The adaptive endoplasmic reticulum stress response to lipotoxicity in progressive human nonalcoholic fatty liver disease

scientific article published on 04 October 2013

The adaptive endoplasmic reticulum stress response to lipotoxicity in progressive human nonalcoholic fatty liver disease is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1093/TOXSCI/KFT230
P932PMC publication ID3871931
P698PubMed publication ID24097666

P50authorPetr NovakQ58827926
Fei ZhaoQ57038292
P2093author name stringWalter T Klimecki
Nathan J Cherrington
April D Lake
Rhiannon N Hardwick
Brieanna Flores-Keown
P2860cites workpXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress responseQ24303865
Unconventional splicing of XBP1 mRNA occurs in the cytoplasm during the mammalian unfolded protein responseQ24316572
In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver diseaseQ79788222
ATF6 is a transcription factor specializing in the regulation of quality control proteins in the endoplasmic reticulumQ80935578
Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver diseaseQ24319917
GAGE: generally applicable gene set enrichment for pathway analysisQ24645628
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocationQ28510062
Characterization of stanniocalcin 2, a novel target of the mammalian unfolded protein response with cytoprotective propertiesQ28578322
XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networksQ28591575
Autophagy regulates lipid metabolismQ29547421
Steatohepatitis: a tale of two "hits"?Q29547771
Design and validation of a histological scoring system for nonalcoholic fatty liver diseaseQ29614930
Constitutive role for IRE1α-XBP1 signaling pathway in the insulin-mediated hepatic lipogenic programQ30426645
Stanniocalcin 2 alters PERK signalling and reduces cellular injury during cerulein induced pancreatitis in miceQ33890582
Differing endoplasmic reticulum stress response to excess lipogenesis versus lipid oversupply in relation to hepatic steatosis and insulin resistance.Q34166238
Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammalsQ34245400
Diversity in antioxidant response enzymes in progressive stages of human nonalcoholic fatty liver diseaseQ34359482
Intersection of the unfolded protein response and hepatic lipid metabolismQ34985745
Autophagy in nonalcoholic steatohepatitisQ35014344
Endoplasmic reticulum stress and the unfolded protein response in nonalcoholic fatty liver diseaseQ35055531
Analysis of global and absorption, distribution, metabolism, and elimination gene expression in the progressive stages of human nonalcoholic fatty liver disease.Q35264808
Differential roles of unsaturated and saturated fatty acids on autophagy and apoptosis in hepatocytesQ35429910
Dysregulation of the unfolded protein response in db/db mice with diet-induced steatohepatitisQ35490178
Variations in ATP-binding cassette transporter regulation during the progression of human nonalcoholic fatty liver diseaseQ35579538
Pathophysiology of nonalcoholic steatohepatitisQ36422705
Apoptosis and autophagy: regulatory connections between two supposedly different processesQ36996255
ATF6 modulates SREBP2-mediated lipogenesis.Q37260315
Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver diseaseQ37310283
Molecular mechanisms and the role of saturated fatty acids in the progression of non-alcoholic fatty liver diseaseQ37405640
New diagnostic and treatment approaches in non-alcoholic fatty liver disease (NAFLD).Q37437435
From sugar to fat: How the transcription factor XBP1 regulates hepatic lipogenesisQ37596560
Autophagy in liver diseases.Q37784560
Apoptosis in nonalcoholic fatty liver disease: diagnostic and therapeutic implicationsQ37863133
Role of obesity and lipotoxicity in the development of nonalcoholic steatohepatitis: pathophysiology and clinical implicationsQ37983300
Endoplasmic reticulum stress in nonalcoholic fatty liver diseaseQ38027194
Lipid-induced endoplasmic reticulum stress in liver cells results in two distinct outcomes: adaptation with enhanced insulin signaling or insulin resistanceQ39388424
Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver diseaseQ44934521
Lipotoxicity in NASH.Q44967579
P4510describes a project that usesImageJQ1659584
P433issue1
P921main subjectendoplasmic reticulumQ79927
metabolic dysfunction–associated steatotic liver diseaseQ1546498
fatty liver diseaseQ6058862
P304page(s)26-35
P577publication date2013-10-04
P1433published inToxicological SciencesQ2446966
P1476titleThe adaptive endoplasmic reticulum stress response to lipotoxicity in progressive human nonalcoholic fatty liver disease
P478volume137

