| scholarly article | Q13442814 |
| P50 | author | David Ron | Q18195722 |
| Frank Sicheri | Q28037300 | ||
| Heather P Harding | Q55457426 | ||
| Cole M Haynes | Q92003191 | ||
| P2093 | author name string | Yuhong Zhang | |
| R Luke Wiseman | |||
| Kenneth P K Lee | |||
| Joshua Price | |||
| P2860 | cites work | Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1 | Q22011167 |
| XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor | Q24292102 | ||
| A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells | Q24309442 | ||
| Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination | Q26778405 | ||
| Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine | Q27628650 | ||
| Structure of the Dual Enzyme Ire1 Reveals the Basis for Catalysis and Regulation in Nonconventional RNA Splicing | Q27649529 | ||
| The unfolded protein response signals through high-order assembly of Ire1 | Q27653139 | ||
| Crystal structure of the Src family tyrosine kinase Hck | Q27734750 | ||
| Coot: model-building tools for molecular graphics | Q27860505 | ||
| Signal integration in the endoplasmic reticulum unfolded protein response | Q27860577 | ||
| UCSF Chimera--a visualization system for exploratory research and analysis | Q27860666 | ||
| Phasercrystallographic software | Q27860930 | ||
| Refinement of macromolecular structures by the maximum-likelihood method | Q27861011 | ||
| Scaling and assessment of data quality | Q27861107 | ||
| The integration of macromolecular diffraction data | Q27861123 | ||
| A transmembrane protein with a cdc2+/CDC28-related kinase activity is required for signaling from the ER to the nucleus | Q27930818 | ||
| Signalling from endoplasmic reticulum to nucleus: transcription factor with a basic-leucine zipper motif is required for the unfolded protein-response pathway | Q27932953 | ||
| The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response | Q27933479 | ||
| IRE1 encodes a putative protein kinase containing a membrane-spanning domain and is required for inositol phototrophy in Saccharomyces cerevisiae | Q27935778 | ||
| A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response | Q27938493 | ||
| Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase | Q27938837 | ||
| IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA | Q28214814 | ||
| Intracellular signaling by the unfolded protein response | Q28250477 | ||
| Regulation of hepatic lipogenesis by the transcription factor XBP1 | Q28507784 | ||
| Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes | Q28575190 | ||
| Cloning of mammalian Ire1 reveals diversity in the ER stress responses | Q28587224 | ||
| Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response | Q29547299 | ||
| Biological and chemical approaches to diseases of proteostasis deficiency | Q29616633 | ||
| Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus | Q29620179 | ||
| On the mechanism of sensing unfolded protein in the endoplasmic reticulum | Q34230593 | ||
| The unfolded protein response coordinates the production of endoplasmic reticulum protein and endoplasmic reticulum membrane | Q34673029 | ||
| Messenger RNA targeting to endoplasmic reticulum stress signalling sites. | Q34903088 | ||
| Orchestrating the unfolded protein response in health and disease | Q35001604 | ||
| XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum. | Q36322684 | ||
| Regulated Ire1-dependent decay of messenger RNAs in mammalian cells | Q37309146 | ||
| Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response. | Q38311676 | ||
| IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates. | Q39814866 | ||
| Bypassing a Kinase Activity with an ATP-Competitive Drug | Q44621093 | ||
| Ligand-independent dimerization activates the stress response kinases IRE1 and PERK in the lumen of the endoplasmic reticulum | Q50336389 | ||
| Characterizing protein-protein interactions by sedimentation velocity analytical ultracentrifugation. | Q51878549 | ||
| Protein synthesis inhibition by flavonoids: roles of eukaryotic initiation factor 2alpha kinases | Q73175455 | ||
| P433 | issue | 2 | |
| P921 | main subject | cell biology | Q7141 |
| ligand binding | Q61659151 | ||
| P304 | page(s) | 291-304 | |
| P577 | publication date | 2010-04-23 | |
| P1433 | published in | Molecular Cell | Q3319468 |
