Molecular mechanisms of mTOR regulation by stress

scientific article published on 3 December 2014

Molecular mechanisms of mTOR regulation by stress is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4161/23723548.2014.970489
P932PMC publication ID4904989
P698PubMed publication ID27308421
P5875ResearchGate publication ID276931793

P50authorBarbara Marleen BakkerQ21551979
Alexander Martin HeberleQ63360169
Kathrin ThedieckQ39372635
P2093author name stringKaren van Eunen
Sushma Nagaraja Grellscheid
Mirja Tamara Prentzell
P2860cites workIdentification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factorsQ22008465
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factorQ22009126
Ultraviolet-induced phosphorylation of p70(S6k) at Thr(389) and Thr(421)/Ser(424) involves hydrogen peroxide and mammalian target of rapamycin but not Akt and atypical protein kinase cQ23923268
TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell deathQ24298384
Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1Q24298767
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinaseQ24300915
mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machineryQ24302549
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR actionQ24302566
BH3-only protein Noxa is a mediator of hypoxic cell death induced by hypoxia-inducible factor 1alphaQ24303563
SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growthQ24309283
Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagyQ24310301
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1Q24315566
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1Q24316075
PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complexQ24316314
Inhibition of mTORC1 by astrin and stress granules prevents apoptosis in cancer cellsQ24318126
Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocationQ24322925
AMPK phosphorylation of raptor mediates a metabolic checkpointQ24329244
Proteomic analysis of cap-dependent translation identifies LARP1 as a key regulator of 5'TOP mRNA translationQ24337405
Regulation of mTOR and cell growth in response to energy stress by REDD1.Q24531971
Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complexQ24559347
Activation of chaperone-mediated autophagy during oxidative stressQ24562065
Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevityQ24598427
Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinasesQ24599204
Eukaryotic stress granules are cleared by autophagy and Cdc48/VCP functionQ24629019
Hypoxia-Inducible Factors and the Response to Hypoxic StressQ24629323
mTOR signaling in growth control and diseaseQ24634174
The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1Q24634783
HIF-1: upstream and downstream of cancer metabolismQ24647482
ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machineryQ24649645
The histidyl-tRNA synthetase-related sequence in the eIF-2 alpha protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acidsQ24651464
ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagyQ24654787
Brick by brick: metabolism and tumor cell growthQ24656187
The RasGAP-associated endoribonuclease G3BP assembles stress granulesQ24671936
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signalingQ24672005
Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttlingQ24677061
Self-consumption: the interplay of autophagy and apoptosisQ26828473
Endoplasmic reticulum stress in malignancyQ27006434
Translation Regulation as a Therapeutic Target in CancerQ27007000
Regulation of mTORC1 by amino acidsQ27025586
Folliculin regulates ampk-dependent autophagy and metabolic stress survivalQ27316476
TSC2 mediates cellular energy response to control cell growth and survivalQ27860970
On the Origin of Cancer CellsQ27861025
Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domainsQ28114920
mTOR is essential for the proteotoxic stress response, HSF1 activation and heat shock protein synthesisQ28116279
eIF4GI links nutrient sensing by mTOR to cell proliferation and inhibition of autophagyQ28118343
Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagyQ28131727
Perk is essential for translational regulation and cell survival during the unfolded protein responseQ28140062
Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinasesQ28187456
Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathwaysQ28242180
Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesisQ28242612
Rheb binds and regulates the mTOR kinaseQ28247033
The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacityQ28252642
Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesisQ28279053
Cancer cell metabolism: Warburg and beyondQ28293198
Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinaseQ28296183
Heme-regulated inhibitor kinase-mediated phosphorylation of eukaryotic translation initiation factor 2 inhibits translation, induces stress granule formation, and mediates survival upon arsenite exposureQ28305175
