Hepatitis C virus comes for dinner: How the hepatitis C virus interferes with autophagy

scientific article (publication date: 28 July 2015)

Hepatitis C virus comes for dinner: How the hepatitis C virus interferes with autophagy is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.3748/WJG.V21.I28.8492
P932PMC publication ID4515832
P698PubMed publication ID26229393

P2093author name stringEberhard Hildt
Daniela Ploen
P2860cites workBinding of hepatitis C virus to CD81Q22004178
Detection of a novel unglycosylated form of hepatitis C virus E2 envelope protein that is located in the cytosol and interacts with PKRQ24292085
Protein synthesis and endoplasmic reticulum stress can be modulated by the hepatitis C virus envelope protein E2 through the eukaryotic initiation factor 2alpha kinase PERKQ24296386
Nrf2 and Nrf1 signaling and ER stress crosstalk: implication for proteasomal degradation and autophagyQ24296827
pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress responseQ24303865
The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomesQ24305372
The human scavenger receptor class B type I is a novel candidate receptor for the hepatitis C virusQ24307963
TIP47: a cargo selection device for mannose 6-phosphate receptor traffickingQ24316494
Rab18 binds to hepatitis C virus NS5A and promotes interaction between sites of viral replication and lipid dropletsQ24317116
Diacylglycerol acyltransferase-1 localizes hepatitis C virus NS5A protein to lipid droplets and enhances NS5A interaction with the viral capsid coreQ24318808
Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A proteinQ24319002
Recruitment and activation of a lipid kinase by hepatitis C virus NS5A is essential for integrity of the membranous replication compartmentQ24337128
Lipid droplet-binding protein TIP47 regulates hepatitis C Virus RNA replication through interaction with the viral NS5A proteinQ24338608
Innate immune recognition of viral infectionQ24498364
Expression of hepatitis C virus proteins induces distinct membrane alterations including a candidate viral replication complexQ24537657
Hepatitis C virus subgenomic replicons induce endoplasmic reticulum stress activating an intracellular signaling pathwayQ24537844
Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacksQ24612235
The Atg16L complex specifies the site of LC3 lipidation for membrane biogenesis in autophagyQ24647053
TIP47 functions in the biogenesis of lipid dropletsQ24648200
Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cellsQ24671346
Emerging therapies for hepatitis CQ26853642
Autophagy in hepatitis C virus-host interactions: potential roles and therapeutic targets for liver-associated diseasesQ26992256
Membranous replication factories induced by plus-strand RNA virusesQ26999023
Three-dimensional architecture and biogenesis of membrane structures associated with hepatitis C virus replicationQ27339861
Molecular determinants and dynamics of hepatitis C virus secretionQ27347838
Trafficking of hepatitis C virus core protein during virus particle assemblyQ27348797
Control of PKR protein kinase by hepatitis C virus nonstructural 5A protein: molecular mechanisms of kinase regulationQ27469500
A retention signal necessary and sufficient for endoplasmic reticulum localization maps to the transmembrane domain of hepatitis C virus glycoprotein E2.Q27469530
Involvement of endoplasmic reticulum chaperones in the folding of hepatitis C virus glycoproteinsQ27469541
Expression of hepatitis C virus proteins interferes with the antiviral action of interferon independently of PKR-mediated control of protein synthesisQ27469667
Characterization of cell lines carrying self-replicating hepatitis C virus RNAsQ27469765
Robust hepatitis C virus infection in vitroQ27470013
Characterization of Low- and Very-Low-Density Hepatitis C Virus RNA-Containing ParticlesQ27472884
Different Domains of CD81 Mediate Distinct Stages of Hepatitis C Virus Pseudoparticle EntryQ27473222
Characterization of the Early Steps of Hepatitis C Virus Infection by Using Luciferase Reporter VirusesQ27473226
Hepatitis C Virus Entry Depends on Clathrin-Mediated EndocytosisQ27473290
Cell culture-grown hepatitis C virus is infectious in vivo and can be recultured in vitroQ27473436
Hepatitis C Virus Entry Requires a Critical Postinternalization Step and Delivery to Early Endosomes via Clathrin-Coated VesiclesQ27477644
Hepatitis C virus production by human hepatocytes dependent on assembly and secretion of very low-density lipoproteinsQ27478188
Participation of Rab5, an Early Endosome Protein, in Hepatitis C Virus RNA Replication MachineryQ27480343
Human Apolipoprotein E Is Required for Infectivity and Production of Hepatitis C Virus in Cell CultureQ27485012
