Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy

scientific article

Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1091/MBC.E08-12-1248
P3181OpenCitations bibliographic resource ID81769
P932PMC publication ID2663915
P698PubMed publication ID19211835
P5875ResearchGate publication ID24002924

P50authorMizushima NoboruQ15055172
P2093author name stringNaoyuki Yamada
Shun-ichiro Iemura
Takeshi Kaizuka
Tohru Natsume
Jun-Lin Guan
Yutaka Miura
Taichi Hara
Kenji Takehana
Chieko Kishi
Akito Takamura
Nao Hosokawa
Noriko Oshiro
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siRNA screening of the kinome identifies ULK1 as a multidomain modulator of autophagyQ24314616
Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanismQ24329236
Atg17 functions in cooperation with Atg1 and Atg13 in yeast autophagyQ24523548
Role of the UBL-UBA protein KPC2 in degradation of p27 at G1 phase of the cell cycleQ24534914
The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formationQ24535862
The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1Q24634783
FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cellsQ24648105
ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machineryQ24649645
Role of FIP200 in cardiac and liver development and its regulation of TNFalpha and TSC-mTOR signaling pathwaysQ24682845
Tor-mediated induction of autophagy via an Apg1 protein kinase complexQ24685670
Autophagy in the Pathogenesis of DiseaseQ27860558
TOR signaling in growth and metabolismQ27860757
Autophagy fights disease through cellular self-digestionQ27860902
Analyses of APG13 gene involved in autophagy in yeast, Saccharomyces cerevisiaeQ27930610
Hierarchy of Atg proteins in pre-autophagosomal structure organizationQ27931408
Atg17 regulates the magnitude of the autophagic responseQ27932508
Characterization of a novel autophagy-specific gene, ATG29.Q27935122
Cis1/Atg31 is required for autophagosome formation in Saccharomyces cerevisiaeQ27938390
Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeastQ27939948
Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeastQ28131604
Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugateQ28187453
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Autophagy and signaling: their role in cell survival and cell deathQ28278893
Functional specificity of the mammalian Beclin-Vps34 PI 3-kinase complex in macroautophagy versus endocytosis and lysosomal enzyme traffickingQ28289648
Identification of mouse ULK1, a novel protein kinase structurally related to C. elegans UNC-51Q28512062
A mouse serine/threonine kinase homologous to C. elegans UNC51 functions in parallel fiber formation of cerebellar granule neuronsQ28512257
Autophagy: process and functionQ29547296
p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell deathQ29547297
Autophagy: from phenomenology to molecular understanding in less than a decadeQ29614174
How to interpret LC3 immunoblottingQ29614175
Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAGQ29614477
Role and regulation of starvation-induced autophagy in the Drosophila fat bodyQ29617035
Mouse ULK2, a novel member of the UNC-51-like protein kinases: unique features of functional domainsQ33879860
Lithium induces autophagy by inhibiting inositol monophosphataseQ36321015
The Atg1 kinase complex is involved in the regulation of protein recruitment to initiate sequestering vesicle formation for nonspecific autophagy in Saccharomyces cerevisiaeQ36438806
FIP200, a key signaling node to coordinately regulate various cellular processesQ36515638
Signalling and autophagy regulation in health, aging and diseaseQ36594286
Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturationQ36835194
Expanding mTOR signalingQ36902840
Unveiling the roles of autophagy in innate and adaptive immunityQ36927499
An Atg1/Atg13 complex with multiple roles in TOR-mediated autophagy regulationQ37146685
LC3, an autophagosome marker, can be incorporated into protein aggregates independent of autophagy: caution in the interpretation of LC3 localizationQ40154056
Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagyQ40250473
Characterization of the phosphoproteins and protein kinase activity in mTOR immunoprecipitates.Q40993000
Generation of cell lines with tetracycline-regulated autophagy and a role for autophagy in controlling cell sizeQ47339876
Autophagy is essential for preimplantation development of mouse embryosQ48745730
Autophagy and p70S6 kinase.Q52670758
Transport of phosphatidylinositol 3-phosphate into the vacuole via autophagic membranes in Saccharomyces cerevisiaeQ57274142
A direct nanoflow liquid chromatography-tandem mass spectrometry system for interaction proteomicsQ78287803
ATG genes involved in non-selective autophagy are conserved from yeast to man, but the selective Cvt and pexophagy pathways also require organism-specific genesQ79495023
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectAutophagy related 13Q4826898
cell biologyQ7141
autophagyQ288322
Atg1/ULK1 kinase complexQ21106564
Regulatory associated protein of MTOR complex 1Q21115067
RB1 inducible coiled-coil 1Q21115135
Unc-51 like autophagy activating kinase 1Q21116760
RB1-inducible coiled-coil 1Q21494756
Unc-51 like kinase 1Q21495318
Autophagy related 13Q21499122
P304page(s)1981-91
P577publication date2009-04-01
P1433published inMolecular Biology of the CellQ2338259
P1476titleNutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy
P478volume20

Reverse relations

described by source (P1343)
Q107514620ULK1-ATG13-RB1CC1-ATG101 autophagy initiation complex
Q107602596ULK1-ATG13-RB1CC1-ATG101 autophagy initiation complex

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Q27005828Eaten alive: novel insights into autophagy from multicellular model systems
Q99370886Eating the unknown: Xenophagy and ER-phagy are cytoprotective defenses against pathogens
Q37859076Effects of rapamycin and TOR on aging and memory: implications for Alzheimer's disease
Q36473735Electroacupuncture protects against ischemic stroke by reducing autophagosome formation and inhibiting autophagy through the mTORC1-ULK1 complex-Beclin1 pathway
Q59757762Elucidating TOR Signaling in Chlamydomonas reinhardtii
Q36194753Emerging role of autophagy in kidney function, diseases and aging
Q39349204Endoplasmic reticulum stress triggers autophagy in malignant glioma cells undergoing cyclosporine a-induced cell death
Q36111664Endothelial cell and podocyte autophagy synergistically protect from diabetes-induced glomerulosclerosis.
Q50090100Everolimus Plus Ku0063794 Regimen Promotes Anticancer Effects against Hepatocellular Carcinoma Cells through the Paradoxical Inhibition of Autophagy
Q34204391Excess leucine intake enhances muscle anabolic signaling but not net protein anabolism in young men and women
Q39420503Exercise-mediated modulation of autophagy in skeletal muscle.
