Targeting IRE1 with small molecules counteracts progression of atherosclerosis

scientific article published on 30 January 2017

Targeting IRE1 with small molecules counteracts progression of atherosclerosis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1073/PNAS.1621188114
P932PMC publication ID5338400
P698PubMed publication ID28137856

P50authorPeter WalterQ106367
Christian WeberQ37838769
Diego Acosta-AlvearQ47463553
Ebru ErbayQ63768542
Pelin TELKOPARAN AKILLILARQ64854241
Ismail CimenQ83606028
P2093author name stringBegum Kocaturk
Ozlem Tufanli
Syed Muhammad Hamid
Umut Inci Onat
P2860cites workPharmacological brake-release of mRNA translation enhances cognitive memoryQ21128794
Inflammation, stress, and diabetesQ24523336
The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small moleculeQ24596804
Blockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myelomaQ24598483
Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myelomaQ24600346
Potent and selective inhibitors of the inositol-requiring enzyme 1 endoribonucleaseQ24628936
The response-to-retention hypothesis of early atherogenesisQ24629974
Endoplasmic reticulum stress and the inflammatory basis of metabolic diseaseQ24633352
Inflammasomes: mechanism of action, role in disease, and therapeuticsQ27001186
Homocysteine-induced endoplasmic reticulum stress and growth arrest leads to specific changes in gene expression in human vascular endothelial cellsQ28140489
Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosisQ28385517
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
The modulation of endoplasmic reticulum stress by chemical chaperone upregulates immune negative cytokine IL-35 in apolipoprotein E-deficient miceQ28539349
Toll-like receptor-mediated IRE1α activation as a therapeutic target for inflammatory arthritisQ28589300
The unfolded protein response: from stress pathway to homeostatic regulationQ29547396
Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signalingQ29616024
Reduced apoptosis and plaque necrosis in advanced atherosclerotic lesions of Apoe-/- and Ldlr-/- mice lacking CHOP.Q30488194
The Role of Endoplasmic Reticulum Stress in the Progression of AtherosclerosisQ34141006
Reduction of endoplasmic reticulum stress inhibits neointima formation after vascular injuryQ34460553
Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunitQ34471020
Lipotoxicity: when tissues overeatQ35168828
IRE1 inhibition perturbs the unfolded protein response in a pancreatic β-cell line expressing mutant proinsulin, but does not sensitize the cells to apoptosisQ35204732
Cleavage of BLOC1S1 mRNA by IRE1 Is Sequence Specific, Temporally Separate from XBP1 Splicing, and Dispensable for Cell Viability under Acute Endoplasmic Reticulum StressQ35626096
Critical role for calcium mobilization in activation of the NLRP3 inflammasomeQ36094313
Silencing of lipid metabolism genes through IRE1α-mediated mRNA decay lowers plasma lipids in mice.Q36330343
Jnk1 Deficiency in Hematopoietic Cells Suppresses Macrophage Apoptosis and Increases Atherosclerosis in Low-Density Lipoprotein Receptor Null Mice.Q36940644
IRE1α cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2.Q37091581
Sustained activation of XBP1 splicing leads to endothelial apoptosis and atherosclerosis development in response to disturbed flowQ37176759
An imbalance between specialized pro-resolving lipid mediators and pro-inflammatory leukotrienes promotes instability of atherosclerotic plaquesQ37282266
Regulated Ire1-dependent decay of messenger RNAs in mammalian cellsQ37309146
The serine-threonine kinase inositol-requiring enzyme 1α (IRE1α) promotes IL-4 production in T helper cellsQ37311417
Collagens in the progression and complications of atherosclerosisQ37368729
Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosisQ37465347
Causal analysis approaches in Ingenuity Pathway AnalysisQ37592031
Macrophage mitochondrial oxidative stress promotes atherosclerosis and nuclear factor-κB-mediated inflammation in macrophages.Q37624935
Restoring endoplasmic reticulum function by chemical chaperones: an emerging therapeutic approach for metabolic diseases.Q37804462
Chemical and/or biological therapeutic strategies to ameliorate protein misfolding diseasesQ37819121
Recent advances on the role of cytokines in atherosclerosisQ37867358
InterfERing with endoplasmic reticulum stressQ37960224
The UPR in atherosclerosisQ38095788
The development and progression of atherosclerosis: evidence supporting a role for endoplasmic reticulum (ER) stress signaling.Q38132458
Targeting the unfolded protein response in disease.Q38132652
Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response.Q38311676
Prevention of atherosclerosis by bioactive palmitoleate through suppression of organelle stress and inflammasome activation.Q39297825
IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress.Q39299575
Hypercholesterolemia is associated with a T helper (Th) 1/Th2 switch of the autoimmune response in atherosclerotic apo E-knockout miceQ39802780
Saturated Fatty Acids Engage an IRE1α-Dependent Pathway to Activate the NLRP3 Inflammasome in Myeloid CellsQ41876369
The unfolded protein response is an important regulator of inflammatory genes in endothelial cellsQ42500350
T helper-cell phenotype regulates atherosclerosis in mice under conditions of mild hypercholesterolemiaQ43624009
IFN-gamma deficiency exerts gender-specific effects on atherogenesis in apolipoprotein E-/- miceQ44090158
The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophagesQ44542540
Requirement of JNK2 for scavenger receptor A-mediated foam cell formation in atherogenesisQ45165256
Characterization of a novel PERK kinase inhibitor with antitumor and antiangiogenic activityQ46379013
Activation of the unfolded protein response occurs at all stages of atherosclerotic lesion development in apolipoprotein E-deficient miceQ46421418
The unfolded protein response in health and diseaseQ47682274
Bax and the mitochondrial permeability transition cooperate in the release of cytochrome c during endoplasmic reticulum-stress-induced apoptosisQ79434810
Increased endoplasmic reticulum stress in atherosclerotic plaques associated with acute coronary syndromeQ80819961
Nrf2 is essential for cholesterol crystal-induced inflammasome activation and exacerbation of atherosclerosisQ83836296
Phospholipolyzed LDL induces an inflammatory response in endothelial cells through endoplasmic reticulum stress signalingQ84133568
P4510describes a project that usesImageJQ1659584
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectatherosclerosisQ12252367
P304page(s)E1395-E1404
P577publication date2017-01-30
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleTargeting IRE1 with small molecules counteracts progression of atherosclerosis
P478volume114

