Autophagy in hepatitis C virus-host interactions: potential roles and therapeutic targets for liver-associated diseases

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Autophagy in hepatitis C virus-host interactions: potential roles and therapeutic targets for liver-associated diseases is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3748/WJG.V20.I19.5773
P932PMC publication ID4024787
P698PubMed publication ID24914338
P5875ResearchGate publication ID262977877

P50authorPo-Yuan KeQ57425886
P2093author name stringSteve S-L Chen
P2860cites workTransfusion-associated hepatitis not due to viral hepatitis type A or B. 1975.Q48789068
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An RNA-binding protein, hnRNP A1, and a scaffold protein, septin 6, facilitate hepatitis C virus replicationQ24293290
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The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1Q24300456
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Annexin A2 is involved in the formation of hepatitis C virus replication complex on the lipid raftQ24304279
Hepatitis C virus RNA replication is regulated by FKBP8 and Hsp90Q24306116
A single-amino-acid mutation in hepatitis C virus NS5A disrupting FKBP8 interaction impairs viral replicationQ24307609
The human scavenger receptor class B type I is a novel candidate receptor for the hepatitis C virusQ24307963
A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formationQ24315723
Involvement of creatine kinase B in hepatitis C virus genome replication through interaction with the viral NS4A proteinQ24317879
The DNA damage sensors ataxia-telangiectasia mutated kinase and checkpoint kinase 2 are required for hepatitis C virus RNA replicationQ24318659
Hepatitis C virus replication is modulated by the interaction of nonstructural protein NS5B and fatty acid synthaseQ24318935
Recruitment and activation of a lipid kinase by hepatitis C virus NS5A is essential for integrity of the membranous replication compartmentQ24337128
Human VAP-B is involved in hepatitis C virus replication through interaction with NS5A and NS5BQ24338324
Lipid droplet-binding protein TIP47 regulates hepatitis C Virus RNA replication through interaction with the viral NS5A proteinQ24338608
Hepatitis C virus NS5A protein interacts with phosphatidylinositol 4-kinase type IIIalpha and regulates viral propagationQ24339370
Expression of hepatitis C virus proteins induces distinct membrane alterations including a candidate viral replication complexQ24537657
Hepatitis C virus glycoproteins interact with DC-SIGN and DC-SIGNRQ24551041
Phosphorylation of hepatitis C virus nonstructural protein 5A modulates its protein interactions and viral RNA replicationQ24561987
Hepatitis C virus induces the mitochondrial translocation of Parkin and subsequent mitophagyQ28489090
3D tomography reveals connections between the phagophore and endoplasmic reticulumQ28610064
Claudin association with CD81 defines hepatitis C virus entry.Q29465808
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The Role of Atg Proteins in Autophagosome FormationQ29547418
Autophagy regulates lipid metabolismQ29547421
Autophagy-dependent viral recognition by plasmacytoid dendritic cellsQ29614177
Functions of lysosomesQ29614182
Two Distinct Pathways for Targeting Proteins from the Cytoplasm to the Vacuole/LysosomeQ29614184
Autophagy in yeast demonstrated with proteinase-deficient mutants and conditions for its inductionQ29614187
Natural history of liver fibrosis progression in patients with chronic hepatitis C. The OBSVIRC, METAVIR, CLINIVIR, and DOSVIRC groupsQ29614459
Autophagy is activated for cell survival after endoplasmic reticulum stressQ29614485
Plasma membrane contributes to the formation of pre-autophagosomal structuresQ29614494
The role of the Atg1/ULK1 complex in autophagy regulationQ29614497
Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulumQ29614500
The role of autophagy in neurodegenerative diseaseQ29614834
Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesisQ29617725
Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunitiesQ29617768
A Unified Nomenclature for Yeast Autophagy-Related GenesQ29618950
CD81 is required for hepatitis C virus glycoprotein-mediated viral infectionQ29619745
Unravelling hepatitis C virus replication from genome to functionQ29620056
Course and outcome of hepatitis CQ29620057
Pancreatic cancers require autophagy for tumor growthQ29620331
Role of autophagy in cancerQ29620348