Hepatitis C Virus Genotype 1a Growth and Induction of AutophagyQ27485449
Regulation of Hepatitis C Virion Production via Phosphorylation of the NS5A ProteinQ27485476
Essential Role of Domain III of Nonstructural Protein 5A for Hepatitis C Virus Infectious Particle AssemblyQ27485487
Hepatitis C virus and other flaviviridae viruses enter cells via low density lipoprotein receptorQ27485871
Cyclophilin A Is an Essential Cofactor for Hepatitis C Virus Infection and the Principal Mediator of Cyclosporine Resistance In VitroQ27486118
Equilibrium centrifugation studies of hepatitis C virus: evidence for circulating immune complexesQ27486195
Interaction of Hepatitis C Virus Nonstructural Protein 5A with Core Protein Is Critical for the Production of Infectious Virus ParticlesQ27486780
Induction of incomplete autophagic response by hepatitis C virus via the unfolded protein responseQ27487012
Tight Junction Proteins Claudin-1 and Occludin Control Hepatitis C Virus Entry and Are Downregulated during Infection To Prevent SuperinfectionQ27487947
Hepatitis C Virus Nonstructural 4B Protein Modulates Sterol Regulatory Element-binding Protein Signaling via the AKT PathwayQ27488294
Autophagy, Immunity, and Microbial AdaptationsQ27489075
The autophagy machinery is required to initiate hepatitis C virus replicationQ27489377
Eating the enemy within: autophagy in infectious diseasesQ27489453
Apolipoprotein E but Not B Is Required for the Formation of Infectious Hepatitis C Virus ParticlesQ27490474
Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active siteQ27619818
Structural and Functional Studies of Nonstructural Protein 2 of the Hepatitis C Virus Reveal Its Key Role as Organizer of Virion AssemblyQ27666400
Identification of a structural motif crucial for infectivity of hepatitis B virusesQ34598012
Hepatitis C virus core protein induces lipid droplet redistribution in a microtubule- and dynein-dependent manner.Q34779622
Identification of HNRNPK as regulator of hepatitis C virus particle productionQ34875666
Autophagy and multivesicular bodies: two closely related partnersQ34880346
Regulation of peptide bond cis/trans isomerization by enzyme catalysis and its implication in physiological processesQ35108317
Syndecan 4 is involved in mediating HCV entry through interaction with lipoviral particle-associated apolipoprotein EQ35153978
Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappaB in response to diverse cellular stressesQ35169632
A genetically humanized mouse model for hepatitis C virus infectionQ35174543
miR-122 activates hepatitis C virus translation by a specialized mechanism requiring particular RNA componentsQ35224344
Impact of the autophagy machinery on hepatitis C virus infectionQ35261712
Rab5 and class III phosphoinositide 3-kinase Vps34 are involved in hepatitis C virus NS4B-induced autophagy.Q35274953
Cyclophilin and NS5A inhibitors, but not other anti-hepatitis C virus (HCV) agents, preclude HCV-mediated formation of double-membrane-vesicle viral factoriesQ35385005
Characterization of hepatitis C virus interaction with heparan sulfate proteoglycansQ35488198
Mammalian nucleoside transportersQ35668173
Knockdown of autophagy enhances the innate immune response in hepatitis C virus-infected hepatocytesQ35910776
Antigen processing by macroautophagy for MHC presentationQ35927580
Autophagy inhibition engages Nrf2-p62 Ub-associated signalingQ35985404
Replication of hepatitis C virus RNA on autophagosomal membranesQ36002897
Endoplasmic reticulum stress in liver diseaseQ36031838
Hepatitis C virus particles and lipoprotein metabolism.Q36054706
Hepatitis C virus upregulates Beclin1 for induction of autophagy and activates mTOR signaling.Q36172124
Coordination of ER and oxidative stress signaling: the PERK/Nrf2 signaling pathwayQ36313774
dsRNA-dependent protein kinase PKR and its role in stress, signaling and HCV infectionQ36432681
Autophagy and antiviral immunityQ36503156
MiR-122 in hepatic function and liver diseasesQ36923038
Identification of transferrin receptor 1 as a hepatitis C virus entry factorQ36967731
Antioxidants Enhance Mammalian Proteasome Expression through the Keap1-Nrf2 Signaling PathwayQ37062266
Global control of hepatitis C: where challenge meets opportunityQ37077112
Innate immune modulation by RNA viruses: emerging insights from functional genomicsQ37226509
Completion of the entire hepatitis C virus life cycle in genetically humanized miceQ37382399
HCV infection selectively impairs type I but not type III IFN signalingQ37415444
PAT proteins, an ancient family of lipid droplet proteins that regulate cellular lipid stores.Q37435661
