XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation

scientific article

XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.IMMUNI.2004.06.010
P698PubMed publication ID15345222
P5875ResearchGate publication ID8368428

P50authorNahum SonenbergQ904654
Laurie GlimcherQ6501587
Andreas RosenwaldQ28379725
Kathryn CalameQ73183923
Jonathan W YewdellQ87490330
Neal N IwakoshiQ96950812
Ann-Hwee LeeQ124214884
P2093author name stringXin Yu
Louis M Staudt
Hong Zhao
Elaine M Hurt
Liming Yang
A L Shaffer
Emmanuel Petroulakis
Bruce K Tan
Shu-Bing Qian
Miriam Shapiro-Shelef
P2860cites workRegulated translation initiation controls stress-induced gene expression in mammalian cellsQ28506388
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectcell differentiationQ210861
P304page(s)81-93
P577publication date2004-07-01
P1433published inImmunityQ6005457
P1476titleXBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation
P478volume21

Reverse relations

cites work (P2860)
Q369240162,3,7,8-Tetrachlorodibenzo-p-dioxin-mediated impairment of B cell differentiation involves dysregulation of paired box 5 (Pax5) isoform, Pax5a
Q343396908,9-Epoxyeicosatrienoic acid inhibits antibody production of B lymphocytes in mice
Q35890025A Network Model to Describe the Terminal Differentiation of B Cells
Q40045210A Novel Extrinsic Pathway for the Unfolded Protein Response in the Kidney
Q59127644A Novel Glycoproteomics Workflow Reveals Dynamic O-GlcNAcylation of COPγ1 as a Candidate Regulator of Protein Trafficking
Q54379648A RIDDle solved: why an intact IRE1α/XBP-1 signaling relay is key for humoral immune responses.
Q40919068A functional link between the co-translational protein translocation pathway and the UPR.
Q33240316A library of gene expression signatures to illuminate normal and pathological lymphoid biology
Q35603385A mouse model suggests two mechanisms for thyroid alterations in infantile cystinosis: decreased thyroglobulin synthesis due to endoplasmic reticulum stress/unfolded protein response and impaired lysosomal processing.
Q34399137A multi-omics analysis of recombinant protein production in Hek293 cells
Q28296585A novel stress-induced EDEM variant regulating endoplasmic reticulum-associated glycoprotein degradation
Q42177453A reversible form of lysine acetylation in the ER and Golgi lumen controls the molecular stabilization of BACE1.
Q35558439A systems biology approach identifies a regulatory network in parotid acinar cell terminal differentiation
Q34374623ADAM10 regulates transcription factor expression required for plasma cell function
Q39104609AMPK regulates ER morphology and function in stressed pancreatic β-cells via phosphorylation of DRP1.
Q34129501AT-1 is the ER membrane acetyl-CoA transporter and is essential for cell viability
Q89717488ATF6 Is a Critical Determinant of CHOP Dynamics during the Unfolded Protein Response
Q36607378ATF6 signaling is required for efficient West Nile virus replication by promoting cell survival and inhibition of innate immune responses
Q37186859ATF6alpha induces XBP1-independent expansion of the endoplasmic reticulum
Q37708694ATF6α regulates morphological changes associated with senescence in human fibroblasts
Q36769690ATG5 regulates plasma cell differentiation
Q36267192Aberrant immunoglobulin class switch recombination and switch translocations in activated B cell-like diffuse large B cell lymphoma
Q24529972Activation of hepatitis B virus S promoter by a cell type-restricted IRE1-dependent pathway induced by endoplasmic reticulum stress
Q39398972Activation of the unfolded protein response by Listeria monocytogenes
Q34824098Activation of unfolded protein response in transgenic mouse lenses.
Q30483089Adaptation of endoplasmic reticulum exit sites to acute and chronic increases in cargo load
Q47774233Adapting Secretory Proteostasis and Function Through the Unfolded Protein Response
Q37280293Advances in Mammalian cell line development technologies for recombinant protein production
Q30436993Affinity of antigen encounter and other early B-cell signals determine B-cell fate
Q97569263Ageing hallmarks exhibit organ-specific temporal signatures
Q28279743Aggressive lymphomas
Q41841514Airway epithelial inflammation-induced endoplasmic reticulum Ca2+ store expansion is mediated by X-box binding protein-1.
Q38349476An in vitro model of differentiation of memory B cells into plasmablasts and plasma cells including detailed phenotypic and molecular characterization
Q35088890An incoherent regulatory network architecture that orchestrates B cell diversification in response to antigen signaling.
Q41762909Analysis of the regulatory role of BAFF in controlling the expression of CD21 and CD23.
Q37844233Animal models in the study of the unfolded protein response.
Q38218335Animal models of inflammatory bowel disease: a review.
Q98302868Antibody-secreting cell destiny emerges during the initial stages of B-cell activation
Q36673300Antigen presentation and the ubiquitin-proteasome system in host-pathogen interactions
Q49843417Artesunate shows potent anti-tumor activity in B-cell lymphoma
Q37223496Assessing the contribution of thrombospondin-4 induction and ATF6α activation to endoplasmic reticulum expansion and phenotypic modulation in bladder outlet obstruction
Q37280181Augmentation of antibody responses by retinoic acid and costimulatory molecules
Q50894540Autophagic dysfunction is improved by intermittent administration of osteocalcin in obese mice.
Q33264844Autophagy counterbalances endoplasmic reticulum expansion during the unfolded protein response
Q42215452Autophagy in Plasma Cell Ontogeny and Malignancy
Q49163388B Cell-Intrinsic Role for IRF5 in TLR9/BCR-Induced Human B Cell Activation, Proliferation, and Plasmablast Differentiation.
