Lipotoxicity pathways intersect in hepatocytes: Endoplasmic reticulum stress, c-Jun N-terminal kinase-1, and death receptors

scientific article published on 3 March 2016

Lipotoxicity pathways intersect in hepatocytes: Endoplasmic reticulum stress, c-Jun N-terminal kinase-1, and death receptors is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/HEPR.12658
P698PubMed publication ID26938481

P2093author name stringKazuhiko Nakao
Yuko Akazawa
P2860cites workmiR-33a/b contribute to the regulation of fatty acid metabolism and insulin signalingQ24627398
Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinaseQ27938837
Mixed lineage kinase 3 deficient mice are protected against the high fat high carbohydrate diet-induced steatohepatitis.Q38627620
S100A8 Production in CXCR2-Expressing CD11b+Gr-1high Cells Aggravates Hepatitis in Mice Fed a High-Fat and High-Cholesterol DietQ38816512
Degradation of Keap1 activates BH3-only proteins Bim and PUMA during hepatocyte lipoapoptosisQ39000961
Degradation of cIAPs contributes to hepatocyte lipoapoptosisQ39099740
A hedgehog survival pathway in 'undead' lipotoxic hepatocytes.Q39340993
Glycogen synthase kinase-3 (GSK-3) inhibition attenuates hepatocyte lipoapoptosisQ39621569
CHOP and AP-1 cooperatively mediate PUMA expression during lipoapoptosisQ39709114
Palmitoleate attenuates palmitate-induced Bim and PUMA up-regulation and hepatocyte lipoapoptosisQ39731721
IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates.Q39814866
TRAIL receptor deletion in mice suppresses the inflammation of nutrient excessQ39817074
Transcriptional regulation of Bim by FoxO3A mediates hepatocyte lipoapoptosisQ40108223
Insulin induces swelling-dependent activation of the epidermal growth factor receptor in rat liverQ41764183
Free fatty acids sensitise hepatocytes to TRAIL mediated cytotoxicityQ42409618
The liver's dance with death: two Bcl-2 guardian proteins from the abyssQ42723851
Hepatocyte caspase-8 is an essential modulator of steatohepatitis in rodentsQ44799911
A lipidomic analysis of nonalcoholic fatty liver disease.Q44931121
Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathwayQ44967749
The treatment with antibody of TNF-alpha reduces the inflammation, necrosis and fibrosis in the non-alcoholic steatohepatitis induced by methionine- and choline-deficient dietQ46860893
JNK1 but not JNK2 promotes the development of steatohepatitis in miceQ46865809
Role of vascular endothelial growth factor in the pathophysiology of nonalcoholic steatohepatitis in two rodent modelsQ49140588
Toll-like receptor-4 mediates obesity-induced non-alcoholic steatohepatitis through activation of X-box binding protein-1 in mice.Q54328614
Hepatocyte Apoptosis, Expression of Death Receptors, and Activation of NF-κB in the Liver of Nonalcoholic and Alcoholic Steatohepatitis PatientsQ57760193
Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinaseQ28296183
Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in miceQ28507402
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulumQ28509611
miR-122 regulation of lipid metabolism revealed by in vivo antisense targetingQ29547487
Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver diseaseQ29619334
Reduced lipoapoptosis, hedgehog pathway activation and fibrosis in caspase-2 deficient mice with non-alcoholic steatohepatitis.Q30365017
Constitutive role for IRE1α-XBP1 signaling pathway in the insulin-mediated hepatic lipogenic programQ30426645
Lipid-induced toxicity stimulates hepatocytes to release angiogenic microparticles that require Vanin-1 for uptake by endothelial cellsQ33593809
Saturated fatty acid induction of endoplasmic reticulum stress and apoptosis in human liver cells via the PERK/ATF4/CHOP signaling pathwayQ34128069
Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: a possible involvement of the ER stress pathway in hepatocarcinogenesisQ34192744
The unfolded protein response (UPR)-activated transcription factor X-box-binding protein 1 (XBP1) induces microRNA-346 expression that targets the human antigen peptide transporter 1 (TAP1) mRNA and governs immune regulatory genes.Q34224697
Circulating extracellular vesicles with specific proteome and liver microRNAs are potential biomarkers for liver injury in experimental fatty liver diseaseQ34626474
Bax inhibition protects against free fatty acid-induced lysosomal permeabilizationQ34665604
The contribution of endoplasmic reticulum stress to liver diseasesQ34860549
A role for miR-296 in the regulation of lipoapoptosis by targeting PUMAQ35107291
Death Receptor-Mediated Cell Death and Proinflammatory Signaling in Nonalcoholic SteatohepatitisQ35122049
Mmu-miR-615-3p regulates lipoapoptosis by inhibiting C/EBP homologous proteinQ35330939
Dysregulation of the unfolded protein response in db/db mice with diet-induced steatohepatitisQ35490178
Death receptor 5 signaling promotes hepatocyte lipoapoptosisQ35604362
ER stress induces NLRP3 inflammasome activation and hepatocyte death.Q36293033
Hepatocyte X-box binding protein 1 deficiency increases liver injury in mice fed a high-fat/sugar dietQ36382065
Apoptosis and necrosis in the liver: a tale of two deaths?Q36382247
Hepatic Xbp1 Gene Deletion Promotes Endoplasmic Reticulum Stress-induced Liver Injury and ApoptosisQ36444262
Overview of microRNA biologyQ36702371
C/EBP homologous protein-induced macrophage apoptosis protects mice from steatohepatitisQ36967242
Cell signaling in oxidative stress-induced liver injuryQ36989693
IRE1α cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2.Q37091581
Oxidative folding: cellular strategies for dealing with the resultant equimolar production of reactive oxygen speciesQ37401266
The adaptive endoplasmic reticulum stress response to lipotoxicity in progressive human nonalcoholic fatty liver diseaseQ37412003
Mcl-1 degradation during hepatocyte lipoapoptosisQ37431628
JNK1-dependent PUMA expression contributes to hepatocyte lipoapoptosisQ37446730
From sugar to fat: How the transcription factor XBP1 regulates hepatic lipogenesisQ37596560
Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver diseaseQ38358419
Cdc42 and Rac1 are major contributors to the saturated fatty acid-stimulated JNK pathway in hepatocytesQ38594016
Mixed lineage kinase 3 mediates release of C-X-C motif ligand 10-bearing chemotactic extracellular vesicles from lipotoxic hepatocytesQ38603408
P433issue10
P921main subjectendoplasmic reticulumQ79927
P304page(s)977-984
P577publication date2016-03-03
P1433published inHepatology ResearchQ15752035
P1476titleLipotoxicity pathways intersect in hepatocytes: Endoplasmic reticulum stress, c-Jun N-terminal kinase-1, and death receptors
P478volume46

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cites work (P2860)
Q64114918Detection of DNA damage response in nonalcoholic fatty liver disease via p53-binding protein 1 nuclear expression
Q92956295Fermented ginseng, GBCK25, ameliorates steatosis and inflammation in nonalcoholic steatohepatitis model
Q41867049Hepatitis C Virus Infection Increases c-Jun N-Terminal Kinase (JNK) Phosphorylation and Accentuates Hepatocyte Lipoapoptosis.
Q58705640Pathogenesis of Nonalcoholic Steatohepatitis and Hormone-Based Therapeutic Approaches
Q33862990Silencing of FABP1 ameliorates hepatic steatosis, inflammation, and oxidative stress in mice with nonalcoholic fatty liver disease
Q60924142The role of hepatic macrophages in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis

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