Nonstructural 5A impairs DNA damage repair: Implication of hepatitis C virus-mediated hepatocarcinogenesis

scientific article published on 21 March 2018

Nonstructural 5A impairs DNA damage repair: Implication of hepatitis C virus-mediated hepatocarcinogenesis is …
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scholarly articleQ13442814

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P356DOI10.1128/JVI.00178-18
P932PMC publication ID5952158
P698PubMed publication ID29563287

P2093author name stringSoon B Hwang
Yun-Sook Lim
Eun-Mee Park
Tram T Nguyen
P2860cites workPromotion of RAD51-Mediated Homologous DNA Pairing by the RAD51AP1-UAF1 ComplexQ37738678
Hepatitis C virus NS5A: enigmatic but still promiscuous 10 years on!Q38284234
Non-structural 5A protein of hepatitis C virus induces a range of liver pathology in transgenic mice.Q38493511
The USP1-UAF1 complex interacts with RAD51AP1 to promote homologous recombination repairQ39554542
Hepatitis C Virus Inhibits DNA Damage Repair through Reactive Oxygen and Nitrogen Species and by Interfering with the ATM-NBS1/Mre11/Rad50 DNA Repair Pathway in Monocytes and HepatocytesQ39639979
Nonstructural 5A protein activates beta-catenin signaling cascades: implication of hepatitis C virus-induced liver pathogenesisQ39804511
Hepatitis C virus NS3/4A protein interacts with ATM, impairs DNA repair and enhances sensitivity to ionizing radiation.Q40068992
Pir51, a Rad51-interacting protein with high expression in aggressive lymphoma, controls mitomycin C sensitivity and prevents chromosomal breaksQ40241813
The Hepatitis C virus NS5A protein activates a phosphoinositide 3-kinase-dependent survival signaling cascadeQ40601685
Quantitative Proteomic Atlas of Ubiquitination and Acetylation in the DNA Damage Response.Q40861699
Hepatitis C virus NS5A protein interacts with beta-catenin and stimulates its transcriptional activity in a phosphoinositide-3 kinase-dependent fashionQ42991911
Hepatitis C virus NS5A protein modulates cell cycle regulatory genes and promotes cell growthQ42993783
RAD51AP1 is a structure-specific DNA binding protein that stimulates joint molecule formation during RAD51-mediated homologous recombinationQ45345097
Antitumour drugs impede DNA uncoiling by topoisomerase IQ59092676
Histone H2AX Phosphorylation as a Predictor of Radiosensitivity and Target for RadiotherapyQ63383950
A SIMPLE METHOD OF ESTIMATING FIFTY PER CENT ENDPOINTSQ107473800
A novel nucleic acid-binding protein that interacts with human rad51 recombinaseQ24312943
UAF1 is a subunit of multiple deubiquitinating enzyme complexesQ24329003
Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray dosesQ24677973
Subversion of Cell Signaling Pathways by Hepatitis C Virus Nonstructural 5A Protein via Interaction with Grb2 and P85 Phosphatidylinositol 3-KinaseQ27472897
Hepatitis C Virus Triggers Mitochondrial Permeability Transition with Production of Reactive Oxygen Species, Leading to DNA Damage and STAT3 ActivationQ27473285
Genes encoding Pir51, Beclin 1, RbAp48 and aldolase b are up or down-regulated in human primary hepatocellular carcinomaQ28245470
Formation and repair of interstrand cross-links in DNAQ28296085
The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathwayQ29616746
Hepatitis C virus NS5A protein blocks epidermal growth factor receptor degradation via a proline motif- dependent interactionQ30009188
Cellular redistribution of Rad51 in response to DNA damage: novel role for Rad51C.Q33553786
The oncogenic role of NS5A of hepatitis C virus is mediated by up-regulation of survivin gene expression in the hepatocellular cell through p53 and NF-κB pathwaysQ33911621
Activation of ATM and Chk2 kinases in relation to the amount of DNA strand breaks.Q34347570
Mechanisms regulating resistance to inhibitors of topoisomerase IIQ34361770
Hepatitis C virus NS2 protein inhibits DNA damage pathway by sequestering p53 to the cytoplasm.Q34701793
Physical and functional interaction between hepatitis C virus NS5A protein and ovarian tumor protein deubiquitinase 7B.Q35674938
Mechanistic insights into RAD51-associated protein 1 (RAD51AP1) action in homologous DNA repair.Q35874501
Activities of human recombination protein Rad51.Q35952348
RAD51, genomic stability, and tumorigenesisQ36020209
Pim Kinase Interacts with Nonstructural 5A Protein and Regulates Hepatitis C Virus Entry.Q36080785
Acute myeloid leukemia with a complex aberrant karyotype is a distinct biological entity characterized by genomic imbalances and a specific gene expression profileQ36104615
Promotion of homologous recombination and genomic stability by RAD51AP1 via RAD51 recombinase enhancementQ36316209
Hepatitis C virus infection activates the immunologic (type II) isoform of nitric oxide synthase and thereby enhances DNA damage and mutations of cellular genesQ36684233
Nonstructural 5A Protein of Hepatitis C Virus Regulates Soluble Resistance-Related Calcium-Binding Protein Activity for Viral PropagationQ36736693
Hepatitis C virus induces a mutator phenotype: enhanced mutations of immunoglobulin and protooncogenesQ37356991
P407language of work or nameEnglishQ1860
P921main subjectHepatitis C virusQ708693
P577publication date2018-03-21
P1433published inJournal of VirologyQ1251128
P1476titleNonstructural 5A impairs DNA damage repair: Implication of hepatitis C virus-mediated hepatocarcinogenesis