Q49886956Exploiting cancer vulnerabilities: mTOR, autophagy, and homeostatic imbalance
Q41504464Expression of a ULK1/2 binding-deficient ATG13 variant can partially restore autophagic activity in ATG13-deficient cells
Q38985509FIP200 is involved in murine pseudomonas infection by regulating HMGB1 intracellular translocation
Q35876573FIP200 is required for the cell-autonomous maintenance of fetal hematopoietic stem cells
Q24314938FIP200 regulates targeting of Atg16L1 to the isolation membrane
Q24302037FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation
Q26851722FOXO transcription factors: key regulators of cellular quality control
Q28243647Fighting neurodegeneration with rapamycin: mechanistic insights
Q100750514Fine-tuning of AMPK-ULK1-mTORC1 regulatory triangle is crucial for autophagy oscillation
Q36181637Fission yeast Ryh1 GTPase activates TOR Complex 2 in response to glucose
Q56877965Flaviviruses and Autophagy
Q41169445Foot-and-mouth disease virus induces autophagosomes during cell entry via a class III phosphatidylinositol 3-kinase-independent pathway
Q35014198Frontier of epilepsy research - mTOR signaling pathway
Q35632729Functions of autophagy in pathological cardiac hypertrophy
Q28548356G9a Inhibition Induces Autophagic Cell Death via AMPK/mTOR Pathway in Bladder Transitional Cell Carcinoma
Q39357584GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy
Q38837034GSK3-mediated raptor phosphorylation supports amino-acid-dependent mTORC1-directed signalling
Q64061443Genome-wide CRISPR screen identifies TMEM41B as a gene required for autophagosome formation
Q28067399Glioblastoma, hypoxia and autophagy: a survival-prone 'ménage-à-trois'
Q35812645Grape seed extract targets mitochondrial electron transport chain complex III and induces oxidative and metabolic stress leading to cytoprotective autophagy and apoptotic death in human head and neck cancer cells
Q38112382Growth or longevity: the TOR's decision on lifespan regulation
Q21996341Guidelines for the use and interpretation of assays for monitoring autophagy
Q22676705Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
Q26996778HCV and Oxidative Stress: Implications for HCV Life Cycle and HCV-Associated Pathogenesis
Q35858374HCV core protein represses the apoptosis and improves the autophagy of human hepatocytes
Q49888642HEPES activates a MiT/TFE-dependent lysosomal-autophagic gene network in cultured cells: A call for caution.
Q39241528Hepatitis C virus inhibits AKT-tuberous sclerosis complex (TSC), the mechanistic target of rapamycin (MTOR) pathway, through endoplasmic reticulum stress to induce autophagy
Q34924245Hexokinase II integrates energy metabolism and cellular protection: Akting on mitochondria and TORCing to autophagy
Q47664663High LC3/Beclin Expression Correlates with Poor Survival in Glioma: a Definitive Role for Autophagy as Evidenced by In Vitro Autophagic Flux
Q48265458High autophagic flux guards ESC identity through coordinating autophagy machinery gene program by FOXO1.
Q35944301High expression levels of unc-51-like kinase 1 as a predictor of poor prognosis in colorectal cancer
Q35852901Histone deacetylase inhibitors induce autophagy through FOXO1-dependent pathways.
Q37977162How phosphoinositide 3-phosphate controls growth downstream of amino acids and autophagy downstream of amino acid withdrawal
Q24323790Hsp90-Cdc37 chaperone complex regulates Ulk1- and Atg13-mediated mitophagy
Q38829905Hydrogen sulfide reduces serum triglyceride by activating liver autophagy via the AMPK-mTOR pathway
Q60934682Hyperoside attenuates renal aging and injury induced by D-galactose via inhibiting AMPK-ULK1 signaling-mediated autophagy
Q39577630Hypothalamic lipophagy and energetic balance
Q41107802Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation.
Q38772023Hypoxia and cellular metabolism in tumour pathophysiology
Q37614300IAPP modulates cellular autophagy, apoptosis, and extracellular matrix metabolism in human intervertebral disc cells
Q47214959IL4 (interleukin 4) induces autophagy in B cells leading to exacerbated asthma
Q30498183Identification of PTPsigma as an autophagic phosphatase.
Q33878961Identification of a novel MTOR activator and discovery of a competing endogenous RNA regulating autophagy in vascular endothelial cells
Q37376186Identification of nasopharyngeal carcinoma metastasis-related biomarkers by iTRAQ combined with 2D-LC-MS/MS.
Q36389858Impact of cellular autophagy on viruses: Insights from hepatitis B virus and human retroviruses
Q47104731Implications of aging and the endoplasmic reticulum unfolded protein response on the molecular modality of breast cancer.
Q37834371Implications of autophagy for glomerular aging and disease
Q48563627In Silico HTS and Structure Based Optimization of Indazole-Derived ULK1 Inhibitors.
Q36621704In situ Proteomic Profiling of Curcumin Targets in HCT116 Colon Cancer Cell Line.
Q89957921Increased autophagy/mitophagy levels in primary tumours of patients with pancreatic neuroendocrine neoplasms
Q36808210Induction of autophagy by valproic acid enhanced lymphoma cell chemosensitivity through HDAC-independent and IP3-mediated PRKAA activation
Q41768449Induction of autophagy supports the bioenergetic demands of quiescent muscle stem cell activation
Q64107126Influence of Normal Aging on Brain Autophagy: A Complex Scenario
Q60954913Influenza A Virus NS1 Protein Suppresses JNK1-Dependent Autophagosome Formation Mediated by Rab11a Recycling Endosomes
Q42108388Inhibition of PI3K/Akt/mTOR signaling by natural products
Q38795848Inhibition of cholesterol metabolism underlies synergy between mTOR pathway inhibition and chloroquine in bladder cancer cells
Q39326047Inhibition of mTOR kinase as a therapeutic target for acute myeloid leukemia
Q43182570Inhibition of target of rapamycin signaling and stress activate autophagy in Chlamydomonas reinhardtii
Q90198375Insulin-induced de novo lipid synthesis occurs mainly via mTOR-dependent regulation of proteostasis of SREBP-1c
Q34313770Integration of Clearance Mechanisms: The Proteasome and Autophagy
Q39553486Intensive expression of UNC-51-like kinase 1 is a novel biomarker of poor prognosis in patients with esophageal squamous cell carcinoma
Q92875825Interactions between Autophagy and DNA Viruses
Q26745577Interactions between Autophagy and Inhibitory Cytokines
Q39419450Interplay between Autophagy, Exosomes and HIV-1 Associated Neurological Disorders: New Insights for Diagnosis and Therapeutic Applications
Q37205898Intestinal epithelium and autophagy: partners in gut homeostasis
Q42516357Ion channels in the regulation of autophagy
Q47108927Is amyotrophic lateral sclerosis/frontotemporal dementia an autophagy disease?
