Endoplasmic Reticulum Stress Regulates Hepatic Bile Acid Metabolism in Mice

scientific article published on 10 December 2016

Endoplasmic Reticulum Stress Regulates Hepatic Bile Acid Metabolism in Mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.JCMGH.2016.11.006
P8608Fatcat IDrelease_ivdfe5en4vcrlgw3us2u7zjhay
P932PMC publication ID5331781
P698PubMed publication ID28275692

P2093author name stringRichard M Green
Shantel Olivares
Anne S Henkel
Brian LeCuyer
P2860cites workCoupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1Q22011167
Molecular basis for feedback regulation of bile acid synthesis by nuclear receptorsQ24290397
A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein responseQ24305069
Unconventional splicing of XBP1 mRNA occurs in the cytoplasm during the mammalian unfolded protein responseQ24316572
Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expressionQ24336351
The heteromeric organic solute transporter alpha-beta, Ostalpha-Ostbeta, is an ileal basolateral bile acid transporterQ24531357
Transport of bile acids in multidrug-resistance-protein 3-overexpressing cells co-transfected with the ileal Na+-dependent bile-acid transporterQ24534978
Hepatitis C virus subgenomic replicons induce endoplasmic reticulum stress activating an intracellular signaling pathwayQ24537844
ER stress controls iron metabolism through induction of hepcidinQ24630714
Bile acid transportersQ24652624
Bile acids: regulation of synthesisQ24658139
The enzymes, regulation, and genetics of bile acid synthesisQ28204726
Regulation of cholesterol-7alpha-hydroxylase: BAREly missing a SHPQ28208653
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNAQ28214814
Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestineQ28242281
Cytochrome P450s and cholesterol homeostasisQ28254484
Endoplasmic reticulum stress activates the hepatic activator protein 1 complex via mitogen activated protein kinase-dependent signaling pathwaysQ28391490
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulumQ28509611
The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liverQ28571688
Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox stateQ28572472
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetesQ28575190
Regulation of oxysterol 7alpha-hydroxylase (CYP7B1) in the ratQ28577847
Obstructive cholestasis induces TNF-alpha- and IL-1 -mediated periportal downregulation of Bsep and zonal regulation of Ntcp, Oatp1a4, and Oatp1b2Q28579409
IRE1 signaling affects cell fate during the unfolded protein responseQ29615502
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetesQ29615503
Hepatic Injury in Nonalcoholic Steatohepatitis Contributes to Altered Intestinal PermeabilityQ30665173
Homocysteine supplementation attenuates the unfolded protein response in a murine nutritional model of steatohepatitisQ33553744
Inflammatory cytokines, but not bile acids, regulate expression of murine hepatic anion transporters in endotoxemia.Q44138937
Hepatic overexpression of murine Abcb11 increases hepatobiliary lipid secretion and reduces hepatic steatosisQ44626804
Quantitative estimations of the contribution of different bile acid pathways to total bile acid synthesis in the rat.Q45108263
Cytokine-dependent regulation of hepatic organic anion transporter gene transactivators in mouse liverQ46463048
FGF19 (fibroblast growth factor 19) as a novel target gene for activating transcription factor 4 in response to endoplasmic reticulum stressQ46735156
CHOP deficiency attenuates cholestasis-induced liver fibrosis by reduction of hepatocyte injuryQ46823993
Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis.Q52541251
Endoplasmic reticulum stress, hepatocyte CD1d and NKT cell abnormalities in murine fatty livers.Q53543252
Regulation of hepatocyte bile salt transporters by endotoxin and inflammatory cytokines in rodentsQ71235032
Farnesoid X receptor responds to bile acids and represses cholesterol 7alpha-hydroxylase gene (CYP7A1) transcriptionQ73643139
Interleukin-6 regulates hepatic transporters during acute-phase responseQ80457063
Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosisQ81441036
Loss of nuclear receptor SHP impairs but does not eliminate negative feedback regulation of bile acid synthesisQ33566678
Contribution of cholesterol 7alpha-hydroxylase to the regulation of lipoprotein metabolismQ33730842
Inflammation-induced cholestasisQ33756581
A chronic high-cholesterol diet paradoxically suppresses hepatic CYP7A1 expression in FVB/NJ miceQ34503382
Efficient drug screening and gene correction for treating liver disease using patient-specific stem cellsQ34550486
Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expressionQ34563098
Hepatocyte-specific ablation of Foxa2 alters bile acid homeostasis and results in endoplasmic reticulum stressQ34801719