The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic miceQ29620765
Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphomaQ29622918
Cellular differentiation in the kidneys of newborn mice studies with the electron microscope.Q31162064
Autophagic machinery activated by dengue virus enhances virus replicationQ33324555
Identification of a lipid kinase as a host factor involved in hepatitis C virus RNA replicationQ33420226
Kinases required in hepatitis C virus entry and replication highlighted by small interference RNA screening.Q33483258
Persistence of viremia and the importance of long-term follow-up after acute hepatitis C infectionQ33853655
p53 and ARF: unexpected players in autophagyQ33936026
Genotype and viral load as prognostic indicators in the treatment of hepatitis C.Q33962266
Dengue virus-induced autophagy regulates lipid metabolismQ34024721
Current and Future Therapies for Hepatitis C Virus InfectionQ34036762
Autophagy protein ATG5 interacts transiently with the hepatitis C virus RNA polymerase (NS5B) early during infectionQ34078007
Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L.Q34083183
Persistent Expression of Hepatitis C Virus Non-Structural Proteins Leads to Increased Autophagy and Mitochondrial Injury in Human Hepatoma CellsQ34099283
IRGM is a common target of RNA viruses that subvert the autophagy network.Q34102728
Identification of the Niemann-Pick C1-like 1 cholesterol absorption receptor as a new hepatitis C virus entry factorQ34245963
The chimpanzee model of hepatitis C virus infectionsQ34282817
Apg14p and Apg6/Vps30p Form a Protein Complex Essential for Autophagy in the Yeast, Saccharomyces cerevisiaeQ27940093
A protein conjugation system essential for autophagyQ27940154
Apg7p/Cvt2p is required for the cytoplasm-to-vacuole targeting, macroautophagy, and peroxisome degradation pathwaysQ27940203
Apg13p and Vac8p are part of a complex of phosphoproteins that are required for cytoplasm to vacuole targetingQ27940283
Claudin-1 is a hepatitis C virus co-receptor required for a late step in entryQ28131832
Assembly of hepatitis C virus particlesQ37822873
Hepatitis C virus: How genetic variability affects pathobiology of diseaseQ37825652
SREBPs: metabolic integrators in physiology and metabolismQ37966406
Control of autophagy as a therapy for neurodegenerative diseaseQ37970303
Animal Models for the Study of Hepatitis C Virus Infection and Related Liver DiseaseQ38005793
Hepatitis C virus diversity and hepatic steatosisQ38072721
Virion Assembly and ReleaseQ38086754
Autophagy: a new target or an old strategy for the treatment of Crohn's disease?Q38099513
Autophagy: shaping the tumor microenvironment and therapeutic response.Q38110096
Current progress in development of hepatitis C virus vaccinesQ38120201
High density lipoproteins facilitate hepatitis C virus entry through the scavenger receptor class B type I.Q38332447
Cellular binding of hepatitis C virus envelope glycoprotein E2 requires cell surface heparan sulfateQ38352468
Hepatitis C virus inhibits AKT-tuberous sclerosis complex (TSC), the mechanistic target of rapamycin (MTOR) pathway, through endoplasmic reticulum stress to induce autophagyQ39241528
Potential roles for cellular cofactors in hepatitis C virus replication complex formationQ39322241
Autophagy protects cells from HCV-induced defects in lipid metabolismQ39430882
Dysfunction of autophagy participates in vacuole formation and cell death in cells replicating hepatitis C virusQ39458949
Autophagy is involved in the early step of Japanese encephalitis virus infectionQ39468337
Induced autophagy reduces virus output in dengue infected monocytic cellsQ39495783
Hepatitis C Virus Inhibits DNA Damage Repair through Reactive Oxygen and Nitrogen Species and by Interfering with the ATM-NBS1/Mre11/Rad50 DNA Repair Pathway in Monocytes and HepatocytesQ39639979
Ultrastructural and quantitative analysis of the lipid droplet clustering induced by hepatitis C virus core proteinQ39710437
Autophagy protects against Sindbis virus infection of the central nervous systemQ39738841
Knockdown of autophagy-related gene decreases the production of infectious hepatitis C virus particlesQ39821948
Cyclophilin A interacts with influenza A virus M1 protein and impairs the early stage of the viral replicationQ39885249
Studying HCV cell entry with HCV pseudoparticles (HCVpp).Q39916912
Activation of sterol regulatory element-binding protein 1c and fatty acid synthase transcription by hepatitis C virus non-structural protein 2.Q39990933
