| review article | Q7318358 |
| scholarly article | Q13442814 |
| P2093 | author name string | Yingfeng Deng | |
| Thomas G Gillette | |||
| Zhao V Wang | |||
| Guangyu Zhang | |||
| Xiaoding Wang | |||
| P2860 | cites work | XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor | Q24292102 |
| The unfolded protein response: integrating stress signals through the stress sensor IRE1α | Q24293771 | ||
| Identification of a potential tumor differentiation factor receptor candidate in prostate cancer cells | Q24324464 | ||
| Blockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myeloma | Q24598483 | ||
| Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicing | Q24627782 | ||
| Potent and selective inhibitors of the inositol-requiring enzyme 1 endoribonuclease | Q24628936 | ||
| Structure and mechanism of action of the hydroxy–aryl–aldehyde class of IRE1 endoribonuclease inhibitors | Q27640568 | ||
| The unfolded protein response signals through high-order assembly of Ire1 | Q27653139 | ||
| The structure of the PERK kinase domain suggests the mechanism for its activation | Q27667715 | ||
| Discovery of 1H-pyrazol-3(2H)-ones as potent and selective inhibitors of protein kinase R-like endoplasmic reticulum kinase (PERK) | Q27697500 | ||
| Signal integration in the endoplasmic reticulum unfolded protein response | Q27860577 | ||
| Tumor progression and the different faces of the PERK kinase | Q28087036 | ||
| Compounds Triggering ER Stress Exert Anti-Melanoma Effects and Overcome BRAF Inhibitor Resistance | Q28115258 | ||
| IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA | Q28214814 | ||
| Folding proteins in fatal ways | Q28235206 | ||
| Binding of activated alpha2-macroglobulin to its cell surface receptor GRP78 in 1-LN prostate cancer cells regulates PAK-2-dependent activation of LIMK | Q28252185 | ||
| Protein quality control and metabolism: bidirectional control in the heart | Q28256472 | ||
| Role of endoplasmic reticulum stress in light-induced photoreceptor degeneration in mice | Q39231671 | ||
| Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2 | Q39315996 | ||
| OSU-03012 suppresses GRP78/BiP expression that causes PERK-dependent increases in tumor cell killing | Q39392716 | ||
| The antidiabetic drug metformin inhibits gastric cancer cell proliferation in vitro and in vivo | Q39416862 | ||
| Hepatic ATF6 Increases Fatty Acid Oxidation to Attenuate Hepatic Steatosis in Mice Through Peroxisome Proliferator-Activated Receptor α. | Q39748140 | ||
| BiP/GRP78 is an intracellular target for MDA-7/IL-24 induction of cancer-specific apoptosis | Q40243264 | ||
| ATF6 Decreases Myocardial Ischemia/Reperfusion Damage and Links ER Stress and Oxidative Stress Signaling Pathways in the Heart. | Q40433966 | ||
| Molecular docking and molecular dynamics studies reveal structural basis of inhibition and selectivity of inhibitors EGCG and OSU-03012 toward glucose regulated protein-78 (GRP78) overexpressed in glioblastoma | Q40485377 | ||
| The glucose-regulated proteins (GRP78 and GRP94): functions, gene regulation, and applications | Q40647911 | ||
| Salubrinal protects cardiomyocytes against apoptosis in a rat myocardial infarction model via suppressing the dephosphorylation of eukaryotic translation initiation factor 2α. | Q40891456 | ||
| Ginkgolide K protects the heart against endoplasmic reticulum stress injury by activating the inositol-requiring enzyme 1α/X box-binding protein-1 pathway | Q42023856 | ||
| Endoplasmic reticulum stress response mediated by the PERK-eIF2(alpha)-ATF4 pathway is involved in osteoblast differentiation induced by BMP2 | Q42094437 | ||
| Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch. | Q42115604 | ||
| The unfolded protein response is an important regulator of inflammatory genes in endothelial cells | Q42500350 | ||
| Role of the unfolded protein response regulator GRP78/BiP in development, cancer, and neurological disorders. | Q42919393 | ||
| Post-treatment of a BiP inducer prevents cell death after middle cerebral artery occlusion in mice | Q42937511 | ||
| Arctigenin blocks the unfolded protein response and shows therapeutic antitumor activity | Q43128390 | ||
