| review article | Q7318358 |
| scholarly article | Q13442814 |
| P50 | author | Afshin Samali | Q42156629 |
| Adrienne M Gorman | Q42252939 | ||
| P2093 | author name string | Sanjeev Gupta | |
| Neysan Donnelly | |||
| P2860 | cites work | Pancreatic eukaryotic initiation factor-2alpha kinase (PEK) homologues in humans, Drosophila melanogaster and Caenorhabditis elegans that mediate translational control in response to endoplasmic reticulum stress | Q22253195 |
| Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2 | Q24293501 | ||
| TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death | Q24298384 | ||
| Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling | Q24298930 | ||
| Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon | Q24301655 | ||
| CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells | Q24301679 | ||
| Roles of CHOP/GADD153 in endoplasmic reticulum stress | Q24302185 | ||
| Nucleophosmin interacts with and inhibits the catalytic function of eukaryotic initiation factor 2 kinase PKR | Q24311493 | ||
| PACT, a protein activator of the interferon-induced protein kinase, PKR. | Q24319677 | ||
| Homologous regions of the alpha subunit of eukaryotic translational initiation factor 2 (eIF2alpha) and the vaccinia virus K3L gene product interact with the same domain within the dsRNA-activated protein kinase (PKR) | Q24321445 | ||
| C/EBP homology protein (CHOP) interacts with activating transcription factor 4 (ATF4) and negatively regulates the stress-dependent induction of the asparagine synthetase gene | Q24336614 | ||
| Protein kinase PKR is required for platelet-derived growth factor signaling of c-fos gene expression via Erks and Stat3. | Q24535156 | ||
| The Hsp90 chaperone complex is both a facilitator and a repressor of the dsRNA-dependent kinase PKR | Q24535594 | ||
| Functional characterization of Drosophila melanogaster PERK eukaryotic initiation factor 2alpha (eIF2alpha) kinase. | Q47071973 | ||
| Nitric oxide: from a mysterious labile factor to the molecule of the Nobel Prize. Recent progress in nitric oxide research | Q48379508 | ||
| UPR induces transient burst of apoptosis in islets of early lactating rats through reduced AKT phosphorylation via ATF4/CHOP stimulation of TRB3 expression. | Q51553333 | ||
| PERK EIF2AK3 control of pancreatic beta cell differentiation and proliferation is required for postnatal glucose homeostasis. | Q52000258 | ||
| Characterization of transgenic mice with targeted disruption of the catalytic domain of the double-stranded RNA-dependent protein kinase, PKR. | Q52533947 | ||
| The GCN2 eIF2alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid. | Q53579178 | ||
| Amino Acid Limitation Induces Expression ofCHOP, a CCAAT/Enhancer Binding Protein-related Gene, at Both Transcriptional and Post-transcriptional Levels | Q57033253 | ||
| Higher-Order Substrate Recognition of eIF2α by the RNA-Dependent Protein Kinase PKR | Q57236274 | ||
| Mechanistic Link between PKR Dimerization, Autophosphorylation, and eIF2α Substrate Recognition | Q57236276 | ||
| Central Role of Double-Stranded RNA-Activated Protein Kinase in Microbial Induction of Nitric Oxide Synthase | Q58666147 | ||
| Involvement of Double-stranded RNA-activated Protein Kinase in the Synergistic Activation of Nuclear Factor-κB by Tumor Necrosis Factor-α and γ-Interferon in Preneuronal Cells | Q58666282 | ||
| A model for the double-stranded RNA (dsRNA)-dependent dimerization and activation of the dsRNA-activated protein kinase PKR. | Q64970986 | ||
| Functional expression and characterization of the interferon-induced double-stranded RNA activated P68 protein kinase from Escherichia coli | Q67702508 | ||
| Kinetic studies on the successive reaction of neuronal nitric oxide synthase from L-arginine to nitric oxide and L-citrulline | Q73277324 | ||
| Two distinct stress signaling pathways converge upon the CHOP promoter during the mammalian unfolded protein response | Q74359929 | ||
| Activation of heme-regulated eukaryotic initiation factor 2alpha kinase by nitric oxide is induced by the formation of a five-coordinate NO-heme complex: optical absorption, electron spin resonance, and resonance raman spectral studies | Q75366715 | ||
| Inhibition of the double-stranded RNA-dependent protein kinase PKR by mammalian ribosomes | Q77508091 | ||
| Neoplastic progression in melanoma and colon cancer is associated with increased expression and activity of the interferon-inducible protein kinase, PKR | Q78666553 | ||
| GCN2 phosphorylation of eIF2alpha activates NF-kappaB in response to UV irradiation | Q80540867 | ||
| The double-strand RNA-dependent protein kinase PKR plays a significant role in a sustained ER stress-induced apoptosis | Q80837343 | ||
| Phosphorylation of the alpha-subunit of the eukaryotic initiation factor-2 (eIF2alpha) reduces protein synthesis and enhances apoptosis in response to proteasome inhibition | Q81347002 | ||
| Tyrosine phosphorylation acts as a molecular switch to full-scale activation of the eIF2alpha RNA-dependent protein kinase | Q24535918 | ||
| Modular structure of PACT: distinct domains for binding and activating PKR | Q24551001 | ||
| Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity | Q24562832 | ||
| Upstream open reading frames: molecular switches in (patho)physiology | Q24614000 | ||
| Autophosphorylation sites participate in the activation of the double-stranded-RNA-activated protein kinase PKR | Q24647918 | ||
| The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress | Q24648021 | ||
| Divergent effects of PERK and IRE1 signaling on cell viability | Q27438124 | ||
| Myxoma virus immunomodulatory protein M156R is a structural mimic of eukaryotic translation initiation factor eIF2alpha | Q27639737 | ||
| The unfolded protein response signals through high-order assembly of Ire1 | Q27653139 | ||
| The structure of the PERK kinase domain suggests the mechanism for its activation | Q27667715 | ||
| Uncharged tRNA activates GCN2 by displacing the protein kinase moiety from a bipartite tRNA-binding domain | Q27936337 | ||
| Ribosome-binding domain of eukaryotic initiation factor-2 kinase GCN2 facilitates translation control | Q27938904 | ||
| PKR; a sentinel kinase for cellular stress | Q28137774 | ||
| Perk is essential for translational regulation and cell survival during the unfolded protein response | Q28140062 | ||
| PERK mediates cell-cycle exit during the mammalian unfolded protein response | Q28141519 | ||
| EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndrome | Q28142981 | ||
| RAX, a cellular activator for double-stranded RNA-dependent protein kinase during stress signaling | Q28144380 | ||
| The double-stranded RNA activated protein kinase PKR physically associates with the tumor suppressor p53 protein and phosphorylates human p53 on serine 392 in vitro | Q28144828 | ||
| Autophosphorylation of threonine 485 in the activation loop is essential for attaining eIF2alpha kinase activity of HRI | Q28206502 | ||
