Hepatitis C Virus Inhibits DNA Damage Repair through Reactive Oxygen and Nitrogen Species and by Interfering with the ATM-NBS1/Mre11/Rad50 DNA Repair Pathway in Monocytes and Hepatocytes

scientific article published on October 25, 2010

Hepatitis C Virus Inhibits DNA Damage Repair through Reactive Oxygen and Nitrogen Species and by Interfering with the ATM-NBS1/Mre11/Rad50 DNA Repair Pathway in Monocytes and Hepatocytes is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.4049/JIMMUNOL.1000618
P953full work available online athttp://www.jimmunol.org/content/185/11/6985.full.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20974981/?tool=EBI
http://www.jimmunol.org/cgi/content/abstract/185/11/6985
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20974981/pdf/?tool=EBI
https://europepmc.org/articles/PMC3101474
https://doi.org/10.4049/jimmunol.1000618
https://europepmc.org/articles/PMC3101474?pdf=render
https://journals.aai.org/jimmunol/article-pdf/185/11/6985/1324856/1000618.pdf
P932PMC publication ID3101474
P698PubMed publication ID20974981
P5875ResearchGate publication ID47544419

P50authorMichael M. C. LaiQ9346569
Keigo MachidaQ41371039
Lucio ComaiQ88670669
Jing-hsiung James OuQ112454847
P2093author name stringJeffrey Huang
Jing-Hsiung James Ou
Chun-Hsiang Wang
Kevin T-H Cheng
George McNamara
P2860cites workDNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytesQ22007974
DNA end-joining catalyzed by human cell-free extractsQ22008041
Activation of the ATM kinase by ionizing radiation and phosphorylation of p53Q24311891
Proteasome activator PA28gamma-dependent nuclear retention and degradation of hepatitis C virus core proteinQ24322067
Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complexQ24604459
The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocationsQ24685574
Establishment of B-cell lymphoma cell lines persistently infected with hepatitis C virus in vivo and in vitro: the apoptotic effects of virus infectionQ27473088
Hepatitis C Virus Triggers Mitochondrial Permeability Transition with Production of Reactive Oxygen Species, Leading to DNA Damage and STAT3 ActivationQ27473285
Hepatitis C virus lymphotropism and peculiar immunological phenotype: Effects on natural history and antiviral therapyQ27488413
Expression cloning of a human DNA repair gene involved in xeroderma pigmentosum group CQ28115748
From polyploidy to aneuploidy, genome instability and cancerQ28237393
Nuclear foci of mammalian Rad51 recombination protein in somatic cells after DNA damage and its localization in synaptonemal complexesQ29620257
Nitric oxide-mediated inhibition of DNA repair potentiates oxidative DNA damage in cholangiocytesQ32033816
Disruption of nucleotide excision repair by the human T-cell leukemia virus type 1 Tax proteinQ33648044
Dna repair: Rad52 - the means to an end.Q33664658
The Mre11 complex is required for ATM activation and the G2/M checkpointQ34052273
Hepatitis C virus and disrupted interferon signaling promote lymphoproliferation via type II CD95 and interleukinsQ34342136
Human xeroderma pigmentosum group D gene encodes a DNA helicaseQ34358690
Histone acetylation: a switch between repressive and permissive chromatin. Second in review series on chromatin dynamics.Q34554335
Sustained small interfering RNA-mediated human immunodeficiency virus type 1 inhibition in primary macrophagesQ35149275
Chromosomal translocations in lymphoid malignancies reveal novel proto-oncogenesQ36135275
Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cellsQ36327408
Infection-associated lymphomas derived from marginal zone B cells: a model of antigen-driven lymphoproliferationQ36362226
bcl-2 inhibits apoptosis of neutrophils but not their engulfment by macrophagesQ36362869
Hepatitis C virus infection and risk of posttransplantation lymphoproliferative disorder among solid organ transplant recipientsQ36447876