| Characterization of the binding sites of the anticancer ruthenium(III) complexes KP1019 and KP1339 on human serum albumin via competition studies | Q43451056 | ||
| Attenuation of endoplasmic reticulum stress using the chemical chaperone 4-phenylbutyric acid prevents cardiac fibrosis induced by isoproterenol | Q43666922 | ||
| The unfolded protein response is associated with early tau pathology in the hippocampus of tauopathies | Q44995707 | ||
| Conformational disease | Q46332791 | ||
| Reduced retinal function in amyloid precursor protein-over-expressing transgenic mice via attenuating glutamate-N-methyl-d-aspartate receptor signaling | Q46437491 | ||
| Biodistribution of the novel anticancer drug sodium trans-[tetrachloridobis(1H-indazole)ruthenate(III)] KP-1339/IT139 in nude BALB/c mice and implications on its mode of action | Q46577268 | ||
| ER Protein Quality Control and the Unfolded Protein Response in the Heart. | Q47659541 | ||
| The chemical chaperone 4-phenylbutyric acid attenuates pressure-overload cardiac hypertrophy by alleviating endoplasmic reticulum stress | Q48554370 | ||
| Heart Disease and Stroke Statistics-2018 Update: A Report From the American Heart Association | Q49546493 | ||
| Pharmacologic inhibition of S1P attenuates ATF6 expression, causes ER stress and contributes to apoptotic cell death. | Q52566833 | ||
| Endoplasmic reticulum stress activates SRC, relocating chaperones to the cell surface where GRP78/CD109 blocks TGF-β signaling. | Q52691191 | ||
| Glucose-regulated protein 78 is essential for cardiac myocyte survival. | Q52718679 | ||
| The unfolded protein response in ischemic heart disease. | Q52730972 | ||
| Glucose-deprived HT-29 human colon carcinoma cells are sensitive to verrucosidin as a GRP78 down-regulator. | Q53583479 | ||
| Role of the unfolded protein response in organ physiology: lessons from mouse models. | Q54397189 | ||
| The serine/threonine-protein kinase/endoribonuclease IRE1α protects the heart against pressure overload-induced heart failure. | Q54978911 | ||
| Endoplasmic Reticulum Chaperone GRP78 Protects Heart From Ischemia/Reperfusion Injury Through Akt Activation. | Q54980775 | ||
| Safety and activity of IT-139, a ruthenium-based compound, in patients with advanced solid tumours: a first-in-human, open-label, dose-escalation phase I study with expansion cohort. | Q55065627 | ||
| Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum proteins | Q56530196 | ||
| Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis | Q60909468 | ||
| Activation of the unfolded protein response in infarcted mouse heart and hypoxic cultured cardiac myocytes | Q64377708 | ||
| Clinical and local biological effects of an intratumoral injection of mda-7 (IL24; INGN 241) in patients with advanced carcinoma: a phase I study | Q64379100 | ||
| Quality Control in the Endoplasmic Reticulum: Crosstalk between ERAD and UPR pathways. | Q64971224 | ||
| Methoxyflavones protect cells against endoplasmic reticulum stress and neurotoxin | Q80258491 | ||
| Cell surface expression of the stress response chaperone GRP78 enables tumor targeting by circulating ligands | Q80591503 | ||
| Endoplasmic reticulum stress gene induction and protection from ischemia/reperfusion injury in the hearts of transgenic mice with a tamoxifen-regulated form of ATF6 | Q83118076 | ||
| Sugarcoating ER Stress | Q87445532 | ||
| Proapoptotic Cyclic Peptide BC71 Targets Cell-Surface GRP78 and Functions as an Anticancer Therapeutic in Mice | Q89118995 | ||
| GRP78 Is a Targetable Receptor on Cancer and Stromal Cells | Q89573688 | ||
| GRP78 (Glucose-Regulated Protein of 78 kDa) Promotes Cardiomyocyte Growth Through Activation of GATA4 (GATA-Binding Protein 4) | Q90725026 | ||
| ATF6 Regulates Cardiac Hypertrophy by Transcriptional Induction of the mTORC1 Activator, Rheb | Q90735566 | ||
| The UPR Activator ATF6 Responds to Proteotoxic and Lipotoxic Stress by Distinct Mechanisms | Q90817500 | ||
| A molecular chaperone inducer protects neurons from ER stress | Q28259344 | ||
| Protein aggregation and neurodegenerative disease | Q28273600 | ||
| Prolonged endoplasmic reticulum stress in hypertrophic and failing heart after aortic constriction: possible contribution of endoplasmic reticulum stress to cardiac myocyte apoptosis | Q28275274 | ||
