Essential amino acid sensing, signaling, and transport in the regulation of human muscle protein metabolism.

scientific article published on January 2011

Essential amino acid sensing, signaling, and transport in the regulation of human muscle protein metabolism. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1097/MCO.0B013E3283406F3E
P8608Fatcat IDrelease_t4a2ju657vaxvjasx3kw56glky
P932PMC publication ID3290995
P698PubMed publication ID21076294
P5875ResearchGate publication ID47791700

P50authorBlake B. RasmussenQ42425454
P2093author name stringJared M Dickinson
P2860cites workHuman muscle protein synthesis is modulated by extracellular, not intramuscular amino acid availability: a dose-response studyQ42445886
Human soleus and vastus lateralis muscle protein metabolism with an amino acid infusionQ42469749
Protein synthesis rates in human muscles: neither anatomical location nor fibre-type composition are major determinantsQ42472104
Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.Q42995176
Amino acid ingestion improves muscle protein synthesis in the young and elderlyQ44635433
Combined ingestion of protein and free leucine with carbohydrate increases postexercise muscle protein synthesis in vivo in male subjects.Q45161621
Tertiary active transport of amino acids reconstituted by coexpression of System A and L transporters in Xenopus oocytes.Q45923707
PAT-related amino acid transporters regulate growth via a novel mechanism that does not require bulk transport of amino acidsQ46447985
A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly.Q46968639
Leucine stimulates translation initiation in skeletal muscle of postabsorptive rats via a rapamycin-sensitive pathwayQ48701446
Orally administered leucine stimulates protein synthesis in skeletal muscle of postabsorptive rats in association with increased eIF4F formation.Q52892576
Leucine supplementation improves muscle protein synthesis in elderly men independently of hyperaminoacidaemia.Q55042094
Flooding with L-[1-13C]leucine stimulates human muscle protein incorporation of continuously infused L-[1-13C]valineQ57134360
Co-ingestion of leucine with protein does not further augment post-exercise muscle protein synthesis rates in elderly menQ57580388
Muscle-specific atrophy of the quadriceps femoris with agingQ73888899
Oral amino acids stimulate muscle protein anabolism in the elderly despite higher first-pass splanchnic extractionQ78252564
Role of the transcription factor ATF4 in the anabolic actions of insulin and the anti-anabolic actions of glucocorticoidsQ80150787
Aging is associated with diminished accretion of muscle proteins after the ingestion of a small bolus of essential amino acidsQ81464932
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1Q24315566
A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signallingQ24678327
Protein supplements and exerciseQ28142286
Invited review: Aging and sarcopeniaQ28206542
Nutritional and contractile regulation of human skeletal muscle protein synthesis and mTORC1 signalingQ28307009
Latency and duration of stimulation of human muscle protein synthesis during continuous infusion of amino acidsQ28362863
Bidirectional transport of amino acids regulates mTOR and autophagyQ29614476
Regulation of TORC1 by Rag GTPases in nutrient responseQ29614478
An increase in essential amino acid availability upregulates amino acid transporter expression in human skeletal muscleQ33840291
Regulation of mTORC1 by the Rab and Arf GTPasesQ33924196
Signaling pathways and molecular mechanisms through which branched-chain amino acids mediate translational control of protein synthesisQ33992368
Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase.Q34063643
Excess leucine intake enhances muscle anabolic signaling but not net protein anabolism in young men and womenQ34204391
Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscleQ34376051
Nutrient signalling in the regulation of human muscle protein synthesisQ34579211
Long-term leucine supplementation does not increase muscle mass or strength in healthy elderly men.Q34969014
Amino acid transporters: roles in amino acid sensing and signalling in animal cellsQ35184476
Oral and intravenously administered amino acids produce similar effects on muscle protein synthesis in the elderly.Q35335181
Essential amino acids are primarily responsible for the amino acid stimulation of muscle protein anabolism in healthy elderly adultsQ35335196
Short-term insulin and nutritional energy provision do not stimulate muscle protein synthesis if blood amino acid availability decreasesQ35335386
Aging muscleQ36121630
The mTOR pathway in the control of protein synthesisQ36600753
The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila.Q36660687
Amino acid transporters and nutrient-sensing mechanisms: new targets for treating insulin-linked disorders?Q36979733
Amino acid transceptors: gate keepers of nutrient exchange and regulators of nutrient signalingQ37374064
Exogenous amino acids stimulate net muscle protein synthesis in the elderlyQ37381675
Essential amino acids increase microRNA-499, -208b, and -23a and downregulate myostatin and myocyte enhancer factor 2C mRNA expression in human skeletal muscleQ37421218
Proton-assisted amino-acid transporters are conserved regulators of proliferation and amino-acid-dependent mTORC1 activationQ39700812
Distinct anabolic signalling responses to amino acids in C2C12 skeletal muscle cells.Q39780564
hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinaseQ40392574
Regulation of protein metabolism during stressQ40428914
Amino acids activate mTOR complex 1 via Ca2+/CaM signaling to hVps34.Q41644777
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectessential amino acidQ245282
P304page(s)83-88
P577publication date2011-01-01
P1433published inCurrent Opinion in Clinical Nutrition and Metabolic CareQ15757962
P1476titleEssential amino acid sensing, signaling, and transport in the regulation of human muscle protein metabolism
P478volume14

Reverse relations

cites work (P2860)
Q37266159Activation of AMPK/TSC2/PLD by alcohol regulates mTORC1 and mTORC2 assembly in C2C12 myocytes
Q38997122Dietary protein supplementation in the elderly for limiting muscle mass loss
Q57472103Digestive Responses to Fortified Cow or Goat Dairy Drinks: A Randomised Controlled Trial
Q48023784Effects of leucine and citrulline versus non-essential amino acids on muscle protein synthesis in fasted rat: a common activation pathway?
Q28077935Human Skeletal Muscle Disuse Atrophy: Effects on Muscle Protein Synthesis, Breakdown, and Insulin Resistance-A Qualitative Review
Q37727865Insulin increases mRNA abundance of the amino acid transporter SLC7A5/LAT1 via an mTORC1-dependent mechanism in skeletal muscle cells.
Q53655233Postprandial nutrient-sensing and metabolic responses after partial dietary fishmeal replacement by soyabean meal in turbot (Scophthalmus maximus L.).
Q35993758Rag GTPases and AMPK/TSC2/Rheb mediate the differential regulation of mTORC1 signaling in response to alcohol and leucine
Q36924317Rapamycin does not affect post-absorptive protein metabolism in human skeletal muscle
Q51075352Skeletal muscle disuse atrophy is not attenuated by dietary protein supplementation in healthy older men.
Q33708188Soy-dairy protein blend and whey protein ingestion after resistance exercise increases amino acid transport and transporter expression in human skeletal muscle.
Q35008883Stimulation of mTORC1 with L-leucine rescues defects associated with Roberts syndrome.
Q64274822Vanillic Acid Suppresses HIF-1α Expression via Inhibition of mTOR/p70S6K/4E-BP1 and Raf/MEK/ERK Pathways in Human Colon Cancer HCT116 Cells