Intersection of the unfolded protein response and hepatic lipid metabolism

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Intersection of the unfolded protein response and hepatic lipid metabolism is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1007/S00018-009-0049-8
P932PMC publication ID3096022
P698PubMed publication ID19468685
P5875ResearchGate publication ID26240205

P50authorLaurie GlimcherQ6501587
Ann-Hwee LeeQ124214884
P2860cites workCharacterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinaseQ22010589
Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stressQ22010800
XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel diseaseQ22252318
Role of LXRs in control of lipogenesisQ24290548
ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPsQ24290776
Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein responseQ24290935
Plasma cell differentiation requires the transcription factor XBP-1Q24291453
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factorQ24292102
Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans developmentQ24292104
Loss of kinase activity in a patient with Wolcott-Rallison syndrome caused by a novel mutation in the EIF2AK3 geneQ24300493
A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cellsQ24309442
SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysisQ24310555
The basic domain/leucine zipper protein hXBP-1 preferentially binds to and transactivates CRE-like sequences containing an ACGT coreQ24317656
Glucose activates ChREBP by increasing its rate of nuclear entry and relieving repression of its transcriptional activityQ24336875
Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational controlQ24522941
A mammalian homologue of GCN2 protein kinase important for translational control by phosphorylation of eukaryotic initiation factor-2alphaQ24548092
Endoplasmic reticulum stress-induced formation of transcription factor complex ERSF including NF-Y (CBF) and activating transcription factors 6alpha and 6beta that activates the mammalian unfolded protein responseQ24548363
Carbohydrate response element binding protein directly promotes lipogenic enzyme gene transcriptionQ24561983
Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbetaQ24598068
Organelle biogenesis and intracellular lipid transport in eukaryotesQ24634717
Nrf2 Is a Direct PERK Substrate and Effector of PERK-Dependent Cell SurvivalQ24653078
Different types of ground glass hepatocytes in chronic hepatitis B virus infection contain specific pre-S mutants that may induce endoplasmic reticulum stressQ24672497
IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein responseQ24672592
Oxidative protein folding in eukaryotes: mechanisms and consequencesQ24676827
Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genesQ24683425
Flavivirus Infection Activates the XBP1 Pathway of the Unfolded Protein Response To Cope with Endoplasmic Reticulum StressQ27477652
Subcellular forms and biochemical events triggered in human cells by HCV polyprotein expression from a viral vectorQ27486946
Hepatitis C Virus Infection Induces Apoptosis through a Bax-Triggered, Mitochondrion-Mediated, Caspase 3-Dependent PathwayQ27487135
Signal integration in the endoplasmic reticulum unfolded protein responseQ27860577
Phospholipid metabolism regulated by a transcription factor sensing phosphatidic acid.Q27930626
A transmembrane protein with a cdc2+/CDC28-related kinase activity is required for signaling from the ER to the nucleusQ27930818
Signalling from endoplasmic reticulum to nucleus: transcription factor with a basic-leucine zipper motif is required for the unfolded protein-response pathwayQ27932953
The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein responseQ27933479
Functional characterization of an inositol-sensitive upstream activation sequence in yeast. A cis-regulatory element responsible for inositol-choline mediated regulation of phospholipid biosynthesisQ27935042
IRE1 encodes a putative protein kinase containing a membrane-spanning domain and is required for inositol phototrophy in Saccharomyces cerevisiaeQ27935778
The unfolded protein response pathway in Saccharomyces cerevisiae. Oligomerization and trans-phosphorylation of Ire1p (Ern1p) are required for kinase activationQ27936284
A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein responseQ27938493
Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinaseQ27938837
tRNA ligase is required for regulated mRNA splicing in the unfolded protein responseQ27940124
Lipid metabolism and vesicle trafficking: more than just greasing the transport machineryQ34499998
Role of the unfolded protein response pathway in secretory stress and regulation of INO1 expression in Saccharomyces cerevisiaeQ34569387
Role of the unfolded protein response pathway in regulation of INO1 and in the sec14 bypass mechanism in Saccharomyces cerevisiae.Q34615963
The unfolded protein response coordinates the production of endoplasmic reticulum protein and endoplasmic reticulum membraneQ34673029
New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: a role for the transcription factor sterol regulatory element binding protein-1cQ34682304
The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein responseQ35029280
Ca2+ signaling and calcium binding chaperones of the endoplasmic reticulumQ35051255
Frame switch splicing and regulated intramembrane proteolysis: key words to understand the unfolded protein responseQ35168508
Translational control of C/EBPalpha and C/EBPbeta isoform expression.Q35199785
Perk-dependent translational regulation promotes tumor cell adaptation and angiogenesis in response to hypoxic stressQ35221396
Transport of proteins across the endoplasmic reticulum membraneQ35235780
Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodentsQ36183590
PKR and eIF2alpha: integration of kinase dimerization, activation, and substrate dockingQ36265197
XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum.Q36322684
Carbohydrate response element binding protein, ChREBP, a transcription factor coupling hepatic glucose utilization and lipid synthesisQ36557194
Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetesQ36698641
