Regulation of Hepatitis C Virion Production via Phosphorylation of the NS5A Protein

scientific article (publication date: 21 March 2008)

Regulation of Hepatitis C Virion Production via Phosphorylation of the NS5A Protein is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PPAT.1000032
P3181OpenCitations bibliographic resource ID1701892
P932PMC publication ID2265800
P698PubMed publication ID18369478
P5875ResearchGate publication ID5484008

P2093author name stringTimothy L Tellinghuisen
Jason Treadaway
Katie L Foss
P2860cites workPurification of a yeast protein kinase sharing properties with type I and type II casein kinasesQ68193837
Hepatitis C: global prevalenceQ73914212
Identification of the major phosphorylation site of the hepatitis C virus H strain NS5A protein as serine 2321Q22010539
Cellular cofactors affecting hepatitis C virus infection and replicationQ24317564
Phosphorylation of hepatitis C virus nonstructural protein 5A modulates its protein interactions and viral RNA replicationQ24561987
Interactions between viral nonstructural proteins and host protein hVAP-33 mediate the formation of hepatitis C virus RNA replication complex on lipid raftQ24600344
Robust hepatitis C virus infection in vitroQ27470013
The Src Family Kinase c-Yes Is Required for Maturation of West Nile Virus ParticlesQ27471553
Quantitative Analysis of the Hepatitis C Virus Replication ComplexQ27472670
Highly permissive cell lines for subgenomic and genomic hepatitis C virus RNA replicationQ27472912
Production of infectious genotype 1a hepatitis C virus (Hutchinson strain) in cultured human hepatoma cellsQ27473106
Structure of the zinc-binding domain of an essential component of the hepatitis C virus replicaseQ27473147
Construction and characterization of infectious intragenotypic and intergenotypic hepatitis C virus chimerasQ27473179
Identification of the Hepatitis C Virus RNA Replication Complex in Huh-7 Cells Harboring Subgenomic RepliconsQ27473471
Differential Biophysical Properties of Infectious Intracellular and Secreted Hepatitis C Virus ParticlesQ27477620
c-Src protein kinase inhibitors block assembly and maturation of dengue virusQ27478101
Phosphorylation of hepatitis C virus-encoded nonstructural protein NS5AQ27478481
Phosphorylation of the hepatitis C virus NS5A protein in vitro and in vivo: properties of the NS5A-associated kinaseQ27480873
Hepatitis C Virus p7 Protein Is Crucial for Assembly and Release of Infectious VirionsQ27480902
Hepatitis C Virus p7 and NS2 Proteins Are Essential for Production of Infectious VirusQ27481018
Identification of Residues Required for RNA Replication in Domains II and III of the Hepatitis C Virus NS5A ProteinQ27485314
Expression and identification of hepatitis C virus polyprotein cleavage productsQ27486022
Internal ribosome entry site within hepatitis C virus RNAQ27486220
Efficient initiation of HCV RNA replication in cell cultureQ27860520
Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genomeQ27860719
Production of infectious hepatitis C virus in tissue culture from a cloned viral genomeQ27860899
Complete replication of hepatitis C virus in cell cultureQ27860934
The lipid droplet is an important organelle for hepatitis C virus productionQ28131709
Prediction of post-translational glycosylation and phosphorylation of proteins from the amino acid sequenceQ29616388
Efficient replication of the genotype 2a hepatitis C virus subgenomic repliconQ29619491
An amino-terminal amphipathic alpha-helix mediates membrane association of the hepatitis C virus nonstructural protein 5AQ29620628
NMR structure and molecular dynamics of the in-plane membrane anchor of nonstructural protein 5A from bovine viral diarrhea virusQ31032305
Insertion of green fluorescent protein into nonstructural protein 5A allows direct visualization of functional hepatitis C virus replication complexesQ33204253
Hepatitis C virus NS2 protein is phosphorylated by the protein kinase CK2 and targeted for degradation to the proteasomeQ33835218
Hepatitis C virus NS5A: tales of a promiscuous proteinQ33980571
Phosphorylation of hepatitis C virus NS5A nonstructural protein: a new paradigm for phosphorylation-dependent viral RNA replication?Q34003264
Protein kinase CK2: a challenge to canonsQ34875408
Order or chaos? An evaluation of the regulation of protein kinase CK2.Q36021539
Hepatitis C virus nonstructural protein 5A (NS5A) is an RNA-binding proteinQ38321693
Phosphorylation of bluetongue virus nonstructural protein 2 is essential for formation of viral inclusion bodies.Q39257481
Hepatitis C virus NS5A is a direct substrate of casein kinase I-alpha, a cellular kinase identified by inhibitor affinity chromatography using specific NS5A hyperphosphorylation inhibitorsQ40196972
Reduction of hepatitis C virus NS5A hyperphosphorylation by selective inhibition of cellular kinases activates viral RNA replication in cell cultureQ40273957
Tagging of NS5A expressed from a functional hepatitis C virus repliconQ40316646
Mutational analysis of hepatitis C virus nonstructural protein 5A: potential role of differential phosphorylation in RNA replication and identification of a genetically flexible domain.Q40458895
Efficient rescue of hepatitis C virus RNA replication by trans-complementation with nonstructural protein 5A.Q40478178
The NS5A protein of hepatitis C virus is a zinc metalloproteinQ40520544
Purification and characterization of hepatitis C virus non-structural protein 5A expressed in Escherichia coliQ40528507
Structure and function of the membrane anchor domain of hepatitis C virus nonstructural protein 5A.Q40536971
Ser(2194) is a highly conserved major phosphorylation site of the hepatitis C virus nonstructural protein NS5A.Q40837290
Hepatitis C virus NS5A protein is phosphorylated by casein kinase II.Q40959885
The Los Alamos hepatitis C sequence databaseQ42987686
Insertion and deletion analyses identify regions of non-structural protein 5A of Hepatitis C virus that are dispensable for viral genome replication.Q42997783
Heterogeneity of CK2 phosphorylation sites in the NS5A protein of different hepatitis C virus genotypesQ43041235
2-Dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole: a novel powerful and selective inhibitor of protein kinase CK2.Q45052212
Human casein kinase II. The subunit alpha protein activates transcription of the subunit beta geneQ48128937
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue3
P407language of work or nameEnglishQ1860
P921main subjecthepatitis CQ154869
phosphorylationQ242736
Hepatitis C virusQ708693
virionQ1757347
P304page(s)e1000032
P577publication date2008-03-21
P1433published inPLOS PathogensQ283209
P1476titleRegulation of Hepatitis C Virion Production via Phosphorylation of the NS5A Protein
P478volume4

Reverse relations

cites work (P2860)
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Q24323080Y-box-binding protein 1 interacts with hepatitis C virus NS3/4A and influences the equilibrium between viral RNA replication and infectious particle production
Q34711864hepatitis c Virus p7 is critical for capsid assembly and envelopment
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