| P1476 | title | Flavonol Activation Defines an Unanticipated Ligand-Binding Site in the Kinase-RNase Domain of IRE1 | |
| P478 | volume | 38 |
| Q35899544 | A Covalent Cysteine-Targeting Kinase Inhibitor of Ire1 Permits Allosteric Control of Endoribonuclease Activity. |
| Q36780339 | A modified UPR stress sensing system reveals a novel tissue distribution of IRE1/XBP1 activity during normal Drosophila development |
| Q99593981 | A phenolic small molecule inhibitor of RNase L prevents cell death from ADAR1 deficiency |
| Q93170718 | A screening platform to monitor RNA processing and protein-RNA interactions in ribonuclease P uncovers a small molecule inhibitor |
| Q27678245 | Assembly of a π–π stack of ligands in the binding site of an acetylcholine-binding protein |
| Q36000128 | BH3-only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1α. |
| Q58581117 | Binding Analysis of the Inositol-Requiring Enzyme 1 Kinase Domain |
| Q35743424 | Cell-Based High-Throughput Luciferase Reporter Gene Assays for Identifying and Profiling Chemical Modulators of Endoplasmic Reticulum Signaling Protein, IRE1. |
| Q34673896 | Chemical screens against a reconstituted multiprotein complex: myricetin blocks DnaJ regulation of DnaK through an allosteric mechanism |
| Q27670678 | Cofactor-mediated conformational control in the bifunctional kinase/RNase Ire1 |
| Q34773696 | Comprehensive analysis of the HEPN superfamily: identification of novel roles in intra-genomic conflicts, defense, pathogenesis and RNA processing |
| Q42584468 | Computational evidence for intramolecular hydrogen bonding and nonbonding X···O interactions in 2'-haloflavonols. |
| Q42514348 | Cooling-Induced ER Stress is Good for Your Brain |
| Q90690936 | Development of a Chemical Toolset for Studying the Paralog-Specific Function of IRE1 |
| Q37529746 | Discovery, Synthesis, and Evaluation of 2,4-Diaminoquinazolines as a Novel Class of Pancreatic β-Cell-Protective Agents against Endoplasmic Reticulum (ER) Stress. |
| Q34630595 | Distinct autophagosomal-lysosomal fusion mechanism revealed by thapsigargin-induced autophagy arrest |
| Q39713276 | Divergence and Conservation of the Major UPR Branch IRE1-bZIP Signaling Pathway across Eukaryotes |
| Q26827965 | Emerging functions of the unfolded protein response in immunity |
| Q35055531 | Endoplasmic reticulum stress and the unfolded protein response in nonalcoholic fatty liver disease |
| Q40051888 | Endoplasmic reticulum stress and unfolded protein response in infection by intracellular parasites. |
| Q36626672 | Endoplasmic reticulum stress sensing in the unfolded protein response |
| Q57243233 | Endoplasmic reticulum stress signalling - from basic mechanisms to clinical applications |
| Q37811174 | Endoplasmic reticulum stress-sensing mechanisms in yeast and mammalian cells |
| Q35333412 | Getting the better of ER stress. |
| Q42023856 | Ginkgolide K protects the heart against endoplasmic reticulum stress injury by activating the inositol-requiring enzyme 1α/X box-binding protein-1 pathway |
| Q34058167 | HacA-independent functions of the ER stress sensor IreA synergize with the canonical UPR to influence virulence traits in Aspergillus fumigatus |
| Q41062525 | High-throughput screen of natural product extracts in a yeast model of polyglutamine proteotoxicity. |
| Q38960360 | IRE1-dependent activation of AMPK in response to nitric oxide |
| Q37261144 | Identification of Doxorubicin as an Inhibitor of the IRE1α-XBP1 Axis of the Unfolded Protein Response |
| Q24600346 | Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma |
| Q34471638 | Identification of autophosphorylation inhibitors of the inositol-requiring enzyme 1 alpha (IRE1α) by high-throughput screening using a DELFIA assay |
| Q34756838 | Identification of small molecules that protect pancreatic β cells against endoplasmic reticulum stress-induced cell death |
| Q38159909 | Impact of the UPR on the virulence of the plant fungal pathogen A. brassicicola |
| Q38996766 | Inhibition of ER stress-associated IRE-1/XBP-1 pathway reduces leukemic cell survival |
| Q35128117 | Inhibition of RNase L and RNA-dependent protein kinase (PKR) by sunitinib impairs antiviral innate immunity. |
| Q41558826 | Inhibition of protein translocation at the endoplasmic reticulum promotes activation of the unfolded protein response |