Q37336043B cell activating factor inhibition impairs bacterial immunity by reducing T cell-independent IgM secretion
Q38196333B cell biology: an overview
Q34009020B cell signature during inactive systemic lupus is heterogeneous: toward a biological dissection of lupus
Q40110061B cell terminal differentiation factor XBP-1 induces reactivation of Kaposi's sarcoma-associated herpesvirus
Q37029874B cells in transplantation
Q38309985B-1 B lymphocytes require Blimp-1 for immunoglobulin secretion
Q49835162B-Cell Metabolic Remodeling and Cancer
Q37480851B7-1/2 (CD80/CD86) direct signaling to B cells enhances IgG secretion.
Q24310536BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha
Q37761495BCL6: master regulator of the germinal center reaction and key oncogene in B cell lymphomagenesis
Q36000128BH3-only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1α.
Q52855754BLIMP-1 is a target of cellular stress and downstream of the unfolded protein response.
Q36983660BLIMP1 guides the fate of effector B and T cells
Q39138911Biogenesis of secretory organelles during B cell differentiation
Q36029236Birth pangs: the stressful origins of lymphocytes
Q36591114Blimp-1 controls plasma cell function through the regulation of immunoglobulin secretion and the unfolded protein response
Q36404002Blimp-1 is required for maintenance of long-lived plasma cells in the bone marrow
Q50656386Blimp1 regulates development of the posterior forelimb, caudal pharyngeal arches, heart and sensory vibrissae in mice.
Q50993571Bone morphogenetic proteins inhibit CD40L/IL-21-induced Ig production in human B cells: differential effects of BMP-6 and BMP-7.
Q41444351Bortezomib initiates endoplasmic reticulum stress, elicits autophagy and death in Echinococcus granulosus larval stage.
Q34542087Bortezomib resistance in mantle cell lymphoma is associated with plasmacytic differentiation
Q37730801Btk-specific inhibition blocks pathogenic plasma cell signatures and myeloid cell-associated damage in IFNα-driven lupus nephritis.
Q35990295Building an antibody factory: a job for the unfolded protein response
Q35005660CDDO-Imidazolide inhibits growth and survival of c-Myc-induced mouse B cell and plasma cell neoplasms
Q39338271CHOP-independent apoptosis and pathway-selective induction of the UPR in developing plasma cells
Q43125021CTP:phosphocholine cytidylyltransferase alpha is required for B-cell proliferation and class switch recombination.
Q80890020Cancer: negative feedback for B cells
Q37074275Candidate genes of Waldenström's macroglobulinemia: current evidence and research.
Q39025066Causes and consequences of endoplasmic reticulum stress in rheumatic disease
Q30614990Cdc42 is a key regulator of B cell differentiation and is required for antiviral humoral immunity.
Q38133611Cell of origin associated classification of B-cell malignancies by gene signatures of the normal B-cell hierarchy
Q43213271Cell-intrinsic expression of TLR9 in autoreactive B cells constrains BCR/TLR7-dependent responses
Q36373409Characteristics of natural antibody-secreting cells
Q50748831Characterization of rapidly degraded polypeptides in mammalian cells reveals a novel layer of nascent protein quality control.
Q36529012Checkpoints in memory B-cell evolution
Q29615503Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes
Q39162575Chinese hamster ovary K1 host cell enables stable cell line development for antibody molecules which are difficult to express in DUXB11-derived dihydrofolate reductase deficient host cell
Q49332631Comparison of the effect of the aerobic glycolysis inhibitor dichloroacetate and of the Krebs cycle inhibitor LW6 on cellular and humoral alloimmunity.
Q36594883Competence and competition: the challenge of becoming a long-lived plasma cell
Q36799606Comprehensive gene expression profiling and immunohistochemical studies support application of immunophenotypic algorithm for molecular subtype classification in diffuse large B-cell lymphoma: a report from the International DLBCL Rituximab-CHOP Con
Q39656290Constitutive CD40 Signaling Calibrates Differentiation Outcomes in Responding B Cells via Multiple Molecular Pathways
Q39112089Contribution of microRNA 24-3p and Erk1/2 to interleukin-6-mediated plasma cell survival
Q34686624Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors
Q37585210Cooperative transcriptional repression by BCL6 and BACH2 in germinal center B-cell differentiation
Q42832143Coordinate regulation of phospholipid biosynthesis and secretory pathway gene expression in XBP-1(S)-induced endoplasmic reticulum biogenesis.
Q43195923Corticosterone exerts immunostimulatory effects on macrophages via endoplasmic reticulum stress
Q39464481Culture temperature modulates aggregation of recombinant antibody in cho cells
Q37589643Cytokine-Mediated Regulation of Plasma Cell Generation: IL-21 Takes Center Stage.
Q46769248Dampening Ab responses using proteasome inhibitors following in vivo B cell activation
Q33689667Defective B-cell response to T-dependent immunization in lupus-prone mice
Q34130632Defective ribosomal products are the major source of antigenic peptides endogenously generated from influenza A virus neuraminidase
Q33605735Deficient import of acetyl-CoA into the ER lumen causes neurodegeneration and propensity to infections, inflammation, and cancer
Q81951815Defining a transcriptional fingerprint of murine splenic B-cell development
Q35563395Defining terminally differentiating B cell populations in rainbow trout immune tissues using the transcription factor XbpI
Q64076943Definition of a multiple myeloma progenitor population in mice driven by enforced expression of XBP1s
Q38750810Development of Genetically Modified Chinese Hamster Ovary Host Cells for the Enhancement of Recombinant Tissue Plasminogen Activator Expression
Q28264704Development of a novel ER stress based selection system for the isolation of highly productive clones
Q37797970Diabetes as a disease of endoplasmic reticulum stress
Q41087457Differential effects of unfolded protein response pathways on axon injury-induced death of retinal ganglion cells.
Q35171263Differential induction of plasma cells by isoforms of human TACI.