Scavenger receptor class B type I is a key host factor for hepatitis C virus infection required for an entry step closely linked to CD81.Q40052203
Hepatitis C virus NS3/4A protein interacts with ATM, impairs DNA repair and enhances sensitivity to ionizing radiation.Q40068992
Genetic interactions between hepatitis C virus replicons.Q40214051
Endogenous MHC class II processing of a viral nuclear antigen after autophagy.Q40481959
Activation of RB/E2F signaling pathway is required for the modulation of hepatitis C virus core protein-induced cell growth in liver and non-liver cells.Q40513204
Diverse hepatitis C virus glycoproteins mediate viral infection in a CD81-dependent mannerQ40530808
Steatosis and liver cancer in transgenic mice expressing the structural and nonstructural proteins of hepatitis C virusQ40588817
A comprehensive glossary of autophagy-related molecules and processesQ40657742
Human La antigen is required for the hepatitis C virus internal ribosome entry site-mediated translationQ40873528
Factors predictive of a beneficial response to therapy of hepatitis CQ40882250
Gene transfer of master autophagy regulator TFEB results in clearance of toxic protein and correction of hepatic disease in alpha-1-anti-trypsin deficiencyQ41106554
Characterization of cell lines allowing tightly regulated expression of hepatitis C virus core proteinQ41179723
Hepatitis C: The clinical spectrum of diseaseQ41598735
Alteration of lysosomal density by sequestered glycogen during deprivation-induced autophagy in rat liverQ41667943
Inhibition of basal and deprivation-induced proteolysis by leupeptin and pepstatin in perfused rat liver and heartQ41668030
Tissue fractionation studies. 6. Intracellular distribution patterns of enzymes in rat-liver tissueQ41845012
Energy dependence of autophagic protein degradation in isolated rat hepatocytesQ41913820
A critical role for autophagy in pancreatic cancerQ41933017
Autophagy and RNA virus interactomes reveal IRGM as a common target.Q42051450
Autophagy-deficient mice develop multiple liver tumorsQ42099409
TIP47 plays a crucial role in the life cycle of hepatitis C virusQ42277402
Autophagy: Snapshot of the networkQ42402949
Tissue fractionation studies. 4. Comparative study of the binding of acid phosphatase, β-glucuronidase and cathepsin by rat-liver particlesQ42978107
Alcohol and hepatitis C virus core protein additively increase lipid peroxidation and synergistically trigger hepatic cytokine expression in a transgenic mouse modelQ42981580
A role for hepatitis C virus infection in type II cryoglobulinemiaQ42983385
Hepatitis C virus core protein induces hepatic steatosis in transgenic miceQ42983905
Impact of amino acid substitutions in the hepatitis C virus genotype 1b core region on liver steatosis and hepatic oxidative stress in patients with chronic hepatitis C.Q42993118
Unscrambling hepatitis C virus-host interactionsQ42994469
Hepatocyte steatosis is a cytopathic effect of hepatitis C virus genotype 3.Q42999424
Steatosis accelerates the progression of liver damage of chronic hepatitis C patients and correlates with specific HCV genotype and visceral obesityQ43031928
Long-term follow-up of chronic hepatitis C in patients diagnosed at a tertiary-care center.Q43753027
A model for the study of hepatitis C virus entryQ45722093
The role of chronic viral hepatitis in hepatocellular carcinoma in the United StatesQ46491337
Amino acid signalling upstream of mTORQ34325138
Ultrastructural analysis of the autophagic process in yeast: detection of autophagosomes and their characterizationQ34337565
Studies of hepatitis C virus in chimpanzees and their importance for vaccine development.Q34339587
Activation of the unfolded protein response and autophagy after hepatitis C virus infection suppresses innate antiviral immunity in vitroQ34428880
Persistent hepatitis C virus infection in a chimpanzee is associated with emergence of a cytotoxic T lymphocyte escape variantQ34499902
Active RNA replication of hepatitis C virus downregulates CD81 expressionQ34563532
Disruption of hepatitis C virus RNA replication through inhibition of host protein geranylgeranylationQ34792600
Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cellsQ34825204
Animal models for studying hepatitis C and alcohol effects on liverQ35012721
A genetically humanized mouse model for hepatitis C virus infectionQ35174543
Hepatitis C virus is primed by CD81 protein for low pH-dependent fusionQ35182834