Q28071388Judicious Toggling of mTOR Activity to Combat Insulin Resistance and Cancer: Current Evidence and Perspectives
Q59085556KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing
Q92376588Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication Interferes with mTORC1 Regulation of Autophagy and Viral Protein Synthesis
Q28830062Knockdown of GSK3β increases basal autophagy and AMPK signalling in nutrient-laden human aortic endothelial cells
Q38931119LC3- and p62-based biochemical methods for the analysis of autophagy progression in mammalian cells
Q47895048LC3-Associated Phagocytosis and Inflammation.
Q28118644La-related Protein 1 (LARP1) Represses Terminal Oligopyrimidine (TOP) mRNA Translation Downstream of mTOR Complex 1 (mTORC1)
Q42085847Let-7 coordinately suppresses components of the amino acid sensing pathway to repress mTORC1 and induce autophagy
Q26866321Leucine and mTORC1: a complex relationship
Q51590526Leucine restores murine hepatic triglyceride accumulation induced by a low-protein diet by suppressing autophagy and excessive endoplasmic reticulum stress.
Q38872712Lipids, lysosomes, and autophagy.
Q38015814Liver autophagy: physiology and pathology
Q98163537LncRNA PVT1 promotes gemcitabine resistance of pancreatic cancer via activating Wnt/β-catenin and autophagy pathway through modulating the miR-619-5p/Pygo2 and miR-619-5p/ATG14 axes
Q58000904Loperamide, pimozide, and STF-62247 trigger autophagy-dependent cell death in glioblastoma cells
Q92039543Loss of BRUCE reduces cellular energy level and induces autophagy by driving activation of the AMPK-ULK1 autophagic initiating axis
Q36193081Loss of ULK1 increases RPS6KB1-NCOR1 repression of NR1H/LXR-mediated Scd1 transcription and augments lipotoxicity in hepatic cells
Q41818511Loss of the starvation-induced gene Rack1 leads to glycogen deficiency and impaired autophagic responses in Drosophila
Q95288907Low FoxO expression in Drosophila somatosensory neurons protects dendrite growth under nutrient restriction
Q36357766Lymphangioleiomyomatosis - a wolf in sheep's clothing.
Q48121086Lysosomal metabolomics reveals V-ATPase- and mTOR-dependent regulation of amino acid efflux from lysosomes.
Q40970806Lysosomal regulation of cholesterol homeostasis in tuberous sclerosis complex is mediated via NPC1 and LDL-R
Q83771997Lysosome positioning coordinates mTORC1 activity and autophagy
Q91452379Lysosomes as dynamic regulators of cell and organismal homeostasis
Q57168286MAPK15 is part of the ULK complex and controls its activity to regulate early phases of the autophagic process
Q57021003MITF-MIR211 axis is a novel autophagy amplifier system during cellular stress
Q34552915MODULATION OF AUTOPHAGY AND ITS POTENTIAL FOR CANCER THERAPY.
Q57795695MTOR-independent autophagy induced by interrupted endoplasmic reticulum-mitochondrial Ca communication: a dead end in cancer cells
Q47820387MTORC1 Regulates both General Autophagy and Mitophagy Induction after Oxidative Phosphorylation Uncoupling
Q50286485MTORC1 dissociates from ULK complex
Q30524356MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB.
Q34999109Macronutrient composition of the diet affects the feeding-mediated down regulation of autophagy in muscle of rainbow trout (O. mykiss).
Q38189969Making new contacts: the mTOR network in metabolism and signalling crosstalk
Q91650616Mammalian Mitophagosome Formation: A Focus on the Early Signals and Steps
Q24595447Mammalian autophagy: core molecular machinery and signaling regulation
Q37491912Mammalian macroautophagy at a glance
Q39104277Mammalian target of rapamycin (mTOR): a central regulator of male fertility?
Q35107703Mammalian target of rapamycin signaling and autophagy: roles in lymphangioleiomyomatosis therapy
Q35157985Mammalian target of rapamycin: hitting the bull's-eye for neurological disorders
Q35696469Mapping autophagy on to your metabolic radar
Q37736362Mapping sites of aspirin-induced acetylations in live cells by quantitative acid-cleavable activity-based protein profiling (QA-ABPP).
Q38260329Mechanism and Regulation of Autophagy and Its Role in Neuronal Diseases
Q57269850Mechanism and medical implications of mammalian autophagy
Q38159574Mechanism and physiological significance of growth factor-related autophagy.
Q94554949Mechanisms governing autophagosome biogenesis
Q39182119Mechanisms of Autophagy Initiation
Q37217474Mechanistically distinct cancer-associated mTOR activation clusters predict sensitivity to rapamycin.
Q38104492Mechanistic / mammalian target protein of rapamycin signaling in hematopoietic stem cells and leukemia
Q37974949Membrane recruitment of autophagy proteins in selective autophagy
Q60949979Mesenchymal Stem Cell-Derived Exosomes Ameliorated Diabetic Nephropathy by Autophagy Induction through the mTOR Signaling Pathway
Q50217787Metabolic Regulation of T Cell Immunity
Q38040587Metabolic regulation, mitochondria and the life-prolonging effect of rapamycin: a mini-review
Q37620679Metabolism addiction in pancreatic cancer
Q29547276Methods in mammalian autophagy research
Q90249849MicroRNA-29 enhances autophagy and cleanses exogenous mutant αB-crystallin in retinal pigment epithelial cells
Q38336639Minireview: Autophagy in pancreatic β-cells and its implication in diabetes
Q40895675Mitochondrial outer-membrane E3 ligase MUL1 ubiquitinates ULK1 and regulates selenite-induced mitophagy
Q64360970MoSnt2-dependent deacetylation of histone H3 mediates MoTor-dependent autophagy and plant infection by the rice blast fungus Magnaporthe oryzae
Q33665207Molecular Pathways: Increased Susceptibility to Infection Is a Complication of mTOR Inhibitor Use in Cancer Therapy
Q38921302Molecular mechanism of hepatic steatosis: pathophysiological role of autophagy
Q30278688Molecular mechanisms for mitochondrial adaptation to exercise training in skeletal muscle
Q35037307Molecular mechanisms of autophagy in the cardiovascular system
Q38866763Molecular mechanisms of mTOR regulation by stress
Q38100537Molecular signaling toward mitophagy and its physiological significance.
Q92608420Monitoring stress-induced autophagic engulfment and degradation of the 26S proteasome in mammalian cells
Q28854564Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator
Q40386133Muscle-specific deletion of BDK amplifies loss of myofibrillar protein during protein undernutrition
Q28119201Nedd4 E3 ubiquitin ligase promotes cell proliferation and autophagy
Q37791832Negative regulation of autophagy
Q38122158Neural plasticity and proliferation in the generation of antidepressant effects: hippocampal implication.
