Hepatic Xbp1 Gene Deletion Promotes Endoplasmic Reticulum Stress-induced Liver Injury and Apoptosis

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Hepatic Xbp1 Gene Deletion Promotes Endoplasmic Reticulum Stress-induced Liver Injury and Apoptosis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M115.676239
P8608Fatcat IDrelease_7r6chkuv7nfxxl7vnfrlwq3uu4
P932PMC publication ID4706001
P698PubMed publication ID26504083

P2093author name stringShantel Olivares
Anne S Henkel
P2860cites workCaspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-betaQ22011091
Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1Q22011167
Induction of early-immediate genes by tumer necrosis factor alpha contribute to liver repair following chemical-induced hepatotoxicityQ23909368
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factorQ24292102
Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans developmentQ24292104
TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell deathQ24298384
CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cellsQ24301679
pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress responseQ24303865
A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein responseQ24305069
Unconventional splicing of XBP1 mRNA occurs in the cytoplasm during the mammalian unfolded protein responseQ24316572
Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alphaQ24322072
Endoplasmic reticulum stress: cell life and death decisions.Q24536108
Hepatitis C virus subgenomic replicons induce endoplasmic reticulum stress activating an intracellular signaling pathwayQ24537844
ER stress controls iron metabolism through induction of hepcidinQ24630714
Divergent effects of PERK and IRE1 signaling on cell viabilityQ27438124
Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathwaysQ28365886
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulumQ28509611
Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox stateQ28572472
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetesQ28575190
Cloning of mammalian Ire1 reveals diversity in the ER stress responsesQ28587224
Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosisQ28588618
Rapid turnover of unspliced Xbp-1 as a factor that modulates the unfolded protein responseQ28589998
The unfolded protein response: from stress pathway to homeostatic regulationQ29547396
Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stressQ29615495
Mediators of endoplasmic reticulum stress-induced apoptosisQ29615496
IRE1 signaling affects cell fate during the unfolded protein responseQ29615502
ER stress triggers apoptosis by activating BH3-only protein BimQ29617730
Homocysteine supplementation attenuates the unfolded protein response in a murine nutritional model of steatohepatitisQ33553744
Liver regenerationQ33870218
A chronic high-cholesterol diet paradoxically suppresses hepatic CYP7A1 expression in FVB/NJ miceQ34503382
Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expressionQ34563098
Signaling the unfolded protein response from the endoplasmic reticulum.Q35740723
Initiation of liver growth by tumor necrosis factor: deficient liver regeneration in mice lacking type I tumor necrosis factor receptorQ35997495
Endoplasmic reticulum stress signaling in diseaseQ36610455
Translational control and the unfolded protein responseQ36924278
The unfolded protein response in fatty liver diseaseQ38162132
Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed miceQ38354947
Molecular imaging of N-linked glycosylation suggests glycan biosynthesis is a novel target for cancer therapyQ39711705
Hepatitis C virus NS4B induces unfolded protein response and endoplasmic reticulum overload response-dependent NF-kappaB activationQ39821567
Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cellsQ40313352
Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver diseaseQ44934521
Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosisQ81441036
P433issue50
P407language of work or nameEnglishQ1860
P921main subjectendoplasmic reticulumQ79927
P304page(s)30142-30151
P577publication date2015-10-26
P1433published inJournal of Biological ChemistryQ867727
P1476titleHepatic Xbp1 Gene Deletion Promotes Endoplasmic Reticulum Stress-induced Liver Injury and Apoptosis
P478volume290

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cites work (P2860)
Q9262636712-h clock regulation of genetic information flow by XBP1s
Q50420689Developmental origins of non-alcoholic fatty liver disease as a risk factor for exaggerated metabolic and cardiovascular-renal disease.
Q37673642Endoplasmic Reticulum Stress Regulates Hepatic Bile Acid Metabolism in Mice
Q97522970Endoplasmic reticulum stress and liver diseases
Q58616116Hepatic Sel1L-Hrd1 ER-associated degradation (ERAD) manages FGF21 levels and systemic metabolism via CREBH
Q102220441Hepatocyte-specific deletion of XBP1 sensitizes mice to liver injury through hyperactivation of IRE1α
Q47104419Induction of fibroblast growth factor 21 does not require activation of the hepatic X-box binding protein 1 in mice
Q38759104Lipotoxicity pathways intersect in hepatocytes: Endoplasmic reticulum stress, c-Jun N-terminal kinase-1, and death receptors
Q42334839Sigmar1 regulates endoplasmic reticulum stress-induced C/EBP-homologous protein expression in cardiomyocytes
Q93350086The role of X-box binding protein 1 in the hepatic response to refeeding in mice
Q36302806Toyocamycin attenuates free fatty acid-induced hepatic steatosis and apoptosis in cultured hepatocytes and ameliorates nonalcoholic fatty liver disease in mice.

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