Endoplasmic reticulum stress induces a caspase-dependent N-terminal cleavage of RBX1 protein in B cells

scientific article published on 20 July 2012

Endoplasmic reticulum stress induces a caspase-dependent N-terminal cleavage of RBX1 protein in B cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M111.314583
P932PMC publication ID3438954
P698PubMed publication ID22822056

P2093author name stringTommer Ravid
Boaz Tirosh
Shimon Shteingart
Itamar Cohen
Rivka Hadar
P2860cites workSAG, a novel zinc RING finger protein that protects cells from apoptosis induced by redox agentsQ22009063
ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activityQ22009487
XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel diseaseQ22252318
Plasma cell differentiation requires the transcription factor XBP-1Q24291453
Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complexQ24294734
Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradationQ24302539
Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugationQ24314520
The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2Q24597101
SCFCdc4-mediated degradation of the Hac1p transcription factor regulates the unfolded protein response in Saccharomyces cerevisiaeQ24681845
A RING E3–substrate complex poised for ubiquitin-like protein transfer: structural insights into cullin-RING ligasesQ27670841
Signal integration in the endoplasmic reticulum unfolded protein responseQ27860577
A regulatory link between ER-associated protein degradation and the unfolded-protein responseQ27931238
Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradationQ28131669
Yeast homolog of human SAG/ROC2/Rbx2/Hrt2 is essential for cell growth, but not for germination: chip profiling implicates its role in cell cycle regulationQ28138144
ERAD: the long road to destructionQ28264823
Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1Q28507338
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glandsQ28510479
Fbs2 is a new member of the E3 ubiquitin ligase family that recognizes sugar chainsQ28590989
Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survivalQ28593963
Activation of interferon-gamma inducing factor mediated by interleukin-1beta converting enzymeQ28610362
A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosisQ29617776
Progressively impaired proteasomal capacity during terminal plasma cell differentiationQ30476988
IRE1α Disruption Causes Histological Abnormality of Exocrine Tissues, Increase of Blood Glucose Level, and Decrease of Serum Immunoglobulin LevelQ33707431
The unfolded protein response sensor IRE1alpha is required at 2 distinct steps in B cell lymphopoiesis.Q33777806
STAT1 affects lymphocyte survival and proliferation partially independent of its role downstream of IFN-gammaQ33887011
Small RING Finger Proteins RBX1 and RBX2 of SCF E3 Ubiquitin Ligases: The Role in Cancer and as Cancer TargetsQ34318259
XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiationQ34345459
SAG/ROC/Rbx/Hrt, a zinc RING finger gene family: molecular cloning, biochemical properties, and biological functionsQ34367608
The Unfolded Protein Response, Degradation from Endoplasmic Reticulum and CancerQ34576070
Caspase-12 and ER-stress-mediated apoptosis: the story so far.Q34649447
ER stress activates the NLRP3 inflammasome via an UPR-independent pathwayQ35723848
XBP-1 specifically promotes IgM synthesis and secretion, but is dispensable for degradation of glycoproteins in primary B cellsQ36402768
The mammalian UPR boosts glycoprotein ERAD by suppressing the proteolytic downregulation of ER mannosidase I.Q37289488
Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune diseaseQ37600558
Caspase-2 functions upstream of mitochondria in endoplasmic reticulum stress-induced apoptosis by bortezomib in human myeloma cellsQ39947772
SAG/ROC2/RBX2 is a HIF-1 target gene that promotes HIF-1 alpha ubiquitination and degradationQ40082905
Sequential waves of functionally related proteins are expressed when B cells prepare for antibody secretionQ40669445
Interleukin-1 production by mouse macrophages is regulated in a feedback fashion by nitric oxideQ40915421
Purification of interleukin-1 beta converting enzyme, the protease that cleaves the interleukin-1 beta precursorQ41612419
The Nlrp3 inflammasome is critical for aluminium hydroxide-mediated IL-1beta secretion but dispensable for adjuvant activityQ41959710
UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators.Q42041480
SAG/ROC2/Rbx2 is a novel activator protein-1 target that promotes c-Jun degradation and inhibits 12-O-tetradecanoylphorbol-13-acetate-induced neoplastic transformationQ42511244
The proteasome load versus capacity balance determines apoptotic sensitivity of multiple myeloma cells to proteasome inhibition.Q44169565
Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN-gamma productionQ50335883
Production of interleukin-1 by bone marrow myeloma cellsQ69519942
Association with cullin partners protects ROC proteins from proteasome-dependent degradationQ73270805
Interleukin-1-producing plasma cells in close contact with hepatocytes in patients with chronic active hepatitisQ73574796
Degradation of proteins from the ER of S. cerevisiae requires an intact unfolded protein response pathwayQ73958524
Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1Q80979487
P433issue37
P407language of work or nameEnglishQ1860
P921main subjectendoplasmic reticulumQ79927
P304page(s)31223-31232
P577publication date2012-07-20
P1433published inJournal of Biological ChemistryQ867727
P1476titleEndoplasmic reticulum stress induces a caspase-dependent N-terminal cleavage of RBX1 protein in B cells
P478volume287

Search more.