Hepatitis C Virus Infection Induces Autophagy as a Prosurvival Mechanism to Alleviate Hepatic ER-Stress Response

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Hepatitis C Virus Infection Induces Autophagy as a Prosurvival Mechanism to Alleviate Hepatic ER-Stress Response is …
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scholarly articleQ13442814
review articleQ7318358

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P356DOI10.3390/V8050150
P3181OpenCitations bibliographic resource ID1422109
P932PMC publication ID4885105
P698PubMed publication ID27223299

P50authorSrikanta DashQ96901165
Srinivas ChavaQ114734960
Luis A BalartQ114734962
Pauline FerrarisQ30089820
Partha K ChandraQ56477437
Robert F. GarryQ66732989
Yucel AydinQ90228663
Weina ChenQ96231626
P2093author name stringTong Wu
P2860cites workComplex formation of the nonstructural protein 3 of hepatitis C virus with the p53 tumor suppressorQ22008046
ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPsQ24290776
Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stagesQ24318814
A receptor for the selective uptake and degradation of proteins by lysosomesQ24319797
Signal peptidase complex subunit 1 participates in the assembly of hepatitis C virus through an interaction with E2 and NS2Q24322876
NS3 protein of Hepatitis C virus associates with the tumour suppressor p53 and inhibits its function in an NS3 sequence-dependent mannerQ24337056
Innate immune recognition of viral infectionQ24498364
Hepatitis C virus subgenomic replicons induce endoplasmic reticulum stress activating an intracellular signaling pathwayQ24537844
Activation of chaperone-mediated autophagy during oxidative stressQ24562065
Mammalian autophagy: core molecular machinery and signaling regulationQ24595447
Identification of three interferon-inducible cellular enzymes that inhibit the replication of hepatitis C virusQ24658111
Autophagy in hepatocellular carcinomas: from pathophysiology to therapeutic responseQ26767245
Chronic hepatitis C virus infection and lipoprotein metabolismQ26784234
The different roles of selective autophagic protein degradation in mammalian cellsQ26785503
Microbial Regulation of p53 Tumor SuppressorQ26785743
Decoding cell death signals in liver inflammationQ26823299
HCV induces the expression of Rubicon and UVRAG to temporally regulate the maturation of autophagosomes and viral replicationQ35586232
Chaperone-Mediated Autophagy Targets IFNAR1 for Lysosomal Degradation in Free Fatty Acid Treated HCV Cell CultureQ35626712
Apoptosis: the nexus of liver injury and fibrosis.Q35651666
Immunomodulatory functions of type I interferonsQ26823904
Architecture and biogenesis of plus-strand RNA virus replication factoriesQ26824445
From non-A, non-B hepatitis to hepatitis C virus cureQ26864968
Modulation of the unfolded protein response by the human hepatitis B virusQ26999215
Role of innate immunity in the development of hepatocellular carcinomaQ27024780
Human cytomegalovirus infection activates and regulates the unfolded protein responseQ27469611
Hepatitis C Virus Genotype 1a Growth and Induction of AutophagyQ27485449
Induction of incomplete autophagic response by hepatitis C virus via the unfolded protein responseQ27487012
HCV Induces Oxidative and ER Stress, and Sensitizes Infected Cells to Apoptosis in SCID/Alb-uPA MiceQ27487963
Autophagy, Immunity, and Microbial AdaptationsQ27489075
The autophagy machinery is required to initiate hepatitis C virus replicationQ27489377
Eating the enemy within: autophagy in infectious diseasesQ27489453
Cellular stress response and innate immune signaling: integrating pathways in host defense and inflammation.Q27692108
Signal integration in the endoplasmic reticulum unfolded protein responseQ27860577
Global epidemiology of hepatitis C virus infectionQ27860799
Autophagy fights disease through cellular self-digestionQ27860902
Getting membrane proteins on and off the shuttle bus between the endoplasmic reticulum and the Golgi complexQ28066509
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNAQ28214814
HCV causes chronic endoplasmic reticulum stress leading to adaptation and interference with the unfolded protein responseQ28477137
Hepatitis C virus induces the mitochondrial translocation of Parkin and subsequent mitophagyQ28489090
Regulated translation initiation controls stress-induced gene expression in mammalian cellsQ28506388
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
