Hepatitis C virus NS5A mediated STAT3 activation requires co-operation of Jak1 kinase

scientific article published on April 2004

Hepatitis C virus NS5A mediated STAT3 activation requires co-operation of Jak1 kinase is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.VIROL.2004.01.008
P8608Fatcat IDrelease_5p5z5srxqneqbc4ifmik4z57xu
P698PubMed publication ID15063116
P5875ResearchGate publication ID8638688

P50authorRatna B RayQ90724777
P2093author name stringRobert Steele
Ranjit Ray
Asish K Ghosh
Bhaswati Sarcar
P2860cites workNS5A, a nonstructural protein of hepatitis C virus, binds growth factor receptor-bound protein 2 adaptor protein in a Src homology 3 domain/ligand-dependent manner and perturbs mitogenic signalingQ22009551
Hepatitis C virus RNA polymerase and NS5A complex with a SNARE-like proteinQ22010735
Hepatitis C virus NS5A protein modulates transcription through a novel cellular transcription factor SRCAPQ22253279
Nonstructural protein 5A of hepatitis C virus inhibits the function of karyopherin beta3Q22254038
Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathwayQ24531184
Activation and association of Stat3 with Src in v-Src-transformed cell linesQ24650319
Hepatitis C virus nonstructural 5A protein induces interleukin-8, leading to partial inhibition of the interferon-induced antiviral responseQ27469808
Persistent and transient replication of full-length hepatitis C virus genomes in cell cultureQ27472869
Subversion of Cell Signaling Pathways by Hepatitis C Virus Nonstructural 5A Protein via Interaction with Grb2 and P85 Phosphatidylinositol 3-KinaseQ27472897
Activation of STAT3 by the Hepatitis C Virus Core Protein Leads to Cellular TransformationQ27485121
Gene mapping of the putative structural region of the hepatitis C virus genome by in vitro processing analysisQ27860603
Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genomeQ27860719
Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteinsQ27860890
Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylationQ28288257
Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6Q28637521
STATs and gene regulationQ29547796
STATs in oncogenesisQ29617571
Transcriptional responses to polypeptide ligands: the JAK-STAT pathwayQ29620287
Hepatitis C virus NS5A physically associates with p53 and regulates p21/waf1 gene expression in a p53-dependent mannerQ33836415
Association of STATs with relatives and friendsQ33838284
Human hepatitis C virus NS5A protein alters intracellular calcium levels, induces oxidative stress, and activates STAT-3 and NF-kappa B.Q33933056
The role of STATs in transcriptional control and their impact on cellular functionQ33941346
Cytokine signaling in 2002: new surprises in the Jak/Stat pathwayQ34126053
The origin and evolution of hepatitis viruses in humansQ34189077
The hepatitis B virus HBx protein is a dual specificity cytoplasmic activator of Ras and nuclear activator of transcription factorsQ36684890
Activation of Stat3 in v-Src-transformed fibroblasts requires cooperation of Jak1 kinase activityQ38312043
Opposite regulation of myc and p21waf1 transcription by STAT3 proteinsQ38360847
Constitutively Activated Jak-STAT Pathway in T Cells Transformed with HTLV-IQ39250459
Stat3 activation by Src induces specific gene regulation and is required for cell transformationQ39583802
Cytoplasmic transport of Stat3 by receptor-mediated endocytosisQ39647602
Cytokine receptor signallingQ40416594
Inhibition of hepatitis C virus protein expression by RNA interferenceQ40638524
HCV NS5A interacts with p53 and inhibits p53-mediated apoptosisQ40720204
Kaposi's Sarcoma-associated herpesvirus open reading frame 50 stimulates the transcriptional activity of STAT3.Q40763723
Hepatitis C virus NS5A protein protects against TNF-alpha mediated apoptotic cell deathQ40871684
Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoproteinQ41326706
Production of two phosphoproteins from the NS5A region of the hepatitis C viral genome.Q42596301
MBP-1 mediated apoptosis involves cytochrome c release from mitochondriaQ42815963
Hepatitis C virus NS5A protein modulates cell cycle regulatory genes and promotes cell growthQ42993783
Hepatitis C virus NS5A protein impairs TNF-mediated hepatic apoptosis, but not by an anti-FAS antibody, in transgenic miceQ45733379
Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factorQ68007089
Molecular virology of hepatitis C virusQ73829009
PTEN transcriptionally modulates c-myc gene expression in human breast carcinoma cells and is involved in cell growth regulationQ78026206
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectHepatitis C virusQ708693
P304page(s)51-60
P577publication date2004-04-01
P1433published inVirologyQ7934867
P1476titleHepatitis C virus NS5A mediated STAT3 activation requires co-operation of Jak1 kinase
P478volume322