Q33661680Neural-specific deletion of FIP200 leads to cerebellar degeneration caused by increased neuronal death and axon degeneration
Q37869692Neuronal autophagy as a mediator of life and death: contrasting roles in chronic neurodegenerative and acute neural disorders
Q38042565Neuronal autophagy in cerebral ischemia
Q33775384Neuropathological role of PI3K/Akt/mTOR axis in Down syndrome brain.
Q48506350New Insights Into the Role of mTOR Signaling in the Cardiovascular System.
Q57464348New Mammalian Target of Rapamycin (mTOR) Modulators Derived from Natural Product Databases and Marine Extracts by Using Molecular Docking Techniques
Q37524096New autophagy reporter mice reveal dynamics of proximal tubular autophagy
Q42738918Noboru Mizushima: All about autophagy. Interview by Caitlin Sedwick
Q28728348Non-canonical functions of the tuberous sclerosis complex-Rheb signalling axis
Q37323116Normalizing translation through 4E-BP prevents mTOR-driven cortical mislamination and ameliorates aberrant neuron integration.
Q38424856Novel Insights into Osteoarthritis Joint Pathology from Studies in Mice.
Q38914171Novel pharmacological modulators of autophagy: an updated patent review (2012-2015).
Q33756641Novel roles for the MiTF/TFE family of transcription factors in organelle biogenesis, nutrient sensing, and energy homeostasis
Q34331244Nutrient signaling to mTOR and cell growth
Q34720900Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPK.
Q37008888Nutrient-sensing mTORC1: Integration of metabolic and autophagic signals
Q42152336O-GlcNAc-modification of SNAP-29 regulates autophagosome maturation
Q37636778O-GlcNAcylation of ATG4B positively regulates autophagy by increasing its hydroxylase activity
Q89977010Oral Microbes and Mucosal Dendritic Cells, "Spark and Flame" of Local and Distant Inflammatory Diseases
Q36223627Orchestrated Action of PP2A Antagonizes Atg13 Phosphorylation and Promotes Autophagy after the Inactivation of TORC1
Q26795727Organelle-Specific Initiation of Autophagy
Q58802893Overexpression of ULK1 Represents a Potential Diagnostic Marker for Clear Cell Renal Carcinoma and the Antitumor Effects of SBI-0206965
Q37765143Overview of macroautophagy regulation in mammalian cells
Q36635744PAQR3 controls autophagy by integrating AMPK signaling to enhance ATG14L-associated PI3K activity
Q42150529PEBP1, a RAF kinase inhibitory protein, negatively regulates starvation-induced autophagy by direct interaction with LC3.
Q36594146PGC-1α promotes exercise-induced autophagy in mouse skeletal muscle
Q38206682PI3K-AKT-mTOR signaling in prostate cancer progression and androgen deprivation therapy resistance
Q52310328PP242 Counteracts Glioblastoma Cell Proliferation, Migration, Invasiveness and Stemness Properties by Inhibiting mTORC2/AKT.
Q47070299PP2A regulates autophagy in two alternative ways in Drosophila
Q52316229Pancreatic Beta Cell Death: Novel Potential Mechanisms in Diabetes Therapy.
Q60955118Perspectives of RAS and RHEB GTPase Signaling Pathways in Regenerating Brain Neurons
Q92809097Pexophagy: A Model for Selective Autophagy
Q35242546Pharmacologic agents targeting autophagy
Q30646716Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy
Q36111810Pharmacological inhibition of lysosomes activates the MTORC1 signaling pathway in chondrocytes in an autophagy-independent manner
Q38890133Phosphoinositide-binding proteins in autophagy
Q34268347Phospholipase D signaling pathways and phosphatidic acid as therapeutic targets in cancer
Q33878926Phosphorylation of NBR1 by GSK3 modulates protein aggregation.
Q29615616Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy
Q48215511Phosphorylation of ULK1 by AMPK is essential for mouse embryonic stem cell self-renewal and pluripotency
Q28508500Phosphorylation of ULK1 by AMPK regulates translocation of ULK1 to mitochondria and mitophagy
Q57054936Plasma cells: the programming of an antibody-secreting machine
Q38223047Pleiotropic roles of mTOR complexes in haemato-lymphopoiesis and leukemogenesis
Q33645471Podocyte Autophagy: A Potential Therapeutic Target to Prevent the Progression of Diabetic Nephropathy
Q99414253Polyphenol-Mediated Autophagy in Cancer: Evidence of In Vitro and In Vivo Studies
Q38851817Polyunsaturated Branched-Chain Fatty Acid Geranylgeranoic Acid Induces Unfolded Protein Response in Human Hepatoma Cells
Q90463782Post-translational modifications of Beclin 1 provide multiple strategies for autophagy regulation
Q35852919Posttranslational modification of autophagy-related proteins in macroautophagy
Q61450099Potential ceRNA networks involved in autophagy suppression of pancreatic cancer caused by chloroquine diphosphate: A study based on differentially‑expressed circRNAs, lncRNAs, miRNAs and mRNAs
Q28731609Preparation of mouse monoclonal antibody for RB1CC1 and its clinical application
Q54577937Prognostic significance of RB1-inducible coiled-coil 1 in salivary gland cancers.
Q37293151Prognostic value of autophagy related proteins ULK1, Beclin 1, ATG3, ATG5, ATG7, ATG9, ATG10, ATG12, LC3B and p62/SQSTM1 in gastric cancer
Q34303405Programmed cell death pathways in cancer: a review of apoptosis, autophagy and programmed necrosis
Q38034272Programmed necrosis and autophagy in immune function
Q41683471Progression of thanatophagy in cadaver brain and heart tissues
Q35064974Promoting autophagic clearance: viable therapeutic targets in Alzheimer's disease
Q97883064Protective Effects of Rapamycin on Trabecular Meshwork Cells in Glucocorticoid-Induced Glaucoma Mice
Q91896679Protective Role of mTOR in Liver Ischemia/Reperfusion Injury: Involvement of Inflammation and Autophagy
Q39043361Protective effect of autophagy inhibition on ischemia-reperfusion-induced injury of N2a cells
Q57036995Protein Quality Control in the Endoplasmic Reticulum and Cancer
Q100532878Protein metabolism and related body function - mechanistic approaches and health consequences
Q91304470Protein: what's on in research on clinical nutrition
Q28543694Proteotoxic stress induces phosphorylation of p62/SQSTM1 by ULK1 to regulate selective autophagic clearance of protein aggregates
Q33627736RB1CC1 activates RB1 pathway and inhibits proliferation and cologenic survival in human cancer
Q35626134RB1CC1 protein suppresses type II collagen synthesis in chondrocytes and causes dwarfism
Q33784718RB1CC1 together with RB1 and p53 predicts long-term survival in Japanese breast cancer patients
Q58712490RB1CC1-enhanced autophagy facilitates PSCs activation and pancreatic fibrogenesis in chronic pancreatitis
Q36939659RES-529: a PI3K/AKT/mTOR pathway inhibitor that dissociates the mTORC1 and mTORC2 complexes
Q34662354ROS inhibit autophagy by downregulating ULK1 mediated by the phosphorylation of p53 in selenite-treated NB4 cells.
