Cellular stress responses in hepatitis C virus infection: Mastering a two-edged sword

scientific article published on 30 March 2015

Cellular stress responses in hepatitis C virus infection: Mastering a two-edged sword is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/J.VIRUSRES.2015.03.013
P698PubMed publication ID25836277
P5875ResearchGate publication ID274396215

P50authorPablo Gastaminza LandartQ73262826
P2093author name stringClaudia Vasallo
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Loss of function of the ALS protein SigR1 leads to ER pathology associated with defective autophagy and lipid raft disturbancesQ30669509
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Oxidative stress in symptom-free HCV carriers: relation with ALT flare-up.Q31898205
Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteinsQ33262919
Hepatitis C virus, steatosis and lipid abnormalities: clinical and pathogenic dataQ33404846
The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5.Q33559643
Sigma-1 receptors regulate Bcl-2 expression by reactive oxygen species-dependent transcriptional regulation of nuclear factor kappaBQ33613556
Hepatitis C virus triggers mitochondrial fission and attenuates apoptosis to promote viral persistenceQ33674227
Hepatitis C virus (HCV) constitutively activates STAT-3 via oxidative stress: role of STAT-3 in HCV replicationQ33717232
Detergent-resistant microdomains determine the localization of sigma-1 receptors to the endoplasmic reticulum-mitochondria junctionQ33754855
Human hepatitis C virus NS5A protein alters intracellular calcium levels, induces oxidative stress, and activates STAT-3 and NF-kappa B.Q33933056
Enhanced hepatitis C virus genome replication and lipid accumulation mediated by inhibition of AMP-activated protein kinaseQ33953064
Hepatitis C virus protein expression causes calcium-mediated mitochondrial bioenergetic dysfunction and nitro-oxidative stressQ40120113
Hepatitis C virus core protein increases mitochondrial ROS production by stimulation of Ca2+ uniporter activity.Q40152885
Hsp90 inhibitors suppress HCV replication in replicon cells and humanized liver miceQ40188501
A small-molecule probe for hepatitis C virus replication that blocks protein folding.Q40217967
Activation of unfolded protein response and autophagy during HCV infection modulates innate immune responseQ40319716
The expression and functional characterization of sigma (sigma) 1 receptors in breast cancer cell linesQ40334631
Differential contribution of hepatitis C virus NS5A and core proteins to the induction of oxidative and nitrosative stress in human hepatocyte-derived cellsQ40383182
Hepatitis C virus core triggers apoptosis in liver cells by inducing ER stress and ER calcium depletionQ40421534
Hepatitis C virus, ER stress, and oxidative stressQ40432170
Impaired expression of the peroxisome proliferator-activated receptor alpha during hepatitis C virus infection.Q40463023
Targeting of hepatitis C virus core protein to mitochondria through a novel C-terminal localization motifQ40535841
Hepatitis C virus suppresses the IRE1-XBP1 pathway of the unfolded protein responseQ40590374
Reactive oxygen species suppress hepatitis C virus RNA replication in human hepatoma cellsQ40593951
The Hepatitis C virus NS5A protein activates a phosphoinositide 3-kinase-dependent survival signaling cascadeQ40601685
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Cellular response to conditional expression of hepatitis C virus core protein in Huh7 cultured human hepatoma cellsQ40735235
Hepatitis C virus NS5A protein enhances gluconeogenesis through upregulation of Akt-/JNK-PEPCK signalling pathwaysQ41682315
Hepatitis C virus core protein activates autophagy through EIF2AK3 and ATF6 UPR pathway-mediated MAP1LC3B and ATG12 expressionQ41981056
Transcriptome sequencing, microarray, and proteomic analyses reveal cellular and metabolic impact of hepatitis C virus infection in vitroQ42143878
Parkin mediates proteasome-dependent protein degradation and rupture of the outer mitochondrial membraneQ42235376