Reverse relations

cites work (P2860)
Q26741576A Central Role for STAT3 in Gammaherpesvirus-Life Cycle and -Diseases
Q35954415Altered p-STAT3 (tyr705) expression is associated with histological grading and intratumour microvessel density in hepatocellular carcinoma
Q27487944Arsenic Trioxide Inhibits Hepatitis C Virus RNA Replication through Modulation of the Glutathione Redox System and Oxidative Stress
Q40786667Differential association of STAT3 and HK-II expression in hepatitis B virus- and hepatitis C virus-related hepatocellular carcinoma
Q83856045Downregulation of GRIM-19 is associated with hyperactivation of p-STAT3 in hepatocellular carcinoma
Q29618976Evasion of intracellular host defence by hepatitis C virus
Q27487140Hepatitis C Virus Core Protein Augments Androgen Receptor-Mediated Signaling
Q27469443Hepatitis C virus NS5A-mediated activation of phosphoinositide 3-kinase results in stabilization of cellular beta-catenin and stimulation of beta-catenin-responsive transcription
Q36397362Hepatitis C virus activates Bcl-2 and MMP-2 expression through multiple cellular signaling pathways
Q56917098Hepatitis C virus and hepatocellular carcinoma
Q36935539Hepatitis C virus infection and apoptosis
Q42991206Hepatitis C virus targets the interferon-α JAK/STAT pathway by promoting proteasomal degradation in immune cells and hepatocytes
Q33779089Hepcidin and the iron enigma in HCV infection
Q36124729Host cell targets in HCV therapy: novel strategy or proven practice?
Q33303326Identification of human kinases involved in hepatitis C virus replication by small interference RNA library screening.
Q27489517Inhibition of Intrahepatic Gamma Interferon Production by Hepatitis C Virus Nonstructural Protein 5A in Transgenic Mice
Q45375947Inhibition of the interferon antiviral response by hepatitis C virus
Q40000685Isolation and gene analysis of interferon alpha-resistant cell clones of the hepatitis C virus subgenome
Q96768636Natural cardenolides suppress coronaviral replication by downregulating JAK1 via a Na+/K+-ATPase independent proteolysis
Q37574403Neurotoxic effects of the HCV core protein are mediated by sustained activation of ERK via TLR2 signaling
Q36841728New animal models for hepatitis C viral infection and pathogenesis studies
Q36255920Nonstructural 5A Protein of Hepatitis C Virus Interferes with Toll-Like Receptor Signaling and Suppresses the Interferon Response in Mouse Liver
Q35261292Oncogenic potential of hepatitis C virus proteins
Q40923110PI3K-Akt signaling pathway upregulates hepatitis C virus RNA translation through the activation of SREBPs
Q45399951Role of hepatitis C virus proteins (C, NS3, NS5A) in hepatic oncogenesis
Q38304391Role of signal transducer and activator of transcription 3 in liver fibrosis progression in chronic hepatitis C-infected patients
Q90576848STAT3 roles in viral infection: antiviral or proviral?
Q38271793TLR4-dependent tumor-initiating stem cell-like cells (TICs) in alcohol-associated hepatocellular carcinogenesis
Q52655043The IL-6/STAT3 pathway upregulates microRNA-125b expression in hepatitis C virus infection.
Q33911621The oncogenic role of NS5A of hepatitis C virus is mediated by up-regulation of survivin gene expression in the hepatocellular cell through p53 and NF-κB pathways
Q39672712The role of signal transducer and activator of transcription 3 in Rift Valley fever virus infection

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