Hepatitis C virus NS5A protein binds TBP and p53, inhibiting their DNA binding and p53 interactions with TBP and ERCC3Q28569202
The unfolded protein response: from stress pathway to homeostatic regulationQ29547396
Regulation mechanisms and signaling pathways of autophagyQ29547416
Live or let die: the cell's response to p53Q29547663
The role of the Atg1/ULK1 complex in autophagy regulationQ29614497
A role for ubiquitin in selective autophagyQ29614499
Mediators of endoplasmic reticulum stress-induced apoptosisQ29615496
The unfolded protein response: controlling cell fate decisions under ER stress and beyondQ29615499
mTOR regulation of autophagyQ29616301
Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunitiesQ29617768
Epidemiology of viral hepatitis and hepatocellular carcinomaQ29617918
Quality control in the endoplasmic reticulumQ29619929
The global burden of hepatitis CQ29620138
Peptide sequences that target proteins for enhanced degradation during serum withdrawalQ68328388
Acetaminophen induces ER dependent signaling in mouse liverQ79505704
That which does not kill me makes me stronger: adapting to chronic ER stressQ81405125
Hyperhomocysteinemia, endoplasmic reticulum stress, and alcoholic liver injuryQ35799626
Knockdown of autophagy enhances the innate immune response in hepatitis C virus-infected hepatocytesQ35910776
Antigen processing by macroautophagy for MHC presentationQ35927580
Chikungunya virus-induced autophagy delays caspase-dependent cell deathQ35946144
Replication of hepatitis C virus RNA on autophagosomal membranesQ36002897
Endoplasmic reticulum stress in liver diseaseQ36031838
Chronic inflammation, immune escape, and oncogenesis in the liver: a unique neighborhood for novel intersectionsQ36055039
Hepatitis C virus upregulates Beclin1 for induction of autophagy and activates mTOR signaling.Q36172124
Hepatitis C virus-induced autophagy is independent of the unfolded protein responseQ36276577
The LMP1 oncogene of EBV activates PERK and the unfolded protein response to drive its own synthesisQ36445900
Emerging roles of interferon-stimulated genes in the innate immune response to hepatitis C virus infectionQ36460968
Autophagy hijacked through viroporin-activated calcium/calmodulin-dependent kinase kinase-β signaling is required for rotavirus replicationQ36483693
Role of the unfolded protein response, GRP78 and GRP94 in organ homeostasis.Q36497621
ER stress: Autophagy induction, inhibition and selection.Q36777229
Virus-specific mechanisms of carcinogenesis in hepatitis C virus associated liver cancerQ36812745
Modification of intracellular membrane structures for virus replicationQ37139313
Innate immune modulation by RNA viruses: emerging insights from functional genomicsQ37226509
The adaptive endoplasmic reticulum stress response to lipotoxicity in progressive human nonalcoholic fatty liver diseaseQ37412003
HCV infection selectively impairs type I but not type III IFN signalingQ37415444
Toll-like receptors in control of immunological autophagy.Q37460134
The ins and outs of hepatitis C virus entry and assemblyQ37498626
Autophagic response in the Rabbit Hemorrhagic Disease, an animal model of virally-induced fulminant hepatic failureQ37580627
Activity of hexokinase is increased by its interaction with hepatitis C virus protein NS5A.Q37643752
Divergent roles of autophagy in virus infectionQ37679218
Understanding the hepatitis C virus life cycle paves the way for highly effective therapies.Q37699395
A new laboratory-based algorithm to predict development of hepatocellular carcinoma in patients with hepatitis C and cirrhosisQ37710955
Abnormal structure and expression of p53 gene in human hepatocellular carcinomaQ37714419
MHC presentation via autophagy and how viruses escape from itQ37790648
Assembly of infectious hepatitis C virus particlesQ37819269
Autophagy as a target for anticancer therapyQ37876679
Dengue virus and autophagyQ37945240
Autophagy in regulation of Toll-like receptor signalingQ37983945
Living in the liver: hepatic infectionsQ37987860
Genome guardian p53 and viral infectionsQ38068825
Hepatitis C virus proteins: from structure to functionQ38086751
West Nile virus differentially modulates the unfolded protein response to facilitate replication and immune evasionQ41971863
Hepatitis C virus core protein activates autophagy through EIF2AK3 and ATF6 UPR pathway-mediated MAP1LC3B and ATG12 expressionQ41981056
Autophagy is an essential component of Drosophila immunity against vesicular stomatitis virusQ42169591