Toll-like receptors in control of immunological autophagy.Q37460134
The ins and outs of hepatitis C virus entry and assemblyQ37498626
Hepatitis C virus-induced hepatocarcinogenesis.Q37527272
Coordination of membrane events during autophagy by multiple class III PI3-kinase complexesQ37606853
EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapyQ37609988
Divergent roles of autophagy in virus infectionQ37679218
Assembly of infectious hepatitis C virus particlesQ37819269
Autophagy in regulation of Toll-like receptor signalingQ37983945
Hepatitis C virus RNA replicationQ38086753
Modulation of the autophagy pathway by human tumor virusesQ38111130
Bidirectional regulation of NF-κB by reactive oxygen species: a role of unfolded protein responseQ38116303
Evolutionarily conserved role and physiological relevance of a STX17/Syx17 (syntaxin 17)-containing SNARE complex in autophagosome fusion with endosomes and lysosomesQ38151369
The autophagosome: origins unknown, biogenesis complexQ38160660
What is the future of ribavirin therapy for hepatitis C?Q38182243
New hepatitis C therapies: the toolbox, strategies, and challengesQ38196150
Persistent hepatitis C virus infection impairs ribavirin antiviral activity through clathrin-mediated trafficking of equilibrative nucleoside transporter 1.Q38262107
The mechanism of HCV entry into host cellsQ38321419
Cellular binding of hepatitis C virus envelope glycoprotein E2 requires cell surface heparan sulfateQ38352468
Impaired autophagy response in human hepatocellular carcinoma.Q38393661
The small GTPase Rab7 as a central regulator of hepatocellular lipophagyQ38922472
Intracellular accumulation of subviral HBsAg particles and diminished Nrf2 activation in HBV genotype G expressing cells lead to an increased ROI levelQ38935919
TIP47 is associated with the hepatitis C virus and its interaction with Rab9 is required for release of viral particlesQ39028987
Syndecan-1 serves as the major receptor for attachment of hepatitis C virus to the surfaces of hepatocytesQ39168236
Molecular pathways for glucose homeostasis, insulin signaling and autophagy in hepatitis C virus induced insulin resistance in a cellular modelQ39302717
Hepatitis C virus attachment mediated by apolipoprotein E binding to cell surface heparan sulfateQ39358973
Dysfunction of autophagy participates in vacuole formation and cell death in cells replicating hepatitis C virusQ39458949
Hepatitis C virus impairs the induction of cytoprotective Nrf2 target genes by delocalization of small Maf proteinsQ39610357
New developments in HCV therapyQ39664147
Ultrastructural and biochemical analyses of hepatitis C virus-associated host cell membranesQ39702289
Apolipoprotein E interacts with hepatitis C virus nonstructural protein 5A and determines assembly of infectious particles.Q39762742
Vps4 and the ESCRT-III complex are required for the release of infectious hepatitis C virus particlesQ39787454
Hepatitis C virus NS4B induces unfolded protein response and endoplasmic reticulum overload response-dependent NF-kappaB activationQ39821567
Knockdown of autophagy-related gene decreases the production of infectious hepatitis C virus particlesQ39821948
The lipid droplet binding domain of hepatitis C virus core protein is a major determinant for efficient virus assemblyQ40066670
Proteomic profiling of lipid droplet proteins in hepatoma cell lines expressing hepatitis C virus core proteinQ40271700
Induction of 26S proteasome subunit PSMB5 by the bifunctional inducer 3-methylcholanthrene through the Nrf2-ARE, but not the AhR/Arnt-XRE, pathwayQ40275810
Thr 446 phosphorylation of PKR by HCV core protein deregulates G2/M phase in HCC cellsQ40425186
Cyclosporin A suppresses replication of hepatitis C virus genome in cultured hepatocytesQ40622941
Differential activation of interferon-inducible genes by hepatitis C virus core protein mediated by the interferon stimulated response element.Q40627485
Cellular glycosaminoglycans and low density lipoprotein receptor are involved in hepatitis C virus adsorptionQ40706735
Syntaxin 17: the autophagosomal SNARE.Q41510414
Morphological and biochemical characterization of the membranous hepatitis C virus replication compartmentQ41851727
Autophagy and RNA virus interactomes reveal IRGM as a common target.Q42051450
TIP47 plays a crucial role in the life cycle of hepatitis C virusQ42277402
Hepatitis C virus: buoyant density of the factor VIII-derived isolate in sucroseQ42984652
HRas signal transduction promotes hepatitis C virus cell entry by triggering assembly of the host tetraspanin receptor complex.Q42990165
Autophagy proteins promote hepatitis C virus replicationQ42991876
Autophagy: a novel guardian of HCV against innate immune responseQ43033289