Q33583930ROS-mediated autophagy induced by dysregulation of lipid metabolism plays a protective role in colorectal cancer cells treated with gambogic acid
Q40326577Rab12 regulates mTORC1 activity and autophagy through controlling the degradation of amino-acid transporter PAT4.
Q38897874Rabin8 suppresses autophagosome formation independently of its guanine nucleotide-exchange activity towards Rab8.
Q99350187Rac1 conditional deletion attenuates retinal ganglion cell apoptosis by accelerating autophagic flux in a mouse model of chronic ocular hypertension
Q36618911Rag GTPases mediate amino acid-dependent recruitment of TFEB and MITF to lysosomes
Q24337344RalB and the exocyst mediate the cellular starvation response by direct activation of autophagosome assembly
Q57182557Rapamycin and FK506 derivative TH2849 could ameliorate neurodegenerative diseases through autophagy with low immunosuppressive effect
Q34718418Rapamycin upregulates autophagy by inhibiting the mTOR-ULK1 pathway, resulting in reduced podocyte injury
Q41325784Reactive Astrocytes Promote ALS-like Degeneration and Intracellular Protein Aggregation in Human Motor Neurons by Disrupting Autophagy through TGF-β1.
Q38022568Reactive oxygen species and autophagy in plants and algae
Q92932473Recent progress in the role of autophagy in neurological diseases
Q35985531Reconstitution of leucine-mediated autophagy via the mTORC1-Barkor pathway in vitro
Q92223680Recruitment and Activation of the ULK1/Atg1 Kinase Complex in Selective Autophagy
Q100332692Regulation and Function of Autophagy During Ferroptosis
Q29547416Regulation mechanisms and signaling pathways of autophagy
Q39420799Regulation of Autophagy through TORC1 and mTORC1.
Q28608455Regulation of B Cell Differentiation by Intracellular Membrane-Associated Proteins and microRNAs: Role in the Antibody Response
Q39802205Regulation of PIK3C3/VPS34 complexes by MTOR in nutrient stress-induced autophagy.
Q40685914Regulation of autophagic flux by CHIP.
Q38224064Regulation of autophagy by amino acid availability in S. cerevisiae and mammalian cells
Q36003000Regulation of autophagy by coordinated action of mTORC1 and protein phosphatase 2A.
Q38161364Regulation of autophagy by kinases
Q34995420Regulation of autophagy by mTOR-dependent and mTOR-independent pathways: autophagy dysfunction in neurodegenerative diseases and therapeutic application of autophagy enhancers.
Q27025162Regulation of cardiac autophagy by insulin-like growth factor 1
Q37765106Regulation of innate immune responses by autophagy-related proteins
Q36662357Regulation of nutrient-sensitive autophagy by uncoordinated 51-like kinases 1 and 2.
Q29614493Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress
Q27311465Regulators of autophagosome formation in Drosophila muscles
Q35096637Relieving autophagy and 4EBP1 from rapamycin resistance
Q38654396Remodeling of ER-exit sites initiates a membrane supply pathway for autophagosome biogenesis
Q41169241Research Progress on Mechanism of Podocyte Depletion in Diabetic Nephropathy.
Q97646299Research Progress on the Pathological Mechanisms of Podocytes in Diabetic Nephropathy
Q58079140Resistance to endocrine therapy in breast cancer: molecular mechanisms and future goals
Q37641525Resveratrol prevents rapamycin-induced upregulation of autophagy and selectively induces apoptosis in TSC2-deficient cells
Q24612235Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks
Q30512687Role of ATG8 and autophagy in programmed nuclear degradation in Tetrahymena thermophila
Q37919739Role of an intrinsically disordered conformation in AMPK-mediated phosphorylation of ULK1 and regulation of autophagy
Q38144288Role of autophagy in cancer prevention, development and therapy
Q35922012Role of autophagy in histone deacetylase inhibitor-induced apoptotic and nonapoptotic cell death
Q26749232Role of autophagy in megakaryocyte differentiation and platelet formation
Q64080622Role of autophagy in osteosarcoma
Q41116590Role of mammalian target of rapamycin signaling in autophagy and the neurodegenerative process using a senescence accelerated mouse-prone 8 model
Q37669247Roles for PI(3,5)P2 in nutrient sensing through TORC1.
Q88515019Roles for neuronal and glial autophagy in synaptic pruning during development
Q47745733Roles of Autophagy in Ischemic Heart Diseases and the Modulatory Effects of Chinese Herbal Medicine
Q28077896Roles of N-Myc and STAT interactor in cancer: From initiation to dissemination
Q38914374Roles of mTOR complexes in the kidney: implications for renal disease and transplantation.
Q38917412Roles of mitophagy in cellular physiology and development
Q110176308SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals
Q24320106SH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1 signaling
Q33757027STAT3 down regulates LC3 to inhibit autophagy and pancreatic cancer cell growth
Q46106014Salen-Mn compounds induces cell apoptosis in human prostate cancer cells through promoting AMPK activity and cell autophagy
Q28476186Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling
Q43208326Selective autophagy and Huntingtin: learning from disease
Q38722026Serine/Threonine Kinase Unc-51-like Kinase-1 (Ulk1) Phosphorylates the Co-chaperone Cell Division Cycle Protein 37 (Cdc37) and Thereby Disrupts the Stability of Cdc37 Client Proteins
Q37736687Sesamol Induces Human Hepatocellular Carcinoma Cells Apoptosis by Impairing Mitochondrial Function and Suppressing Autophagy
Q33684305Sestrin 1 ameliorates cardiac hypertrophy via autophagy activation
Q24300990Sestrin2 promotes Unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1
Q64885927Shen-Yuan-Dan Capsule Attenuates Atherosclerosis and Foam Cell Formation by Enhancing Autophagy and Inhibiting the PI3K/Akt/mTORC1 Signaling Pathway.
Q38111226Signal integration by mTORC1 coordinates nutrient input with biosynthetic output.
Q90589491Signaling networks in immunometabolism
Q34340780Signals from the lysosome: a control centre for cellular clearance and energy metabolism
Q38982072Silencing of EEF2K (eukaryotic elongation factor-2 kinase) reveals AMPK-ULK1-dependent autophagy in colon cancer cells
Q26749011Sirolimus and Everolimus Pathway: Reviewing Candidate Genes Influencing Their Intracellular Effects
Q33944130Skeletal muscle homeostasis in duchenne muscular dystrophy: modulating autophagy as a promising therapeutic strategy
Q34043851Skin healing and scale regeneration in fed and unfed sea bream, Sparus auratus.