Bile acids and cytokines inhibit the human cholesterol 7 alpha-hydroxylase gene via the JNK/c-jun pathway in human liver cellsQ34894300
Treatment of mouse liver slices with cholestatic hepatotoxicants results in down-regulation of Fxr and its target genesQ35013686
Death Receptor-Mediated Cell Death and Proinflammatory Signaling in Nonalcoholic SteatohepatitisQ35122049
Lowering bile acid pool size with a synthetic farnesoid X receptor (FXR) agonist induces obesity and diabetes through reduced energy expenditureQ35128295
IRE1α activation protects mice against acetaminophen-induced hepatotoxicityQ35760821
Regulation of bile acid synthesis: pathways, nuclear receptors, and mechanisms.Q35763029
Dysregulated intrahepatic CD4(+) T-cell activation drives liver inflammation in ileitis-prone SAMP1/YitFc miceQ35880725
Endoplasmic reticulum stress in liver diseaseQ36031838
Silencing of lipid metabolism genes through IRE1α-mediated mRNA decay lowers plasma lipids in mice.Q36330343
Hepatic Xbp1 Gene Deletion Promotes Endoplasmic Reticulum Stress-induced Liver Injury and ApoptosisQ36444262
IRE1α-XBP1s induces PDI expression to increase MTP activity for hepatic VLDL assembly and lipid homeostasisQ36600595
Principles of hepatic organic anion transporter regulation during cholestasis, inflammation and liver regenerationQ36732805
IRE1α cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2.Q37091581
Regulated Ire1-dependent decay of messenger RNAs in mammalian cellsQ37309146
Role of bile acids and bile acid receptors in metabolic regulationQ37363616
Rat cholangiocytes absorb bile acids at their apical domain via the ileal sodium-dependent bile acid transporterQ37375465
Endotoxin downregulates rat hepatic ntcp gene expression via decreased activity of critical transcription factorsQ37381843
Getting RIDD of RNA: IRE1 in cell fate regulationQ38198370
Dietary cholesterol fails to stimulate the human cholesterol 7alpha-hydroxylase gene (CYP7A1) in transgenic miceQ38289975
Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response.Q38311676
Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed miceQ38354947
Effects of triglyceride on ER stress and insulin resistanceQ40080488
Bile Salt Binding to Serum Components. Taurocholate Incorporation into High-Density Lipoprotein Revealed by Photoaffinity LabellingQ40280260
Cytokine regulation of human sterol 12alpha-hydroxylase (CYP8B1) gene.Q40490287
Activation of the promoters of genes associated with DNA damage, oxidative stress, ER stress and protein malfolding by the bile salt, deoxycholateQ40931435
Hepatocyte nuclear factor 1 binds to and transactivates the human but not the rat CYP7A1 promoterQ41678786
Mechanism of tissue-specific farnesoid X receptor in suppressing the expression of genes in bile-acid synthesis in miceQ42110387
Endotoxin, TNF, and IL-1 decrease cholesterol 7 alpha-hydroxylase mRNA levels and activityQ42529069
Down-regulation of cholesterol 7alpha-hydroxylase (CYP7A1) gene expression by bile acids in primary rat hepatocytes is mediated by the c-Jun N-terminal kinase pathwayQ43559873
Cellular localization and up-regulation of multidrug resistance-associated protein 3 in hepatocytes and cholangiocytes during obstructive cholestasis in rat liverQ43563069
The negative effects of bile acids and tumor necrosis factor-alpha on the transcription of cholesterol 7alpha-hydroxylase gene (CYP7A1) converge to hepatic nuclear factor-4: a novel mechanism of feedback regulation of bile acid synthesis mediated byQ43636951
Mice expressing the human CYP7A1 gene in the mouse CYP7A1 knock-out background lack induction of CYP7A1 expression by cholesterol feeding and have increased hypercholesterolemia when fed a high fat dietQ44119079
P4510describes a project that usesImageJQ1659584
P433issue2
P921main subjectendoplasmic reticulumQ79927
P304page(s)261-271
P577publication date2016-12-10
P1433published inCellular and molecular gastroenterology and hepatologyQ27726289
P1476titleEndoplasmic Reticulum Stress Regulates Hepatic Bile Acid Metabolism in Mice
P478volume3

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cites work (P2860)
Q98193720A Fibrosis-Independent Hepatic Transcriptomic Signature Identifies Novel Drivers of Disease Progression in Primary Sclerosing Cholangitis
Q90575053Calnexin Depletion by Endoplasmic Reticulum Stress During Cholestasis Inhibits the Na+-Taurocholate Cotransporting Polypeptide
Q42319052Endoplasmic Reticulum Stress Emerges as Novel Regulator for Bile Acid Synthesis
Q97522970Endoplasmic reticulum stress and liver diseases
Q55344969Organic Solute Transporter α-β Protects Ileal Enterocytes From Bile Acid-Induced Injury.

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