Q39770218Direct proteasome binding and subsequent degradation of unspliced XBP-1 prevent its intracellular aggregation
Q92351754Disruption of IRE1α through its kinase domain attenuates multiple myeloma
Q35709954Dissociation of inositol-requiring enzyme (IRE1α)-mediated c-Jun N-terminal kinase activation from hepatic insulin resistance in conditional X-box-binding protein-1 (XBP1) knock-out mice
Q35008217Dual and opposing roles of the unfolded protein response regulated by IRE1alpha and XBP1 in proinsulin processing and insulin secretion
Q47379003Dynamic Glycosylation Governs the Vertebrate COPII Protein Trafficking Pathway.
Q36949937Dynamic changes in Id3 and E-protein activity orchestrate germinal center and plasma cell development.
Q92188856ER Stress and the UPR in Shaping Intestinal Tissue Homeostasis and Immunity
Q47301158ER homeostasis and autophagy
Q38919078ER stress response in NG108-15 cells involves upregulation of syntaxin 5 expression and reduced amyloid β peptide secretion
Q34003896ER stress, autophagy, and RNA viruses
Q36777229ER stress: Autophagy induction, inhibition and selection.
Q24318838ERdj4 and ERdj5 are required for endoplasmic reticulum-associated protein degradation of misfolded surfactant protein C
Q47232451EZH2 Represses the B Cell Transcriptional Program and Regulates Antibody-Secreting Cell Metabolism and Antibody Production
Q28484077Early dengue virus protein synthesis induces extensive rearrangement of the endoplasmic reticulum independent of the UPR and SREBP-2 pathway
Q42413559Editorial: Proteostenosis: cancer's Achilles heel?
Q38823757Effect of modulation of unfolded protein response pathway on dengue virus infection.
Q33829736Effectors and memories: Bcl-6 and Blimp-1 in T and B lymphocyte differentiation
Q36634922Elimination of endoplasmic reticulum stress and cardiovascular, type 2 diabetic, and other metabolic diseases
Q26827965Emerging functions of the unfolded protein response in immunity
Q37808199Emerging roles for XBP1, a sUPeR transcription factor
Q47146318Endoplasmic Reticulum Stress and Allergic Diseases.
Q26799567Endoplasmic Reticulum Stress in the Diabetic Kidney, the Good, the Bad and the Ugly
Q36835107Endoplasmic reticulum HSP90b1 (gp96, grp94) optimizes B-cell function via chaperoning integrin and TLR but not immunoglobulin
Q38296280Endoplasmic reticulum proteins quality control and the unfolded protein response: the regulative mechanism of organisms against stress injuries
Q39011260Endoplasmic reticulum proteostasis: a key checkpoint in cancer
Q38385700Endoplasmic reticulum quality control in cancer: Friend or foe.
Q36300785Endoplasmic reticulum stress and the making of a professional secretory cell
Q36842308Endoplasmic reticulum stress in disease pathogenesis
Q26864340Endoplasmic reticulum stress in the β-cell pathogenesis of type 2 diabetes
Q42324534Endoplasmic reticulum stress induces a caspase-dependent N-terminal cleavage of RBX1 protein in B cells
Q34679601Endoplasmic reticulum stress regulates rat mandibular cartilage thinning under compressive mechanical stress
Q37811174Endoplasmic reticulum stress-sensing mechanisms in yeast and mammalian cells
Q37288073Endoplasmic reticulum stress: its role in disease and novel prospects for therapy
Q92778054Endoplasmic reticulum: a focal point of Zika virus infection
Q37730868Engineering mammalian cells in bioprocessing - current achievements and future perspectives
Q42837135Engineering of chaperone systems and of the unfolded protein response
Q39107996Establishment of a three-dimensional culture system of gastric stem cells supporting mucous cell differentiation using microfibrous polycaprolactone scaffolds
Q37168900Examination of a second node of translational control in the unfolded protein response
Q41132806Expansion, harvest and cryopreservation of human mesenchymal stem cells in a serum-free microcarrier process
Q46105066Expression and function of blimp1/krox, an alternatively transcribed regulatory gene of the sea urchin endomesoderm network
Q40408501Expression clustering reveals detailed co-expression patterns of functionally related proteins during B cell differentiation: a proteomic study using a combination of one-dimensional gel electrophoresis, LC-MS/MS, and stable isotope labeling by amin
Q36068948Expression of MALT1 oncogene in hematopoietic stem/progenitor cells recapitulates the pathogenesis of human lymphoma in mice
Q92947929Expression of UPR effector proteins ATF6 and XBP1 reduce colorectal cancer cell proliferation and stemness by activating PERK signaling
Q39143899Expression of peroxiredoxins I and IV in multiple myeloma: association with immunoglobulin accumulation
Q37112853Expression pattern of XBP1(S) in human B-cell lymphomas
Q27021855Factors regulating immunoglobulin production by normal and disease-associated plasma cells
Q37408346Fas apoptosis inhibitory molecule enhances CD40 signaling in B cells and augments the plasma cell compartment
Q60268649FcγRIIb controls bone marrow plasma cell persistence and apoptosis
Q37596032Fine-tuning of the unfolded protein response: Assembling the IRE1alpha interactome
Q56877864Flaviviral regulation of the unfolded protein response: can stress be beneficial?
Q27477652Flavivirus Infection Activates the XBP1 Pathway of the Unfolded Protein Response To Cope with Endoplasmic Reticulum Stress
Q39063397Flow signaling and atherosclerosis
Q64949783Food Perception Primes Hepatic ER Homeostasis via Melanocortin-Dependent Control of mTOR Activation.
Q36362397From acute ER stress to physiological roles of the Unfolded Protein Response
Q37596560From sugar to fat: How the transcription factor XBP1 regulates hepatic lipogenesis
Q64097340Function and dysfunction of plasma cells in intestine
Q34116716Functional RNA interference (RNAi) screen identifies system A neutral amino acid transporter 2 (SNAT2) as a mediator of arsenic-induced endoplasmic reticulum stress
Q42637800Functional signatures identified in B-cell non-Hodgkin lymphoma profiles.
Q42030999Functionally Distinct Subpopulations of CpG-Activated Memory B Cells.