Hepatitis C virus dysregulates glucose homeostasis by a dual mechanism involving induction of PGC1α and dephosphorylation of FoxO1.Q42249714
Hepatitis C virus infection alters lipid metabolism depending on IL28B polymorphism and viral genotype and modulates gene expression in vivo and in vitro.Q42257920
Visualizing hepatitis C virus infections in human liver by two-photon microscopyQ42989638
Intracellular localization of NS3 and C proteins in chronic hepatitis C.Q42993606
Hepatitis C virus core protein inhibits mitochondrial electron transport and increases reactive oxygen species (ROS) productionQ42995051
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Hepatitis C virus nonstructural proteins are localized in a modified endoplasmic reticulum of cells expressing viral subgenomic repliconsQ43036635
Autophagic control of RLR signalingQ43114797
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No evidence of the unfolded protein response in patients with chronic hepatitis C virus infectionQ45369635
Function of sigma1 receptors in Parkinson's diseaseQ46594020
Comparison of hepatic oxidative DNA damage in patients with chronic hepatitis B and C.Q46709785
Biosynthesis and processing of endogenous BDNF: CNS neurons store and secrete BDNF, not pro-BDNF.Q46801720
Sigma-1 receptors bind cholesterol and remodel lipid rafts in breast cancer cell linesQ46868548
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NBR1 cooperates with p62 in selective autophagy of ubiquitinated targets.Q47929108
Bcl-2 family proteins participate in mitochondrial quality control by regulating Parkin/PINK1-dependent mitophagy.Q50453392
Sigma-1Rs are upregulated via PERK/eIF2α/ATF4 pathway and execute protective function in ER stress.Q50779931
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SIGMAR1 mutations, genetic heterogeneity at the chromosome 9p locus, and the expanding etiological diversity of amyotrophic lateral sclerosisQ83099765
Hepatitis C virus blocks interferon effector function by inducing protein kinase R phosphorylationQ34000124
ER stress, autophagy, and RNA virusesQ34003896
Regulation of the hepatitis C virus RNA replicase by endogenous lipid peroxidation.Q34020915
Hepatitis C virus proteins activate NRF2/ARE pathway by distinct ROS-dependent and independent mechanisms in HUH7 cells.Q34024112
Endoplasmic reticulum stress links hepatitis C virus RNA replication to wild-type PGC-1α/liver-specific PGC-1α upregulationQ34057855
Autophagy protein ATG5 interacts transiently with the hepatitis C virus RNA polymerase (NS5B) early during infectionQ34078007
IRGM is a common target of RNA viruses that subvert the autophagy network.Q34102728
Visualization and measurement of ATP levels in living cells replicating hepatitis C virus genome RNA.Q34186975
Hepatitis viruses and the MAPK pathway: is this a survival strategy?Q34189599
Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: a possible involvement of the ER stress pathway in hepatocarcinogenesisQ34192744
The molecular biology of hepatitis C virus. Genotypes and quasispeciesQ34210660
Role of Hepatitis C virus core protein in viral-induced mitochondrial dysfunctionQ34267922
Apolipoprotein J, a glucose-upregulated molecular chaperone, stabilizes core and NS5A to promote infectious hepatitis C virus virion productionQ34427925
Activation of the unfolded protein response and autophagy after hepatitis C virus infection suppresses innate antiviral immunity in vitroQ34428880
COX5B regulates MAVS-mediated antiviral signaling through interaction with ATG5 and repressing ROS productionQ34544423
Stearoyl coenzyme A desaturase 1 is associated with hepatitis C virus replication complex and regulates viral replicationQ34593867
Proteomic profiling of human liver biopsies: hepatitis C virus-induced fibrosis and mitochondrial dysfunctionQ34656176
PKR-like endoplasmic reticulum kinase is necessary for lipogenic activation during HCMV infectionQ34671888
Phosphorylation of eIF2 facilitates ribosomal bypass of an inhibitory upstream ORF to enhance CHOP translationQ34719370
Hepatitis C virus NS2 protein triggers endoplasmic reticulum stress and suppresses its own viral replicationQ34797179