| S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration | Q28242222 | ||
| A synthetic peptide substrate for initiation factor-2 kinases | Q28246248 | ||
| Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase | Q28296183 | ||
| The dsRNA protein kinase PKR: virus and cell control | Q28298945 | ||
| ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cells | Q28307506 | ||
| The protein kinase PKR is required for p38 MAPK activation and the innate immune response to bacterial endotoxin | Q28344558 | ||
| Heme-regulated eIF2alpha kinase (HRI) is required for translational regulation and survival of erythroid precursors in iron deficiency | Q28365535 | ||
| Nrf2 signaling and cell survival | Q28394210 | ||
| Viral control of mitochondrial apoptosis | Q28472776 | ||
| Regulated translation initiation controls stress-induced gene expression in mammalian cells | Q28506388 | ||
| Two heme-binding domains of heme-regulated eukaryotic initiation factor-2alpha kinase. N terminus and kinase insertion | Q28506814 | ||
| PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation | Q28507769 | ||
| Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response | Q28508156 | ||
| CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum | Q28509611 | ||
| P58IPK, a novel endoplasmic reticulum stress-inducible protein and potential negative regulator of eIF2alpha signaling | Q34179244 | ||
| PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control | Q34202681 | ||
| Control of activating transcription factor 4 (ATF4) persistence by multisite phosphorylation impacts cell cycle progression and neurogenesis. | Q34236497 | ||
| Both Transcriptional Regulation and Translational Control of ATF4 Are Central to the Integrated Stress Response | Q34236755 | ||
| The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice | Q34286263 | ||
| NADPH oxidase links endoplasmic reticulum stress, oxidative stress, and PKR activation to induce apoptosis | Q34406716 | ||
| GCN2 whets the appetite for amino acids | Q34412184 | ||
| PACT and PKR: turning on NF-kappa B in the absence of virus | Q34467902 | ||
| Double-stranded RNA-dependent protein kinase phosphorylation of the alpha-subunit of eukaryotic translation initiation factor 2 mediates apoptosis | Q34529304 | ||
| Impaired dexamethasone-mediated induction of tryptophan 2,3-dioxygenase in heme-deficient rat hepatocytes: translational control by a hepatic eIF2alpha kinase, the heme-regulated inhibitor | Q34654876 | ||
| Requirement for kinase-induced conformational change in eukaryotic initiation factor 2alpha (eIF2alpha) restricts phosphorylation of Ser51. | Q34693970 | ||
| Intrinsic capacities of molecular sensors of the unfolded protein response to sense alternate forms of endoplasmic reticulum stress | Q34698161 | ||
| Phosphorylation of eIF2 facilitates ribosomal bypass of an inhibitory upstream ORF to enhance CHOP translation | Q34719370 | ||
| PKR-dependent CHOP induction limits hyperoxia-induced lung injury. | Q34720222 | ||
| Translational control of inducible nitric oxide synthase expression by arginine can explain the arginine paradox | Q34961072 | ||
| Eukaryotic translation initiation factors and regulators | Q35064522 | ||
| Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappaB in response to diverse cellular stresses | Q35169632 | ||
| Tumour hypoxia, chemotherapeutic resistance and hypoxia-related therapies. | Q35202899 | ||
| eIF2alpha kinases GCN2 and PERK modulate transcription and translation of distinct sets of mRNAs in mouse liver | Q35209983 | ||
| Increased susceptibility of breast cancer cells to stress mediated inhibition of protein synthesis. | Q35560439 | ||
| Double-stranded RNA-dependent protein kinase activates transcription factor NF-kappa B by phosphorylating I kappa B. | Q35566028 | ||
| Regulation of protein synthesis by the heme-regulated eIF2alpha kinase: relevance to anemias | Q35750943 | ||
| The role of p58IPK in protecting the stressed endoplasmic reticulum | Q35949048 | ||
| Translational control by TOR and TAP42 through dephosphorylation of eIF2alpha kinase GCN2. | Q35964633 | ||
| Role of protein kinase R in double-stranded RNA-induced expression of nitric oxide synthase in human astroglia | Q36002790 | ||
| Nutritional control of gene expression: how mammalian cells respond to amino acid limitation | Q36191074 | ||
| Coordination of ER and oxidative stress signaling: the PERK/Nrf2 signaling pathway | Q36313774 | ||
| ER stress, hypoxia tolerance and tumor progression. | Q36393499 | ||
| Mutations in the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2 alpha) that overcome the inhibitory effect of eIF-2 alpha phosphorylation on translation initiation | Q36456457 | ||
| Nitric oxide and endoplasmic reticulum stress | Q36462710 | ||
| Inhibition of PKR by RNA and DNA viruses | Q36480640 | ||
| Regulation of the protein kinase PKR by the vaccinia virus pseudosubstrate inhibitor K3L is dependent on residues conserved between the K3L protein and the PKR substrate eIF2alpha. | Q36569456 | ||
| Erythroid expression of the heme-regulated eIF-2 alpha kinase | Q36654746 | ||
| Snf1 promotes phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2 by activating Gcn2 and inhibiting phosphatases Glc7 and Sit4. | Q33877596 | ||
| Gcn4p, a master regulator of gene expression, is controlled at multiple levels by diverse signals of starvation and stress | Q33905702 | ||
| Identification of activating transcription factor 4 (ATF4) as an Nrf2-interacting protein. Implication for heme oxygenase-1 gene regulation | Q33939961 | ||
| Inhibition of CHOP translation by a peptide encoded by an open reading frame localized in the chop 5'UTR | Q33948307 | ||
| Double-stranded-RNA-activated protein kinase PKR enhances transcriptional activation by tumor suppressor p53 | Q33957610 | ||
| Glucose limitation induces GCN4 translation by activation of Gcn2 protein kinase | Q33962759 | ||
| PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage | Q33977034 | ||
| Autophosphorylation in the activation loop is required for full kinase activity in vivo of human and yeast eukaryotic initiation factor 2alpha kinases PKR and GCN2 | Q33996300 | ||
| Translation initiation control by heme-regulated eukaryotic initiation factor 2alpha kinase in erythroid cells under cytoplasmic stresses | Q34012817 | ||
| PERK (EIF2AK3) regulates proinsulin trafficking and quality control in the secretory pathway | Q34024253 | ||
| Unactivated PKR exists in an open conformation capable of binding nucleotides | Q34034965 | ||
| Impaired tissue growth is mediated by checkpoint kinase 1 (CHK1) in the integrated stress response | Q34072906 | ||
| Heterologous dimerization domains functionally substitute for the double-stranded RNA binding domains of the kinase PKR. | Q34080544 | ||
| Inactivation of the PKR protein kinase and stimulation of mRNA translation by the cellular co-chaperone P58(IPK) does not require J domain function | Q34122632 | ||
| Multiple autophosphorylation is essential for the formation of the active and stable homodimer of heme-regulated eIF2alpha kinase | Q28509936 | ||
| Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis | Q28510028 | ||
| The GCN2 kinase biases feeding behavior to maintain amino acid homeostasis in omnivores | Q28511717 | ||
| Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha | Q28512201 | ||
| Double-stranded RNA-activated protein kinase is required for the LPS-induced activation of STAT1 inflammatory signaling in rat brain glial cells | Q28566143 | ||
| Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state | Q28572472 | ||
| Antiviral effect of the mammalian translation initiation factor 2alpha kinase GCN2 against RNA viruses | Q28586515 | ||
| Role of ERO1-alpha-mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress-induced apoptosis | Q28586997 | ||
| ER stress disrupts Ca2+-signaling complexes and Ca2+ regulation in secretory and muscle cells from PERK-knockout mice | Q28587474 | ||
| The function of heme-regulated eIF2alpha kinase in murine iron homeostasis and macrophage maturation | Q28592020 | ||
| PERK and GCN2 contribute to eIF2alpha phosphorylation and cell cycle arrest after activation of the unfolded protein response pathway | Q28592902 | ||
| Heme-regulated eIF2alpha kinase modifies the phenotypic severity of murine models of erythropoietic protoporphyria and beta-thalassemia | Q28592905 | ||
| Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival | Q28593963 | ||
| The mechanism of eukaryotic translation initiation and principles of its regulation | Q29547270 | ||
| Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response | Q29547299 | ||
| An integrated stress response regulates amino acid metabolism and resistance to oxidative stress | Q29547441 | ||
| Activators and target genes of Rel/NF-kappaB transcription factors | Q29547882 | ||
| A global map of p53 transcription-factor binding sites in the human genome | Q29614400 | ||
| RNA-binding proteins TIA-1 and TIAR link the phosphorylation of eIF-2 alpha to the assembly of mammalian stress granules | Q29615265 | ||
| Translational regulation of GCN4 and the general amino acid control of yeast | Q29615275 | ||
| Mediators of endoplasmic reticulum stress-induced apoptosis | Q29615496 | ||
| Translational control in stress and apoptosis | Q29615497 | ||
| IRE1 signaling affects cell fate during the unfolded protein response | Q29615502 | ||
| ER stress triggers apoptosis by activating BH3-only protein Bim | Q29617730 | ||
| Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase | Q29620280 | ||
| An RNA-dependent protein kinase is involved in tunicamycin-induced apoptosis and Alzheimer's disease | Q31041277 | ||
| Different effect of proteasome inhibition on vesicular stomatitis virus and poliovirus replication | Q33326624 | ||
| The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5. | Q33559643 | ||
| Regulation of G(1) arrest and apoptosis in hypoxia by PERK and GCN2-mediated eIF2alpha phosphorylation | Q33588288 | ||
| Differential regulation of CHOP translation by phosphorylated eIF4E under stress conditions | Q33633701 | ||
| Mechanisms of ER Stress-Mediated Mitochondrial Membrane Permeabilization | Q33651806 | ||
| Calcineurin interacts with PERK and dephosphorylates calnexin to relieve ER stress in mammals and frogs | Q33654233 | ||
| IRE1α Disruption Causes Histological Abnormality of Exocrine Tissues, Increase of Blood Glucose Level, and Decrease of Serum Immunoglobulin Level | Q33707431 | ||
| PKR and GCN2 kinases and guanine nucleotide exchange factor eukaryotic translation initiation factor 2B (eIF2B) recognize overlapping surfaces on eIF2alpha | Q33724522 | ||
| Hepatic heme-regulated inhibitor (HRI) eukaryotic initiation factor 2alpha kinase: a protagonist of heme-mediated translational control of CYP2B enzymes and a modulator of basal endoplasmic reticulum stress tone | Q33754847 | ||
| Inhibition of RNA-dependent protein kinase (PKR) leads to cancer cell death and increases chemosensitivity | Q33787696 | ||
| The murine double-stranded RNA-dependent protein kinase PKR is required for resistance to vesicular stomatitis virus. | Q33811639 | ||
| Modulation of the eukaryotic initiation factor 2 alpha-subunit kinase PERK by tyrosine phosphorylation | Q40052972 | ||
| The eIF2alpha kinases PERK and PKR activate glycogen synthase kinase 3 to promote the proteasomal degradation of p53. | Q40085524 | ||
| Ribosomal stress couples the unfolded protein response to p53-dependent cell cycle arrest | Q40246328 | ||
| Regulation of c-myc expression by IFN-gamma through Stat1-dependent and -independent pathways. | Q40386886 | ||
| A dynamically tuned double-stranded RNA binding mechanism for the activation of antiviral kinase PKR. | Q40430436 | ||
| Melanoma differentiation-associated gene-7 protein physically associates with the double-stranded RNA-activated protein kinase PKR. | Q40430862 | ||
| Critical role of endogenous Akt/IAPs and MEK1/ERK pathways in counteracting endoplasmic reticulum stress-induced cell death | Q40520566 | ||
| Defects in translational regulation mediated by the alpha subunit of eukaryotic initiation factor 2 inhibit antiviral activity and facilitate the malignant transformation of human fibroblasts | Q40589545 | ||
| Thalassemia: pathophysiology of red cell changes | Q40759623 | ||
| Essential role for the dsRNA-dependent protein kinase PKR in innate immunity to viral infection | Q40863327 | ||
| Human breast cancer cells contain elevated levels and activity of the protein kinase, PKR. | Q40871190 | ||
| JNK2 and IKKbeta are required for activating the innate response to viral infection | Q40907787 | ||
| The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation. | Q41465002 | ||
| Haem-regulated eIF2alpha kinase is necessary for adaptive gene expression in erythroid precursors under the stress of iron deficiency. | Q41516680 | ||
| Phosphorylation of eIF2 directs ATF5 translational control in response to diverse stress conditions | Q42523594 | ||
| PACT, a stress-modulated cellular activator of interferon-induced double-stranded RNA-activated protein kinase, PKR. | Q42796205 | ||
| Phosphorylation of eukaryotic translation initiation factor 2 mediates apoptosis in response to activation of the double-stranded RNA-dependent protein kinase | Q42833009 | ||
| PKR-like endoplasmic reticulum kinase (PERK) activation following brain ischemia is independent of unfolded nascent proteins | Q43032260 | ||
| PKR is not a universal target of tumor suppressor p53 in response to genotoxic stress | Q43259476 | ||
| Ceramide regulates protein synthesis by a novel mechanism involving the cellular PKR activator RAX. | Q43517016 | ||
| Brain ischemia and reperfusion activates the eukaryotic initiation factor 2alpha kinase, PERK. | Q43627961 | ||
| Adenoviral transfer of the melanoma differentiation-associated gene 7 (mda7) induces apoptosis of lung cancer cells via up-regulation of the double-stranded RNA-dependent protein kinase (PKR). | Q43961098 | ||
