ISG12a inhibits HCV replication and potentiates the anti-HCV activity of IFN-α through activation of the Jak/STAT signaling pathway independent of autophagy and apoptosis

scientific article

ISG12a inhibits HCV replication and potentiates the anti-HCV activity of IFN-α through activation of the Jak/STAT signaling pathway independent of autophagy and apoptosis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.VIRUSRES.2016.10.013
P698PubMed publication ID27777077

P2093author name stringShilin Li
Min Yao
Limin Chen
Yanzhao Chen
Baihai Jiao
Xuezhen Shi
Zhebin Zheng
P2860cites workReview of direct-acting antiviral agents for the treatment of chronic hepatitis CQ38111844
Activation of endogenous type I IFN signaling contributes to persistent HCV infectionQ38210107
Impaired autophagy response in human hepatocellular carcinoma.Q38393661
Interferon-inducible Protein 6-16 (IFI-6-16, ISG16) promotes Hepatitis C virus replication in vitroQ38860627
The mitochondrial targeting chaperone 14-3-3ε regulates a RIG-I translocon that mediates membrane association and innate antiviral immunity.Q39346072
ISG15, a ubiquitin-like interferon-stimulated gene, promotes hepatitis C virus production in vitro: implications for chronic infection and response to treatmentQ39784912
Knockdown of autophagy-related gene decreases the production of infectious hepatitis C virus particlesQ39821948
Silencing of USP18 potentiates the antiviral activity of interferon against hepatitis C virus infectionQ40209074
The evolutionarily conserved domain of Beclin 1 is required for Vps34 binding, autophagy and tumor suppressor functionQ40250486
TLR3 can directly trigger apoptosis in human cancer cells.Q40296182
The interferon-induced gene ISG12 is regulated by various cytokines as the gene 6-16 in human cell linesQ40895802
A sustained virologic response is durable in patients with chronic hepatitis C treated with peginterferon alfa-2a and ribavirinQ42967977
Molecular profiling of early stage liver fibrosis in patients with chronic hepatitis C virus infection.Q42990096
Antiviral effects of the interferon-induced protein guanylate binding protein 1 and its interaction with the hepatitis C virus NS5B proteinQ42991703
Induction of a unique gene expression profile in primary human hepatocytes by hepatitis C virus core, NS3 and NS5A proteinsQ43036920
Hepatic gene expression discriminates responders and nonresponders in treatment of chronic hepatitis C viral infectionQ50579007
Identification of a novel gene family that includes the interferon-inducible human genes 6-16 and ISG12Q21266614
Mitochondrial localization and pro-apoptotic effects of the interferon-inducible protein ISG12aQ24309131
Regulation of hepatic innate immunity by hepatitis C virusQ26824743
Autophagy in hepatitis C virus-host interactions: potential roles and therapeutic targets for liver-associated diseasesQ26992256
The autophagy machinery is required to initiate hepatitis C virus replicationQ27489377
Structural basis of RNA recognition and activation by innate immune receptor RIG-IQ27674465
Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genomeQ27860719
Genetic variations in humans associated with differences in the course of hepatitis CQ28254610
Autophagy and the Integrated Stress ResponseQ29547398
Prevalence and burden of HCV co-infection in people living with HIV: a global systematic review and meta-analysisQ30251862
Endogenous intrahepatic IFNs and association with IFN-free HCV treatment outcomeQ33944295
Autophagy: assays and artifactsQ34341096
Interferon-stimulated genes: a complex web of host defensesQ34405609
MiR-942 mediates hepatitis C virus-induced apoptosis via regulation of ISG12aQ35146636
Hepatitis C virus upregulates Beclin1 for induction of autophagy and activates mTOR signaling.Q36172124
ISG12a Restricts Hepatitis C Virus Infection through the Ubiquitination-Dependent Degradation PathwayQ37093500
P921main subjectautophagyQ288322
apoptotic processQ14599311
type I interferon signaling pathwayQ14864809
Interferon alpha inducible protein 27Q21111061
P304page(s)231-239
P577publication date2016-10-21
P1433published inVirus ResearchQ15749215
P1476titleISG12a inhibits HCV replication and potentiates the anti-HCV activity of IFN-α through activation of the Jak/STAT signaling pathway independent of autophagy and apoptosis
P478volume227

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cites work (P2860)
Q37700932Autophagy impacts on oxaliplatin-induced hepatocarcinoma apoptosis via the IL-17/IL-17R-JAK2/STAT3 signaling pathway
Q90795498High level expression of ISG12(1) promotes cell apoptosis via mitochondrial-dependent pathway and so as to hinder Newcastle disease virus replication
Q56396247Long Non-coding RNAs: Regulators of Viral Infection and the Interferon Antiviral Response
Q90114574Single-Cell Transcriptome Analysis of Mouse Liver Cell-Specific Tropism and Transcriptional Dysregulation Following Intravenous Administration of AAVrh.10 Vectors
Q39388632The role of JAK-STAT signaling pathway and its regulators in the fate of T helper cells.
Q110175579Verification of SARS-CoV-2-Encoded small RNAs and contribution to Infection-Associated lung inflammation

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