Reverse relations

cites work (P2860)
Q58697388A nonalcoholic fatty liver disease model in human induced pluripotent stem cell-derived hepatocytes, created by endoplasmic reticulum stress-induced steatosis
Q88541514Alcohol Metabolism in the Progression of Human Nonalcoholic Steatohepatitis
Q41641615Alcoholic steatohepatitis (ASH) causes more UPR-ER stress than non-alcoholic steatohepatitis (NASH).
Q35120968Biomarkers of NAFLD progression: a lipidomics approach to an epidemic
Q38577570Caring for children with NAFLD and navigating their care into adulthood
Q89558686Cellular Interactions in the Human Fatty Liver
Q34200914Decreasing mitochondrial fission alleviates hepatic steatosis in a murine model of nonalcoholic fatty liver disease
Q41115099Development of gene polymorphisms in meditators of nonalcoholic fatty liver disease
Q50420689Developmental origins of non-alcoholic fatty liver disease as a risk factor for exaggerated metabolic and cardiovascular-renal disease.
Q42362670Dysregulated expression of proteins associated with ER stress, autophagy and apoptosis in tissues from nonalcoholic fatty liver disease
Q38303313Early to Phase II drugs currently under investigation for the treatment of liver fibrosis
Q97522970Endoplasmic reticulum stress and liver diseases
Q27027733Endoplasmic reticulum stress in hepatic steatosis and inflammatory bowel diseases
Q51664532Genomics of human fatty liver disease reveal mechanistically linked lipid droplet-associated gene regulations in bland steatosis and nonalcoholic steatohepatitis.
Q26745984Hepatitis C Virus Infection Induces Autophagy as a Prosurvival Mechanism to Alleviate Hepatic ER-Stress Response
Q36382065Hepatocyte X-box binding protein 1 deficiency increases liver injury in mice fed a high-fat/sugar diet
Q36244747IL-1β-induced modulation of gene expression profile in human dermal fibroblasts: the effects of Thai herbal Sahatsatara formula, piperine and gallic acid possessing antioxidant properties
Q64999429IRE1α prevents hepatic steatosis by processing and promoting the degradation of select microRNAs.
Q38365029Immunoregulation by lipids during the development of non-alcoholic steatohepatitis
Q37710429Impact of high cholesterol and endoplasmic reticulum stress on metabolic diseases: An updated mini-review
Q37726154Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD.
Q92861341Inflammation and fibrosis in chronic liver diseases including non-alcoholic fatty liver disease and hepatitis C
Q38538187Interactions of Hepatitis B Virus Infection with Nonalcoholic Fatty Liver Disease: Possible Mechanisms and Clinical Impact
Q38759104Lipotoxicity pathways intersect in hepatocytes: Endoplasmic reticulum stress, c-Jun N-terminal kinase-1, and death receptors
Q36193081Loss of ULK1 increases RPS6KB1-NCOR1 repression of NR1H/LXR-mediated Scd1 transcription and augments lipotoxicity in hepatic cells
Q47413881Mitogen-Activated Protein Kinase Regulation in Hepatic Metabolism
Q33755566Molecular mechanisms and new treatment strategies for non-alcoholic steatohepatitis (NASH)
Q37062751Molecular mechanisms of lipotoxicity and glucotoxicity in nonalcoholic fatty liver disease
Q30375036Mouse models of diet-induced nonalcoholic steatohepatitis reproduce the heterogeneity of the human disease.
Q90143394Novel Role of Macrophage Migration Inhibitory Factor in Upstream Control of the Unfolded Protein Response After Ethanol Feeding in Mice
Q28071596Pathogenesis of Nonalcoholic Steatohepatitis: Interactions between Liver Parenchymal and Nonparenchymal Cells
Q36329720Polyphenol-Rich Fraction of Ecklonia cava Improves Nonalcoholic Fatty Liver Disease in High Fat Diet-Fed Mice
Q46577839Punicalagin attenuates palmitate-induced lipotoxicity in HepG2 cells by activating the Keap1-Nrf2 antioxidant defense system
Q56979449Role of X-Box Binding Protein-1 in Fructose-Induced Lipogenesis in HepG2 Cells
Q50977546The constitutive lipid droplet protein PLIN2 regulates autophagy in liver.
Q38235454The role of fibroblast growth factor 21 in the pathogenesis of liver disease: a novel predictor and therapeutic target
Q54119547To die or not to die: death signaling in nonalcoholic fatty liver disease.
Q36298151Undernourishment in utero Primes Hepatic Steatosis in Adult Mice Offspring on an Obesogenic Diet; Involvement of Endoplasmic Reticulum Stress
Q38793946Undernourishment in utero and hepatic steatosis in later life: A potential issue in Japanese people

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