| Serine 577 is phosphorylated and negatively affects the tRNA binding and eIF2alpha kinase activities of GCN2. | Q44031815 | ||
| Dimerization is required for activation of eIF2 kinase Gcn2 in response to diverse environmental stress conditions | Q44792904 | ||
| Preservation of liver protein synthesis during dietary leucine deprivation occurs at the expense of skeletal muscle mass in mice deleted for eIF2 kinase GCN2. | Q44948914 | ||
| Mechanisms of ferriheme reduction by nitric oxide: nitrite and general base catalysis | Q45265438 | ||
| The eIF2alpha kinases inhibit vesicular stomatitis virus replication independently of eIF2alpha phosphorylation | Q45392345 | ||
| Uncharged tRNA and sensing of amino acid deficiency in mammalian piriform cortex. | Q46386380 | ||
| Activation of PKR: an open and shut case? | Q36695833 | ||
| Activating transcription factor 4. | Q36805075 | ||
| Chemical genetics identify eIF2α kinase heme-regulated inhibitor as an anticancer target | Q36934029 | ||
| Dual function of pancreatic endoplasmic reticulum kinase in tumor cell growth arrest and survival. | Q36983432 | ||
| NF-kappaB and cancer-identifying targets and mechanisms | Q36984251 | ||
| The Gcn2 kinase as a cell cycle regulator | Q36995007 | ||
| Ero1 and redox homeostasis in the endoplasmic reticulum. | Q37055746 | ||
| Akt determines cell fate through inhibition of the PERK-eIF2α phosphorylation pathway | Q37119471 | ||
| Analysis of PKR structure by small-angle scattering | Q37144662 | ||
| PKR, a p53 target gene, plays a crucial role in the tumor-suppressor function of p53 | Q37194715 | ||
| An essential role for the interferon-inducible, double-stranded RNA-activated protein kinase PKR in the tumor necrosis factor-induced apoptosis in U937 cells | Q37241099 | ||
| Domain stabilities in protein kinase R (PKR): evidence for weak interdomain interactions | Q37312236 | ||
| Hepatic CYP3A suppression by high concentrations of proteasomal inhibitors: a consequence of endoplasmic reticulum (ER) stress induction, activation of RNA-dependent protein kinase-like ER-bound eukaryotic initiation factor 2alpha (eIF2alpha)-kinase | Q37314375 | ||
| Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells | Q37343526 | ||
| RNA dimerization promotes PKR dimerization and activation | Q37389973 | ||
| Oxidative folding: cellular strategies for dealing with the resultant equimolar production of reactive oxygen species | Q37401266 | ||
| 5' untranslated sequences are required for the translational control of a yeast regulatory gene | Q37563115 | ||
| Evidence for translational regulation of the activator of general amino acid control in yeast | Q37573526 | ||
| Targeting the endoplasmic reticulum-stress response as an anticancer strategy | Q37616303 | ||
| Abrogation of translation initiation factor eIF-2 phosphorylation causes malignant transformation of NIH 3T3 cells | Q37621199 | ||
| Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2 | Q37622629 | ||
| PI(3)king apart PTEN's role in cancer. | Q37771785 | ||
| RNA granules: the good, the bad and the ugly | Q37784866 | ||
| PERK in beta cell biology and insulin biogenesis | Q37789918 | ||
| Stress hypERactivation in the β-cell | Q37811730 | ||
| Stress-induced phosphorylation of PACT reduces its interaction with TRBP and leads to PKR activation | Q38335635 | ||
| Regulation of autophagy by ATF4 in response to severe hypoxia. | Q38343634 | ||
| Mechanism of activation of the double-stranded-RNA-dependent protein kinase, PKR: role of dimerization and cellular localization in the stimulation of PKR phosphorylation of eukaryotic initiation factor-2 (eIF2). | Q39417308 | ||
| Induction of apoptosis by double-stranded-RNA-dependent protein kinase (PKR) involves the alpha subunit of eukaryotic translation initiation factor 2 and NF-kappaB. | Q39446101 | ||
| Deficiency of heme-regulated eIF2alpha kinase decreases hepcidin expression and splenic iron in HFE-/- mice | Q39709129 | ||
| Phosphorylation of eIF2alpha in response to 26S proteasome inhibition is mediated by the haem-regulated inhibitor (HRI) kinase. | Q39709983 | ||
| Stress-induced gene expression requires programmed recovery from translational repression | Q39735685 | ||
| Essential role of PACT-mediated PKR activation in tunicamycin-induced apoptosis | Q39745125 | ||
| Tumor suppression by PTEN requires the activation of the PKR-eIF2alpha phosphorylation pathway | Q39759975 | ||
| Regulation of endoplasmic reticulum stress-induced cell death by ATF4 in neuroectodermal tumor cells | Q39761314 | ||
| An upstream open reading frame regulates translation of GADD34 during cellular stresses that induce eIF2alpha phosphorylation | Q39897560 | ||
| Amino acid limitation regulates the expression of genes involved in several specific biological processes through GCN2-dependent and GCN2-independent pathways | Q39899171 | ||
| P433 | issue | 19 | |
| P304 | page(s) | 3493-3511 | |
| P577 | publication date | 2013-01-26 | |
| P1433 | published in | Cellular and Molecular Life Sciences | Q5058352 |
| P1476 | title | The eIF2α kinases: their structures and functions | |
| P478 | volume | 70 |
| Q38922283 | 2017 Clinical trials update in new treatments of β-thalassemia |
| Q37388798 | 25-Hydroxycholesterol activates the integrated stress response to reprogram transcription and translation in macrophages |
| Q48278176 | 4-Phenylbutyric Acid (4-PBA) and Lithium Cooperatively Attenuate Cell Death during Oxygen-Glucose Deprivation (OGD) and Reoxygenation |
| Q91106503 | A MYC-GCN2-eIF2α negative feedback loop limits protein synthesis to prevent MYC-dependent apoptosis in colorectal cancer |
| Q38702369 | A Map of the Arenavirus Nucleoprotein-Host Protein Interactome Reveals that Junín Virus Selectively Impairs the Antiviral Activity of Double-Stranded RNA-Activated Protein Kinase (PKR). |
| Q36447782 | A Novel Inhibitor of Topoisomerase I Is Selectively Toxic for a Subset of Non-Small Cell Lung Cancer Cell Lines. |
| Q90461874 | A Retrospective on eIF2A-and Not the Alpha Subunit of eIF2 |
| Q35556532 | A membrane-bound eIF2 alpha kinase located in endosomes is regulated by heme and controls differentiation and ROS levels in Trypanosoma cruzi |
| Q57813809 | ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUS |
| Q36748678 | ATF4 induction through an atypical integrated stress response to ONC201 triggers p53-independent apoptosis in hematological malignancies |
| Q93165000 | ATF6 as a Nodal Regulator of Proteostasis in the Heart |
| Q104073685 | Activating transcription factor-4 promotes neuronal death induced by Parkinson's disease neurotoxins and α-synuclein aggregates |
| Q37029489 | Activation of GCN2 kinase by ribosome stalling links translation elongation with translation initiation |
| Q37566448 | Activation of SsoPK4, an Archaeal eIF2α Kinase Homolog, by Oxidized CoA. |
| Q90713399 | Activation of integrated stress response pathway regulates IL-1β production through posttranscriptional and translational reprogramming in macrophages |
| Q90260414 | Adaptive Protein Translation by the Integrated Stress Response Maintains the Proliferative and Migratory Capacity of Lung Adenocarcinoma Cells |