Dengue virus modulates the unfolded protein response in a time-dependent mannerQ34800188
Impaired mitochondrial β-oxidation in patients with chronic hepatitis C: relation with viral load and insulin resistanceQ34809921
Calcium trafficking integrates endoplasmic reticulum function with mitochondrial bioenergeticsQ34841551
Formation of stress granules inhibits apoptosis by suppressing stress-responsive MAPK pathwaysQ34845865
Use of laser capture microdissection to map hepatitis C virus-positive hepatocytes in human liverQ34969032
Endoplasmic reticulum (ER) stress: hepatitis C virus induces an ER-nucleus signal transduction pathway and activates NF-kappaB and STAT-3.Q34989433
Hepatitis C virus-induced cytoplasmic organelles use the nuclear transport machinery to establish an environment conducive to virus replicationQ35034273
Sigma-1 receptor chaperone at the ER-mitochondrion interface mediates the mitochondrion-ER-nucleus signaling for cellular survivalQ35034908
Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stressQ35041282
Changes in autophagic response in patients with chronic hepatitis C virus infectionQ35071429
Hepatitis C virus co-opts Ras-GTPase-activating protein-binding protein 1 for its genome replicationQ35077661
Hepatocyte NAD(P)H oxidases as an endogenous source of reactive oxygen species during hepatitis C virus infectionQ35121963
Prominent steatosis with hypermetabolism of the cell line permissive for years of infection with hepatitis C virusQ35143996
Cholesterol at the endoplasmic reticulum: roles of the sigma-1 receptor chaperone and implications thereof in human diseasesQ35163209
Mitochondrial-associated endoplasmic reticulum membranes (MAM) form innate immune synapses and are targeted by hepatitis C virusQ35197999
Impact of the autophagy machinery on hepatitis C virus infectionQ35261712
Rab5 and class III phosphoinositide 3-kinase Vps34 are involved in hepatitis C virus NS4B-induced autophagy.Q35274953
The sigma1 receptor interacts with N-alkyl amines and endogenous sphingolipids.Q35356324
Role of the endoplasmic reticulum-associated degradation (ERAD) pathway in degradation of hepatitis C virus envelope proteins and production of virus particlesQ35423569
Activation and evasion of antiviral innate immunity by hepatitis C virus.Q35606341
Unique function of the Nrf2-Keap1 pathway in the inducible expression of antioxidant and detoxifying enzymesQ35708009
Sigma receptors and cancer: possible involvement of ion channelsQ35853739
The sigma-1 receptor protects against cellular oxidative stress and activates antioxidant response elementsQ35856904
Knockdown of autophagy enhances the innate immune response in hepatitis C virus-infected hepatocytesQ35910776
The ubiquitin E3 ligase parkin regulates the proapoptotic function of BaxQ35925042
The Atg5 Atg12 conjugate associates with innate antiviral immune responsesQ35956883
Mitochondrial division ensures the survival of postmitotic neurons by suppressing oxidative damageQ35962319
Compromising σ-1 receptors at the endoplasmic reticulum render cytotoxicity to physiologically relevant concentrations of dopamine in a nuclear factor-κB/Bcl-2-dependent mechanism: potential relevance to Parkinson's diseaseQ35996703
Replication of hepatitis C virus RNA on autophagosomal membranesQ36002897
Endoplasmic reticulum stress in liver diseaseQ36031838
The heat shock cognate protein 70 is associated with hepatitis C virus particles and modulates virus infectivityQ36161414
Hepatitis C virus upregulates Beclin1 for induction of autophagy and activates mTOR signaling.Q36172124
The potential role of sigma-1 receptors in lipid transport and lipid raft reconstitution in the brain: implication for drug abuseQ36185739
Hepatitis C virus-induced autophagy is independent of the unfolded protein responseQ36276577
XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum.Q36322684
Inhibition of tumor cell growth by Sigma1 ligand mediated translational repressionQ36344534
Phosphoinositides in the hepatitis C virus life cycle.Q36395871
Hepatitis C virus activates Bcl-2 and MMP-2 expression through multiple cellular signaling pathwaysQ36397362