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKBQ28306356
Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosomeQ28307704
Rapid turnover of the mTOR complex 1 (mTORC1) repressor REDD1 and activation of mTORC1 signaling following inhibition of protein synthesisQ28387775
Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1Q28505561
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1Q28506431
The cold-inducible RNA-binding protein migrates from the nucleus to cytoplasmic stress granules by a methylation-dependent mechanism and acts as a translational repressorQ28506482
The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteinsQ28507365
The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4Q28508613
CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulumQ28512249
hnRNP A1 mediates the activation of the IRES-dependent SREBP-1a mRNA translation in response to endoplasmic reticulum stressQ28573820
Hypoxia-induced endothelial proliferation requires both mTORC1 and mTORC2Q28575983
mTORC1 serves ER stress-triggered apoptosis via selective activation of the IRE1–JNK pathwayQ28583302
Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesisQ28595034
Mitochondrial Genome Instability and ROS Enhance Intestinal Tumorigenesis in APC MiceQ28730326
Dual specificity kinase DYRK3 couples stress granule condensation/dissolution to mTORC1 signalingQ28771726
Mitochondrial reactive oxygen species trigger hypoxia-induced transcriptionQ29614203
Regulation of TORC1 by Rag GTPases in nutrient responseQ29614478
JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagyQ29614479
Autophagy is activated for cell survival after endoplasmic reticulum stressQ29614485
Activation of a metabolic gene regulatory network downstream of mTOR complex 1Q29615179
RNA-binding proteins TIA-1 and TIAR link the phosphorylation of eIF-2 alpha to the assembly of mammalian stress granulesQ29615265
AMPK: a nutrient and energy sensor that maintains energy homeostasisQ29615410
Targeting hypoxia in cancer therapyQ29615491
Translational control in stress and apoptosisQ29615497
The unfolded protein response: controlling cell fate decisions under ER stress and beyondQ29615499
Molecular mechanisms of mTOR-mediated translational controlQ29615529
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?Q29616804
Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40Q29617097
mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complexQ29617214
Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensingQ29617570
Otto Warburg's contributions to current concepts of cancer metabolismQ29617601
Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesisQ29617725
Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stressQ29619552
Eukaryotic stress granules: the ins and outs of translationQ29619569
Both G3BP1 and G3BP2 contribute to stress granule formationQ30009952
Stress Granules Inhibit Apoptosis by Reducing Reactive Oxygen Species ProductionQ30009960
Dynamic shuttling of TIA-1 accompanies the recruitment of mRNA to mammalian stress granulesQ30014821
The expression of Ras-GTPase activating protein SH3 domain-binding proteins, G3BPs, in human breast cancersQ30164896
Oxidative stress-dependent structural and functional switching of a human 2-Cys peroxiredoxin isotype II that enhances HeLa cell resistance to H2O2-induced cell death.Q30350844
Regulation of proline-rich Akt substrate of 40 kDa (PRAS40) function by mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylationQ30439476
Differential dependence of hypoxia-inducible factors 1 alpha and 2 alpha on mTORC1 and mTORC2.Q39926383
Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3, and BNIP3L.Q39972651
Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosisQ40002274
Repression of sestrin family genes contributes to oncogenic Ras-induced reactive oxygen species up-regulation and genetic instabilityQ40131334
JNK interaction with Sab mediates ER stress induced inhibition of mitochondrial respiration and cell deathQ40138480
Inhibition of fatty acid synthase induces endoplasmic reticulum stress in tumor cells.Q40174155
Inactivation of the mTORC1-eukaryotic translation initiation factor 4E pathway alters stress granule formationQ40525689
Inhibition of phosphatidylcholine synthesis induces expression of the endoplasmic reticulum stress and apoptosis-related protein CCAAT/enhancer-binding protein-homologous protein (CHOP/GADD153).Q40699167
Stressful initiationsQ40715443
Hydrogen peroxide activates p70(S6k) signaling pathwayQ40919286
Osmotic stress inhibits p70/85 S6 kinase through activation of a protein phosphataseQ40934280
Metabolic oxidative stress activates signal transduction and gene expression during glucose deprivation in human tumor cells.Q40979215