| Q36049945 | Altered activation of protein kinase PKR and enhanced apoptosis in dystonia cells carrying a mutation in PKR activator protein PACT. |
| Q36336723 | Altered machinery of protein synthesis is region- and stage-dependent and is associated with α-synuclein oligomers in Parkinson's disease. |
| Q61409070 | Amino acid deprivation triggers a novel GCN2-independent response leading to the transcriptional reactivation of non-native DNA sequences |
| Q35691201 | Amino acid metabolism inhibits antibody-driven kidney injury by inducing autophagy. |
| Q52604652 | Amino acid starvation sensing dampens IL-1β production by activating riboclustering and autophagy. |
| Q41788377 | Amphetamine elevates phosphorylation of eukaryotic initiation factor 2α (eIF2α) in the rat forebrain via activating dopamine D1 and D2 receptors |
| Q36263251 | Amyloid β-protein oligomers upregulate the β-secretase, BACE1, through a post-translational mechanism involving its altered subcellular distribution in neurons |
| Q36483172 | An inhibitor of HIV-1 protease modulates constitutive eIF2α dephosphorylation to trigger a specific integrated stress response. |
| Q90334874 | Analysis of Promoter-Associated Chromatin Interactions Reveals Biologically Relevant Candidate Target Genes at Endometrial Cancer Risk Loci |
| Q92893087 | Analysis of the translatome in solid tumors using polyribosome profiling/RNA-Seq |
| Q24701804 | Apoptosis, autophagy and unfolded protein response pathways in Arbovirus replication and pathogenesis |
| Q92716440 | Arabidopsis GCN2 kinase contributes to ABA homeostasis and stomatal immunity |
| Q36974463 | Arginase-1-dependent promotion of TH17 differentiation and disease progression by MDSCs in systemic lupus erythematosus |
| Q46197347 | Argininosuccinate Synthetase 1 Loss in Invasive Bladder Cancer Regulates Survival through General Control Nonderepressible 2 Kinase-Mediated Eukaryotic Initiation Factor 2α Activity and Is Targetable by Pegylated Arginine Deiminase. |
| Q50573662 | ArnS, a kinase involved in starvation-induced archaellum expression. |
| Q90142456 | Articular Cartilage Stem Cells Influence the Postoperative Repair of Hip Replacement by Regulating Endoplasmic Reticulum Stress in Chondrocytes via PERK Pathway |
| Q92124647 | Atovaquone is active against AML by upregulating the integrated stress pathway and suppressing oxidative phosphorylation |
| Q35856564 | Autism-associated R451C mutation in neuroligin3 leads to activation of the unfolded protein response in a PC12 Tet-On inducible system |
| Q47097481 | Autophosphorylation and Cross-Phosphorylation of Protein Kinases from the Crenarchaeon Sulfolobus islandicus |
| Q92603327 | Bovine papillomavirus E5 oncoprotein expression and its association with an interactor network in aggresome-autophagy pathway |
| Q35863466 | C/EBPβ-LAP*/LAP Expression Is Mediated by RSK/eIF4B-Dependent Signalling and Boosted by Increased Protein Stability in Models of Monocytic Differentiation |
| Q90425876 | CD98hc (SLC3A2) sustains amino acid and nucleotide availability for cell cycle progression |
| Q38971267 | Cell Signaling and Stress Responses. |
| Q38639996 | Cell death induced by endoplasmic reticulum stress. |
| Q55346318 | Cellular stress alters 3'UTR landscape through alternative polyadenylation and isoform-specific degradation. |
| Q44163648 | Cellular stress associated with the differentiation of Plasmodium berghei ookinetes |
| Q92455023 | Cellular stress leads to the formation of membraneless stress assemblies in eukaryotic cells |
| Q37439715 | Changes in translation rate modulate stress-induced damage of diverse proteins |
| Q64274774 | Characterizing Cellular Responses During Oncolytic Maraba Virus Infection |
| Q39445809 | Clinical and therapeutic potential of protein kinase PKR in cancer and metabolism |
| Q35701896 | Complementation of the human adenovirus type 5 VA RNAI defect by the Vaccinia virus E3L protein and serotype-specific VA RNAIs |
| Q64072541 | Concomitant Nrf2- and ATF4-activation by Carnosic Acid Cooperatively Induces Expression of Cytoprotective Genes |
| Q92040199 | Contribution of IDO to human respiratory syncytial virus infection |
| Q38502021 | Control of translation in the cold: implications for therapeutic hypothermia. |
| Q64132759 | Coxsackievirus B3 Infection Triggers Autophagy through 3 Pathways of Endoplasmic Reticulum Stress |
| Q38954159 | Crystal structure of eIF2B and insights into eIF2-eIF2B interactions |
| Q63384570 | Deconvoluting Stress-Responsive Proteostasis Signaling Pathways for Pharmacologic Activation Using Targeted RNA Sequencing |
| Q35023108 | Deletion of the eIF2α Kinase GCN2 fails to rescue the memory decline associated with Alzheimer's disease |
| Q38835635 | Design and synthesis of novel protein kinase R (PKR) inhibitors |
| Q38700977 | Development of 1-((1,4-trans)-4-Aryloxycyclohexyl)-3-arylurea Activators of Heme-Regulated Inhibitor as Selective Activators of the Eukaryotic Initiation Factor 2 Alpha (eIF2α) Phosphorylation Arm of the Integrated Endoplasmic Reticulum Stress Respo |
| Q34792629 | Direct activation of ribosome-associated double-stranded RNA-dependent protein kinase (PKR) by deoxynivalenol, anisomycin and ricin: a new model for ribotoxic stress response induction |
| Q38335714 | Dissecting the roles of TRBP and PACT in double-stranded RNA recognition and processing of noncoding RNAs |
| Q48340159 | Docosahexaenoic acid reduces ER stress and abnormal protein accumulation and improves neuronal function following traumatic brain injury. |
| Q92844890 | EIF2A promotes cell survival during paclitaxel treatment in vitro and in vivo |
| Q44360290 | EIF2AK4 mutations cause pulmonary veno-occlusive disease, a recessive form of pulmonary hypertension. |
| Q28548490 | Embryonic Stem Cell Growth Factors Regulate eIF2α Phosphorylation |
| Q39441238 | Emerging Role of the Unfolded Protein Response in Tumor Immunosurveillance. |
| Q26827965 | Emerging functions of the unfolded protein response in immunity |
| Q38298151 | Emerging roles of tRNA in adaptive translation, signalling dynamics and disease |
| Q39094240 | Endoplasmic Reticulum Protein Quality Control Failure in Myelin Disorders |
| Q38925531 | Endoplasmic reticulum proteostasis in hepatic steatosis. |
| Q90604542 | Endorepellin evokes an angiostatic stress signaling cascade in endothelial cells |
| Q38501220 | Enhancement of osteoblastogenesis and suppression of osteoclastogenesis by inhibition of de-phosphorylation of eukaryotic translation initiation factor 2 alpha |
| Q34527000 | Enterovirus 71 induces mitochondrial reactive oxygen species generation that is required for efficient replication |
| Q97540028 | Environmental enrichment during forced abstinence from cocaine self-administration opposes gene network expression changes associated with the incubation effect |
| Q97521963 | Evidence That Phosphorylation of the α-Subunit of eIF2 Does Not Essentially Inhibit mRNA Translation in Wheat Germ Cell-Free System |