| Oral treatment targeting the unfolded protein response prevents neurodegeneration and clinical disease in prion-infected mice | Q28300013 | ||
| Regulation of hepatic lipogenesis by the transcription factor XBP1 | Q28507784 | ||
| ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals | Q28646129 | ||
| The unfolded protein response: from stress pathway to homeostatic regulation | Q29547396 | ||
| The mammalian unfolded protein response | Q29547400 | ||
| Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress | Q29615495 | ||
| Pyrvinium targets the unfolded protein response to hypoglycemia and its anti-tumor activity is enhanced by combination therapy | Q33392721 | ||
| Cancer antineovascular therapy with liposome drug delivery systems targeted to BiP/GRP78. | Q33533593 | ||
| Structural determinants of PERK inhibitor potency and selectivity | Q33744382 | ||
| GRP78 is a novel receptor initiating a vascular barrier protective response to oxidized phospholipids | Q33811945 | ||
| Cell surface relocalization of the endoplasmic reticulum chaperone and unfolded protein response regulator GRP78/BiP. | Q33832578 | ||
| Targeted nanoparticles that deliver a sustained, specific release of Paclitaxel to irradiated tumors | Q33891952 | ||
| Finding the missing link between the unfolded protein response and O-GlcNAcylation in the heart | Q34127646 | ||
| Toxic proteins in neurodegenerative disease | Q34133493 | ||
| The Role of Endoplasmic Reticulum Stress in the Progression of Atherosclerosis | Q34141006 | ||
| Roles for ATF6 and the sarco/endoplasmic reticulum protein quality control system in the heart | Q34150205 | ||
| Endoplasmic reticulum stress sensor protein kinase R-like endoplasmic reticulum kinase (PERK) protects against pressure overload-induced heart failure and lung remodeling | Q34173536 | ||
| Protein kinase RNA-like endoplasmic reticulum kinase (PERK) signaling pathway plays a major role in reactive oxygen species (ROS)-mediated endoplasmic reticulum stress-induced apoptosis in diabetic cardiomyopathy | Q34252960 | ||
| Guanabenz, which enhances the unfolded protein response, ameliorates mutant SOD1-induced amyotrophic lateral sclerosis. | Q34266579 | ||
| The glucose-regulated proteins: stress induction and clinical applications | Q34336908 | ||
| Dilated cardiomyopathy caused by aberrant endoplasmic reticulum quality control in mutant KDEL receptor transgenic mice | Q34344775 | ||
| A peptidic unconjugated GRP78/BiP ligand modulates the unfolded protein response and induces prostate cancer cell death | Q34437578 | ||
| Organelle-specific initiation of cell death pathways | Q34443559 | ||
| Repositioning of Verrucosidin, a purported inhibitor of chaperone protein GRP78, as an inhibitor of mitochondrial electron transport chain complex I. | Q34766688 | ||
| Pharmacokinetics of a novel anticancer ruthenium complex (KP1019, FFC14A) in a phase I dose-escalation study | Q34942271 | ||
| Chemical chaperones: a pharmacological strategy for disorders of protein folding and trafficking | Q35001649 | ||
| GRP78/BiP is required for cell proliferation and protecting the inner cell mass from apoptosis during early mouse embryonic development | Q35070987 | ||
| NELL2 function in the protection of cells against endoplasmic reticulum stress | Q35093814 | ||
| Roles for endoplasmic reticulum-associated degradation and the novel endoplasmic reticulum stress response gene Derlin-3 in the ischemic heart | Q35898986 | ||
| Beyond the endoplasmic reticulum: atypical GRP78 in cell viability, signalling and therapeutic targeting | Q35964550 | ||
| The impact of the unfolded protein response on human disease | Q36062081 | ||
| A window of opportunity: timing protein degradation by trimming of sugars and ubiquitins | Q36160302 | ||
| Protein kinase R-like endoplasmic reticulum kinase and glycogen synthase kinase-3α/β regulate foam cell formation | Q36196818 | ||
| MicroRNA regulation of unfolded protein response transcription factor XBP1 in the progression of cardiac hypertrophy and heart failure in vivo | Q36286532 | ||
| Structure activity relationship and optimization of N-(3-(2-aminothiazol-4-yl)aryl)benzenesulfonamides as anti-cancer compounds against sensitive and resistant cells | Q36333246 | ||