Reversible phosphorylation of eukaryotic initiation factor 2 alpha in response to endoplasmic reticular signalingQ41518651
ROS-generating NADPH oxidase NOX4 is a critical mediator in oncogenic H-Ras-induced DNA damage and subsequent senescenceQ41821426
Endoplasmic reticulum stress activates autophagy but not the proteasome in neuronal cells: implications for Alzheimer's diseaseQ41870879
Stimulation of de Novo Pyrimidine Synthesis by Growth Signaling Through mTOR and S6K1Q41983843
Inhibition of autophagy, lysosome and VCP function impairs stress granule assemblyQ42030945
BNIP3 is an RB/E2F target gene required for hypoxia-induced autophagyQ42058524
Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosisQ42207479
mTOR signaling regulates the processing of pre-rRNA in human cellsQ42562707
Chemotherapeutic induction of mitochondrial oxidative stress activates GSK-3α/β and Bax, leading to permeability transition pore opening and tumor cell deathQ42695021
G3BP is overexpressed in human tumors and promotes S phase entryQ42832825
Interferon-dependent engagement of eukaryotic initiation factor 4B via S6 kinase (S6K)- and ribosomal protein S6K-mediated signalsQ43127521
Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2.Q43170208
ER stress negatively regulates AKT/TSC/mTOR pathway to enhance autophagyQ43183361
The FAD- and O(2)-dependent reaction cycle of Ero1-mediated oxidative protein folding in the endoplasmic reticulumQ44230446
Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficienciesQ45067792
A novel function of poly(ADP-ribose) polymerase-1 in modulation of autophagy and necrosis under oxidative stress.Q46272227
PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP.Q46592766
Endoplasmic reticulum stress compromises the ubiquitin-proteasome systemQ46652698
AMPK: a cellular energy sensor primarily regulated by AMP.Q47098601
Mitochondrial DNA mutations in primary leukemia cells after chemotherapy: clinical significance and therapeutic implicationsQ51661489
Glutaminolysis activates Rag-mTORC1 signaling.Q52301079
Roles of the mammalian target of rapamycin, mTOR, in controlling ribosome biogenesis and protein synthesisQ53191116
ER stress (PERK/eIF2alpha phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formationQ53616050
In vivo up-regulation of the unfolded protein response after hypoxiaQ54317393
Gene expression profiles of non-small cell lung cancer: survival prediction and new biomarkersQ54382783
mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulationQ54398394
Ribosomal protein S6 kinase activity controls the ribosome biogenesis transcriptional programQ54457299
Evaluation of mTOR-regulated mRNA translationQ54546873
ER stress inhibits mTORC2 and Akt signaling through GSK-3β-mediated phosphorylation of rictor.Q54610967
Inhibition of fatty acid synthesis induces programmed cell death in human breast cancer cellsQ71148397
p70 S6 kinase is activated by sodium arsenite in adult rat cardiomyocytes: roles for phosphatidylinositol 3-kinase and p38 MAP kinaseQ73703012
c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instabilityQ74243929
Specific and Reversible Inactivation of Protein Tyrosine Phosphatases by Hydrogen Peroxide: Evidence for a Sulfenic Acid Intermediate and Implications for Redox RegulationQ74457509
Dissociation of the eukaryotic initiation factor-4E/4E-BP1 complex involves phosphorylation of 4E-BP1 by an mTOR-associated kinaseQ78203633
Frequent somatic mutations of mitochondrial DNA in esophageal squamous cell carcinomaQ79324879
Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1Q80979487
Mitochondrial dysfunction in cancerQ81110774
Stable isotope-labelling analysis of the impact of inhibition of the mammalian target of rapamycin on protein synthesisQ83687490
Transient Sequestration of TORC1 into Stress Granules during Heat StressQ84444073
Amino acid-induced translation of TOP mRNAs is fully dependent on phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylationQ30453740
PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosis.Q33306700
Low expression of a few genes indicates good prognosis in estrogen receptor positive breast cancerQ33484404
The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5.Q33559643
The variability of autophagy and cell death susceptibility: Unanswered questionsQ33631208
Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner.Q33668452
Sequestration of TRAF2 into stress granules interrupts tumor necrosis factor signaling under stress conditionsQ33707613
ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROSQ33733064
The association of AMPK with ULK1 regulates autophagyQ33745164
Thiol-based redox switchesQ33762400
The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling.Q33928657