| Q35113639 | Evidence for multiple, distinct ADAR-containing complexes in Xenopus laevis |
| Q40247985 | Expression, purification, and crystallization of Schizosaccharomyces pombe eIF2B. |
| Q39393398 | Fine-tuning PERK signaling for neuroprotection. |
| Q60927723 | Focus on Translation Initiation of the HIV-1 mRNAs |
| Q92932318 | Foie gras and liver regeneration: a fat dilemma |
| Q45324396 | Foot-and-mouth disease virus capsid protein VP2 activates the cellular EIF2S1-ATF4 pathway and induces autophagy via HSPB1. |
| Q34215234 | Fucoidan induces cancer cell apoptosis by modulating the endoplasmic reticulum stress cascades |
| Q54114870 | Functions and Signaling Pathways of Amino Acids in Intestinal Inflammation. |
| Q39110425 | G-rich DNA-induced stress response blocks type-I-IFN but not CXCL10 secretion in monocytes |
| Q33720257 | GCN2 phosphorylates HIV-1 integrase and decreases HIV-1 replication by limiting viral integration. |
| Q45926902 | GCN2- and eIF2α-phosphorylation-independent, but ATF4-dependent, induction of CARE-containing genes in methionine-deficient cells. |
| Q37625365 | GCN2-like eIF2α kinase manages the amino acid starvation response in Toxoplasma gondii |
| Q28254667 | GRP78/BiP/HSPA5/Dna K is a universal therapeutic target for human disease |
| Q36830763 | GRP78/Dna K Is a Target for Nexavar/Stivarga/Votrient in the Treatment of Human Malignancies, Viral Infections and Bacterial Diseases |
| Q42427957 | General Control Nonderepressible 2 (GCN2) Kinase Inhibits Target of Rapamycin Complex 1 in Response to Amino Acid Starvation in Saccharomyces cerevisiae |
| Q39457267 | Glutamatergic stimulation induces GluN2B translation by the nitric oxide-Heme-Regulated eIF2α kinase in cortical neurons. |
| Q42364281 | Glutaminase is essential for the growth of triple-negative breast cancer cells with a deregulated glutamine metabolism pathway and its suppression synergizes with mTOR inhibition |
| Q47414816 | HIV-1 NC-induced stress granule assembly and translation arrest are inhibited by the dsRNA binding protein Staufen1. |
| Q36689566 | Harnessing the integrated stress response for the treatment of multiple sclerosis. |
| Q41630569 | Hepatocellular autophagy modulates the unfolded protein response and fasting-induced steatosis in mice. |
| Q31123604 | Hippocampal gene expression meta-analysis identifies aging and age-associated spatial learning impairment (ASLI) genes and pathways |
| Q61812432 | Hydrogen Indirectly Suppresses Increases in Hydrogen Peroxide in Cytoplasmic Hydroxyl Radical-Induced Cells and Suppresses Cellular Senescence |
| Q41934210 | Hypothalamic eIF2α signaling regulates food intake |
| Q34679101 | IMPACT is a GCN2 inhibitor that limits lifespan in Caenorhabditis elegans. |
| Q28594198 | IMPACT is a developmentally regulated protein in neurons that opposes the eukaryotic initiation factor 2α kinase GCN2 in the modulation of neurite outgrowth |
| Q51732698 | Identification of di-substituted ureas that prevent growth of trypanosomes through inhibition of translation initiation. |
| Q92445240 | Impact and Relevance of the Unfolded Protein Response in HNSCC |
| Q47596329 | Impairment of protein degradation and proteasome function in hereditary neuropathies. |
| Q50463159 | Importance of eIF2α phosphorylation as a protective mechanism against heat stress in mouse male germ cells. |
| Q59333146 | Imprinted and ancient gene: a potential mediator of cancer cell survival during tryptophan deprivation |
| Q57174327 | In vivo imaging of the spatiotemporal activity of the eIF2 -ATF4 signaling pathway: Insights into stress and related disorders |
| Q36485185 | Inadequate fine-tuning of protein synthesis and failure of amino acid homeostasis following inhibition of the ATPase VCP/p97 |
| Q36186464 | Increased ubiquitination and reduced plasma membrane trafficking of placental amino acid transporter SNAT-2 in human IUGR. |
| Q41293411 | Inhibition of the integrated stress response reverses cognitive deficits after traumatic brain injury |
| Q55262733 | Integrated Stress Responses to Bacterial Pathogenesis Patterns. |
| Q47104587 | Intestinal Epithelial Cell Endoplasmic Reticulum Stress and Inflammatory Bowel Disease Pathogenesis: An Update Review |
| Q38771285 | Intra-axonal protein synthesis in development and beyond |
| Q41128127 | Intracellular Bacterial Pathogens Trigger the Formation of U Small Nuclear RNA Bodies (U Bodies) through Metabolic Stress Induction |
| Q45183417 | KSHV inhibits stress granule formation by viral ORF57 blocking PKR activation |
| Q43476509 | Kinases of eIF2a Switch Translation of mRNA Subset during Neuronal Plasticity |
| Q90414581 | Leishmania donovani induced Unfolded Protein Response delays host cell apoptosis in PERK dependent manner |
| Q37142401 | Leucine pulses enhance skeletal muscle protein synthesis during continuous feeding in neonatal pigs |
| Q49046809 | Limited Unfolded Protein Response and Inflammation in Neuroserpinopathy |
| Q26783555 | MYC, Metabolism, and Cancer |
| Q26795779 | Macrophage Expression of Inflammatory Genes in Response to EMCV Infection |
| Q90192287 | Mechanical Forces and Their Effect on the Ribosome and Protein Translation Machinery |
| Q89823740 | Mechanical Regulation of Protein Translation in the Cardiovascular System |
| Q35636275 | Mechanism of cytoplasmic mRNA translation |
| Q26995280 | Mechanisms and models of endoplasmic reticulum stress in chondrodysplasia |
| Q48685286 | Melatonin reduces endoplasmic reticulum stress and preserves sirtuin 1 expression in neuronal cells of newborn rats after hypoxia-ischemia |
| Q90741828 | Meta-analysis of blood genome-wide expression profiling studies in pulmonary arterial hypertension |
| Q26777647 | Metabolic Enzymes Enjoying New Partnerships as RNA-Binding Proteins |
| Q26799891 | Mitochondria Retrograde Signaling and the UPR mt: Where Are We in Mammals? |
| Q47827839 | Mitochondrial Division Inhibitor 1 (mdivi-1) Protects Neurons against Excitotoxicity through the Modulation of Mitochondrial Function and Intracellular Ca2+ Signaling. |
| Q36650395 | Mitochondrial Sulfide Quinone Oxidoreductase Prevents Activation of the Unfolded Protein Response in Hydrogen Sulfide |
| Q38765948 | Mitonuclear communication in homeostasis and stress |
| Q64120967 | Modulating the 3' end-DNA and the fermentation process for enhanced production and biological activity of porcine interferon-gamma |
| Q26770085 | Molecular Mechanisms of White Spot Syndrome Virus Infection and Perspectives on Treatments |
| Q54121396 | Molecular evolution and functional divergence of eukaryotic translation initiation factor 2-alpha kinases. |
| Q38866763 | Molecular mechanisms of mTOR regulation by stress |
| Q35751132 | Monitoring activation of the antiviral pattern recognition receptors RIG-I and PKR by limited protease digestion and native PAGE. |
| Q48215735 | NDRG2 contributes to cisplatin sensitivity through modulation of BAK-to-Mcl-1 ratio. |
| Q90287011 | NF-κB Activation Promotes Alphavirus Replication in Mature Neurons |