Simeprevir plus sofosbuvir, with or without ribavirin, to treat chronic infection with hepatitis C virus genotype 1 in non-responders to pegylated interferon and ribavirin and treatment-naive patients: the COSMOS randomised studyQ42202756
All-oral daclatasvir plus asunaprevir for hepatitis C virus genotype 1b: a multinational, phase 3, multicohort studyQ42202767
Virus-induced unfolded protein response attenuates antiviral defenses via phosphorylation-dependent degradation of the type I interferon receptorQ42551996
Randomized trial of peginterferon alfa-2b and ribavirin for 48 or 72 weeks in patients with hepatitis C virus genotype 1 and slow virologic responseQ42670765
p53-dependent transcriptional repression of p21(waf1) by hepatitis C virus NS3.Q42826294
Hepatitis C virus NS5A protein modulates cell cycle regulatory genes and promotes cell growthQ42993783
Activation of endoplasmic reticulum stress response by hepatitis viruses up-regulates protein phosphatase 2A.Q43037981
In vivo hepatic endoplasmic reticulum stress in patients with chronic hepatitis C.Q44332232
Endoplasmic reticulum stress induces hepatic steatosis via increased expression of the hepatic very low-density lipoprotein receptorQ45200756
No evidence of the unfolded protein response in patients with chronic hepatitis C virus infectionQ45369635
Correction: SH2 Modified STAT1 Induces HLA-I Expression and Improves IFN-γ Signaling in IFN-α Resistant HCV Replicon Cells.Q45766026
Hepatitis C virus RNA translationQ38086752
Virion assembly and releaseQ38086754
Emerging regulation and functions of autophagyQ38118567
The autophagosome: origins unknown, biogenesis complexQ38160660
Immune dysfunction in cirrhosisQ38195835
Glucose-regulated proteins in cancer: molecular mechanisms and therapeutic potentialQ38198491
A new paradigm: innate immune sensing of viruses via the unfolded protein responseQ38218106
Unfolded protein response in hepatitis C virus infectionQ38218108
The impact of the endoplasmic reticulum protein-folding environment on cancer developmentQ38241996
Endoplasmic reticulum stress is the crossroads of autophagy, inflammation, and apoptosis signaling pathways and participates in liver fibrosisQ38257120
Persistent hepatitis C virus infection impairs ribavirin antiviral activity through clathrin-mediated trafficking of equilibrative nucleoside transporter 1.Q38262107
Virology and cell biology of the hepatitis C virus life cycle: an updateQ38274457
Autophagosome formation during varicella-zoster virus infection following endoplasmic reticulum stress and the unfolded protein responseQ38286153
Hepatitis C virus RNA replication and assembly: living on the fat of the landQ38294573
Hepatitis C virus core protein enhances p53 function through augmentation of DNA binding affinity and transcriptional abilityQ38309880
Single-point mutations of hepatitis C virus NS3 that impair p53 interaction and anti-apoptotic activity of NS3.Q38317301
Complexes containing activating transcription factor (ATF)/cAMP-responsive-element-binding protein (CREB) interact with the CCAAT/enhancer-binding protein (C/EBP)-ATF composite site to regulate Gadd153 expression during the stress responseQ38326929
Endoplasmic reticulum stress, genome damage, and cancer.Q38359856
Cross talk between ER stress, oxidative stress, and inflammation in health and diseaseQ38389425
Cellular stress responses in hepatitis C virus infection: Mastering a two-edged swordQ38402247
The evolving paradigm of cell-nonautonomous UPR-based regulation of immunity by cancer cellsQ38429699
Unfolded protein response pathways regulate Hepatitis C virus replication via modulation of autophagyQ39197168
Hepatitis C virus inhibits AKT-tuberous sclerosis complex (TSC), the mechanistic target of rapamycin (MTOR) pathway, through endoplasmic reticulum stress to induce autophagyQ39241528
Autophagy protects cells from HCV-induced defects in lipid metabolismQ39430882
Dysfunction of autophagy participates in vacuole formation and cell death in cells replicating hepatitis C virusQ39458949
Mechanism of HCV's resistance to IFN-α in cell culture involves expression of functional IFN-α receptor 1.Q39506888
Cell culture and in vivo analyses of cytopathic hepatitis C virus mutantsQ39683340
Knockdown of autophagy-related gene decreases the production of infectious hepatitis C virus particlesQ39821948
Hepatitis B virus X protein (HBx) activates ATF6 and IRE1-XBP1 pathways of unfolded protein responseQ40210691