Glucose deprivation-induced oxidative stress in human tumor cells. A fundamental defect in metabolism?Q33948122
Modulation of glucose transporter 1 (GLUT1) expression levels alters mouse mammary tumor cell growth in vitro and in vivo.Q33986152
Internal ribosome initiation of translation and the control of cell death.Q34069648
ATM Activation by Oxidative StressQ34145092
mTORC1 drives HIF-1α and VEGF-A signalling via multiple mechanisms involving 4E-BP1, S6K1 and STAT3Q34231591
Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1cQ34269920
Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granulesQ34320910
Insulin receptor substrate-1 mediates phosphatidylinositol 3'-kinase and p70S6k signaling during insulin, insulin-like growth factor-1, and interleukin-4 stimulationQ34325752
Apoptosis and autophagy in breast cancer cells following exemestane treatmentQ34388747
NADPH oxidase links endoplasmic reticulum stress, oxidative stress, and PKR activation to induce apoptosisQ34406716
Mitogenic signaling mediated by oxidants in Ras-transformed fibroblastsQ34418354
mTORC1 signaling under hypoxic conditions is controlled by ATM-dependent phosphorylation of HIF-1αQ34418791
PTEN/Akt Signaling Controls Mitochondrial Respiratory Capacity through 4E-BP1Q34438439
Mitochondrial telomerase protects cancer cells from nuclear DNA damage and apoptosisQ34551106
A GSK-3/TSC2/mTOR pathway regulates glucose uptake and GLUT1 glucose transporter expressionQ34656781
mTORC1 Dependent Regulation of REDD1 Protein StabilityQ34744964
Formation of stress granules inhibits apoptosis by suppressing stress-responsive MAPK pathwaysQ34845865
A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagyQ34962715
The importance of mitochondrial DNA in aging and cancerQ34974582
Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cellsQ34979866
mTOR phosphorylates IMP2 to promote IGF2 mRNA translation by internal ribosomal entryQ35033877
Hypoxia-induced angiogenesis during carcinogenesisQ35051138
ROS enhances CXCR4-mediated functions through inactivation of PTEN in prostate cancer cellsQ35185336
Hypoxia induces autophagic cell death in apoptosis-competent cells through a mechanism involving BNIP3.Q35189872
Redox Regulates Mammalian Target of Rapamycin Complex 1 (mTORC1) Activity by Modulating the TSC1/TSC2-Rheb GTPase PathwayQ35213308
Heteroplasmic mitochondrial DNA mutations in normal and tumour cellsQ35222494
Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signalingQ35370616
Translational coregulation of 5'TOP mRNAs by TIA-1 and TIAR.Q35393305
Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistanceQ35484801
Paclitaxel resistance is associated with switch from apoptotic to autophagic cell death in MCF-7 breast cancer cellsQ35723911
mTOR complex 2 signaling and functionsQ35878519
Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viabilityQ35916071
A unifying model for mTORC1-mediated regulation of mRNA translation.Q35945036
Spectrum of somatic mitochondrial mutations in five cancersQ36212908
IRES-dependent translation of egr2 is induced under inflammatory conditionsQ36246640
Redox regulation of PI 3-kinase signalling via inactivation of PTENQ36266420
Translation suppression promotes stress granule formation and cell survival in response to cold shockQ36284492
Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex.Q36532572
AMPK is a negative regulator of the Warburg effect and suppresses tumor growth in vivoQ36532941
The PERK/eIF2alpha/ATF4 module of the UPR in hypoxia resistance and tumor growthQ36544374
Hypoxia induces a novel signature of chromatin modifications and global repression of transcriptionQ36593766
Oxidants, antioxidants and the current incurability of metastatic cancersQ36702422
PERK/eIF2α signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS.Q36712792
The translational landscape of mTOR signalling steers cancer initiation and metastasisQ36873513
Mammalian stress granules and processing bodiesQ36965220
Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword?Q36989869
Hypoxia and cancerQ37008506
Cells lacking the fragile X mental retardation protein (FMRP) have normal RISC activity but exhibit altered stress granule assemblyQ37035053
The TSC-mTOR pathway mediates translational activation of TOP mRNAs by insulin largely in a raptor- or rictor-independent mannerQ37072152
Role of JNK1-dependent Bcl-2 phosphorylation in ceramide-induced macroautophagyQ37075287
Reprogramming mRNA translation during stressQ37115046
Akt Determines Cell Fate Through Inhibition of the PERK-eIF2α Phosphorylation PathwayQ37119471
A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS.Q37213565
Tuberous sclerosis complex activity is required to control neuronal stress responses in an mTOR-dependent mannerQ37215418
The fragile X protein binds mRNAs involved in cancer progression and modulates metastasis formationQ37237119