| Q58805802 | Nakai Has Synergetic Effects on Doxorubicin-Induced Apoptosis |
| Q26770670 | Naïve T Cell Homeostasis Regulated by Stress Responses and TCR Signaling |
| Q58797101 | Neuronal Mitochondrial Dysfunction Activates the Integrated Stress Response to Induce Fibroblast Growth Factor 21 |
| Q61448849 | Normal Ribosomal Biogenesis but Shortened Protein Synthetic Response to Acute Eccentric Resistance Exercise in Old Skeletal Muscle |
| Q36964927 | Nutrient shortage triggers the hexosamine biosynthetic pathway via the GCN2-ATF4 signalling pathway. |
| Q53688940 | ONC201 kills breast cancer cells in vitro by targeting mitochondria. |
| Q38736720 | ONC201: Stressing tumors to death |
| Q36808317 | OSU-03012 and Viagra Treatment Inhibits the Activity of Multiple Chaperone Proteins and Disrupts the Blood-Brain Barrier: Implications for Anti-Cancer Therapies |
| Q47217421 | Oncogenic KRAS Regulates Amino Acid Homeostasis and Asparagine Biosynthesis via ATF4 and Alters Sensitivity to L-Asparaginase |
| Q47130450 | Oncogenic p95HER2/611CTF primes human breast epithelial cells for metabolic stress-induced down-regulation of FLIP and activation of TRAIL-R/Caspase-8-dependent apoptosis. |
| Q54308363 | Overexpression of eukaryotic initiation factor 5 rescues the translational defect of tpk1w in a manner that necessitates a novel phosphorylation site. |
| Q37482581 | Oxyphenisatin acetate (NSC 59687) triggers a cell starvation response leading to autophagy, mitochondrial dysfunction, and autocrine TNFα-mediated apoptosis |
| Q92494250 | Oxytocin Suppresses Inflammatory Responses Induced by Lipopolysaccharide through Inhibition of the eIF-2-ATF4 Pathway in Mouse Microglia |
| Q34024468 | PERK mediates eIF2α phosphorylation responsible for BACE1 elevation, CREB dysfunction and neurodegeneration in a mouse model of Alzheimer's disease |
| Q35944970 | PKR Transduces MDA5-Dependent Signals for Type I IFN Induction |
| Q91973677 | PKZ, a Fish-Unique eIF2α Kinase Involved in Innate Immune Response |
| Q48247015 | Pathophysiology and treatment of patients with beta-thalassemia - an update. |
| Q42212169 | Pathway analysis of cervical cancer genome-wide association study highlights the MHC region and pathways involved in response to infection |
| Q35180234 | Pharmaceutical integrated stress response enhancement protects oligodendrocytes and provides a potential multiple sclerosis therapeutic |
| Q90288795 | Pharmacological modulation of nucleic acid sensors - therapeutic potential and persisting obstacles |
| Q37538574 | Phosphorylation of Translation Initiation Factor 2-Alpha in Leishmania donovani under Stress Is Necessary for Parasite Survival |
| Q58599917 | Phosphorylation of eIF2α promotes cell survival in response to benzo[a]pyrene exposure |
| Q27937914 | Phosphorylation of initiation factor eIF2 in response to stress conditions is mediated by acidic ribosomal P1/P2 proteins in Saccharomyces cerevisiae |
| Q90705902 | Phosphorylation of translation initiation factor eIF2α at Ser51 depends on site- and context-specific information |
| Q38823597 | Physiological and pathophysiological role of nonsense-mediated mRNA decay |
| Q33863389 | Physiology of iron metabolism |
| Q93086685 | Pituitary cell translation and secretory capacities are enhanced cell autonomously by the transcription factor Creb3l2 |
| Q38214041 | Post-transcriptional regulation of gene expression in innate immunity. |
| Q35549258 | Potential role for snoRNAs in PKR activation during metabolic stress |
| Q90020506 | Prematurity blunts the feeding-induced stimulation of translation initiation signaling and protein synthesis in muscle of neonatal piglets |
| Q34405587 | Protein Ser/Thr/Tyr phosphorylation in the Archaea |
| Q38819666 | Protein kinase R(PKR)-like endoplasmic reticulum kinase (PERK) inhibitors: a patent review (2010-2015). |
| Q26801543 | Protein kinase R-like ER kinase and its role in endoplasmic reticulum stress-decided cell fate |
| Q36900071 | Proteome and Protein Network Analyses of Memory T Cells Find Altered Translation and Cell Stress Signaling in Treated Human Immunodeficiency Virus Patients Exhibiting Poor CD4 Recovery. |
| Q36769101 | Pulmonary Arterial Hypertension: A Current Perspective on Established and Emerging Molecular Genetic Defects |
| Q26795562 | Pulmonary capillary hemangiomatosis: a focus on the EIF2AK4 mutation in onset and pathogenesis |
| Q36810786 | Pulsatile delivery of a leucine supplement during long-term continuous enteral feeding enhances lean growth in term neonatal pigs |
| Q91173398 | RITA requires eIF2α-dependent modulation of mRNA translation for its anti-cancer activity |
| Q93210279 | RNA Recognition-like Motifs Activate a Mitogen-Activated Protein Kinase |
| Q38171458 | RNA in development: how ribonucleoprotein granules regulate the life cycles of pathogenic protozoa |
| Q93089064 | RNAs and RNA-Binding Proteins in Immuno-Metabolic Homeostasis and Diseases |
| Q40357011 | Re-examination of Dietary Amino Acid Sensing Reveals a GCN2-Independent Mechanism |
| Q37058610 | Reduced protein synthesis in schizophrenia patient-derived olfactory cells |
| Q36157810 | Reducing Ribosomal Protein S6 Kinase 1 Expression Improves Spatial Memory and Synaptic Plasticity in a Mouse Model of Alzheimer's Disease |
| Q42494301 | Regulating the expression of therapeutic transgenes by controlled intake of dietary essential amino acids |
| Q38685455 | Regulation of Translation by TOR, eIF4E and eIF2α in Plants: Current Knowledge, Challenges and Future Perspectives |
| Q41823803 | Residues required for phosphorylation of translation initiation factor eIF2α under diverse stress conditions are divergent between yeast and human |
| Q100166039 | Response of EIF2AK1 (HRI) to heme deficiency |
| Q100166036 | Response of EIF2AK4 (GCN2) to amino acid deficiency |
| Q38756727 | Response of Three Different Viruses to Interferon Priming and Dithiothreitol Treatment of Avian Cells. |
| Q35212492 | Retroviral vectors elevate coexpressed protein levels in trans through cap-dependent translation |
| Q34979422 | Reversible and rapid transfer-RNA deactivation as a mechanism of translational repression in stress. |
| Q38445441 | Rheb Inhibits Protein Synthesis by Activating the PERK-eIF2α Signaling Cascade |
| Q36930792 | Role of GCN2-Independent Signaling Through a Noncanonical PERK/NRF2 Pathway in the Physiological Responses to Dietary Methionine Restriction. |
| Q27024299 | Role of HRI in apoptosis resistance |
| Q39041928 | Roles of PKR in differentiation and apoptosis of bone-related cells |
| Q37718976 | Roles of eIF2α kinases in the pathogenesis of Alzheimer's disease |
| Q49868718 | SIRT1 protects the heart from ER stress-induced cell death through eIF2α deacetylation |
| Q35675772 | Saccharomyces cerevisiae Eukaryotic Elongation Factor 1A (eEF1A) Is Methylated at Lys-390 by a METTL21-Like Methyltransferase |
| Q58598588 | Selective Editing of HSV-1 Enables IFN Induction and Viral Replication That Destruct Malignant Cells |