Q57465065So Many Roads: the Multifaceted Regulation of Autophagy Induction
Q24612853Spatial regulation of the mTORC1 system in amino acids sensing pathway
Q28084945Sphingolipids as cell fate regulators in lung development and disease
Q41784281Src Family Kinase Inhibitor PP2 Induces LC3 Conversion in a Manner That is Uncoupled from Autophagy and Increases Apoptosis in Multidrug-Resistant Cells
Q58425656Starvation induces rapid degradation of selective autophagy receptors by endosomal microautophagy
Q90065524Starvation-induced autophagy via calcium-dependent TFEB dephosphorylation is suppressed by Shigyakusan
Q36023733Staying alive: metabolic adaptations to quiescence
Q35206722Stearoyl-CoA desaturase 1 activity is required for autophagosome formation
Q37041854Strategies Used by Bacteria to Grow in Macrophages
Q38050926Stress-induced self-cannibalism: on the regulation of autophagy by endoplasmic reticulum stress
Q37780207Stress-responsive sestrins link p53 with redox regulation and mammalian target of rapamycin signaling
Q37794096Stressin' Sestrins take an aging fight
Q92013467Structural Biology and Electron Microscopy of the Autophagy Molecular Machinery
Q36788728Structure and function of the ULK1 complex in autophagy
Q27700943Structure of the Atg101-Atg13 complex reveals essential roles of Atg101 in autophagy initiation
Q30378254Structure of the Human Atg13-Atg101 HORMA Heterodimer: an Interaction Hub within the ULK1 Complex.
Q39389338Suppressed translation and ULK1 degradation as potential mechanisms of autophagy limitation under prolonged starvation
Q38498596Suppression of autophagy by FIP200 deletion impairs DNA damage repair and increases cell death upon treatments with anticancer agents
Q35128818Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis
Q34697502Suppression of autophagy by FIP200 deletion leads to osteopenia in mice through the inhibition of osteoblast terminal differentiation.
Q60049861Suppression of mTORC1 activity in senescent Ras-transformed cells neither restores autophagy nor abrogates apoptotic death caused by inhibition of MEK/ERK kinases
Q47367395Systematic analysis of ATG13 domain requirements for autophagy induction.
Q52671436Systems-Level Feedbacks of NRF2 Controlling Autophagy upon Oxidative Stress Response.
Q45256565TFEB and TFE3: The art of multi-tasking under stress conditions
Q33649816TOR is a negative regulator of autophagy in Arabidopsis thaliana
Q33787702TOR-dependent control of autophagy: biting the hand that feeds
Q39411030TORC1-Dependent Phosphorylation Targets in Fission Yeast
Q33784625TRPC5-induced autophagy promotes drug resistance in breast carcinoma via CaMKKβ/AMPKα/mTOR pathway
Q47100954Targeted elimination of senescent Ras-transformed cells by suppression of MEK/ERK pathway
Q35138543Targeting Rb inactivation in cancers by synthetic lethality.
Q59353835Targeting autophagy in liver cancer
Q91480154Targeting autophagy using natural compounds for cancer prevention and therapy
Q38607849Targeting molecules to medicine with mTOR, autophagy and neurodegenerative disorders
Q37610497Targeting tissue-specific metabolic signaling pathways in aging: the promise and limitations
Q35812423Telomerase deficiency delays renal recovery in mice after ischemia-reperfusion injury by impairing autophagy
Q46508073The ATG1/ATG13 protein kinase complex is both a regulator and a target of autophagic recycling in Arabidopsis
Q41619017The Activation and Function of Autophagy in Alcoholic Liver Disease
Q40121425The Atg1-kinase complex tethers Atg9-vesicles to initiate autophagy
Q38698993The Atg17-Atg31-Atg29 Complex Coordinates with Atg11 to Recruit the Vam7 SNARE and Mediate Autophagosome-Vacuole Fusion
Q44464070The C. elegans ATG101 homolog EPG-9 directly interacts with EPG-1/Atg13 and is essential for autophagy
Q30235555The Complex Roles of Mechanistic Target of Rapamycin in Adipocytes and Beyond
Q84315437The ER stress sensor IRE1 and MAP kinase ERK modulate autophagy induction in cells infected with coronavirus infectious bronchitis virus
Q89496691The Emerging Role of Sestrin2 in Cell Metabolism, and Cardiovascular and Age-Related Diseases
Q35808638The Emerging Roles of Viroporins in ER Stress Response and Autophagy Induction during Virus Infection
Q90283881The Emerging Roles of mTORC1 in Macromanaging Autophagy
Q26777018The Function of Autophagy in Neurodegenerative Diseases
Q90704578The Impairments of α-Synuclein and Mechanistic Target of Rapamycin in Rotenone-Induced SH-SY5Y Cells and Mice Model of Parkinson's Disease
Q27718642The Intrinsically Disordered Protein Atg13 Mediates Supramolecular Assembly of Autophagy Initiation Complexes
Q30502008The LC3 recruitment mechanism is separate from Atg9L1-dependent membrane formation in the autophagic response against Salmonella
Q91692839The Lysosome Signaling Platform: Adapting With the Times
Q26742170The Mucosal Immune System and Its Regulation by Autophagy
Q37194679The Noncanonical Role of ULK/ATG1 in ER-to-Golgi Trafficking Is Essential for Cellular Homeostasis
Q28117863The PtdIns3-phosphatase MTMR3 interacts with mTORC1 and suppresses its activity
Q64930743The Role of Autophagy in Liver Epithelial Cells and Its Impact on Systemic Homeostasis.
Q39223884The Role of Autophagy in Subarachnoid Hemorrhage: An Update.
Q64092333The Role of Primary Cilia in the Crosstalk between the Ubiquitin⁻Proteasome System and Autophagy
Q38714678The TOR Signaling Pathway in Spatial and Temporal Control of Cell Size and Growth
Q42002950The Three Musketeers of Autophagy: phosphorylation, ubiquitylation and acetylation
Q37386075The Tor and PKA signaling pathways independently target the Atg1/Atg13 protein kinase complex to control autophagy
Q38780596The ULK1 complex mediates MTORC1 signaling to the autophagy initiation machinery via binding and phosphorylating ATG14.
Q38072216The ULK1 complex: sensing nutrient signals for autophagy activation.
Q91962615The Upstream Pathway of mTOR-Mediated Autophagy in Liver Diseases
Q33745164The association of AMPK with ULK1 regulates autophagy
Q52687668The autophagic network and cancer.
