Nonstructural 5A Protein of Hepatitis C Virus Interferes with Toll-Like Receptor Signaling and Suppresses the Interferon Response in Mouse Liver

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Nonstructural 5A Protein of Hepatitis C Virus Interferes with Toll-Like Receptor Signaling and Suppresses the Interferon Response in Mouse Liver is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2017PLoSO..1270461T
P356DOI10.1371/JOURNAL.PONE.0170461
P932PMC publication ID5249188
P698PubMed publication ID28107512

P50authorYoshiharu MatsuuraQ60077839
Kazuhiko KoikeQ21699620
P2093author name stringKyoji Moriya
Takeya Tsutsumi
Tetsuro Suzuki
Hideki Aizaki
Hiroshi Yotsuyanagi
Hidetaka Fujinaga
Kenichiro Enooku
Kazuya Okushin
P2860cites workHepatitis C virus NS5A protein impairs TNF-mediated hepatic apoptosis, but not by an anti-FAS antibody, in transgenic miceQ45733379
Human hepatocytes express an array of proinflammatory cytokines after agonist stimulation or bacterial invasion.Q45979869
HCV NS5A inhibits interferon-alpha signaling through suppression of STAT1 phosphorylation in hepatocyte-derived cell linesQ24295166
Hepatitis C virus nonstructural protein 5A modulates the toll-like receptor-MyD88-dependent signaling pathway in macrophage cell linesQ24310415
Toll-like receptor signallingQ24570126
Gut microbiota and liver diseasesQ27015127
Control of PKR protein kinase by hepatitis C virus nonstructural 5A protein: molecular mechanisms of kinase regulationQ27469500
Hepatitis C virus nonstructural 5A protein induces interleukin-8, leading to partial inhibition of the interferon-induced antiviral responseQ27469808
Host-Specific Response to HCV Infection in the Chimeric SCID-beige/Alb-uPA Mouse Model: Role of the Innate Antiviral Immune ResponseQ27473258
Phosphorylation of hepatitis C virus-encoded nonstructural protein NS5AQ27478481
Regulation of Hepatitis C Virion Production via Phosphorylation of the NS5A ProteinQ27485476
Toll-like receptor 4 mediates synergism between alcohol and HCV in hepatic oncogenesis involving stem cell marker NanogQ27487860
Inhibition of Intrahepatic Gamma Interferon Production by Hepatitis C Virus Nonstructural Protein 5A in Transgenic MiceQ27489517
The hepatitis C virus non-structural NS5A protein impairs both the innate and adaptive hepatic immune response in vivoQ27490490
Hepatitis C virus infection is associated with the development of hepatocellular carcinomaQ28131791
Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infectionQ29620702
The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic miceQ29620765
Microbiota-liver axis in hepatic disease.Q33855414
Phosphorylation of hepatitis C virus NS5A nonstructural protein: a new paradigm for phosphorylation-dependent viral RNA replication?Q34003264
Hepatitis C virus infection suppresses the interferon response in the liver of the human hepatocyte chimeric mouseQ34009002
Gut-liver axis and fibrosis in nonalcoholic fatty liver disease: an input for novel therapiesQ34528777
Viral hepatitis and liver cancer: the case of hepatitis C.Q34568619
The role of the gut microbiota in NAFLD.Q36044190
Alcoholic liver disease and the gut-liver axisQ37711304
Innate immunity and HCV.Q38051911
Gut-liver axis in alcoholic liver diseaseQ38275213
Hepatitis C virus NS5A: enigmatic but still promiscuous 10 years on!Q38284234
Non-structural 5A protein of hepatitis C virus induces a range of liver pathology in transgenic mice.Q38493511
Hepatitis C virus NS5A mediated STAT3 activation requires co-operation of Jak1 kinaseQ40570423
Hepatitis C virus core protein induces hepatic steatosis in transgenic miceQ42983905
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjecttoll-like receptorQ408004
Hepatitis C virusQ708693
P304page(s)e0170461
P577publication date2017-01-20
P1433published inPLOS OneQ564954
P1476titleNonstructural 5A Protein of Hepatitis C Virus Interferes with Toll-Like Receptor Signaling and Suppresses the Interferon Response in Mouse Liver
P478volume12

Reverse relations

Q39327457Immune Evasion Strategies during Chronic Hepatitis B and C Virus Infectioncites workP2860

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