Inhibition of hepatitis C virus protein expression by RNA interference

scientific article published on October 2003

Inhibition of hepatitis C virus protein expression by RNA interference is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/S0168-1702(03)00170-9
P698PubMed publication ID12951263

P50authorRatna B RayQ90724777
P2093author name stringRobert Steele
Ranjit Ray
Arnab Basu
Asish K Ghosh
Adrish Sen
P2860cites workPhenotypic silencing of cytoplasmic genes using sequence-specific double-stranded short interfering RNA and its application in the reverse genetics of wild type negative-strand RNA virusesQ24797827
Evolution of hepatitis C virus quasispecies in hypervariable region 1 and the putative interferon sensitivity-determining region during interferon therapy and natural infection.Q27469549
Hepatitis C virus nonstructural 5A protein induces interleukin-8, leading to partial inhibition of the interferon-induced antiviral responseQ27469808
Persistent and transient replication of full-length hepatitis C virus genomes in cell cultureQ27472869
Small Interfering RNA-Mediated Inhibition of Hepatitis C Virus Replication in the Human Hepatoma Cell Line Huh-7Q27473072
Clearance of replicating hepatitis C virus replicon RNAs in cell culture by small interfering RNAsQ27473092
Interference of hepatitis C virus RNA replication by short interfering RNAsQ27473349
Alpha Interferon Inhibits Hepatitis C Virus Replication in Primary Human Hepatocytes Infected In VitroQ27473519
Comparison of full-length sequences of interferon-sensitive and resistant hepatitis C virus 1b. Sensitivity to interferon is conferred by amino acid substitutions in the NS5A regionQ27478292
Phosphorylation of the hepatitis C virus NS5A protein in vitro and in vivo: properties of the NS5A-associated kinaseQ27480873
Transcripts from a single full-length cDNA clone of hepatitis C virus are infectious when directly transfected into the liver of a chimpanzeeQ27485872
Transmission of hepatitis C by intrahepatic inoculation with transcribed RNAQ27860484
Efficient initiation of HCV RNA replication in cell cultureQ27860520
Gene mapping of the putative structural region of the hepatitis C virus genome by in vitro processing analysisQ27860603
Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genomeQ27860719
A system for stable expression of short interfering RNAs in mammalian cellsQ27860875
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cellsQ27860926
How cells respond to interferonsQ27861006
Interferon alfa-2b alone or in combination with ribavirin as initial treatment for chronic hepatitis C. Hepatitis Interventional Therapy GroupQ27861083
Hepatitis C virus infection is associated with the development of hepatocellular carcinomaQ28131791
Modulation of interferon expression by hepatitis C virus NS5A protein and human homeodomain protein PTX1Q28181097
Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infectionQ29620702
Recovery, persistence, and sequelae in hepatitis C virus infection: a perspective on long-term outcomeQ29620780
Viruses and interferonsQ29620788
Lack of Protective Immunity Against Reinfection with Hepatitis C VirusQ29620909
Cytokines in viral hepatitisQ33697052
Hepatitis C virus and hepatocarcinogenesis.Q33749393
Current and evolving therapies for hepatitis C.Q33774667
Hepatitis C virus NS5A physically associates with p53 and regulates p21/waf1 gene expression in a p53-dependent mannerQ33836415
siRNA-mediated gene silencing in vitro and in vivo.Q34150604
RNA interference--2001.Q34174586
RNA interference blocks gene expression and RNA synthesis from hepatitis C replicons propagated in human liver cellsQ34178401
How hepatitis C virus counteracts the interferon response: the jury is still out on NS5A.Q34250843
RNA interference: listening to the sound of silenceQ34347832
In vitro models for hepatitis C.Q34556317
RNAi targeting an animal virus: news from the frontQ34671263
Hepatitis viruses: changing patterns of human diseaseQ35112094
Potent and specific inhibition of human immunodeficiency virus type 1 replication by RNA interferenceQ39684598
RNA interference directed against viral and cellular targets inhibits human immunodeficiency Virus Type 1 replicationQ39685491
Inhibition of gammaherpesvirus replication by RNA interferenceQ39733511
Characterization of a live, attenuated human parainfluenza type 3 virus candidate vaccine strain.Q39869335
Modulation of HIV-1 replication by RNA interferenceQ40721798
Short interfering RNA confers intracellular antiviral immunity in human cellsQ40721804
siRNA-directed inhibition of HIV-1 infectionQ40727988
Expression of small interfering RNAs targeted against HIV-1 rev transcripts in human cellsQ40735249
Hepatitis C virus NS5A protein protects against TNF-alpha mediated apoptotic cell deathQ40871684
The treatment of chronic viral hepatitisQ41332870
Production of two phosphoproteins from the NS5A region of the hepatitis C viral genome.Q42596301
Hepatitis C virus particle detected by immunoelectron microscopic studyQ43035885
Treatment of acute hepatitis C with interferon alfa-2bQ43036093
Relationship of hepatitis C genotype 1 NS5A sequence mutations to early phase viral kinetics and interferon effectivenessQ43037249
Early hepatitis C viral kinetics correlate with long-term outcome in patients receiving high dose induction followed by combination interferon and ribavirin therapyQ43038360
RNA interference in adult mice.Q43038702
Hepatitis C virus type 1b (II) infection in France and Italy. Collaborative Study GroupQ43040410
Hepatitis C virus NS5A protein impairs TNF-mediated hepatic apoptosis, but not by an anti-FAS antibody, in transgenic miceQ45733379
Meta-analysis of interferon randomized trials in the treatment of viral hepatitis C: effects of dose and durationQ71650797
Hepatocellular carcinomaQ77355684
P433issue1-2
P921main subjectRNA interferenceQ201993
Hepatitis C virusQ708693
P304page(s)27-35
P577publication date2003-10-01
P1433published inVirus ResearchQ15749215
P1476titleInhibition of hepatitis C virus protein expression by RNA interference
P478volume96

