A hedgehog survival pathway in 'undead' lipotoxic hepatocytes.

scientific article published on 26 May 2012

A hedgehog survival pathway in 'undead' lipotoxic hepatocytes. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.JHEP.2012.05.011
P932PMC publication ID3467008
P698PubMed publication ID22641094

P50authorKeisuke KakisakaQ82520912
Gregory J GoresQ91520926
Joachim C. MertensQ39450778
P2093author name stringNathan W Werneburg
Sophie C Cazanave
Steve F Bronk
Nataliya Razumilava
P2860cites workCHOP and AP-1 cooperatively mediate PUMA expression during lipoapoptosisQ39709114
Hedgehog-mediated epithelial-to-mesenchymal transition and fibrogenic repair in nonalcoholic fatty liver disease.Q39829317
Compensatory proliferation in Drosophila imaginal discs requires Dronc-dependent p53 activityQ42272663
Pan-caspase inhibitor VX-166 reduces fibrosis in an animal model of nonalcoholic steatohepatitisQ43292661
Viral fusogenic membrane glycoprotein expression causes syncytia formation with bioenergetic cell death: implications for gene therapyQ45872868
Fluorescent detection of lipid droplets and associated proteinsQ46785353
Apoptotic cells can induce compensatory cell proliferation through the JNK and the Wingless signaling pathways.Q52652438
A novel murine model for non-alcoholic steatohepatitis developed by combination of a high-fat diet and oxidized low-density lipoprotein.Q54340432
Dissociation of Hepatic Steatosis and Insulin Resistance in Mice Overexpressing DGAT in the LiverQ57016669
Ballooned hepatocytes in steatohepatitis: the value of keratin immunohistochemistry for diagnosisQ80841895
Free fatty acids induce JNK-dependent hepatocyte lipoapoptosisQ82677113
Activation of the BCL2 promoter in response to Hedgehog/GLI signal transduction is predominantly mediated by GLI2Q28291091
Mitochondria and cell death: outer membrane permeabilization and beyondQ29615459
AP-1: a double-edged sword in tumorigenesisQ30014831
Hepatocellular ballooning in NASH.Q30430478
Hedgehog/Wnt feedback supports regenerative proliferation of epithelial stem cells in bladderQ30540440
Developmental pathways: Sonic hedgehog-Patched-GLIQ33538044
Hepatocyte Death: A Clear and Present DangerQ34147508
Peroxisomal beta-oxidation and peroxisome proliferator-activated receptor alpha: an adaptive metabolic systemQ34262892
Decreased apoptosis in the brain and premature lethality in CPP32-deficient miceQ34408475
Caspase-independent cell deathQ34433759
Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis.Q34511187
Triglyceride accumulation protects against fatty acid-induced lipotoxicityQ34866329
Regulatory enzymes of mitochondrial beta-oxidation as targets for treatment of the metabolic syndromeQ34998494
DRONC coordinates cell death and compensatory proliferation.Q35071338
Death receptor 5 signaling promotes hepatocyte lipoapoptosisQ35604362
Mechanisms of lysophosphatidylcholine-induced hepatocyte lipoapoptosisQ35939383
Hedgehog pathway activation parallels histologic severity of injury and fibrosis in human nonalcoholic fatty liver diseaseQ36402141
Distinct mechanisms of apoptosis-induced compensatory proliferation in proliferating and differentiating tissues in the Drosophila eye.Q36514191
Increased production of sonic hedgehog by ballooned hepatocytesQ36773522
Signals from dying hepatocytes trigger growth of liver progenitorsQ36785147
Cellular and molecular mechanisms of liver injuryQ36908855
Apoptosis-induced compensatory proliferation. The Cell is dead. Long live the Cell!Q37251077
Hedgehog signaling regulates the survival of gastric cancer cells by regulating the expression of Bcl-2.Q37335411
Hedgehog-Gli signaling pathway inhibitors as anticancer agents.Q37345013
Mcl-1 degradation during hepatocyte lipoapoptosisQ37431628
JNK1-dependent PUMA expression contributes to hepatocyte lipoapoptosisQ37446730
Lipotoxicity in nonalcoholic fatty liver disease: not all lipids are created equalQ37578517
Ductular reactions in human liver: diversity at the interfaceQ37943729
P433issue4
P304page(s)844-851
P577publication date2012-05-26
P1433published inJournal of HepatologyQ15724402
P1476titleA hedgehog survival pathway in 'undead' lipotoxic hepatocytes
P478volume57

Reverse relations

cites work (P2860)
Q36075087Accumulation of duct cells with activated YAP parallels fibrosis progression in non-alcoholic fatty liver disease.
Q55503094Apoptosis and non-alcoholic fatty liver diseases.
Q40326054Association between endotoxemia and histological features of nonalcoholic fatty liver disease
Q34777399Ballooned hepatocytes, undead cells, sonic hedgehog, and vitamin E: therapeutic implications for nonalcoholic steatohepatitis
Q88431630Evaluation of ballooned hepatocytes as a risk factor for future progression of fibrosis in patients with non-alcoholic fatty liver disease
Q90047443Hepatocyte Injury and Hepatic Stem Cell Niche in the Progression of Non-Alcoholic Steatohepatitis
Q61099995Hepatocyte Lethal and Nonlethal Lipotoxic Injury
Q57218880Inhibitory effects of extracts on palmitate-induced lipotoxicity in HepG2 cells
Q38799232Lipotoxic lethal and sublethal stress signaling in hepatocytes: relevance to NASH pathogenesis.
Q38759104Lipotoxicity pathways intersect in hepatocytes: Endoplasmic reticulum stress, c-Jun N-terminal kinase-1, and death receptors
Q37398932Liver microRNA-21 is overexpressed in non-alcoholic steatohepatitis and contributes to the disease in experimental models by inhibiting PPARα expression
Q33886995Liver zonation: Novel aspects of its regulation and its impact on homeostasis
Q57807657Molecular pathways of nonalcoholic fatty liver disease development and progression
Q49790075Non-alcoholic steatohepatitis pathogenesis: sublethal hepatocyte injury as a driver of liver inflammation
Q30365017Reduced lipoapoptosis, hedgehog pathway activation and fibrosis in caspase-2 deficient mice with non-alcoholic steatohepatitis.
Q45008552Reversing Advanced Hepatic Fibrosis in NASH: Clearly Possible, but Widely at Hand?
Q26743373Role of Hedgehog Signaling Pathway in NASH
Q58758006Role of canonical Hedgehog signaling pathway in liver
Q52349162The hedgehog pathway in nonalcoholic fatty liver disease.
Q54119547To die or not to die: death signaling in nonalcoholic fatty liver disease.
Q34560114Treatment response in the PIVENS trial is associated with decreased Hedgehog pathway activity
Q46103131Using non-thermal irreversible electroporation to create an in vivo niche for exogenous cell engraftment
Q38747634c-Jun N-terminal kinase-mediated Rubicon expression enhances hepatocyte lipoapoptosis and promotes hepatocyte ballooning.

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