Q98286415The autophagy adaptor NDP52 and the FIP200 coiled-coil allosterically activate ULK1 complex membrane recruitment
Q37888463The autophagy conundrum in cancer: influence of tumorigenic metabolic reprogramming
Q47663963The autophagy-inducing kinases, ULK1 and ULK2, regulate axon guidance in the developing mouse forebrain via a noncanonical pathway
Q26749374The autophagy-lysosomal system in subarachnoid haemorrhage
Q41851030The bacterial and cellular determinants controlling the recruitment of mTOR to the Salmonella-containing vacuole
Q26865666The beginning of the end: how scaffolds nucleate autophagosome biogenesis
Q57021022The cargo receptor SQSTM1 ameliorates neurofibrillary tangle pathology and spreading through selective targeting of pathological MAPT (microtubule associated protein tau)
Q92952207The circadian rhythm in intervertebral disc degeneration: an autophagy connection
Q35298106The complex interplay between autophagy and NF-κB signaling pathways in cancer cells
Q34252212The complex interplay between autophagy, apoptosis, and necrotic signals promotes T-cell homeostasis
Q52682539The deubiquitinating enzyme USP20 stabilizes ULK1 and promotes autophagy initiation.
Q34191643The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy
Q37781878The elimination of accumulated and aggregated proteins: a role for aggrephagy in neurodegeneration
Q33894424The emerging role of autophagy in alcoholic liver disease.
Q38166578The emerging role of the phosphatidylinositol 3-kinase/ akt/mammalian target of rapamycin signaling network in cancer stem cell biology
Q90482001The functions and properties of cullin-5, a potential therapeutic target for cancers
Q35146049The identification and analysis of phosphorylation sites on the Atg1 protein kinase.
Q38196807The impact of autophagy on cell death modalities.
Q37993106The incredible ULKs
Q89395265The independence of and associations among apoptosis, autophagy, and necrosis
Q38062538The interplay between autophagy and ROS in tumorigenesis
Q90345270The interplay of autophagy and enterovirus
Q33727929The intestinal TORC2 signaling pathway contributes to associative learning in Caenorhabditis elegans
Q38122224The kinase triad, AMPK, mTORC1 and ULK1, maintains energy and nutrient homoeostasis
Q37831801The long and winding road to rational treatment of cancer associated with LKB1/AMPK/TSC/mTORC1 signaling
Q33928657The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling.
Q38173673The machinery of macroautophagy
Q47301180The mammalian ULK1 complex and autophagy initiation.
Q38254507The molecular mechanisms between autophagy and apoptosis: potential role in central nervous system disorders.
Q37840892The multiple roles of autophagy in cancer
Q36418450The nutrient-responsive transcription factor TFE3 promotes autophagy, lysosomal biogenesis, and clearance of cellular debris
Q38559901The opposing actions of target of rapamycin and AMP-activated protein kinase in cell growth control
Q38889413The pathophysiology of defective proteostasis in the hypothalamus - from obesity to ageing
Q33720239The pleiotropic roles of sphingolipid signaling in autophagy
Q39957350The putative HORMA domain protein Atg101 dimerizes and is required for starvation-induced and selective autophagy in Drosophila.
Q36698649The regulation of autophagy during exercise in skeletal muscle
Q38740000The renewed battle against RAS-mutant cancers
Q35146045The requirement of uncoordinated 51-like kinase 1 (ULK1) and ULK2 in the regulation of autophagy
Q41339988The role of autophagy in hepatocellular carcinoma: friend or foe.
Q90295253The role of autophagy in intestinal epithelial injury
Q26851073The role of autophagy in the pathogenesis of diabetic nephropathy
Q34317238The role of autophagy in the placenta as a regulator of cell death
Q37954130The role of mammalian target of rapamycin (mTOR) in the regulation of pancreatic β-cell mass: implications in the development of type-2 diabetes.
Q38655147The role of mechanistic target of rapamycin in maintenance of glomerular epithelial cells
Q38199772The role of mitochondria in mTOR-regulated longevity
Q41470238The role of the selective adaptor p62 and ubiquitin-like proteins in autophagy.
Q34347017The role of ubiquitin in autophagy-dependent protein aggregate processing
Q50335546The serine/threonine kinase ULK1 is a target of multiple phosphorylation events.
Q34535073The ubiquitin-proteasome system and autophagy: Coordinated and independent activities
Q40051484Therapeutic Implications of Autophagy Inducers in Immunological Disorders, Infection, and Cancer
Q38176862Therapeutic potential and adverse events of everolimus for treatment of hepatocellular carcinoma - systematic review and meta-analysis
Q38648562Therapeutic potential of mTOR inhibitors for targeting cancer stem cells
Q37236107Therapeutic targeting of autophagy in disease: biology and pharmacology
Q27021382Therapeutic targeting of autophagy in neurodegenerative and infectious diseases
Q26830282Therapeutic targeting of autophagy: potential and concerns in treating cardiovascular disease
Q49886970To be or not to be cell autonomous? Autophagy says both
Q38809310To eat, or NOt to eat: S-nitrosylation signaling in autophagy.
Q33627273Tor directly controls the Atg1 kinase complex to regulate autophagy
Q38344277Transcription factors and cognate signalling cascades in the regulation of autophagy
Q91942557Transcriptional Regulation of Autophagy: Mechanisms and Diseases
Q37572139Transcriptional activation of TFEB/ZKSCAN3 target genes underlies enhanced autophagy in spinobulbar muscular atrophy
Q36034647Transcriptional control of circadian metabolic rhythms in the liver
Q38953220Transient overexpression of Werner protein rescues starvation induced autophagy in Werner syndrome cells
Q47103021Transiently expressed ATG16L1 inhibits autophagosome biogenesis and aberrantly targets RAB11-positive recycling endosomes
Q47108526Triptolide Restores Autophagy to Alleviate Diabetic Renal Fibrosis through the miR-141-3p/PTEN/Akt/mTOR Pathway
Q24632884Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly
Q36049513Tuberous sclerosis complex 2 loss increases lysophosphatidylcholine synthesis in lymphangioleiomyomatosis.
Q42136875Tumor suppression and promotion by autophagy
Q34199557Tumorigenesis in tuberous sclerosis complex is autophagy and p62/sequestosome 1 (SQSTM1)-dependent
Q42366609Tunicamycin induced endoplasmic reticulum stress promotes apoptosis of prostate cancer cells by activating mTORC1.
Q24649645ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery
Q96950740ULK1 and ULK2 are less redundant than previously thought: computational analysis uncovers distinct regulation and functions of these autophagy induction proteins
Q34728044ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase.