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cites work (P2860)
Q98224918Analysis of Differentially Expressed Genes and Molecular Pathways in Familial Hypercholesterolemia Involved in Atherosclerosis: A Systematic and Bioinformatics Approach
Q90439211Anti-Inflammatory Effects of HDL (High-Density Lipoprotein) in Macrophages Predominate Over Proinflammatory Effects in Atherosclerotic Plaques
Q49850608Bax Inhibitor-1 protects from Non-Alcoholic Steatohepatitis by limiting IRE1α signaling
Q47708298CAMKIIγ suppresses an efferocytosis pathway in macrophages and promotes atherosclerotic plaque necrosis.
Q104111317Calsequestrin: a well-known but curious protein in skeletal muscle
Q64255361Carbon monoxide releasing molecule-3 alleviates neuron death after spinal cord injury via inflammasome regulation
Q90380813Catestatin improves insulin sensitivity by attenuating endoplasmic reticulum stress: In vivo and in silico validation
Q93052031Crosstalk Between Hypoxia and ER Stress Response: A Key Regulator of Macrophage Polarization
Q92676587Double bond configuration of palmitoleate is critical for atheroprotection
Q93155378Dual role of Endoplasmic Reticulum Stress-Mediated Unfolded Protein Response Signaling Pathway in Carcinogenesis
Q90361766ER Stress Responses: An Emerging Modulator for Innate Immunity
Q58554232Emerging Roles for Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) in Pancreatic Beta Cells and Diabetes
Q41673313Endoplasmic Reticulum Stress Mediates Methamphetamine-Induced Blood-Brain Barrier Damage
Q41102193Endoplasmic Reticulum Stress Sensor IRE1α Enhances IL-23 Expression by Human Dendritic Cells.
Q55456504Endoplasmic Reticulum Stress in Metabolic Disorders.
Q64080392Endoplasmic Reticulum Stress: A Critical Molecular Driver of Endothelial Dysfunction and Cardiovascular Disturbances Associated with Diabetes
Q64933372Epsilon-Globin HBE1 Enhances Radiotherapy Resistance by Down-Regulating BCL11A in Colorectal Cancer Cells.
Q55283549IRE1α Implications in Endoplasmic Reticulum Stress-Mediated Development and Pathogenesis of Autoimmune Diseases.
Q90073188IRE1α Promotes Zika Virus Infection via XBP1
Q42677134IRE1α/XBP1s branch of UPR links HIF1α activation to mediate ANGII-dependent endothelial dysfunction under particulate matter (PM) 2.5 exposure
Q92647382Inhibition of IRE1α RNase activity reduces NLRP3 inflammasome assembly and processing of pro-IL1β
Q64076341Intercepting the Lipid-Induced Integrated Stress Response Reduces Atherosclerosis
Q49026058Macrophages and lipid metabolism
Q97636448Pharmacologic IRE1/XBP1s activation confers targeted ER proteostasis reprogramming
Q33653691Recent Insights into the Role of Unfolded Protein Response in ER Stress in Health and Disease
Q42380832Regulated Ire1-dependent mRNA decay requires no-go mRNA degradation to maintain endoplasmic reticulum homeostasis in S. pombe.
Q88732947Regulation of macrophage immunometabolism in atherosclerosis
Q64052546Right place, right time: localisation and assembly of the NLRP3 inflammasome
Q89848670Suppression of IRE1α Attenuated the Fatty Degeneration in Parenteral Nutrition-Related Liver Disease (PNALD) Cell Model
Q89965531The Emerging Roles of Endoplasmic Reticulum Stress in Balancing Immunity and Tolerance in Health and Diseases: Mechanisms and Opportunities
Q91994816The Role of Protein Tyrosine Phosphatase (PTP)-1B in Cardiovascular Disease and Its Interplay with Insulin Resistance
Q74440818The Turkish paradox: Can scientists thrive in a state of emergency?
Q54977802The kinase receptor-interacting protein 1 is required for inflammasome activation induced by endoplasmic reticulum stress.
Q52730972The unfolded protein response in ischemic heart disease.
Q91732402Two pools of IRE1α in cardiac and skeletal muscle cells
Q92166012Unfolded Protein Response as a Therapeutic Target in Cardiovascular Disease

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