Q38519535Gene expression profiling identifies molecular subgroups among nodal peripheral T-cell lymphomas.
Q37851178Gene interaction network regulates plasma cell differentiation.
Q37785950Generating humoral immune memory following infection or vaccination
Q33471405Genetic variation of promoter sequence modulates XBP1 expression and genetic risk for vitiligo
Q34356834Genome-wide expression analysis upon constitutive activation of the HacA bZIP transcription factor in Aspergillus niger reveals a coordinated cellular response to counteract ER stress
Q37039584Germinal centres: role in B-cell physiology and malignancy
Q33741100Global miRNA expression analysis identifies novel key regulators of plasma cell differentiation and malignant plasma cell
Q37622642Glucose-dependent de novo lipogenesis in B lymphocytes: a requirement for atp-citrate lyase in lipopolysaccharide-induced differentiation.
Q91932452Gm40600 suppressed SP 2/0 isograft tumor by reducing Blimp1 and Xbp1 proteins
Q91704713HDACi mediate UNG2 depletion, dysregulated genomic uracil and altered expression of oncoproteins and tumor suppressors in B- and T-cell lines
Q64056478HSP-4/BiP expression in secretory cells is regulated by a developmental program and not by the unfolded protein response
Q37452148Hedgehog and retinoid signaling alters multiple myeloma microenvironment and generates bortezomib resistance
Q35182826Heightened induction of proapoptotic signals in response to endoplasmic reticulum stress in primary fibroblasts from a mouse model of longevity
Q38762525Hepatocyte nuclear factor 4α is required for cell differentiation and homeostasis in the adult mouse gastric epithelium
Q38727217Herpes Simplex Virus 1 UL41 Protein Suppresses the IRE1/XBP1 Signal Pathway of the Unfolded Protein Response via Its RNase Activity
Q92255602Herpesviruses and the Unfolded Protein Response
Q30541968High-resolution temporal response patterns to influenza vaccine reveal a distinct human plasma cell gene signature
Q34647217Histone deacetylase inhibitors upregulate B cell microRNAs that silence AID and Blimp-1 expression for epigenetic modulation of antibody and autoantibody responses
Q33979830Homeostatic expansion of autoreactive immunoglobulin-secreting cells in the Rag2 mouse model of Omenn syndrome
Q38781238Hypoxia reduces ER-to-Golgi protein trafficking and increases cell death by inhibiting the adaptive unfolded protein response in mouse beta cells.
Q57288911IL-6 mediates ER expansion during hyperpolarization of alternatively activated macrophages
Q36094982IL-6 triggers IL-21 production by human CD4+ T cells to drive STAT3-dependent plasma cell differentiation in B cells
Q55283549IRE1α Implications in Endoplasmic Reticulum Stress-Mediated Development and Pathogenesis of Autoimmune Diseases.
Q90073188IRE1α Promotes Zika Virus Infection via XBP1
Q35868391IRE1α-Dependent Decay of CReP/Ppp1r15b mRNA Increases Eukaryotic Initiation Factor 2α Phosphorylation and Suppresses Protein Synthesis
Q39527323Identification of novel myeloma-specific XBP1 peptides able to generate cytotoxic T lymphocytes: a potential therapeutic application in multiple myeloma
Q93267893Immunoglobulin expression in the endoplasmic reticulum shapes the metabolic fitness of B lymphocytes
Q28084887Immunological function of Blimp-1 in dendritic cells and relevance to autoimmune diseases
Q43777054Implication of eIF2α kinase GCN2 in induction of apoptosis and endoplasmic reticulum stress-responsive genes by sodium salicylate
Q47104731Implications of aging and the endoplasmic reticulum unfolded protein response on the molecular modality of breast cancer.
Q35812550Increased p190RhoGEF expression in activated B cells correlates with the induction of the plasma cell differentiation
Q46201368Inducible expression of hyperactive Syk in B cells activates Blimp-1-dependent terminal differentiation
Q54227237Inducible nitric oxide synthase is a major intermediate in signaling pathways for the survival of plasma cells.
Q28236897Inflammation and cellular stress: a mechanistic link between immune-mediated and metabolically driven pathologies
Q35318479Inhibition of B lymphocyte-induced maturation protein-1 reduces the production of autoantibody and alleviates symptoms of systemic lupus erythematosus
Q39639974Inhibition of Terminal Differentiation of B Cells Mediated by CD27 and CD40 Involves Signaling through JNK
Q90401529Innate Immune Evasion of Alphaherpesvirus Tegument Proteins
Q39850541Interleukin-21 regulates expression of the immediate-early lytic cycle genes and proteins in Epstein-Barr Virus infected B cells
Q88562718Interleukin-6: designing specific therapeutics for a complex cytokine
Q37075911Intermittent injections of osteocalcin reverse autophagic dysfunction and endoplasmic reticulum stress resulting from diet-induced obesity in the vascular tissue via the NFκB-p65-dependent mechanism
Q34985745Intersection of the unfolded protein response and hepatic lipid metabolism
Q37512312Intricately Regulated: A Cellular Toolbox for Fine-Tuning XBP1 Expression and Activity
Q39143583Intrinsic Plasma Cell Differentiation Defects in B Cell Expansion with NF-κB and T Cell Anergy Patient B Cells.
Q27015015Involvement of the IRE1α-XBP1 pathway and XBP1s-dependent transcriptional reprogramming in metabolic diseases
Q39190900JUN is a key transcriptional regulator of the unfolded protein response in acute myeloid leukemia
Q91605042KSHV activates unfolded protein response sensors but suppresses downstream transcriptional responses to support lytic replication
Q55279342Leptin Promotes Allergic Airway Inflammation through Targeting the Unfolded Protein Response Pathway.
Q33633401Linking ER Stress to Autophagy: Potential Implications for Cancer Therapy.
