | ||
| Peptides derived from the bifunctional kinase/RNase enzyme IRE1α modulate IRE1α activity and protect cells from endoplasmic reticulum stress. | Q39523027 | ||
| IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates. | Q39814866 | ||
| Chemical biology investigation of cell death pathways activated by endoplasmic reticulum stress reveals cytoprotective modulators of ASK1. | Q39917756 | ||
| IRE1 signaling is essential for ischemia-induced vascular endothelial growth factor-A expression and contributes to angiogenesis and tumor growth in vivo. | Q40105547 | ||
| Heat shock protein inhibition is associated with activation of the unfolded protein response pathway in myeloma plasma cells | Q40128062 | ||
| Activation of the endoplasmic reticulum stress pathway is associated with survival of myeloma cells | Q40333400 | ||
| Ire1 has distinct catalytic mechanisms for XBP1/HAC1 splicing and RIDD. | Q41585784 | ||
| Imaging the unfolded protein response in primary tumors reveals microenvironments with metabolic variations that predict tumor growth. | Q41844309 | ||
| X box-binding protein 1 regulates angiogenesis in human pancreatic adenocarcinomas. | Q41859494 | ||
| Activation of the unfolded protein response enhances motor recovery after spinal cord injury | Q42143560 | ||
| Delineation of a negative feedback regulatory loop that controls protein translation during endoplasmic reticulum stress | Q42163338 | ||
| Xbp1s-negative tumor B cells and pre-plasmablasts mediate therapeutic proteasome inhibitor resistance in multiple myeloma | Q42762683 | ||
| Autocrine control of glioma cells adhesion and migration through IRE1α-mediated cleavage of SPARC mRNA. | Q43811645 | ||
| Expression and splicing of the unfolded protein response gene XBP-1 are significantly associated with clinical outcome of endocrine-treated breast cancer | Q46665995 | ||
| Involvement of endoplasmic reticulum stress after middle cerebral artery occlusion in mice | Q48126818 | ||
| Increased Expression of Endoplasmic Reticulum Stress-Related Signaling Pathway Molecules in Multiple Sclerosis Lesions | Q62391380 | ||
| P304 | page(s) | 48-56 | |
| P577 | publication date | 2015-05-16 | |
| P1433 | published in | Seminars in Cancer Biology | Q1908668 |
| P1476 | title | Targeting the IRE1α-XBP1 branch of the unfolded protein response in human diseases | |
| P478 | volume | 33 |
| Q50026357 | A Human Genome-wide RNAi Screen Reveals Diverse Modulators that Mediate IRE1α-XBP1 Activation. |
| Q96303232 | A multi-omics analysis reveals the unfolded protein response regulon and stress-induced resistance to folate-based antimetabolites |
| Q57065820 | Acinar cell injury induced by inadequate unfolded protein response in acute pancreatitis |
| Q36053744 | Acridine Derivatives as Inhibitors of the IRE1α-XBP1 Pathway Are Cytotoxic to Human Multiple Myeloma. |
| Q41985154 | Activation of TGF-β signaling induces cell death via the unfolded protein response in Fuchs endothelial corneal dystrophy |
| Q89619563 | Alpha-Synuclein Physiology and Pathology: A Perspective on Cellular Structures and Organelles |
| Q90618648 | Antimetastatic Effect of Fucoidan-Sargassum against Liver Cancer Cell Invadopodia Formation via Targeting Integrin αVβ3 and Mediating αVβ3/Src/E2F1 Signaling |
| Q47596098 | Are sigma receptor modulators a weapon against multiple sclerosis disease? |
| Q36296461 | Chemical Space Mimicry for Drug Discovery |
| Q89058295 | Comprehensive Analysis of the Unfolded Protein Response in Breast Cancer Subtypes |
| Q38785751 | Critical role of X-box binding protein 1 in NADPH oxidase 4-triggered cardiac hypertrophy is mediated by receptor interacting protein kinase 1. |
| Q89920678 | Crosstalk between RNA Metabolism and Cellular Stress Responses during Zika Virus Replication |
| Q92351754 | Disruption of IRE1α through its kinase domain attenuates multiple myeloma |
| Q93159480 | Efavirenz and Efavirenz-like Compounds Activate Human, Murine, and Macaque Hepatic IRE1α-XBP1 |
| Q39456845 | Endoplasmic Reticulum Stress and the Hallmarks of Cancer |
| Q61808975 | Endoplasmic Reticulum Stress: Implications for Neuropsychiatric Disorders |