Projected future increase in aging hepatitis C virus-infected liver transplant candidates: a potential effect of hepatocellular carcinomaQ36456976
Modulation of hepatitis C virus RNA abundance and virus release by dispersion of processing bodies and enrichment of stress granulesQ36501665
Hepatitis C virus infection down-regulates the expression of peroxisome proliferator-activated receptor alpha and carnitine palmitoyl acyl-CoA transferase 1A.Q36503299
Lucidone suppresses hepatitis C virus replication by Nrf2-mediated heme oxygenase-1 inductionQ36667217
XBP-1u suppresses autophagy by promoting the degradation of FoxO1 in cancer cellsQ36739979
Interplay between Hepatitis C Virus and Redox Cell SignalingQ36790471
Glycoprotein folding and the role of EDEM1, EDEM2 and EDEM3 in degradation of folding-defective glycoproteinsQ36820743
Sigma-1 receptor regulates early steps of viral RNA replication at the onset of hepatitis C virus infectionQ36827249
Lack of sigma-1 receptor exacerbates ALS progression in miceQ36880259
Hepatitis C virus-induced mitochondrial dysfunctionsQ36993948
Insights into the Sigma-1 receptor chaperone's cellular functions: a microarray reportQ36995785
Endoplasmic reticulum stress responsesQ37014237
Immunobiology and pathogenesis of viral hepatitisQ37014739
Hepatitis C virus, cholesterol and lipoproteins--impact for the viral life cycle and pathogenesis of liver diseaseQ37015738
Interactions Between Hepatitis C Virus and Mitochondria: Impact on Pathogenesis and Innate ImmunityQ37095314
Mitochondrial dysfunction induces formation of lipid droplets as a generalized response to stressQ37224850
Sigma-1 receptor chaperones regulate the secretion of brain-derived neurotrophic factorQ37300447
The double-edged sword of autophagy modulation in cancerQ37331327
HCV infection induces mitochondrial bioenergetic unbalance: causes and effectsQ37354396
Dynamic oscillation of translation and stress granule formation mark the cellular response to virus infectionQ37416617
Andrographolide exerts anti-hepatitis C virus activity by up-regulating haeme oxygenase-1 via the p38 MAPK/Nrf2 pathway in human hepatoma cells.Q37418256
The ins and outs of hepatitis C virus entry and assemblyQ37498626
Activity of hexokinase is increased by its interaction with hepatitis C virus protein NS5A.Q37643752
Simultaneous detection of hepatitis C virus and interferon stimulated gene expression in infected human liverQ37684887
Understanding the hepatitis C virus life cycle paves the way for highly effective therapies.Q37699395
Forkhead box transcription factor regulation and lipid accumulation by hepatitis C virusQ37713887
Abnormalities of lipid metabolism in hepatitis C virus infectionQ37775831
The interplay between mitochondrial dynamics and mitophagyQ37815475
Unique ties between hepatitis C virus replication and intracellular lipids.Q37865821
Hepatitis C virus and host cell lipids: an intimate connectionQ37877090
Mitochondria in innate immunityQ37907827
Mitochondrial quality control by the ubiquitin-proteasome systemQ37936564
The crosstalk between autophagy and apoptosis: where does this lead?Q37982296
Aggrephagy: selective disposal of protein aggregates by macroautophagy.Q38003982
The emerging role of ROS-generating NADPH oxidase NOX4 in DNA-damage responsesQ38009625
Targeting mitochondria in the infection strategy of the hepatitis C virusQ38019735
Protein folding and quality control in the ERQ38031470
Lipids and HCV.Q38056643
Mitochondrial adaptations and dysfunctions in nonalcoholic fatty liver diseaseQ38072666
HCV and oxidative stress in the liver.Q38077447
Modulation of the autophagy pathway by human tumor virusesQ38111130
The molecular and structural basis of advanced antiviral therapy for hepatitis C virus infectionQ38113079
P921main subjecthepatitis CQ154869
Hepatitis C virusQ708693
P304page(s)100-117
P577publication date2015-03-30
P1433published inVirus ResearchQ15749215
P1476titleCellular stress responses in hepatitis C virus infection: Mastering a two-edged sword
P478volume209

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