Q35783785Long Noncoding RNA Expression during Human B-Cell Development
Q59798186Long-Lived Plasma Cells in Mice and Men
Q36706220Loss of Fancc Impairs Antibody-Secreting Cell Differentiation in Mice through Deregulating the Wnt Signaling Pathway.
Q38068055Lysine acetylation in the lumen of the ER: a novel and essential function under the control of the UPR.
Q33660823MYD88 L265P mutations are correlated with 6q deletion in Korean patients with Waldenström macroglobulinemia
Q40553936MZB1 is a GRP94 cochaperone that enables proper immunoglobulin heavy chain biosynthesis upon ER stress
Q64067953Macrophage-B Cell Interactions in the Inverted Porcine Lymph Node and Their Response to Porcine Reproductive and Respiratory Syndrome Virus
Q34360347Mantle cell lymphoma activation enhances bortezomib sensitivity
Q36640334Matched and mismatched metabolic fuels in lymphocyte function
Q39845029Mechanisms and clinical implications of hepatocyte lipoapoptosis
Q95840450Mechanisms, regulation and functions of the unfolded protein response
Q90229388Mechanistic Connections between Endoplasmic Reticulum (ER) Redox Control and Mitochondrial Metabolism
Q33694514Mechanistic rationale for targeting the unfolded protein response in pre-B acute lymphoblastic leukemia
Q42916164Membrane biogenesis and the unfolded protein response
Q37425584Membrane expansion alleviates endoplasmic reticulum stress independently of the unfolded protein response.
Q37308781Membrane phospholipid synthesis and endoplasmic reticulum function
Q38748145Metabolic Control of Plasma Cell Differentiation- What We Know and What We Don't Know
Q41997253Metabolic Links between Plasma Cell Survival, Secretion, and Stress
Q39200395Metabolism and metabolic burden by α1-antitrypsin production in human AGE1.HN cells
Q27001727Micro(RNA)managing endoplasmic reticulum stress
Q35841763MicroRNA-30c-2* limits expression of proadaptive factor XBP1 in the unfolded protein response
Q36453354Microarray-based understanding of normal and malignant plasma cells
Q52642682Mild hypothermia upregulates myc and xbp1s expression and improves anti-TNFα production in CHO cells.
Q91975800Mining Data From Plasma Cell Differentiation Identified Novel Genes for Engineering of a Yeast Antibody Factory
Q37970025Mitochondria at the interface between danger signaling and metabolism: role of unfolded protein responses in chronic inflammation
Q37116099Mitochondrial Pyruvate Import Promotes Long-Term Survival of Antibody-Secreting Plasma Cells
Q35488455Mitochondrial function provides instructive signals for activation-induced B-cell fates
Q39089474Model-directed engineering of "difficult-to-express" monoclonal antibody production by Chinese hamster ovary cells.
Q39962950Molecular and cellular analysis of B-cell populations in the rainbow trout using Pax5 and immunoglobulin markers
Q24814355Molecular and cytological features of the mouse B-cell lymphoma line iMycEmu-1
Q39090150Molecular chaperone gp96 is a novel therapeutic target of multiple myeloma
Q34427053Molecular characterization of circulating plasma cells in patients with active systemic lupus erythematosus.
Q45411188Mouse hepatitis virus infection activates the Ire1/XBP1 pathway of the unfolded protein response
Q55038802Mouse models of multiple myeloma: technologic platforms and perspectives.
Q49414498Multifunctional role of the transcription factor Blimp-1 in coordinating plasma cell differentiation
Q38467774Multiple Mechanisms of Unfolded Protein Response-Induced Cell Death
Q35093910Multiple autophosphorylations significantly enhance the endoribonuclease activity of human inositol requiring enzyme 1α.
Q43113067Myelomatous plasma cells display an aberrant gene expression pattern similar to that observed in normal memory B cells
Q35558871NADPH oxidase-dependent production of reactive oxygen species induces endoplasmatic reticulum stress in neutrophil-like HL60 cells
Q38304615Nodal signaling activates differentiation genes during zebrafish gastrulation
Q27304386Novel drug targets for personalized precision medicine in relapsed/refractory diffuse large B-cell lymphoma: a comprehensive review
Q33361478Novel insights into the unfolded protein response using Pichia pastoris specific DNA microarrays.
Q93183043Nε-lysine acetylation in the endoplasmic reticulum - a novel cellular mechanism that regulates proteostasis and autophagy
Q38366678Oct2 and Obf1 as Facilitators of B:T Cell Collaboration during a Humoral Immune Response
Q33849388Oncogenic activation of NF-kappaB.
Q37410944Ontogeny of human IgE-expressing B cells and plasma cells
Q35146134Optimization of heterologous protein production in Chinese hamster ovary cells under overexpression of spliced form of human X-box binding protein
Q38702294Overexpression of B-cell lymphoma 6 alters gene expression profile in a myeloma cell line and is associated with decreased DNA damage response
Q39649757Overexpression of PAX5 induces apoptosis in multiple myeloma cells
Q37401266Oxidative folding: cellular strategies for dealing with the resultant equimolar production of reactive oxygen species
Q38672664PERK-opathies: An Endoplasmic Reticulum Stress Mechanism Underlying Neurodegeneration
Q35669016Pathogenesis and immunobiology of brucellosis: review of Brucella-host interactions
Q37187523Patterns of microRNA expression characterize stages of human B-cell differentiation.
Q36570655Pax5--a critical inhibitor of plasma cell fate
Q34052050Phorbol myristate acetate, but not CD40L, induces the differentiation of CLL B cells into Ab-secreting cells
Q36581971Phospholipids: "greasing the wheels" of humoral immunity
Q28478056Physiological IRE-1-XBP-1 and PEK-1 signaling in Caenorhabditis elegans larval development and immunity
Q38209331Physiological roles of regulated Ire1 dependent decay
Q37857795Physiological unfolded protein response regulated by OASIS family members, transmembrane bZIP transcription factors
Q93086685Pituitary cell translation and secretory capacities are enhanced cell autonomously by the transcription factor Creb3l2
Q55266542Plasma Cell Differentiation Pathways in Systemic Lupus Erythematosus.