| Q49596452 | Sensing and signaling mechanisms linking dietary methionine restriction to the behavioral and physiological components of the response |
| Q38818265 | Short Chemical Ischemia Triggers Phosphorylation of eIF2α and Death of SH-SY5Y Cells but not Proteasome Stress and Heat Shock Protein Response in both SH-SY5Y and T98G Cells |
| Q35796921 | Signaling through alternative Integrated Stress Response pathways compensates for GCN2 loss in a mouse model of soft tissue sarcoma |
| Q38820303 | Sorafenib, a multikinase inhibitor, induces formation of stress granules in hepatocarcinoma cells. |
| Q56529591 | Ssd1 and Gcn2 suppress global translation efficiency in replicatively aged yeast while their activation extends lifespan |
| Q40438223 | Stress Kinase GCN2 Controls the Proliferative Fitness and Trafficking of Cytotoxic T Cells Independent of Environmental Amino Acid Sensing |
| Q26747461 | Stress Response and Translation Control in Rotavirus Infection |
| Q35689148 | Stress granules, P-bodies and cancer. |
| Q38720884 | Stress-specific differences in assembly and composition of stress granules and related foci |
| Q50282444 | Strong TCR-mediated signals suppress integrated stress responses induced by KDELR1 deficiency in naive T cells. |
| Q42611868 | Structure of SgK223 pseudokinase reveals novel mechanisms of homotypic and heterotypic association |
| Q46468408 | Structure-Activity Studies of Bis-O-Arylglycolamides: Inhibitors of the Integrated Stress Response |
| Q40875488 | Suppression of NYVAC Infection in HeLa Cells Requires RNase L but Is Independent of Protein Kinase R Activity |
| Q42051272 | Synergistic antileukemic therapies in NOTCH1-induced T-ALL. |
| Q35064944 | Targeting axonal protein synthesis in neuroregeneration and degeneration. |
| Q92541411 | The GCN2 inhibitor IMPACT contributes to diet-induced obesity and body temperature control |
| Q50117575 | The Regulation of Translation in Alphavirus-Infected Cells. |
| Q36301254 | The Regulatory and Kinase Domains but Not the Interdomain Linker Determine Human Double-stranded RNA-activated Kinase (PKR) Sensitivity to Inhibition by Viral Non-coding RNAs |
| Q36862843 | The amino acid sensor GCN2 controls gut inflammation by inhibiting inflammasome activation |
| Q51170783 | The eIF2-alpha kinase HRI is a novel therapeutic target in multiple myeloma. |
| Q47611637 | The eIF2-alpha kinase HRI: a potential target beyond the red blood cell |
| Q41664311 | The eIF2A knockout mouse |
| Q38201042 | The essential biology of the endoplasmic reticulum stress response for structural and computational biologists. |
| Q26750763 | The expanding universe of ribonucleoproteins: of novel RNA-binding proteins and unconventional interactions |
| Q39090716 | The genetics of isoflurane-induced developmental neurotoxicity. |
| Q49309709 | The integrated stress response in hypoxia-induced diffuse white matter injury |
| Q38954583 | The integrated stress response. |
| Q89926078 | The kinase PERK represses translation of the G-protein-coupled receptor LGR5 and receptor tyrosine kinase ERBB3 during ER stress in cancer cells |
| Q29144900 | The novel lysine specific methyltransferase METTL21B affects mRNA translation through inducible and dynamic methylation of Lys-165 in human eukaryotic elongation factor 1 alpha (eEF1A) |
| Q37842253 | The role of endoplasmic reticulum-related BiP/GRP78 in interferon gamma-induced persistent Chlamydia pneumoniae infection |
| Q38981518 | The role of the p53 protein in nitrosative stress-induced apoptosis of PC12 rat pheochromocytoma cells |
| Q28834524 | The small molecule '1-(4-biphenylylcarbonyl)-4-(5-bromo-2-methoxybenzyl) piperazine oxalate' and its derivatives regulate global protein synthesis by inactivating eukaryotic translation initiation factor 2-alpha |
| Q93205353 | The switch-like expression of Heme-regulated kinase 1 mediates neuronal proteostasis following proteasome inhibition |
| Q42708314 | The transcription factor CHOP, an effector of the integrated stress response, is required for host sensitivity to the fungal intracellular pathogen Histoplasma capsulatum |
| Q36113399 | The transcriptional and splicing landscape of intestinal organoids undergoing nutrient starvation or endoplasmic reticulum stress. |
| Q26799511 | The unfolded protein response in neurodegenerative diseases: a neuropathological perspective |
| Q26852080 | The unfolded protein response in retinal vascular diseases: implications and therapeutic potential beyond protein folding |
| Q50006995 | Trans-acting translational regulatory RNA binding proteins |
| Q34425391 | Transcriptional and epigenetic substrates of methamphetamine addiction and withdrawal: evidence from a long-access self-administration model in the rat. |
| Q37741390 | Transgenic mouse model for imaging of ATF4 translational activation-related cellular stress responses in vivo |
| Q64244241 | Translating the Hypoxic Response-the Role of HIF Protein Translation in the Cellular Response to Low Oxygen |
| Q52593667 | Translation and Translational Control in Dinoflagellates. |
| Q47753919 | Translational Control in the Latency of Apicomplexan Parasites |
| Q92162430 | Translational Regulation by Upstream Open Reading Frames and Human Diseases |
| Q36054263 | Translational Repression Protects Human Keratinocytes from UVB-Induced Apoptosis through a Discordant eIF2 Kinase Stress Response |
| Q89115530 | Translational regulation is a key determinant of the cellular response to benzo[a]pyrene |
| Q94512213 | Treatment of cancer cells with Lapatinib negatively regulates general translation and induces stress granules formation |
| Q35122358 | UPR, autophagy, and mitochondria crosstalk underlies the ER stress response |
| Q99241248 | Understanding the roles of stress granule during chemotherapy for patients with malignant tumors |
| Q37709545 | Upregulation of capacity for glutathione synthesis in response to amino acid deprivation: regulation of glutamate-cysteine ligase subunits. |
| Q36694043 | Venezuelan Equine Encephalitis Virus Induces Apoptosis through the Unfolded Protein Response Activation of EGR1. |
| Q37327483 | Vinca alkaloid drugs promote stress-induced translational repression and stress granule formation |
| Q36300688 | Waterpipe smoking induces epigenetic changes in the small airway epithelium. |
| Q33843219 | dsRNA Binding Domain of PKR Is Proteolytically Released by Enterovirus A71 to Facilitate Viral Replication. |
| Q37369248 | eIF2α phosphorylation controls thermal nociception |
| Q47557785 | eIF2α phosphorylation is pathognomonic for immunogenic cell death |
| Q52602508 | eIF2β, a subunit of translation-initiation factor EIF2, is a potential therapeutic target for non-small cell lung cancer. |
| Q100305048 | eIF5B drives integrated stress response-dependent translation of PD-L1 in lung cancer |
| Q36189835 | mRNP granules. Assembly, function, and connections with disease |
| Q26824181 | tRNA fragments in human health and disease |
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