| Q102211135 | Endoplasmic reticulum stress signals in the tumour and its microenvironment |
| Q64276682 | Hypoxia Induced ER Stress Response as an Adaptive Mechanism in Cancer |
| Q60922809 | Hypoxia imaging in upper gastrointestinal tumors and application to radiation therapy |
| Q55283549 | IRE1α Implications in Endoplasmic Reticulum Stress-Mediated Development and Pathogenesis of Autoimmune Diseases. |
| Q91691839 | IRE1α maintains HSC stemness under ER-stress |
| Q37261144 | Identification of Doxorubicin as an Inhibitor of the IRE1α-XBP1 Axis of the Unfolded Protein Response |
| Q47189096 | Inhibition of IRE1 Results in Decreased Scar Formation |
| Q90074418 | Interplay between Endoplasmic Reticulum (ER) Stress and Autophagy Induces Mutant p53H273 Degradation |
| Q47927511 | Knockdown of IRE1α inhibits colonic tumorigenesis through decreasing β-catenin and IRE1α targeting suppresses colon cancer cells |
| Q53240576 | Lipopolysaccharide Activates the Unfolded Protein Response in Human Periodontal Ligament Fibroblasts. |
| Q93216150 | LncRNA GOLGA2P10 is induced by PERK/ATF4/CHOP signaling and protects tumor cells from ER stress-induced apoptosis by regulating Bcl-2 family members |
| Q36355151 | Mutant uromodulin expression leads to altered homeostasis of the endoplasmic reticulum and activates the unfolded protein response. |
| Q89157677 | Neoadjuvant-Intensive Androgen Deprivation Therapy Selects for Prostate Tumor Foci with Diverse Subclonal Oncogenic Alterations |
| Q90752087 | Nucleotide-binding oligomerization domain protein 2 attenuates ER stress-induced cell death in vascular smooth muscle cells |
| Q55025408 | Old and Young Actors Playing Novel Roles in the Drama of Multiple Myeloma Bone Marrow Microenvironment Dependent Drug Resistance. |
| Q92783522 | Oriented attachment of VNAR proteins, via site-selective modification, on PLGA-PEG nanoparticles enhances nanoconjugate performance |
| Q45072108 | Orientia tsutsugamushi modulates endoplasmic reticulum-associated degradation to benefit its growth |
| Q36404060 | Overexpression of X-Box Binding Protein 1 (XBP1) Correlates to Poor Prognosis and Up-Regulation of PI3K/mTOR in Human Osteosarcoma |
| Q57175095 | Perspective of Future Potent Therapies for Fuchs Endothelial Corneal Dystrophy |
| Q98466198 | Prognostic and Clinicopathological Significance of X-Box-Binding Protein 1 and N-Acetyltransferase 1 in Gallbladder Cancer |
| Q33653691 | Recent Insights into the Role of Unfolded Protein Response in ER Stress in Health and Disease |
| Q39396098 | Regulating Secretory Proteostasis through the Unfolded Protein Response: From Function to Therapy |
| Q92035617 | Role of ghrelin isoforms in the mitigation of hepatic inflammation, mitochondrial dysfunction, and endoplasmic reticulum stress after bariatric surgery in rats |
| Q42334839 | Sigmar1 regulates endoplasmic reticulum stress-induced C/EBP-homologous protein expression in cardiomyocytes |
| Q89965531 | The Emerging Roles of Endoplasmic Reticulum Stress in Balancing Immunity and Tolerance in Health and Diseases: Mechanisms and Opportunities |
| Q41828232 | The transcription factor XBP1 in memory and cognition: Implications in Alzheimer disease |
| Q39229321 | Therapeutics for APOL1 nephropathies: putting out the fire in the podocyte |
| Q64883325 | Unfolded Protein Response (UPR) in Survival, Dormancy, Immunosuppression, Metastasis, and Treatments of Cancer Cells. |
| Q93044600 | Vitamin D, bone alkaline phosphatase and parathyroid hormone in healthy subjects and haemodialysed patients from West Africa: impact of reference ranges and parathyroid hormone generation assays on the KDIGO guidelines |
| Q40980456 | YD277 Suppresses Triple-Negative Breast Cancer Partially Through Activating the Endoplasmic Reticulum Stress Pathway |
| Q38801551 | c-Jun N-terminal Kinase-Dependent Endoplasmic Reticulum Stress Pathway is Critically Involved in Arjunic Acid Induced Apoptosis in Non-Small Cell Lung Cancer Cells |
| Q38637035 | β cell ER stress and the implications for immunogenicity in type 1 diabetes |
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