Q40104307Plasma cell deficiency in human subjects with heterozygous mutations in Sec61 translocon alpha 1 subunit (SEC61A1).
Q33838972Plasma cell differentiation initiates a limited ER stress response by specifically suppressing the PERK-dependent branch of the unfolded protein response
Q40075775Plasma cell-specific transcription factor XBP-1s binds to and transactivates the Epstein-Barr virus BZLF1 promoter
Q92383022Plasma cells: You are what you eat
Q57054936Plasma cells: the programming of an antibody-secreting machine
Q92203848Programming Isotype-Specific Plasma Cell Function
Q89091464Progressive Upregulation of Oxidative Metabolism Facilitates Plasmablast Differentiation to a T-Independent Antigen
Q30476988Progressively impaired proteasomal capacity during terminal plasma cell differentiation
Q47847125Prolonged Ex vivo expansion and differentiation of naïve murine CD43(-) B splenocytes.
Q38022591Promising personalized therapeutic options for diffuse large B-cell Lymphoma Subtypes with oncogene addictions
Q40310345Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells
Q45324229Protection of mice deficient in mature B cells from West Nile virus infection by passive and active immunization
Q38704807Protein misfolding in the endoplasmic reticulum as a conduit to human disease
Q83300064Protein synthesis in plasma cells is regulated by crosstalk between endoplasmic reticulum stress and mTOR signaling
Q24293415RAB26 and RAB3D are direct transcriptional targets of MIST1 that regulate exocrine granule maturation
Q35035144RNA-sequencing analysis of TCDD-induced responses in zebrafish liver reveals high relatedness to in vivo mammalian models and conserved biological pathways
Q34573419RTCB-1 mediates neuroprotection via XBP-1 mRNA splicing in the unfolded protein response pathway
Q52038310Rapid B cell receptor-induced unfolded protein response in nonsecretory B cells correlates with pro- versus antiapoptotic cell fate.
Q35187659Rapid, massively parallel single-cell drug response measurements via live cell interferometry.
Q38258197Recent advances and future directions in targeting the secretory apparatus in multiple myeloma
Q45387412Regulated IRE1-dependent decay participates in curtailing immunoglobulin secretion from plasma cells
Q42362506Regulation of B cell differentiation by the ubiquitin-binding protein TAX1BP1
Q55260956Regulation of Cytokine Production by the Unfolded Protein Response; Implications for Infection and Autoimmunity.
Q24633098Regulation of aicda expression and AID activity: relevance to somatic hypermutation and class switch DNA recombination
Q28507784Regulation of hepatic lipogenesis by the transcription factor XBP1
Q36058417Regulation of plasma-cell development
Q26799208Regulation of protein homeostasis in neurodegenerative diseases: the role of coding and non-coding genes
Q37423378Regulation of the unfolded protein response by microRNAs
Q24303825Regulation of unfolded protein response modulator XBP1s by acetylation and deacetylation
Q38153592Regulatory crosstalk within the mammalian unfolded protein response
Q93032482Regulatory mechanisms of B cell responses and the implication in B cell-related diseases
Q36229240Repression of BCL-6 is required for the formation of human memory B cells in vitro
Q35643032Response of myeloma to the proteasome inhibitor bortezomib is correlated with the unfolded protein response regulator XBP-1.
Q41820521Reticulophagy and ribophagy: regulated degradation of protein production factories.
Q43214685Robust Endoplasmic Reticulum-Associated Degradation of Rhodopsin Precedes Retinal Degeneration.
Q37804627Role of Endoplasmic Reticulum Stress in Cystic Fibrosis-Related Airway Inflammatory Responses
Q37631563Role of IRE1α/XBP-1 in Cystic Fibrosis Airway Inflammation
Q56979449Role of X-Box Binding Protein-1 in Fructose-Induced Lipogenesis in HepG2 Cells
Q54397189Role of the unfolded protein response in organ physiology: lessons from mouse models.
Q33559303Roles of tau protein in health and disease
Q90435275Rotavirus Infection Alters Splicing of the Stress-Related Transcription Factor XBP1
Q39279718SERCA2 dysfunction in Darier disease causes endoplasmic reticulum stress and impaired cell-to-cell adhesion strength: rescue by Miglustat
Q34287569SLC33A1/AT-1 protein regulates the induction of autophagy downstream of IRE1/XBP1 pathway
Q26774797SLE-associated risk factors affect DC function
Q33738889SNIPER(TACC3) induces cytoplasmic vacuolization and sensitizes cancer cells to Bortezomib.
Q36677337STAT3-mediated up-regulation of BLIMP1 Is coordinated with BCL6 down-regulation to control human plasma cell differentiation.
Q24307512SUMO modification regulates the transcriptional activity of XBP1
Q35719978Sec63 and Xbp1 regulate IRE1α activity and polycystic disease severity
Q40223778Secretagogues differentially activate endoplasmic reticulum stress responses in pancreatic acinar cells
Q33948902Selective transcriptional regulation by Myc in cellular growth control and lymphomagenesis.
Q39235911Shaping proteostasis at the cellular, tissue, and organismal level
Q41669177Shiga Toxin Therapeutics: Beyond Neutralization.
Q27860577Signal integration in the endoplasmic reticulum unfolded protein response
Q28243253Signal peptide peptidase is required for dislocation from the endoplasmic reticulum
Q28587852Signalling mediated by the endoplasmic reticulum stress transducer OASIS is involved in bone formation
Q36330343Silencing of lipid metabolism genes through IRE1α-mediated mRNA decay lowers plasma lipids in mice.