Hepatitis C Virus Infection: Molecular Pathways to Steatosis, Insulin Resistance and Oxidative StressQ35259669
Rab5 and class III phosphoinositide 3-kinase Vps34 are involved in hepatitis C virus NS4B-induced autophagy.Q35274953
The dynamic nature of autophagy in cancerQ35393206
Proline-Serine-Threonine Phosphatase-Interacting Protein 2 (PSTPIP2), a Host Membrane-Deforming Protein, Is Critical for Membranous Web Formation in Hepatitis C Virus ReplicationQ35689635
Host factors and failure of interferon-alpha treatment in hepatitis C virusQ35730979
Knockdown of autophagy enhances the innate immune response in hepatitis C virus-infected hepatocytesQ35910776
Replication of hepatitis C virus RNA on autophagosomal membranesQ36002897
Hepatitis C virus upregulates Beclin1 for induction of autophagy and activates mTOR signaling.Q36172124
The proximal tubule cell in experimental hydronephrosisQ36437174
Treating viral hepatitis C: efficacy, side effects, and complicationsQ36564615
Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agentsQ36917074
Aggresomes and pericentriolar sites of virus assembly: cellular defense or viral design?Q36951982
Hepatitis C virus entry into host cellsQ36959983
Identification of transferrin receptor 1 as a hepatitis C virus entry factorQ36967731
Endoplasmic reticulum stress responsesQ37014237
The roles of therapy-induced autophagy and necrosis in cancer treatmentQ37038235
Functions of autophagy in normal and diseased liverQ37107125
Glucagon-induced autophagy and proteolysis in rat liver: mediation by selective deprivation of intracellular amino acidsQ37335657
Enhancing immunity through autophagyQ37357281
Hepatitis C virus-induced cryoglobulinemiaQ37371397
Completion of the entire hepatitis C virus life cycle in genetically humanized miceQ37382399
Autophagy regulates adipose mass and differentiation in miceQ37403082
EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapyQ37609988
Specific Polymorphisms in Hepatitis C Virus Genotype 3 Core Protein Associated with Intracellular Lipid AccumulationQ27486390
Induction of incomplete autophagic response by hepatitis C virus via the unfolded protein responseQ27487012
Fatty acid synthase is up-regulated during hepatitis C virus infection and regulates hepatitis C virus entry and productionQ27487550
Hepatitis C Virus Nonstructural 4B Protein Modulates Sterol Regulatory Element-binding Protein Signaling via the AKT PathwayQ27488294
Roles for endocytic trafficking and phosphatidylinositol 4-kinase III alpha in hepatitis C virus replicationQ27488365
Critical Role of Cyclophilin A and Its Prolyl-Peptidyl Isomerase Activity in the Structure and Function of the Hepatitis C Virus Replication ComplexQ27488788
Essential Role of Cyclophilin A for Hepatitis C Virus Replication and Virus Production and Possible Link to Polyprotein Cleavage KineticsQ27489037
Autophagy, Immunity, and Microbial AdaptationsQ27489075
The autophagy machinery is required to initiate hepatitis C virus replicationQ27489377
Eating the enemy within: autophagy in infectious diseasesQ27489453
Class III Phosphatidylinositol 4-Kinase Alpha and Beta Are Novel Host Factor Regulators of Hepatitis C Virus ReplicationQ27489697
A genome-wide genetic screen for host factors required for hepatitis C virus propagationQ27489773
A Functional Genomic Screen Identifies Cellular Cofactors of Hepatitis C Virus ReplicationQ27489843
Human occludin is a hepatitis C virus entry factor required for infection of mouse cellsQ27490169
Hepatoma Cell Density Promotes Claudin-1 and Scavenger Receptor BI Expression and Hepatitis C Virus InternalizationQ27490466
Transmission of Hepatitis C by Intrahepatic Inoculation with Transcribed RNAQ27860484
Efficient initiation of HCV RNA replication in cell cultureQ27860520
Autophagy in the Pathogenesis of DiseaseQ27860558
Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell lineQ27860561
Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genomeQ27860719
Production of infectious hepatitis C virus in tissue culture from a cloned viral genomeQ27860899
Autophagy fights disease through cellular self-digestionQ27860902
Replication of hepatitis C virusQ27860957
Consensus proposals for a unified system of nomenclature of hepatitis C virus genotypesQ27861119
Analyses of APG13 gene involved in autophagy in yeast, Saccharomyces cerevisiaeQ27930610
Atg9 cycles between mitochondria and the pre-autophagosomal structure in yeastsQ27931774
Cvt19 is a receptor for the cytoplasm-to-vacuole targeting pathway.Q27931961