Chromosomal aberrations in human hepatocellular carcinomas associated with hepatitis C virus infection detected by comparative genomic hybridizationQ36620680
Hepatitis C virus infection activates the immunologic (type II) isoform of nitric oxide synthase and thereby enhances DNA damage and mutations of cellular genesQ36684233
Hepatitis C virus induces a mutator phenotype: enhanced mutations of immunoglobulin and protooncogenesQ37356991
Multicolor spectral karyotyping identifies new recurring breakpoints and translocations in multiple myelomaQ38502154
Multicolour spectral karyotyping of mouse chromosomesQ38506181
Hepatitis C virus NS3/4A protein interacts with ATM, impairs DNA repair and enhances sensitivity to ionizing radiation.Q40068992
Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repairQ40135858
Activation of RB/E2F signaling pathway is required for the modulation of hepatitis C virus core protein-induced cell growth in liver and non-liver cells.Q40513204
Adenovirus oncoproteins inactivate the Mre11-Rad50-NBS1 DNA repair complexQ40717443
Increased accumulation of hybrid V(D)J joins in cells expressing truncated versus full-length RAGs.Q40758604
Human Ogg1, a protein involved in the repair of 8-oxoguanine, is inhibited by nitric oxide.Q40783678
Hepatitis C virus core protein induces apoptosis and impairs cell-cycle regulation in stably transformed Chinese hamster ovary cellsQ40877562
Nuclear localization of the truncated hepatitis C virus core protein with its hydrophobic C terminus deletedQ41390367
HTLV-I trans-activator protein, tax, is a trans-repressor of the human beta-polymerase geneQ41740897
Functional interaction of p53 with HPV18 E6, c-myc and H-ras in 3T3 cellsQ42817774
Hepatitis C virus infection in hepatocellular carcinoma. Detection of plus-strand and minus-strand viral RNAQ42981925
Hepatitis C virus infection in patients with non-Hodgkin's lymphomaQ43040331
Risk of non-Hodgkin lymphoma and lymphoproliferative precursor diseases in US veterans with hepatitis C virusQ45332364
Characterization of liver histopathology in a transgenic mouse model expressing genotype 1a hepatitis C virus core and envelope proteins 1 and 2.Q45435048
Regulation of Mre11/Rad50 by Nbs1: effects on nucleotide-dependent DNA binding and association with ataxia-telangiectasia-like disorder mutant complexes.Q47635097
Transcription enhancer identified near the human C mu immunoglobulin heavy chain gene is unavailable to the translocated c-myc gene in a Burkitt lymphoma.Q48394103
Transformation by human papillomavirus 16 E6 and E7: role of the insulin-like growth factor 1 receptorQ52522097
Inflammatory cytokines induce DNA damage and inhibit DNA repair in cholangiocarcinoma cells by a nitric oxide-dependent mechanismQ53414391
Hepatitis C infection and risk of malignant lymphomaQ54546863
Yeast RAD14 and human xeroderma pigmentosum group A DNA-repair genes encode homologous proteinsQ67756410
Micronuclei, kinetochores and hypoploidy: tests with some agentsQ69569055
Bcl-2 rearrangement in patients with chronic hepatitis C associated with essential mixed cryoglobulinemia type IIQ73053045
Sensitivity of Protein Sulfhydryl Repair Enzymes to Oxidative StressQ73492239
P433issue11
P407language of work or nameEnglishQ1860
P921main subjecthepatitis CQ154869
Hepatitis C virusQ708693
DNA damageQ5205747
P304page(s)6985-6998
P577publication date2010-10-25
P1433published inJournal of ImmunologyQ3521441
P1476titleHepatitis C virus inhibits DNA damage repair through reactive oxygen and nitrogen species and by interfering with the ATM-NBS1/Mre11/Rad50 DNA repair pathway in monocytes and hepatocytes
Hepatitis C Virus Inhibits DNA Damage Repair through Reactive Oxygen and Nitrogen Species and by Interfering with the ATM-NBS1/Mre11/Rad50 DNA Repair Pathway in Monocytes and Hepatocytes
P478volume185