Q24300776Simultaneous induction of the four subunits of the TRAP complex by ER stress accelerates ER degradation
Q36605667Somatic stem cells and the origin of cancer
Q93240067Spec-seq unveils transcriptional subpopulations of antibody-secreting cells following influenza vaccination
Q36843718Spi-B inhibits human plasma cell differentiation by repressing BLIMP1 and XBP-1 expression
Q60044509Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha
Q37894253Stressed out about obesity: IRE1α-XBP1 in metabolic disorders
Q64983280Structural and mutational analysis of the ribosome-arresting human XBP1u.
Q40077904Study of transcription activity of X-box binding protein 1 gene in human different cell lines
Q47143373Suppression by TFR cells leads to durable and selective inhibition of B cell effector function
Q94585461Suppression of miR-330-3p alleviates DSS-induced ulcerative colitis and apoptosis by upregulating the endoplasmic reticulum stress components XBP1
Q35963221Sustained secretion of immunoglobulin by long-lived human tonsil plasma cells.
Q38760595Syndecan-1 (CD138) Suppresses Apoptosis in Multiple Myeloma by Activating IGF1 Receptor: Prevention by SynstatinIGF1R Inhibits Tumor Growth
Q34936998TLR2, TLR4 and the MyD88 signaling are crucial for the in vivo generation and the longevity of long-lived antibody-secreting cells
Q59804792TLR9 Signaling Suppresses the Canonical Plasma Cell Differentiation Program in Follicular B Cells
Q36871730TRC8-dependent degradation of hepatitis C virus immature core protein regulates viral propagation and pathogenesis
Q38068534Targeting plasma cells with proteasome inhibitors: possible roles in treating myasthenia gravis?
Q38104475Targeting unfolded protein response signaling pathways to ameliorate protein misfolding diseases
Q39380162Tetraspanins stimulate protein synthesis in myeloma cell lines
Q33569863The BTB-ZF transcription factor Zbtb20 is driven by Irf4 to promote plasma cell differentiation and longevity
Q35252633The BiP cochaperone ERdj4 is required for B cell development and function
Q28078919The Biological Effects of IL-21 Signaling on B-Cell-Mediated Responses in Organ Transplantation
Q34412358The CrebA/Creb3-like transcription factors are major and direct regulators of secretory capacity
Q33652759The ER stress transducer IRE1β is required for airway epithelial mucin production
Q89965531The Emerging Roles of Endoplasmic Reticulum Stress in Balancing Immunity and Tolerance in Health and Diseases: Mechanisms and Opportunities
Q60960086The Epigenome in Multiple Myeloma: Impact on Tumor Cell Plasticity and Drug Response
Q90412483The IL-15-AKT-XBP1s signaling pathway contributes to effector functions and survival in human NK cells
Q39843795The IRE1alpha-XBP1 pathway of the unfolded protein response is required for adipogenesis
Q36445900The LMP1 oncogene of EBV activates PERK and the unfolded protein response to drive its own synthesis
Q64071635The Maintenance of Memory Plasma Cells
Q38701700The SAT Protein of Porcine Parvovirus Accelerates Viral Spreading through Induction of Irreversible Endoplasmic Reticulum Stress
Q35128761The SWI/SNF chromatin remodeling complex regulates germinal center formation by repressing Blimp-1 expression.
Q58762992The Transcriptional Regulation of Germinal Center Formation
Q38093786The UPR and lung disease
Q38818892The Unfolded Protein Response in Homeostasis and Modulation of Mammalian Immune Cells.
Q39431986The Unfolded Protein Response in the Immune Cell Development: Putting the Caretaker in the Driving Seat
Q34313320The biology of human lymphoid malignancies revealed by gene expression profiling.
Q35830099The differentiation and stress response factor XBP-1 drives multiple myeloma pathogenesis
Q38002486The diverse roles of IRF4 in late germinal center B-cell differentiation
Q38206145The endoplasmic reticulum and unfolded protein response in the control of mammalian recombinant protein production
Q37231726The endoplasmic reticulum stress response in immunity and autoimmunity
Q37429810The endosomal transcriptional regulator RNF11 integrates degradation and transport of EGFR.
Q38244316The expanding roles of endoplasmic reticulum stress in virus replication and pathogenesis
Q38842444The forkhead transcription factor FOXP1 represses human plasma cell differentiation
Q38001913The genetic architecture of multiple myeloma.
Q34994764The hierarchical process of differentiation of long-lived antibody-secreting cells is dependent on integrated signals derived from antigen and IL-17A.
Q38241996The impact of the endoplasmic reticulum protein-folding environment on cancer development
Q33798887The importance of the genomic landscape in Waldenström's Macroglobulinemia for targeted therapeutical interventions
Q35850668The in vivo function of a noncanonical TRAF2-binding domain in the C-terminus of CD40 in driving B-cell growth and differentiation
Q34807567The mammalian tRNA ligase complex mediates splicing of XBP1 mRNA and controls antibody secretion in plasma cells
Q36612630The molecular biology of diffuse large B-cell lymphoma
Q35791706The role of endoplasmic reticulum stress in autoimmune-mediated beta-cell destruction in type 1 diabetes.
Q36917366The role of endoplasmic reticulum stress in maintaining and targeting multiple myeloma: a double-edged sword of adaptation and apoptosis
Q35981133The specialized unfolded protein response of B lymphocytes: ATF6α-independent development of antibody-secreting B cells.
Q28512302The transcription factor XBP-1 is essential for the development and survival of dendritic cells
Q34375208The transcription factors IRF8 and PU.1 negatively regulate plasma cell differentiation
Q34224697The unfolded protein response (UPR)-activated transcription factor X-box-binding protein 1 (XBP1) induces microRNA-346 expression that targets the human antigen peptide transporter 1 (TAP1) mRNA and governs immune regulatory genes.