Activation of the interferon-inducible protein kinase PKR by hepatocellular carcinoma derived-hepatitis C virus core proteinQ43034820
In vivo hepatic endoplasmic reticulum stress in patients with chronic hepatitis C.Q44332232
Structure of a lipid droplet protein; the PAT family member TIP47.Q47227013
Structure of the core ectodomain of the hepatitis C virus envelope glycoprotein 2Q27681839
Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagyQ27685461
Viral replication. Structural basis for RNA replication by the hepatitis C virus polymeraseQ27697984
Autophagy fights disease through cellular self-digestionQ27860902
Complete replication of hepatitis C virus in cell cultureQ27860934
Replication of hepatitis C virusQ27860957
Atg9 cycles between mitochondria and the pre-autophagosomal structure in yeastsQ27931774
The conserved oligomeric Golgi complex is involved in double-membrane vesicle formation during autophagyQ27935788
The lipid droplet is an important organelle for hepatitis C virus productionQ28131709
Claudin-1 is a hepatitis C virus co-receptor required for a late step in entryQ28131832
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNAQ28214814
Impaired liver regeneration in Nrf2 knockout mice: role of ROS-mediated insulin/IGF-1 resistanceQ28505114
ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signalsQ28646129
Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathwayQ29547371
Autophagy and the Integrated Stress ResponseQ29547398
Genetic diversity and evolution of hepatitis C virus--15 years onQ29547888
Plasma membrane contributes to the formation of pre-autophagosomal structuresQ29614494
Mechanism of action of interferon and ribavirin in treatment of hepatitis CQ29619805
Ultrastructural and biophysical characterization of hepatitis C virus particles produced in cell cultureQ30432551
Nrf2: friend or foe for chemoprevention?Q33575690
The ESCRT system is required for hepatitis C virus productionQ33802795
NS2 protein of hepatitis C virus interacts with structural and non-structural proteins towards virus assemblyQ33828601
Hepatitis C virus NS5A hijacks ARFGAP1 to maintain a phosphatidylinositol 4-phosphate-enriched microenvironmentQ33887705
Regulation of mTORC1 by the Rab and Arf GTPasesQ33924196
Hepatitis C virus blocks interferon effector function by inducing protein kinase R phosphorylationQ34000124
Autophagy in HCV infection: keeping fat and inflammation at bayQ34069393
Autophagy protein ATG5 interacts transiently with the hepatitis C virus RNA polymerase (NS5B) early during infectionQ34078007
IRGM is a common target of RNA viruses that subvert the autophagy network.Q34102728
Characterization of the envelope glycoproteins associated with infectious hepatitis C virusQ34120689
The C-terminal alpha-helix domain of apolipoprotein E is required for interaction with nonstructural protein 5A and assembly of hepatitis C virusQ34190545
Identification of the Niemann-Pick C1-like 1 cholesterol absorption receptor as a new hepatitis C virus entry factorQ34245963
Identification of conserved residues in hepatitis C virus envelope glycoprotein E2 that modulate virus dependence on CD81 and SRB1 entry factorsQ34262175
MAP-kinase regulated cytosolic phospholipase A2 activity is essential for production of infectious hepatitis C virus particlesQ34387277
Activation of the unfolded protein response and autophagy after hepatitis C virus infection suppresses innate antiviral immunity in vitroQ34428880
Global distribution and prevalence of hepatitis C virus genotypesQ34431175
P433issue28
P407language of work or nameEnglishQ1860
P921main subjectdinnerQ657221
hepatitis CQ154869
autophagyQ288322
Hepatitis C virusQ708693
P304page(s)8492-507
P577publication date2015-07-28
P1433published inWorld Journal of GastroenterologyQ15708885
P1476titleHepatitis C virus comes for dinner: How the hepatitis C virus interferes with autophagy
P478volume21

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cites work (P2860)
Q90151313Flaviviridae Viruses and Oxidative Stress: Implications for Viral Pathogenesis
Q26996778HCV and Oxidative Stress: Implications for HCV Life Cycle and HCV-Associated Pathogenesis
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Q57246430Influenza A Virus Induces Autophagosomal Targeting of Ribosomal Proteins
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Q32182890Rab33B Controls Hepatitis B Virus Assembly by Regulating Core Membrane Association and Nucleocapsid Processing
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Q38893853p62/SQSTM1-Dr. Jekyll and Mr. Hyde that prevents oxidative stress but promotes liver cancer

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