Two phases of disulfide bond formation have differing requirements for oxygen.Q37343919
Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cellsQ37388595
The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1.Q37402791
Membrane expansion alleviates endoplasmic reticulum stress independently of the unfolded protein response.Q37425584
De novo fatty-acid synthesis and related pathways as molecular targets for cancer therapyQ37437194
Oligopyrimidine tract at the 5' end of mammalian ribosomal protein mRNAs is required for their translational controlQ37483613
Hypoxia-inducible factor 1 regulation through cross talk between mTOR and MT1-MMP.Q37546037
Translational and posttranslational regulation of XIAP by eIF2α and ATF4 promotes ER stress-induced cell death during the unfolded protein responseQ37732157
RNA granules: the good, the bad and the uglyQ37784866
mTOR links oncogenic signaling to tumor cell metabolismQ37837598
The role of autophagy in cancer: therapeutic implicationsQ37924056
SREBPs: metabolic integrators in physiology and metabolismQ37966406
Bidirectional crosstalk between endoplasmic reticulum stress and mTOR signalingQ37996626
Cancer cell metabolism: one hallmark, many faces.Q38046274
Oxidative stress and cancer: An overviewQ38057533
The role of the apoptotic machinery in tumor suppressionQ38057709
Expression of glucose transporters in cancersQ38069750
mTOR in aging, metabolism, and cancerQ38073906
The eIF2α kinases: their structures and functionsQ38077051
Protein Folding in the Endoplasmic ReticulumQ38103530
AMPK: A Contextual Oncogene or Tumor Suppressor?Q38104227
Emerging regulation and functions of autophagyQ38118567
Stress granules and cell signaling: more than just a passing phase?Q38136844
Making new contacts: the mTOR network in metabolism and signalling crosstalkQ38189969
AMPK: regulating energy balance at the cellular and whole body levels.Q38192428
Activation of p70 ribosomal protein S6 kinase is an essential step in the DNA damage-dependent signaling pathway responsible for the ultraviolet B-mediated increase in interstitial collagenase (MMP-1) and stromelysin-1 (MMP-3) protein levels in humaQ38315747
Regulation of autophagy by ATF4 in response to severe hypoxia.Q38343634
17β-Estradiol Activates Glucose Uptake via GLUT4 Translocation and PI3K/Akt Signaling Pathway in MCF-7 CellsQ39172784
ROS‐generating oxidases Nox1 and Nox4 contribute to oncogenic Ras‐induced premature senescenceQ39231615
Transcriptional up-regulation of ULK1 by ATF4 contributes to cancer cell survival.Q39256984
The TSC1 and TSC2 tumor suppressors are required for proper ER stress response and protect cells from ER stress-induced apoptosisQ39682487
Phosphorylation of PRAS40 on Thr246 by PKB/AKT facilitates efficient phosphorylation of Ser183 by mTORC1.Q39742546
Vascular endothelial growth factor-C protects prostate cancer cells from oxidative stress by the activation of mammalian target of rapamycin complex-2 and AKT-1.Q39819698
P433issue2
P304page(s)e970489
P577publication date2014-12-03
P13046publication type of scholarly workreview articleQ7318358
P1433published inMolecular & cellular oncologyQ27725948
P1476titleMolecular mechanisms of mTOR regulation by stress
P478volume2

Reverse relations

cites work (P2860)
Q41889379A systems study reveals concurrent activation of AMPK and mTOR by amino acids
Q92445423Functional Interaction of Hypoxia-Inducible Factor 2-Alpha and Autophagy Mediates Drug Resistance in Colon Cancer Cells
Q55284922Hypoxic Signalling in Tumour Stroma.
Q59340268Inhibition of FAO in AML co-cultured with BM adipocytes: mechanisms of survival and chemosensitization to cytarabine
Q38636818Integrative metabolomics as emerging tool to study autophagy regulation
Q96431469Iron chelation inhibits mTORC1 signaling involving activation of AMPK and REDD1/Bnip3 pathways
Q91899278Mammalian Target of Rapamycin: A Metabolic Rheostat for Regulating Adipose Tissue Function and Cardiovascular Health
Q112641678MicroRNAs and their target mRNAs as potential biomarkers among smokers and non-smokers with lung adenocarcinoma
Q58595903Nutrient Sensor Signaling Pathways and Cellular Stress in Fetal Growth Restriction
Q39012724PLK1 (polo like kinase 1) inhibits MTOR complex 1 and promotes autophagy
Q48717613Progranulin Protects Hippocampal Neurogenesis via Suppression of Neuroinflammatory Responses Under Acute Immune Stress
Q64107904The PI3K and MAPK/p38 pathways control stress granule assembly in a hierarchical manner
Q61443921The associations of DNA methylation alterations in oxidative stress-related genes with cancer incidence and mortality outcomes: a population-based cohort study
Q99241248Understanding the roles of stress granule during chemotherapy for patients with malignant tumors

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