Q38300472The unfolded protein response and cellular senescence. A review in the theme: cellular mechanisms of endoplasmic reticulum stress signaling in health and disease
Q29248713The unfolded protein response in immunity and inflammation
Q38784676The unfolded protein response in skeletal development and homeostasis
Q37181198The unfolded protein response of B-lymphocytes: PERK-independent development of antibody-secreting cells
Q37825926The unfolded protein response: how protein folding became a restrictive aspect for innate immunity and B lymphocytes
Q24293771The unfolded protein response: integrating stress signals through the stress sensor IRE1α
Q38309617The unfolded-protein-response sensor IRE-1α regulates the function of CD8α+ dendritic cells.
Q27933618The yeast lipin Smp2 couples phospholipid biosynthesis to nuclear membrane growth
Q37338168Thrombospondin expression in myofibers stabilizes muscle membranes.
Q34036779Trachealess (Trh) regulates all tracheal genes during Drosophila embryogenesis
Q38202086Tracking plasma cell differentiation and survival
Q37408113Transcription elongation factor ELL2 directs immunoglobulin secretion in plasma cells by stimulating altered RNA processing.
Q34364860Transcription elongation factor ELL2 drives Ig secretory-specific mRNA production and the unfolded protein response
Q51981842Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination.
Q34661930Transcription factor MIST1 in terminal differentiation of mouse and human plasma cells
Q37237457Transcription factor Zfx controls BCR-induced proliferation and survival of B lymphocytes
Q38583565Transcription factors regulating B cell fate in the germinal centre.
Q36529017Transcription factors that regulate memory in humoral responses
Q64107226Transcriptional Analysis of the Human IgE-Expressing Plasma Cell Differentiation Pathway
Q33686864Transcriptional and post-transcriptional regulation of proangiogenic factors by the unfolded protein response
Q38841691Transcriptional and post-transcriptional targeting for enhanced transient gene expression in CHO cells
Q50927930Transcriptional profiling of mouse B cell terminal differentiation defines a signature for antibody-secreting plasma cells.
Q28485361Transcriptional regulation of VEGFA by the endoplasmic reticulum stress transducer OASIS in ARPE-19 cells
Q38395499Transcriptional regulation of secretory capacity by bZip transcription factors
Q82974924Transcriptional repressor Blimp-1 regulates T cell homeostasis and function
Q33402631Transcriptomic comparison of Aspergillus niger growing on two different sugars reveals coordinated regulation of the secretory pathway
Q37644973Translating DRiPs: MHC class I immunosurveillance of pathogens and tumors.
Q37854496Translating DRiPs: progress in understanding viral and cellular sources of MHC class I peptide ligands
Q60912415Treatment of established TH2 cells with 4μ8c, an inhibitor of IRE1α, blocks IL-5 but not IL-4 secretion
Q35503584UPR-Mediated Membrane Biogenesis in B Cells
Q34431021Ubiquitination of inositol-requiring enzyme 1 (IRE1) by the E3 ligase CHIP mediates the IRE1/TRAF2/JNK pathway
Q64058079Ufbp1 promotes plasma cell development and ER expansion by modulating distinct branches of UPR
Q91809029Understanding the Role of the Unfolded Protein Response Sensor IRE1 in the Biology of Antigen Presenting Cells
Q42385107Understanding the multiple biological aspects leading to myeloma
Q34574453Unfolded Protein Response (UPR) is activated during normal lens development
Q57812386Unfolded Protein Response-Dependent Communication and Contact among Endoplasmic Reticulum, Mitochondria, and Plasma Membrane
Q36393034Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis.
Q58802711Unfolded protein response, a link between endometrioid ovarian carcinoma and endometriosis: A pilot study
Q92795478Unravel the molecular mechanism of XBP1 in regulating the biology of cancer cells
Q49360155Urinary Angiogenin Reflects the Magnitude of Kidney Injury at the Infrahistologic Level
Q35022542Using molecular markers to characterize productivity in Chinese hamster ovary cell lines
Q92857761Virus-Specific Secondary Plasma Cells Produce Elevated Levels of High-Avidity Antibodies but Are Functionally Short Lived
Q38072035Virus-induced ER stress and the unfolded protein response
Q41971863West Nile virus differentially modulates the unfolded protein response to facilitate replication and immune evasion
Q38297437X box binding protein XBP-1s transactivates the Kaposi's sarcoma-associated herpesvirus (KSHV) ORF50 promoter, linking plasma cell differentiation to KSHV reactivation from latency
Q37015048X-box binding protein 1 is essential for insulin regulation of pancreatic α-cell function
Q35914523X-box-binding protein 1 activates lytic Epstein-Barr virus gene expression in combination with protein kinase D.
Q28510479XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glands
Q36402768XBP-1 specifically promotes IgM synthesis and secretion, but is dispensable for degradation of glycoproteins in primary B cells
Q36540100XBP-1, a novel human T-lymphotropic virus type 1 (HTLV-1) tax binding protein, activates HTLV-1 basal and tax-activated transcription
Q33739777XBP-1-deficient plasmablasts show normal protein folding but altered glycosylation and lipid synthesis.
Q39659690XBP1 Controls Maturation of Gastric Zymogenic Cells by Induction of MIST1 and Expansion of the Rough Endoplasmic Reticulum
Q37377432XBP1 governs late events in plasma cell differentiation and is not required for antigen-specific memory B cell development
Q22252318XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease
Q41379228XBP1 may determine the size of the ameloblast endoplasmic reticulum.
Q36322684XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum.
Q51219525Xbp1-based engineering of secretory capacity enhances the productivity of Chinese hamster ovary cells.
Q42762683Xbp1s-negative tumor B cells and pre-plasmablasts mediate therapeutic proteasome inhibitor resistance in multiple myeloma
Q48090774Zinc transport complexes contribute to the homeostatic maintenance of secretory pathway function in vertebrate cells
Q43107132mTOR activation promotes plasma cell differentiation and bypasses XBP-1 for immunoglobulin secretion
Q89555604mTORC1 coordinates an immediate unfolded protein response-related transcriptome in activated B cells preceding antibody secretion
Q28510139pERp1 is significantly up-regulated during plasma cell differentiation and contributes to the oxidative folding of immunoglobulin

Search more.