B cells in chronically hepatitis C virus-infected individuals lack a virus-induced mutation signature in the TP53, CTNNB1, and BCL6 genes

scientific article published on 26 December 2012

B cells in chronically hepatitis C virus-infected individuals lack a virus-induced mutation signature in the TP53, CTNNB1, and BCL6 genes is …
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scholarly articleQ13442814

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P356DOI10.1128/JVI.03081-12
P932PMC publication ID3571368
P698PubMed publication ID23269799
P5875ResearchGate publication ID233995534

P50authorFelicia Anna TucciQ50569758
Ruth BroeringQ80942093
Ralf KüppersQ23661843
Joerg F. SchlaakQ39806746
P2093author name stringPatricia Johansson
P2860cites workIn vivo tropism of hepatitis C virus genomic sequences in hematopoietic cells: influence of viral load, viral genotype, and cell phenotypeQ42987798
Visualizing hepatitis C virus infections in human liver by two-photon microscopyQ42989638
Analysis of aberrant somatic hypermutation (SHM) in non-Hodgkin's lymphomas of patients with chronic HCV infectionQ42991641
Hepatitis C virus drives the unconstrained monoclonal expansion of VH1-69-expressing memory B cells in type II cryoglobulinemia: a model of infection-driven lymphomagenesisQ42992297
Detection of hepatitis C virus RNA sequences in B-cell non-Hodgkin lymphomaQ42997598
Productive replication of hepatitis C virus in perihepatic lymph nodes in vivo: implications of HCV lymphotropismQ42999482
Sequence analysis of the immunoglobulin antigen receptor of hepatitis C virus-associated non-Hodgkin lymphomas suggests that the malignant cells are derived from the rheumatoid factor-producing cells that occur mainly in type II cryoglobulinemia.Q43000908
The B-cell receptor of a hepatitis C virus (HCV)–associated non-Hodgkin lymphoma binds the viral E2 envelope protein, implicating HCV in lymphomagenesisQ43035602
Hepatitis C virus proteins: direct link to hepatic oxidative stress, steatosis, carcinogenesis and moreQ43036470
Somatic hypermutation and mRNA expression levels of the BCL-6 gene in patients with hepatitis C virus-associated lymphoproliferative diseasesQ43038575
Alterations of RB1, p53 and Wnt pathways in hepatocellular carcinomas associated with hepatitis C, hepatitis B and alcoholic liver cirrhosisQ44503107
Molecular characterization of B cell clonal expansions in the liver of chronically hepatitis C virus-infected patientsQ45736807
Hepatitis C Virus Infection in Patients with B-Cell Non-Hodgkin LymphomaQ45760281
Somatic hypermutation in the heavy chain locus correlates with transcriptionQ47713194
Mutation of BCL-6 Gene in Normal B Cells by the Process of Somatic Hypermutation of Ig GenesQ47982616
Mutation of the p53 gene is not a typical feature of Hodgkin and Reed-Sternberg cells in Hodgkin's diseaseQ57198293
Hepatitis C virus association with peripheral blood B lymphocytes potentiates viral infection of liver-derived hepatoma cellsQ27487754
Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomasQ28207345
Frequent compartmentalization of hepatitis C virus variants in circulating B cells and monocytes.Q30758796
The lymphoid system in hepatitis C virus infection: autoimmunity, mixed cryoglobulinemia, and Overt B-cell malignancyQ33914312
Hepatitis C and B-cell lymphomaQ34227717
Clonal analysis of intrahepatic B cells from HCV-infected patients with and without mixed cryoglobulinemiaQ34746694
Prevalence of hepatitis C virus infection in B-cell non-Hodgkin's lymphoma: systematic review and meta-analysis.Q35629704
Beta-catenin mutations are frequent in human hepatocellular carcinomas associated with hepatitis C virus infectionQ35788005
BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig lociQ36322298
Extrahepatic replication of HCV: insights into clinical manifestations and biological consequencesQ36519154
Hepatitis C virus infection activates the immunologic (type II) isoform of nitric oxide synthase and thereby enhances DNA damage and mutations of cellular genesQ36684233
Hepatitis C virus lymphotropism: lessons from a decade of studies.Q36971058
Hepatitis C virus induces a mutator phenotype: enhanced mutations of immunoglobulin and protooncogenesQ37356991
Hepatitis C Virus Inhibits DNA Damage Repair through Reactive Oxygen and Nitrogen Species and by Interfering with the ATM-NBS1/Mre11/Rad50 DNA Repair Pathway in Monocytes and HepatocytesQ39639979
Increased transcription levels induce higher mutation rates in a hypermutating cell lineQ40814374
Hepatitis C virus and mixed cryoglobulinaemiaQ40857968
Molecular footprints of a germinal center derivation of human IgM+(IgD+)CD27+ B cells and the dynamics of memory B cell generationQ41763906
Human immunoglobulin (Ig)M+IgD+ peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cellsQ42108183
Intrahepatic B cell clonal expansions and extrahepatic manifestations of chronic HCV infection.Q42983323
A role for hepatitis C virus infection in type II cryoglobulinemiaQ42983385
Infection of B cells with hepatitis C virus for the development of lymphoproliferative disorders in patients with chronic hepatitis C.Q42985551
Somatic hypermutation, clonal diversity, and preferential expression of the VH 51p1/VL kv325 immunoglobulin gene combination in hepatitis C virus-associated immunocytomas.Q42987134
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectHepatitis C virusQ708693
P304page(s)2956-2962
P577publication date2012-12-26
P1433published inJournal of VirologyQ1251128
P1476titleB cells in chronically hepatitis C virus-infected individuals lack a virus-induced mutation signature in the TP53, CTNNB1, and BCL6 genes
P478volume87