Hepatocyte-specific deletion of XBP1 sensitizes mice to liver injury through hyperactivation of IRE1α

scientific article published on 20 November 2020

Hepatocyte-specific deletion of XBP1 sensitizes mice to liver injury through hyperactivation of IRE1α is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41418-020-00671-1
P932PMC publication ID8166833
P698PubMed publication ID33219328

P50authorKenji KohnoQ87970327
Jacquelyn MaherQ102220439
P2093author name stringAras N Mattis
Takao Iwawaki
Russell K Soon
Chris Her
Caroline C Duwaerts
Kevin Siao
P2860cites workX-box Binding Protein 1 Regulates Unfolded Protein, Acute-Phase, and DNA Damage Responses During Regeneration of Mouse LiverQ45863602
Endoplasmic reticulum stress plays a central role in development of leptin resistanceQ46178586
Bax Inhibitor-1 protects from Non-Alcoholic Steatohepatitis by limiting IRE1α signalingQ49850608
IRE1-XBP1 pathway regulates oxidative proinsulin folding in pancreatic β cells.Q52728755
A simple method to determine nanogram levels of 4-hydroxyproline in biological tissuesQ70859629
ER stress signaling by regulated splicing: IRE1/HAC1/XBP1Q81604032
Endoplasmic reticulum stress signalling and the pathogenesis of non-alcoholic fatty liver diseaseQ89235898
IRE1A Stimulates Hepatocyte-derived Extracellular Vesicles That Promote Inflammation in Mice With SteatohepatitisQ96648187
XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel diseaseQ22252318
Plasma cell differentiation requires the transcription factor XBP-1Q24291453
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein ResponseQ28585314
Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stressQ29615495
The unfolded protein response: controlling cell fate decisions under ER stress and beyondQ29615499
Hepatocytes release ceramide-enriched pro-inflammatory extracellular vesicles in an IRE1α-dependent mannerQ30701525
Allosteric inhibition of the IRE1α RNase preserves cell viability and function during endoplasmic reticulum stress.Q34572339
The contribution of endoplasmic reticulum stress to liver diseasesQ34860549
Dissociation of inositol-requiring enzyme (IRE1α)-mediated c-Jun N-terminal kinase activation from hepatic insulin resistance in conditional X-box-binding protein-1 (XBP1) knock-out miceQ35709954
IRE1α activation protects mice against acetaminophen-induced hepatotoxicityQ35760821
IRE1α-Dependent Decay of CReP/Ppp1r15b mRNA Increases Eukaryotic Initiation Factor 2α Phosphorylation and Suppresses Protein SynthesisQ35868391
Endoplasmic reticulum stress in liver diseaseQ36031838
XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum.Q36322684
Silencing of lipid metabolism genes through IRE1α-mediated mRNA decay lowers plasma lipids in mice.Q36330343
Hepatocyte X-box binding protein 1 deficiency increases liver injury in mice fed a high-fat/sugar dietQ36382065
Hepatic Xbp1 Gene Deletion Promotes Endoplasmic Reticulum Stress-induced Liver Injury and ApoptosisQ36444262
IRE1α-XBP1s induces PDI expression to increase MTP activity for hepatic VLDL assembly and lipid homeostasisQ36600595
IRE1α cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2.Q37091581
Regulated Ire1-dependent decay of messenger RNAs in mammalian cellsQ37309146
Dietary sucrose is essential to the development of liver injury in the methionine-choline-deficient model of steatohepatitisQ37337488
Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways.Q37363053
Function of IRE1 alpha in the placenta is essential for placental development and embryonic viabilityQ37377347
Getting RIDD of RNA: IRE1 in cell fate regulationQ38198370
XBP1s Is an Anti-lipogenic ProteinQ38291938
IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress.Q39299575
Integrated stress response of vertebrates is regulated by four eIF2α kinasesQ39384642
Coordinate regulation of phospholipid biosynthesis and secretory pathway gene expression in XBP-1(S)-induced endoplasmic reticulum biogenesis.Q42832143
Polyunsaturated fat in the methionine-choline-deficient diet influences hepatic inflammation but not hepatocellular injuryQ44680230
P577publication date2020-11-20
P1433published inCell Death & DifferentiationQ2943974
P1476titleHepatocyte-specific deletion of XBP1 sensitizes mice to liver injury through hyperactivation of IRE1α

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