The role of BiP in endoplasmic reticulum-associated degradation of major histocompatibility complex class I heavy chain induced by cytomegalovirus proteins.Q40274580
Alpha interferon inhibits translation mediated by the internal ribosome entry site of six different hepatitis C virus genotypesQ40361695
Interferons alpha, beta, gamma each inhibit hepatitis C virus replication at the level of internal ribosome entry site-mediated translationQ40418675
Modulation of p53 transcription regulatory activity and post-translational modification by hepatitis C virus core proteinQ40589165
Hepatitis C virus suppresses the IRE1-XBP1 pathway of the unfolded protein responseQ40590374
DOT1L Activity Promotes Proliferation and Protects Cortical Neural Stem Cells from Activation of ATF4-DDIT3-Mediated ER Stress In VitroQ40615754
HCV NS5A interacts with p53 and inhibits p53-mediated apoptosisQ40720204
Activation of the promoters of genes associated with DNA damage, oxidative stress, ER stress and protein malfolding by the bile salt, deoxycholateQ40931435
Hepatitis C virus core protein represses p21WAF1/Cip1/Sid1 promoter activityQ41055268
The dysregulation of endoplasmic reticulum stress response in acute-on-chronic liver failure patients caused by acute exacerbation of chronic hepatitis B.Q41076537
Activation of p53 tumor suppressor by hepatitis C virus core proteinQ41699712
When autophagy meets cancer through p62/SQSTM1.Q41853953
Hepatitis C virus infection promotes hepatic gluconeogenesis through an NS5A-mediated, FoxO1-dependent pathwayQ30395512
Hepatitis C virus triggers mitochondrial fission and attenuates apoptosis to promote viral persistenceQ33674227
Herpes simplex virus 1 infection activates the endoplasmic reticulum resident kinase PERK and mediates eIF-2alpha dephosphorylation by the gamma(1)34.5 proteinQ33717136
SH2 modified STAT1 induces HLA-I expression and improves IFN-γ signaling in IFN-α resistant HCV replicon cellsQ33719537
Hepatitis C virus NS5A physically associates with p53 and regulates p21/waf1 gene expression in a p53-dependent mannerQ33836415
Integration of interferon-alpha/beta signalling to p53 responses in tumour suppression and antiviral defence.Q33967257
ER stress, autophagy, and RNA virusesQ34003896
Autophagy protein ATG5 interacts transiently with the hepatitis C virus RNA polymerase (NS5B) early during infectionQ34078007
Human immunodeficiency virus-1 inhibition of immunoamphisomes in dendritic cells impairs early innate and adaptive immune responsesQ34089158
Persistent expression of hepatitis C virus non-structural proteins leads to increased autophagy and mitochondrial injury in human hepatoma cellsQ34099283
IRGM is a common target of RNA viruses that subvert the autophagy network.Q34102728
Hepatocyte Death: A Clear and Present DangerQ34147508
Chaperone-mediated autophagy in protein quality controlQ34150995
Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: a possible involvement of the ER stress pathway in hepatocarcinogenesisQ34192744
Peptide sequences that target cytosolic proteins for lysosomal proteolysisQ34229121
Intracellular expression of IRF9 Stat fusion protein overcomes the defective Jak-Stat signaling and inhibits HCV RNA replicationQ34243927
Regulation of p53 localizationQ34254613
Impaired expression of type I and type II interferon receptors in HCV-associated chronic liver disease and liver cirrhosisQ34271143
Amino acid signalling upstream of mTORQ34325138
Mechanisms of HCV-induced liver cancer: what did we learn from in vitro and animal studies?Q34358742
Structure and function of the p53 tumor suppressor gene: clues for rational cancer therapeutic strategiesQ34400583
Activation of the unfolded protein response and autophagy after hepatitis C virus infection suppresses innate antiviral immunity in vitroQ34428880
Global distribution and prevalence of hepatitis C virus genotypesQ34431175
Cytoprotective gene bi-1 is required for intrinsic protection from endoplasmic reticulum stress and ischemia-reperfusion injuryQ34479417
Viruses, endoplasmic reticulum stress, and interferon responsesQ34482331
Role of the host cell's unfolded protein response in arenavirus infection.Q34529827
IL28B inhibits hepatitis C virus replication through the JAK-STAT pathwayQ34744565
The contribution of endoplasmic reticulum stress to liver diseasesQ34860549
Interferon and ribavirin combination treatment synergistically inhibit HCV internal ribosome entry site mediated translation at the level of polyribosome formationQ34979630