Reverse relations

cites work (P2860)
Q40288450A Role for RNA Viruses in the Pathogenesis of Burkitt's Lymphoma: The Need for Reappraisal
Q40512450A pre-neoplastic epigenetic field defect in HCV-infected liver at transcription factor binding sites and polycomb targets
Q26769967Activation of the DNA Damage Response by RNA Viruses
Q35856687Alteration of DNA damage signaling pathway profile in radiation-treated glioblastoma stem-like cells
Q26992256Autophagy in hepatitis C virus-host interactions: potential roles and therapeutic targets for liver-associated diseases
Q36607038B cells in chronically hepatitis C virus-infected individuals lack a virus-induced mutation signature in the TP53, CTNNB1, and BCL6 genes
Q36610180DNA damage promotes herpes simplex virus-1 protein expression in a neuroblastoma cell line
Q38619642DNA damage response and sphingolipid signaling in liver diseases
Q59034315DNA damage sensor γ -H2AX is increased in preneoplastic lesions of hepatocellular carcinoma
Q53518354DNA double-strand break repair gene XRCC7 genotypes were associated with hepatocellular carcinoma risk in Taiwanese males and alcohol drinkers
Q92267314DNA mismatch repair is required for the host innate response and controls cellular fate after influenza virus infection
Q64255287Dysregulation of the cohesin subunit RAD21 by Hepatitis C virus mediates host-virus interactions
Q47552769Extrahepatic cancers and chronic HCV infection
Q90151313Flaviviridae Viruses and Oxidative Stress: Implications for Viral Pathogenesis
Q38974653Genetic basis of hepatitis virus-associated hepatocellular carcinoma: linkage between infection, inflammation, and tumorigenesis
Q29417113Genome-wide association study identifies variants associated with progression of liver fibrosis from HCV infection
Q40417381Genotoxic effect of iron overload and disease complications in transfused β thalassaemic patients
Q92964678Hepatitis C Virus NS3 Protein Plays a Dual Role in WRN-Mediated Repair of Nonhomologous End Joining
Q33917901Hepatitis C Virus NS5B Protein Delays S Phase Progression in Human Hepatocyte-derived Cells by Relocalizing Cyclin-dependent Kinase 2-interacting Protein (CINP)
Q45325989Hepatitis C Virus-Associated Cancers
Q36395865Hepatitis C virus and cellular stress response: implications to molecular pathogenesis of liver diseases
Q38244519Hepatitis C virus and diffuse large B-cell lymphoma: Pathogenesis, behavior and treatment
Q58089566Hepatitis C virus downregulates ubiquitin conjugating enzyme E2S expression to prevent proteasomal degradation of NS5A, leading to host cells more sensitive to DNA damage
Q37447666Hepatitis C virus promotes hepatocellular carcinogenesis by targeting TIPE2, a new regulator of DNA damage response
Q36768153Hepatitis C virus upregulates B-cell receptor signaling: a novel mechanism for HCV-associated B-cell lymphoproliferative disorders
Q36236839How do persistent infections with hepatitis C virus cause liver cancer?
Q38156891How virus persistence can initiate the tumorigenesis process
Q40078339Human Papillomavirus and the DNA Damage Response: Exploiting Host Repair Pathways for Viral Replication
Q36039573In Situ Hepatitis C NS3 Protein Detection Is Associated with High Grade Features in Hepatitis C-Associated B-Cell Non-Hodgkin Lymphomas
Q37734105Increased frequency of micronuclei in the lymphocytes of patients chronically infected with hepatitis B or hepatitis C virus
Q58733026Increased genomic instability following treatment with direct acting anti-hepatitis C virus drugs
Q42232853Intrahepatic B-cell follicles of chronically hepatitis C virus-infected individuals lack signs of an ectopic germinal center reaction.
Q33616812Involvement of DNA damage response pathways in hepatocellular carcinoma
Q64977889Mechanisms of hepatocarcinogenesis in chronic hepatitis C.
Q26825783Modulation of DNA damage and repair pathways by human tumour viruses
Q30455825Molecular profiles of HCV cirrhotic tissues derived in a panel of markers with clinical utility for hepatocellular carcinoma surveillance
Q52347275Nonstructural 5A impairs DNA damage repair: Implication of hepatitis C virus-mediated hepatocarcinogenesis
Q33904328Oxidative stress and hepatic Nox proteins in chronic hepatitis C and hepatocellular carcinoma
Q38127242Oxidative stress and hepatitis C virus
Q26774003Oxidative stress modulation in hepatitis C virus infected cells
Q28284012Pathogenic mechanisms in HBV- and HCV-associated hepatocellular carcinoma
Q41366464Presence of HCV RNA in peripheral blood mononuclear cells may predict patients response to interferon and ribavirin therapy
Q33645331Prevalence of Hepatitis C virus Genotype 3a in patients with Hodgkin and Non-Hodgkin Lymphoma
Q33668416RNA Viruses: ROS-Mediated Cell Death
Q97414284Risk Factors Contributing to the Occurrence and Recurrence of Hepatocellular Carcinoma in Hepatitis C Virus Patients Treated with Direct-Acting Antivirals
Q26863363Role of Oxidative Stress in Hepatocarcinogenesis Induced by Hepatitis C Virus
Q26773251Significance of hepatitis virus infection in the oncogenic initiation of hepatocellular carcinoma
Q26863522Smad3 phospho-isoform signaling in hepatitis C virus-related chronic liver diseases
Q26825363The DNA damage response induced by infection with human cytomegalovirus and other viruses
Q36316676Theoretical basis of a beneficial role for vitamin D in viral hepatitis
Q90357642Tissue specificity of DNA damage response and tumorigenesis
Q92237158Urinary 8-hydroxydeoxyguanosine in relation to XRCC1 rs25487 G/A (Arg399Gln) and OGG1 rs1052133 C/G (Ser326Cys) DNA repair genes polymorphisms in patients with chronic hepatitis C and related hepatocellular carcinoma
Q40046596Viral hepatitis and liver cancer.
Q38164707Viruses as modulators of mitochondrial functions

Search more.