IRE1α Disruption Causes Histological Abnormality of Exocrine Tissues, Increase of Blood Glucose Level, and Decrease of Serum Immunoglobulin Level

scientific article published on September 27, 2010

IRE1α Disruption Causes Histological Abnormality of Exocrine Tissues, Increase of Blood Glucose Level, and Decrease of Serum Immunoglobulin Level is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2010PLoSO...513052I
P356DOI10.1371/JOURNAL.PONE.0013052
P953full work available at URLhttps://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0013052&type=printable
https://europepmc.org/articles/PMC2946364
https://europepmc.org/articles/PMC2946364?pdf=render
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20885949/?tool=EBI
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20885949/pdf/?tool=EBI
P932PMC publication ID2946364
P698PubMed publication ID20885949
P5875ResearchGate publication ID47157581

P50authorTakao IwawakiQ80174205
P2093author name stringKenji Kohno
Ryoko Akai
P2860cites workPositive contribution of ERdj5/JPDI to endoplasmic reticulum protein quality control in the salivary glandQ84595044
Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factorsQ22008465
Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stressQ22010800
Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1Q22011167
ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPsQ24290776
Translational control by the ER transmembrane kinase/ribonuclease IRE1 under ER stressQ24290818
Plasma cell differentiation requires the transcription factor XBP-1Q24291453
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factorQ24292102
A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cellsQ24309442
A transmembrane protein with a cdc2+/CDC28-related kinase activity is required for signaling from the ER to the nucleusQ27930818
A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein responseQ27938493
Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinaseQ27938837
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNAQ28214814
Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinaseQ28296183
Increased sensitivity to dextran sodium sulfate colitis in IRE1beta-deficient miceQ28359871
Regulated translation initiation controls stress-induced gene expression in mammalian cellsQ28506388
Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1Q28507338
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glandsQ28510479
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetesQ28575190
Cloning of mammalian Ire1 reveals diversity in the ER stress responsesQ28587224
An essential role in liver development for transcription factor XBP-1Q28593777
Quality control in the endoplasmic reticulumQ29619929
Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleusQ29620179
The role of IRE1alpha in the degradation of insulin mRNA in pancreatic beta-cellsQ33320542
The unfolded protein response sensor IRE1alpha is required at 2 distinct steps in B cell lymphopoiesis.Q33777806
Protein quality control in the early secretory pathwayQ36446833
ER stress and diseases.Q36731474
Endoplasmic reticulum stress responsesQ37014237
Function of IRE1 alpha in the placenta is essential for placental development and embryonic viabilityQ37377347
Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1.Q40236795
A transgenic mouse model for monitoring endoplasmic reticulum stressQ44711192
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectgene silencingQ1431332
P304page(s)e13052
P577publication date2010-09-27
P1433published inPLOS OneQ564954
P1476titleIRE1α disruption causes histological abnormality of exocrine tissues, increase of blood glucose level, and decrease of serum immunoglobulin level
IRE1α Disruption Causes Histological Abnormality of Exocrine Tissues, Increase of Blood Glucose Level, and Decrease of Serum Immunoglobulin Level
P478volume5

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cites work (P2860)
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Q42823590Constitutive role of GADD34 and CReP in cancellation of phospho-eIF2α-dependent translational attenuation and insulin biosynthesis in pancreatic β cells
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