Reverse relations

cites work (P2860)
Q24816212Actively replicating West Nile virus is resistant to cytoplasmic delivery of siRNA.
Q45422183Avian metapneumovirus phosphoprotein targeted RNA interference silences the expression of viral proteins and inhibits virus replication
Q28263142Characteristics of RNA silencing in plants: similarities and differences across kingdoms
Q37120441Delivering small interfering RNA for novel therapeutics
Q35932393Development of gene-specific double-stranded RNA drugs
Q35565539Evaluation of canonical siRNA and Dicer substrate RNA for inhibition of hepatitis C virus genome replication--a comparative study
Q35842662Gene therapy of liver diseases
Q36396538Harnessing in vivo siRNA delivery for drug discovery and therapeutic development
Q40570423Hepatitis C virus NS5A mediated STAT3 activation requires co-operation of Jak1 kinase
Q24672548Impact of protein kinase PKR in cell biology: from antiviral to antiproliferative action
Q33569123In vitro RNA interference targeting the DNA polymerase gene inhibits orf virus replication in primary ovine fetal turbinate cells
Q36226774In vivo application of RNA interference: from functional genomics to therapeutics
Q40444001Nonstructural proteins 4A and 4B of hepatitis C virus transactivate the interleukin 8 promoter
Q40170241Positional effects and strand preference of RNA interference against hepatitis C virus target sequences
Q36508943RNA interference for antiviral therapy
Q35819608RNA interference targeting virion core protein ORF095 inhibits Goatpox virus replication in Vero cells
Q36440302RNA interference: its use as antiviral therapy.
Q27477464Relationships between Hepatitis C Virus Replication and CXCL-8 Production In Vitro
Q33243420Short interfering RNA (siRNA) as a novel therapeutic
Q36093470Silencing viruses by RNA interference
Q27478036Small Interfering RNA Targeted to Hepatitis C Virus 5' Nontranslated Region Exerts Potent Antiviral Effect
Q40410236Small hairpin RNAs efficiently inhibit hepatitis C IRES-mediated gene expression in human tissue culture cells and a mouse model
Q27477778Small interfering RNA targeted to stem-loop II of the 5' untranslated region effectively inhibits expression of six HCV genotypes
Q40217867Suppression of bovine viral diarrhea virus replication by small interfering RNA and short hairpin RNA-mediated RNA interference.
Q42115595The hydrodynamic tail vein assay as a tool for the study of liver promoters and enhancers
Q38050165Therapeutic potential of RNA interference: a new molecular approach to antiviral treatment for hepatitis C.
Q34360881siRNA therapeutics: big potential from small RNAs