| Q26827218 | Innate immunity at mucosal surfaces: the IRE1-RIDD-RIG-I pathway |
| Q37635791 | Inositol-requiring enzyme 1 inhibits respiratory syncytial virus replication |
| Q29615495 | Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress |
| Q41585784 | Ire1 has distinct catalytic mechanisms for XBP1/HAC1 splicing and RIDD. |
| Q38297313 | METABOLISM. S-Nitrosylation links obesity-associated inflammation to endoplasmic reticulum dysfunction. |
| Q38394944 | Membrane aberrancy and unfolded proteins activate the endoplasmic reticulum stress sensor Ire1 in different ways |
| Q36712468 | Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domains |
| Q42410200 | Modulating protein quality control |
| Q30404387 | Molecular mechanisms of human IRE1 activation through dimerization and ligand binding |
| Q35590995 | Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response |
| Q35139989 | Phosphoregulation of Ire1 RNase splicing activity. |
| Q41583320 | Physiological/pathological ramifications of transcription factors in the unfolded protein response |
| Q35140089 | Pirin1 (PRN1) is a multifunctional protein that regulates quercetin, and impacts specific light and UV responses in the seed-to-seedling transition of Arabidopsis thaliana |
| Q24628936 | Potent and selective inhibitors of the inositol-requiring enzyme 1 endoribonuclease |
| Q89944484 | Potential Implications of Quercetin and its Derivatives in Cardioprotection |
| Q26801512 | Protein Folding and Mechanisms of Proteostasis |
| Q42790541 | Proteostasis: a new therapeutic paradigm for pulmonary disease |
| Q92723713 | Quercetin Regulates the Integrated Stress Response to Improve Memory |
| Q33886820 | Regulation of basal cellular physiology by the homeostatic unfolded protein response |
| Q92534980 | Screening and identification of inhibitors of endoplasmic reticulum stress-induced activation of the IRE1α-XBP1 branch |
| Q27640568 | Structure and mechanism of action of the hydroxy–aryl–aldehyde class of IRE1 endoribonuclease inhibitors |
| Q24292966 | Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response |
| Q24602153 | Sustained translational repression by eIF2α-P mediates prion neurodegeneration |
| Q38489729 | Targeting the IRE1α-XBP1 branch of the unfolded protein response in human diseases |
| Q38545670 | Targeting the unfolded protein response for disease intervention |
| Q38104475 | Targeting unfolded protein response signaling pathways to ameliorate protein misfolding diseases |
| Q26738803 | The Natural Occurring Compounds Targeting Endoplasmic Reticulum Stress |
| Q38095788 | The UPR in atherosclerosis |
| Q57105740 | The Unfolded Protein Response in Breast Cancer |
| Q38818892 | The Unfolded Protein Response in Homeostasis and Modulation of Mammalian Immune Cells. |
| Q39431986 | The Unfolded Protein Response in the Immune Cell Development: Putting the Caretaker in the Driving Seat |
| Q33717397 | The endoplasmic reticulum protein folding factory and its chaperones: new targets for drug discovery? |
| Q38201042 | The essential biology of the endoplasmic reticulum stress response for structural and computational biologists. |
| Q41869460 | The inhibitory effect of quercetin on asymmetric dimethylarginine-induced apoptosis is mediated by the endoplasmic reticulum stress pathway in glomerular endothelial cells |
| Q24596804 | The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule |
| Q38994927 | The rise of proteostasis promoters |
| Q37641509 | The unfolded protein response (UPR) pathway in Cryptococcus |
| Q29615499 | The unfolded protein response: controlling cell fate decisions under ER stress and beyond |
| Q29547396 | The unfolded protein response: from stress pathway to homeostatic regulation |
| Q24293771 | The unfolded protein response: integrating stress signals through the stress sensor IRE1α |
| Q38091948 | UPR Signal Activation by Luminal Sensor Domains |
| Q27936554 | Unfolded protein response regulates yeast small GTPase Arl1p activation at late Golgi via phosphorylation of Arf GEF Syt1p |
| Q41889596 | Unfolded protein responses with or without unfolded proteins? |
| Q37381743 | Xbp1-independent Ire1 signaling is required for photoreceptor differentiation and rhabdomere morphogenesis in Drosophila |
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