| Hrd1 and ER-Associated Protein Degradation, ERAD, are Critical Elements of the Adaptive ER Stress Response in Cardiac Myocytes | Q36348263 | ||
| ER stress, hypoxia tolerance and tumor progression. | Q36393499 | ||
| PERK is required in the adult pancreas and is essential for maintenance of glucose homeostasis | Q36435206 | ||
| Role of the unfolded protein response, GRP78 and GRP94 in organ homeostasis. | Q36497621 | ||
| A cell-penetrating peptidic GRP78 ligand for tumor cell-specific prodrug therapy | Q36528120 | ||
| GRP78 plays an essential role in adipogenesis and postnatal growth in mice | Q36615162 | ||
| Harnessing the integrated stress response for the treatment of multiple sclerosis. | Q36689566 | ||
| Identification of proteins associating with glycosylphosphatidylinositol- anchored T-cadherin on the surface of vascular endothelial cells: role for Grp78/BiP in T-cadherin-dependent cell survival | Q36710808 | ||
| ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death. | Q36954378 | ||
| Dual function of pancreatic endoplasmic reticulum kinase in tumor cell growth arrest and survival. | Q36983432 | ||
| Deregulation of XBP1 expression contributes to myocardial vascular endothelial growth factor-A expression and angiogenesis during cardiac hypertrophy in vivo. | Q37066974 | ||
| The 78-kD Glucose-Regulated Protein Regulates Endoplasmic Reticulum Homeostasis and Distal Epithelial Cell Survival during Lung Development | Q37088283 | ||
| Cardiotoxicity associated with tyrosine kinase inhibitor sunitinib | Q37098098 | ||
| OSU-03012 stimulates PKR-like endoplasmic reticulum-dependent increases in 70-kDa heat shock protein expression, attenuating its lethal actions in transformed cells | Q37172898 | ||
| Sustained activation of XBP1 splicing leads to endothelial apoptosis and atherosclerosis development in response to disturbed flow | Q37176759 | ||
| Metallothionein alleviates oxidative stress-induced endoplasmic reticulum stress and myocardial dysfunction | Q37245087 | ||
| IRE1: ER stress sensor and cell fate executor | Q37282044 | ||
| Ischemia activates the ATF6 branch of the endoplasmic reticulum stress response | Q37447782 | ||
| Unfolded protein response regulates cardiac sodium current in systolic human heart failure | Q37540104 | ||
| Endoplasmic reticulum stress promotes macrophage-derived foam cell formation by up-regulating cluster of differentiation 36 (CD36) expression | Q37583467 | ||
| Spliced X-box binding protein 1 couples the unfolded protein response to hexosamine biosynthetic pathway | Q37648367 | ||
| XBP1: the last two decades | Q37649065 | ||
| Targeting IRE1 with small molecules counteracts progression of atherosclerosis | Q37682288 | ||
| Biology of Endoplasmic Reticulum Stress in the Heart | Q37808904 | ||
| Glucose-regulated proteins in cancer: molecular mechanisms and therapeutic potential | Q38198491 | ||
| Targeted disruption of CRE-binding factor TREB5 gene leads to cellular necrosis in cardiac myocytes at the embryonic stage | Q38322371 | ||
| Effect on tumor cells of blocking survival response to glucose deprivation | Q38337197 | ||
| GRP78 at the Centre of the Stage in Cancer and Neuroprotection | Q38692967 | ||
| CF3 Derivatives of the Anticancer Ru(III) Complexes KP1019, NKP-1339, and Their Imidazole and Pyridine Analogues Show Enhanced Lipophilicity, Albumin Interactions, and Cytotoxicity | Q38773341 | ||
| Protein kinase R(PKR)-like endoplasmic reticulum kinase (PERK) inhibitors: a patent review (2010-2015). | Q38819666 | ||
| Matrine attenuates cardiac fibrosis by affecting ATF6 signaling pathway in diabetic cardiomyopathy | Q39185537 | ||
| P433 | issue | 21 | |
| P921 | main subject | cardiovascular disease | Q389735 |
| P304 | page(s) | 1902-1917 | |
| P577 | publication date | 2019-01-01 | |
| P1433 | published in | Current Topics in Medicinal Chemistry | Q2734725 |
| P1476 | title | Unfolded Protein Response as a Therapeutic Target in Cardiovascular Disease | |
| P478 | volume | 19 |
| Q89497717 | Integrating ER and Mitochondrial Proteostasis in the Healthy and Diseased Heart | cites work | P2860 |
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