Cvt18/Gsa12 Is Required for Cytoplasm-to-Vacuole Transport, Pexophagy, and Autophagy inSaccharomyces cerevisiaeandPichia pastorisQ27932749
Apg2 is a novel protein required for the cytoplasm to vacuole targeting, autophagy, and pexophagy pathwaysQ27933193
Apg1p, a novel protein kinase required for the autophagic process in Saccharomyces cerevisiaeQ27933914
Apg9p/Cvt7p is an integral membrane protein required for transport vesicle formation in the Cvt and autophagy pathwaysQ27935410
The conserved oligomeric Golgi complex is involved in double-membrane vesicle formation during autophagyQ27935788
Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeastQ27939948
Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressorQ24569647
Autophagy in immunity and inflammationQ24595707
Interactions between viral nonstructural proteins and host protein hVAP-33 mediate the formation of hepatitis C virus RNA replication complex on lipid raftQ24600344
Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy geneQ24617547
The Atg16L complex specifies the site of LC3 lipidation for membrane biogenesis in autophagyQ24647053
The tight junction proteins claudin-1, -6, and -9 are entry cofactors for hepatitis C virusQ24652906
Hepatitis C virus and type 2 diabetesQ24658049
Infectious hepatitis C virus pseudo-particles containing functional E1-E2 envelope protein complexesQ24673768
Cvt9/Gsa9 functions in sequestering selective cytosolic cargo destined for the vacuoleQ24680389
Claudin-6 and claudin-9 function as additional coreceptors for hepatitis C virusQ24681592
Cytolysomes and mitochondrial degenerationQ24683054
Cytoplasmic components in hepatic cell lysosomesQ24683078
Heterogeneous Nuclear Ribonucleoprotein L Interacts with the 3′ Border of the Internal Ribosomal Entry Site of Hepatitis C VirusQ27469579
Robust hepatitis C virus infection in vitroQ27470013
Down-regulation of the retinoblastoma tumor suppressor by the hepatitis C virus NS5B RNA-dependent RNA polymeraseQ27472746
Time- and Temperature-Dependent Activation of Hepatitis C Virus for Low-pH-Triggered EntryQ27472926
Characterization of the Early Steps of Hepatitis C Virus Infection by Using Luciferase Reporter VirusesQ27473226
hnRNP C and polypyrimidine tract-binding protein specifically interact with the pyrimidine-rich region within the 3'NTR of the HCV RNA genomeQ27473270
Viral and Cellular Determinants of Hepatitis C Virus RNA Replication in Cell CultureQ27473345
Identification of the Hepatitis C Virus RNA Replication Complex in Huh-7 Cells Harboring Subgenomic RepliconsQ27473471
Hepatitis C virus glycoproteins mediate pH-dependent cell entry of pseudotyped retroviral particlesQ27477687
Steatosis affects chronic hepatitis C progression in a genotype specific wayQ27477969
Participation of Rab5, an Early Endosome Protein, in Hepatitis C Virus RNA Replication MachineryQ27480343
Hepatitis C Virus Induces Proteolytic Cleavage of Sterol Regulatory Element Binding Proteins and Stimulates Their Phosphorylation via Oxidative StressQ27481013
Hepatitis C virus core protein shows a cytoplasmic localization and associates to cellular lipid storage dropletsQ27481061
Nuclear factors are involved in hepatitis C virus RNA replicationQ27481075
The La antigen binds 5' noncoding region of the hepatitis C virus RNA in the context of the initiator AUG codon and stimulates internal ribosome entry site-mediated translationQ27481261
Hepatitis C Virus Genotype 1a Growth and Induction of AutophagyQ27485449
The genotype 3-specific hepatitis C virus core protein residue phenylalanine 164 increases steatosis in an in vitro cellular modelQ27485480
Hepatitis C virus and other flaviviridae viruses enter cells via low density lipoprotein receptorQ27485871
Transcripts from a single full-length cDNA clone of hepatitis C virus are infectious when directly transfected into the liver of a chimpanzeeQ27485872
CD81 and Claudin 1 Coreceptor Association: Role in Hepatitis C Virus EntryQ27485899
The FUSE Binding Protein Is a Cellular Factor Required for Efficient Replication of Hepatitis C VirusQ27486114
P433issue19
P407language of work or nameEnglishQ1860
P921main subjecthepatitis CQ154869
autophagyQ288322
Hepatitis C virusQ708693
P304page(s)5773-5793
P577publication date2014-05-01
P1433published inWorld Journal of GastroenterologyQ15708885
P1476titleAutophagy in hepatitis C virus-host interactions: potential roles and therapeutic targets for liver-associated diseases
P478volume20

Reverse relations

cites work (P2860)
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