Synthesis and function of membrane phosphoinositides in budding yeast, Saccharomyces cerevisiaeQ36768641
ChREBP, a transcriptional regulator of glucose and lipid metabolismQ36788526
Dissection of endoplasmic reticulum stress signaling in alcoholic and non-alcoholic liver injuryQ36800154
Cholesterol feeding reduces nuclear forms of sterol regulatory element binding proteins in hamster liverQ36806480
Translational control and the unfolded protein responseQ36924278
Transmembrane bZIP transcription factors in ER stress signaling and the unfolded protein responseQ36948672
Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesityQ36981204
The recognition and retrotranslocation of misfolded proteins from the endoplasmic reticulumQ37100233
Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight lossQ37105351
Feedback regulation of cholesterol synthesis: sterol-accelerated ubiquitination and degradation of HMG CoA reductaseQ37173755
Mice with a deletion in the gene for CCAAT/enhancer-binding protein beta are protected against diet-induced obesityQ37178851
The endoplasmic reticulum stress response in immunity and autoimmunityQ37231726
Real-time redox measurements during endoplasmic reticulum stress reveal interlinked protein folding functionsQ37335994
Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cellsQ37364195
Regulation of sterol regulatory element binding proteins in livers of fasted and refed miceQ37375695
Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2.Q37382401
Liver-specific inhibition of ChREBP improves hepatic steatosis and insulin resistance in ob/ob mice.Q38311106
ATF6 is a transcription factor specializing in the regulation of quality control proteins in the endoplasmic reticulumQ80935578
Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1Q80979487
Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosisQ81441036
Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradationQ28131669
EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndromeQ28142981
Translational control is required for the unfolded protein response and in vivo glucose homeostasisQ28204066
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNAQ28214814
The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factorQ28238069
Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasisQ28258427
The emergence of yeast lipidomicsQ28258926
Unfolding new mechanisms of alcoholic liver disease in the endoplasmic reticulumQ28262304
ERAD: the long road to destructionQ28264823
Protein folding and quality control in the endoplasmic reticulumQ28272791
Proteolytic activation of sterol regulatory element-binding protein induced by cellular stress through depletion of Insig-1Q28276509
SREBP-1c transcription factor and lipid homeostasis: clinical perspectiveQ28291930
Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinaseQ28296183
Regulation of protein synthesis by heme-regulated eIF-2 alpha kinaseQ28299534
Tunicamycin induces ubiquitination and degradation of apolipoprotein B in HepG2 cellsQ28347626
Increased sensitivity to dextran sodium sulfate colitis in IRE1beta-deficient miceQ28359871
Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathwaysQ28365886
The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreasQ28505821
Regulated translation initiation controls stress-induced gene expression in mammalian cellsQ28506388
Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetesQ28506402
PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiationQ28507769
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysisQ28508851
CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulumQ28509611
XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glandsQ28510479
PERK-dependent activation of Nrf2 contributes to redox homeostasis and cell survival following endoplasmic reticulum stressQ28511471
Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alphaQ28512201
CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulumQ28512249
The transcription factor XBP-1 is essential for the development and survival of dendritic cellsQ28512302
Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox stateQ28572472
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetesQ28575190
Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosisQ28576685
A glucose-responsive transcription factor that regulates carbohydrate metabolism in the liverQ28583240
c-Myc and ChREBP regulate glucose-mediated expression of the L-type pyruvate kinase gene in INS-1-derived 832/13 cellsQ28584276
XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein ResponseQ28585314
An essential role in liver development for transcription factor XBP-1Q28593777
Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survivalQ28593963
ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein responseQ28611502
The endoribonuclease activity of mammalian IRE1 autoregulates its mRNA and is required for the unfolded protein responseQ28646118
ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signalsQ28646129
Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genesQ28646399
An integrated stress response regulates amino acid metabolism and resistance to oxidative stressQ29547441
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liverQ29547646
Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controlsQ29547730
A central role for JNK in obesity and insulin resistanceQ29619778
Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleusQ29620179
PERK eIF2 alpha kinase is required to regulate the viability of the exocrine pancreas in miceQ33295459
Stable binding of ATF6 to BiP in the endoplasmic reticulum stress responseQ33713564
The unfolded protein response sensor IRE1alpha is required at 2 distinct steps in B cell lymphopoiesis.Q33777806
Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genesQ33878155
CCAAT/enhancer-binding protein beta deletion reduces adiposity, hepatic steatosis, and diabetes in Lepr(db/db) miceQ33943164
APOLIPOPROTEIN B: mRNA editing, lipoprotein assembly, and presecretory degradationQ34001437
Lipid metabolism and regulation of membrane traffickingQ34156587
On the mechanism of sensing unfolded protein in the endoplasmic reticulumQ34230593
XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiationQ34345459
Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1.Q34451430
Mutant mammalian cells as tools to delineate the sterol regulatory element-binding protein pathway for feedback regulation of lipid synthesisQ34497858
Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed miceQ38354947
Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2Q39315996
ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growthQ39470144
Intracellular retention of surface protein by a hepatitis B virus mutant that releases virion particlesQ39872988
Endoplasmic reticulum stress induces leptin resistanceQ39945899
Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in miceQ39975807
Development of plaque assays for hepatitis C virus-JFH1 strain and isolation of mutants with enhanced cytopathogenicity and replication capacityQ40065076
Activation of the ER stress gene gadd153 by hepatitis C virus sensitizes cells to oxidant injuryQ40157434
Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetesQ40176269
Hepatitis B virus X protein (HBx) activates ATF6 and IRE1-XBP1 pathways of unfolded protein responseQ40210691
Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosisQ40294776
Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cellsQ40313352
Glucose activation of ChREBP in hepatocytes occurs via a two-step mechanismQ40336619
Hepatitis C virus core triggers apoptosis in liver cells by inducing ER stress and ER calcium depletionQ40421534
Glucosamine-induced endoplasmic reticulum stress promotes ApoB100 degradation: evidence for Grp78-mediated targeting to proteasomal degradation.Q40477226
Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stressQ40527936
Human CCAAT/enhancer-binding protein beta gene expression is activated by endoplasmic reticulum stress through an unfolded protein response element downstream of the protein coding sequenceQ40563931
Hepatitis C virus suppresses the IRE1-XBP1 pathway of the unfolded protein responseQ40590374
The modification and assembly of proteins in the endoplasmic reticulumQ40619093
P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature.Q41142872
Regulation of the expression of lipogenic enzyme genes by carbohydrateQ41548602
Genome-wide analysis reveals inositol, not choline, as the major effector of Ino2p-Ino4p and unfolded protein response target gene expression in yeastQ42010811
UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators.Q42041480
Switch-like control of SREBP-2 transport triggered by small changes in ER cholesterol: a delicate balanceQ42254249
ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stressQ42518206
Phosphorylation of eIF2 directs ATF5 translational control in response to diverse stress conditionsQ42523594
Coordinate regulation of phospholipid biosynthesis and secretory pathway gene expression in XBP-1(S)-induced endoplasmic reticulum biogenesis.Q42832143
Regulation of sterol regulatory-element binding protein 1 gene expression in liver: role of insulin and protein kinase B/cAktQ42996869
Insulin effects on sterol regulatory-element-binding protein-1c (SREBP-1c) transcriptional activity in rat hepatocytes.Q42997321
Activation of endoplasmic reticulum stress response by hepatitis viruses up-regulates protein phosphatase 2A.Q43037981
Wolcott-Rallison syndrome: pathogenic insights into neonatal diabetes from new mutation and expression studies of EIF2AK3.Q43073998
Adenovirus-mediated overexpression of sterol regulatory element binding protein-1c mimics insulin effects on hepatic gene expression and glucose homeostasis in diabetic mice.Q43778752
Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1cQ43848640
Blocking microsomal triglyceride transfer protein interferes with apoB secretion without causing retention or stress in the ER.Q44317091
The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophagesQ44542540
Involvement of endoplasmic reticulum stress in insulin resistance and diabetesQ45127777
Activation of ATF6 and an ATF6 DNA binding site by the endoplasmic reticulum stress response.Q45345766
Predominant role of sterol response element binding proteins (SREBP) lipogenic pathways in hepatic steatosis in the murine intragastric ethanol feeding modelQ46243875
Prevalence and mechanisms of hyperhomocysteinemia in chronic alcoholicsQ46565148
Blood glucose-lowering nuclear receptor agonists only partially normalize hepatic gene expression in db/db miceQ46783954
ChREBP*Mlx is the principal mediator of glucose-induced gene expression in the liverQ50336015
PERK is essential for neonatal skeletal development to regulate osteoblast proliferation and differentiation.Q51951390
PERK EIF2AK3 control of pancreatic beta cell differentiation and proliferation is required for postnatal glucose homeostasis.Q52000258
Targeted disruption of ATF4 discloses its essential role in the formation of eye lens fibres.Q52178375
In situ hybridization studies suggest a role for the basic region‐leucine zipper protein hXBP‐1 in exocrine gland and skeletal development during mouse embryogenesisQ52224944
Dissociation of Hepatic Steatosis and Insulin Resistance in Mice Overexpressing DGAT in the LiverQ57016669
Microphthalmia due to p53-mediated apoptosis of anterior lens epithelial cells in mice lacking the CREB-2 transcription factorQ73967308
Two distinct stress signaling pathways converge upon the CHOP promoter during the mammalian unfolded protein responseQ74359929
Genetic regulation of phospholipid metabolism: yeast as a model eukaryoteQ77347125
Overproduction of the Opi1 repressor inhibits transcriptional activation of structural genes required for phospholipid biosynthesis in the yeast Saccharomyces cerevisiaeQ78004043
Multiple endoplasmic reticulum-to-nucleus signaling pathways coordinate phospholipid metabolism with gene expression by distinct mechanismsQ79733627
Endoplasmic reticulum stress causes the activation of sterol regulatory element binding protein-2Q80553475
P433issue17
P304page(s)2835-2850
P577publication date2009-05-26
P1433published inCellular and Molecular Life SciencesQ5058352
P1476titleIntersection of the unfolded protein response and hepatic lipid metabolism
P478volume66

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