Nutrient-sensing mechanisms and pathways.Q35036374
Changes in autophagic response in patients with chronic hepatitis C virus infectionQ35071429
Temporal trends of nonalcoholic fatty liver disease-related hepatocellular carcinoma in the veteran affairs populationQ35096951
Decision making by p53: life, death and cancerQ35116663
Rab5 and class III phosphoinositide 3-kinase Vps34 are involved in hepatitis C virus NS4B-induced autophagy.Q35274953
P275copyright licenseCreative Commons AttributionQ6905323
P6216copyright statuscopyrightedQ50423863
P433issue5
P407language of work or nameEnglishQ1860
P921main subjecthepatitis CQ154869
autophagyQ288322
Hepatitis C virusQ708693
HepacivirusQ2082778
viral genome replicationQ3933202
host-pathogen interactionQ5909198
endoplasmic reticulum unfolded protein responseQ14633900
endoplasmic reticulum stressQ66305937
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)150
P577publication date2016-05-23
P1433published inVirusesQ7935305
P1476titleHepatitis C Virus Infection Induces Autophagy as a Prosurvival Mechanism to Alleviate Hepatic ER-Stress Response
P478volume8

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cites work (P2860)
Q91656850A Comprehensive Review of Autophagy and Its Various Roles in Infectious, Non-Infectious, and Lifestyle Diseases: Current Knowledge and Prospects for Disease Prevention, Novel Drug Design, and Therapy
Q40072826Activation of PERK-Nrf2 oncogenic signaling promotes Mdm2-mediated Rb degradation in persistently infected HCV culture
Q58763820Alcohol-induced autophagy via upregulation of PIASy promotes HCV replication in human hepatoma cells
Q54253029Autophagy during viral infection - a double-edged sword.
Q89986946Autophagy, Mitophagy and MicroRNA Expression in Chronic Hepatitis C and Autoimmune Hepatitis
Q39037205Autophagy-from molecular mechanisms to clinical relevance.
Q59355376Chaperone-Mediated Autophagy Promotes Beclin1 Degradation in Persistently Infected Hepatitis C Virus Cell Culture
Q41092750Chaperone-mediated autophagy compensates for impaired macroautophagy in the cirrhotic liver to promote hepatocellular carcinoma
Q91670313Classical Swine Fever Virus Infection Induces Endoplasmic Reticulum Stress-Mediated Autophagy to Sustain Viral Replication in vivo and in vitro
Q47555446Dengue virus-induced ER stress is required for autophagy activation, viral replication, and pathogenesis both in vitro and in vivo
Q90227288Effect of Hepatitis Viruses on the Nrf2/Keap1-Signaling Pathway and Its Impact on Viral Replication and Pathogenesis
Q52716681Hepatitis C virus NS5A protein promotes the lysosomal degradation of hepatocyte nuclear factor 1α via chaperone-mediated autophagy.
Q58089566Hepatitis C virus downregulates ubiquitin conjugating enzyme E2S expression to prevent proteasomal degradation of NS5A, leading to host cells more sensitive to DNA damage
Q52733603Interferon-alpha-induced hepatitis C virus clearance restores p53 tumor suppressor more than direct-acting antivirals.
Q36227134Look who's talking-the crosstalk between oxidative stress and autophagy supports exosomal-dependent release of HCV particles
Q50320474Mitochondrial Proteins Coded by Human Tumor Viruses
Q45325177Modulation of Cell Death Pathways by Hepatitis C Virus Proteins in Huh7.5 Hepatoma Cells.
Q109918710Multiplex Gene Tagging with CRISPR-Cas9 for Live-Cell Microscopy and Application to Study the Role of SARS-CoV-2 Proteins in Autophagy, Mitochondrial Dynamics, and Cell Growth
Q55100149Opposite Effects of Two Human ATG10 Isoforms on Replication of a HCV Sub-genomic Replicon Are Mediated via Regulating Autophagy Flux in Zebrafish.
Q38637134Reciprocal antagonism between the netrin-1 receptor uncoordinated-phenotype-5A (UNC5A) and the hepatitis C virus
Q92112830Repression of MicroRNA-30e by Hepatitis C Virus Enhances Fatty Acid Synthesis
Q91568169Significance of Autophagy in Dengue Virus Infection: A Brief Review
Q38701700The SAT Protein of Porcine Parvovirus Accelerates Viral Spreading through Induction of Irreversible Endoplasmic Reticulum Stress
Q91364063Tumor Microenvironment Regulation by the Endoplasmic Reticulum Stress Transmission Mediator Golgi Protein 73 in Mice
Q54558276Zika Virus Induces Autophagy in Human Umbilical Vein Endothelial Cells.
Q38893853p62/SQSTM1-Dr. Jekyll and Mr. Hyde that prevents oxidative stress but promotes liver cancer

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