Regulation of mTORC1 by the Rab and Arf GTPases

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Regulation of mTORC1 by the Rab and Arf GTPases is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.C110.102483
P932PMC publication ID2888380
P698PubMed publication ID20457610

P2093author name stringLi Li
Thomas P Neufeld
Eunjung Kim
Haixin Yuan
Kun-Liang Guan
Ken Inoki
Pankuri Goraksha-Hicks
Rachel L Schiesher
P2860cites workStructural plasticity of an invariant hydrophobic triad in the switch regions of Rab GTPases is a determinant of effector recognitionQ27630885
TOR signaling in growth and metabolismQ27860757
Rab proteins as membrane organizersQ27860861
TSC2 mediates cellular energy response to control cell growth and survivalQ27860970
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signallingQ28131740
Rheb is a direct target of the tuberous sclerosis tumour suppressor proteinsQ28207283
Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiencyQ28249019
Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathwayQ28646919
Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward RhebQ28646935
Regulation of TORC1 by Rag GTPases in nutrient responseQ29614478
Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanismQ29614737
Rab conversion as a mechanism of progression from early to late endosomesQ29616151
Brefeldin A inhibits Golgi membrane-catalysed exchange of guanine nucleotide onto ARF proteinQ29618202
Akt regulates growth by directly phosphorylating Tsc2Q29620397
4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathwayQ29620730
Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways.Q30169019
A genetic screen in Drosophila reveals novel cytoprotective functions of the autophagy-lysosome pathwayQ33475622
The S6 kinase signaling pathway in the control of development and growth.Q34988715
Membrane targeting of Rab GTPases is influenced by the prenylation motifQ35153478
The small G proteins of the Arf family and their regulatorsQ36824194
Nutrient-dependent regulation of autophagy through the target of rapamycin pathway.Q37368307
Ran on tracks--cytoplasmic roles for a nuclear regulatorQ37395610
Inhibition by brefeldin A of a Golgi membrane enzyme that catalyses exchange of guanine nucleotide bound to ARFQ59066677
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complexQ24295120
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinaseQ24300915
Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth controlQ24314363
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1Q24315566
AMPK phosphorylation of raptor mediates a metabolic checkpointQ24329244
Insulin stimulates phosphatidylinositol 3-phosphate production via the activation of Rab5Q24649644
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signalingQ24672005
P433issue26
P407language of work or nameEnglishQ1860
P1104number of pages5
P304page(s)19705-19709
P577publication date2010-05-10
P1433published inJournal of Biological ChemistryQ867727
P1476titleRegulation of mTORC1 by the Rab and Arf GTPases
P478volume285

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cites work (P2860)
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