Q41953170ULK1 inhibits mTORC1 signaling, promotes multisite Raptor phosphorylation and hinders substrate binding
Q38976176ULK1 inhibits the kinase activity of mTORC1 and cell proliferation
Q50286492ULK1 phosphorylates ATG13 and RB1CC1
Q91769899ULK1 phosphorylates Mad1 to regulate spindle assembly checkpoint
Q36367255ULK1 phosphorylates Sec23A and mediates autophagy-induced inhibition of ER-to-Golgi traffic.
Q47219778ULK1 phosphorylates Ser30 of BECN1 in association with ATG14 to stimulate autophagy induction.
Q34805831ULK1, mammalian target of rapamycin, and mitochondria: linking nutrient availability and autophagy
Q38261262UNC51-like kinase 1, autophagic regulator and cancer therapeutic target
Q36650365Ubiquilin-mediated Small Molecule Inhibition of Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling
Q35667361Unbreak my heart: targeting mitochondrial autophagy in diabetic cardiomyopathy
Q47442783Uncoordinated 51-like kinase 2 signaling pathway regulates epithelial-mesenchymal transition in A549 lung cancer cells
Q92613379Understanding the role of key amino acids in regulation of proline dehydrogenase/proline oxidase (prodh/pox)-dependent apoptosis/autophagy as an approach to targeted cancer therapy
Q26382049Unified theory of Alzheimer's disease (UTAD): implications for prevention and curative therapy
Q38810023Unraveling the actions of AMP-activated protein kinase in metabolic diseases: Systemic to molecular insights
Q38198765Unravelling the multifaceted roles of Atg proteins to improve cancer therapy
Q40994687Upregulation of autophagy components in alcoholic hepatitis and nonalcoholic steatohepatitis
Q35210639Upregulation of human autophagy-initiation kinase ULK1 by tumor suppressor p53 contributes to DNA-damage-induced cell death
Q37448146Vesicular trafficking and autophagosome formation
Q27491341Viruses and autophagy
Q37501726Voluntary resistance wheel exercise from mid-life prevents sarcopenia and increases markers of mitochondrial function and autophagy in muscles of old male and female C57BL/6J mice.
Q30854841WIPI3 and WIPI4 β-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy
Q35965763WISP1 (CCN4) autoregulates its expression and nuclear trafficking of β-catenin during oxidant stress with limited effects upon neuronal autophagy
Q41853953When autophagy meets cancer through p62/SQSTM1.
Q37791919When autophagy meets viruses: a double-edged sword with functions in defense and offense
Q28305068Where is mTOR and what is it doing there?
Q41312189Withdrawal of essential amino acids increases autophagy by a pathway involving Ca2+/calmodulin-dependent kinase kinase-β (CaMKK-β)
Q46621260Ypt1 and COPII vesicles act in autophagosome biogenesis and the early secretory pathway
Q37831557Zebrafish as a model to understand autophagy and its role in neurological disease
Q54577849[« Self-eating » to survive - coordinated regulation of autophagy by nutrients].
Q48530866mTOR Cross-Talk in Cancer and Potential for Combination Therapy.
Q37771869mTOR Mediated Anti-Cancer Drug Discovery
Q49259139mTOR Pathways in Cancer and Autophagy
Q33962054mTOR Signaling from Cellular Senescence to Organismal Aging
Q64274877mTOR Signaling in Cancer and mTOR Inhibitors in Solid Tumor Targeting Therapy
Q27007511mTOR Signaling in Protein Translation Regulation: Implications in Cancer Genesis and Therapeutic Interventions
Q40771740mTOR activates the VPS34-UVRAG complex to regulate autolysosomal tubulation and cell survival
Q33942076mTOR and lysosome regulation
Q90854370mTOR as a central hub of nutrient signalling and cell growth
Q92643974mTOR at the nexus of nutrition, growth, ageing and disease
Q38199194mTOR complex 1: a key player in neuroadaptations induced by drugs of abuse
Q36189549mTOR coordinates protein synthesis, mitochondrial activity and proliferation
Q37667610mTOR enhances foam cell formation by suppressing the autophagy pathway
Q41792378mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6.
Q38814395mTOR kinase inhibitor pp242 causes mitophagy terminated by apoptotic cell death in E1A-Ras transformed cells
Q29616301mTOR regulation of autophagy
Q29619857mTOR signaling at a glance
Q38229078mTOR signaling in T cell immunity and autoimmunity
Q38184060mTOR signaling in autophagy regulation in the kidney
Q24634174mTOR signaling in growth control and disease
Q38057633mTOR signaling in neural stem cells: from basic biology to disease
Q37693034mTOR's role in ageing: protein synthesis or autophagy?
Q42790841mTOR, AMBRA1, and autophagy: an intricate relationship
Q60800989mTOR-Related Brain Dysfunctions in Neuropsychiatric Disorders
Q24294367mTOR-dependent abnormalities in autophagy characterize human malformations of cortical development: evidence from focal cortical dysplasia and tuberous sclerosis
Q26864688mTOR-dependent cell survival mechanisms
Q28078490mTOR: An attractive therapeutic target for osteosarcoma?
Q38345168mTOR: a pharmacologic target for autophagy regulation
Q28087019mTOR: a potential therapeutic target in osteoarthritis?
Q24633662mTOR: from growth signal integration to cancer, diabetes and ageing
Q52357229mTORC1 and Nutrient Homeostasis: The Central Role of the Lysosome.
Q36005418mTORC1 is essential for leukemia propagation but not stem cell self-renewal
Q35007765mTORC1 phosphorylates UVRAG to negatively regulate autophagosome and endosome maturation
Q37166913mTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin
Q27012468mTORC1 signaling activates NRF1 to increase cellular proteasome levels
Q39243905mTORC1 signaling and the metabolic control of cell growth
Q39256910mTORC1 signaling in hepatic lipid metabolism
Q37817590mTORC1 signaling: what we still don't know
Q37929699mTORC1- and mTORC2-interacting proteins keep their multifunctional partners focused.
Q55413938miR-519a enhances chemosensitivity and promotes autophagy in glioblastoma by targeting STAT3/Bcl2 signaling pathway.
Q98513731p27 controls Ragulator and mTOR activity in amino acid-deprived cells to regulate the autophagy-lysosomal pathway and coordinate cell cycle and cell growth
Q47292147p38 MAPK inhibits autophagy and promotes microglial inflammatory responses by phosphorylating ULK1.
Q28508630p62 Targeting to the autophagosome formation site requires self-oligomerization but not LC3 binding
Q33738032p62/SQSTM1 synergizes with autophagy for tumor growth in vivo
Q36022303α-Solanine induces ROS-mediated autophagy through activation of endoplasmic reticulum stress and inhibition of Akt/mTOR pathway.

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