Mechanism and Regulation of Autophagy and Its Role in Neuronal Diseases

scientific article

Mechanism and Regulation of Autophagy and Its Role in Neuronal Diseases is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1007629080
P356DOI10.1007/S12035-014-8921-4
P698PubMed publication ID25316381

P2093author name stringZhiping Hu
Han Xiao
Binbin Yang
Xiaoye Mo
P2860cites workAutophagy protects neuron from Abeta-induced cytotoxicityQ39875550
Autophagy inhibition compromises degradation of ubiquitin-proteasome pathway substrates.Q39878605
A dual role of p53 in the control of autophagyQ39964629
Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking.Q39972493
The Beclin 1 interactomeQ40011745
Autophagy promotes survival of retinal ganglion cells after optic nerve axotomy in mice.Q40213268
Depletion of type IA regulatory subunit (RIalpha) of protein kinase A (PKA) in mammalian cells and tissues activates mTOR and causes autophagic deficiencyQ40233725
The proteasome participates in degradation of mutant alpha 1-antitrypsin Z in the endoplasmic reticulum of hepatoma-derived hepatocytesQ40778050
Mitochondrial clearance is regulated by Atg7-dependent and -independent mechanisms during reticulocyte maturationQ41819102
Akt suppresses retrograde degeneration of dopaminergic axons by inhibition of macroautophagyQ41861209
Autophagy activation and enhanced mitophagy characterize the Purkinje cells of pcd mice prior to neuronal deathQ41862071
Inhibition of autophagy induction delays neuronal cell loss caused by dysfunctional ESCRT-III in frontotemporal dementiaQ41909984
Novel targets for Huntington's disease in an mTOR-independent autophagy pathwayQ41978909
Autophagy aids membrane expansion by neuropathic Schwann cellsQ42030227
Autophagy is required for preconditioning by the adenosine A1 receptor-selective agonist CCPA.Q42032448
Mutant A53T α-Synuclein Induces Neuronal Death by Increasing Mitochondrial AutophagyQ42089641
Changes in the proteolytic activities of proteasomes and lysosomes in human fibroblasts produced by serum withdrawal, amino-acid deprivation and confluent conditionsQ42157082
Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activationQ42472879
AMP-activated protein kinase: a universal regulator of autophagy?Q42511676
p53: The Janus of autophagy?Q42549018
Parkin mediates beclin-dependent autophagic clearance of defective mitochondria and ubiquitinated A in AD modelsQ42729244
Autophagy was activated in injured astrocytes and mildly decreased cell survival following glucose and oxygen deprivation and focal cerebral ischemiaQ43007194
Dynein- and activity-dependent retrograde transport of autophagosomes in neuronal axonsQ43164584
Nutrient deprivation induces neuronal autophagy and implicates reduced insulin signaling in neuroprotective autophagy activationQ43195965
V-ATPase engagement in autophagic processesQ43653039
Expression of A53T Mutant But Not Wild-Type α-Synuclein in PC12 Cells Induces Alterations of the Ubiquitin-Dependent Degradation System, Loss of Dopamine Release, and Autophagic Cell DeathQ43819951
Role of proteasomes in the degradation of short-lived proteins in human fibroblasts under various growth conditionsQ44388304
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factorQ22009126
Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation updateQ22252904
Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5pQ24292251
Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesisQ24294860
Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranesQ24300526
Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomesQ24301020
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acidsQ24306330
Dynamic and transient interactions of Atg9 with autophagosomes, but not membrane integration, are required for autophagy.Q24310187
Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagyQ24310301
The mouse APG10 homologue, an E2-like enzyme for Apg12p conjugation, facilitates MAP-LC3 modificationQ24312905
Ambra1 regulates autophagy and development of the nervous systemQ24313508
Atg101, a novel mammalian autophagy protein interacting with Atg13Q24314434
Parkin is recruited selectively to impaired mitochondria and promotes their autophagyQ24317471
DAP1, a novel substrate of mTOR, negatively regulates autophagyQ24318729
Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stagesQ24318814
DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagyQ24323360
TBC1D14 regulates autophagosome formation via Rab11- and ULK1-positive recycling endosomesQ24324535
AMPK phosphorylation of raptor mediates a metabolic checkpointQ24329244
Atg17 functions in cooperation with Atg1 and Atg13 in yeast autophagyQ24523548
Characterization of an ERAD gene as VPS30/ATG6 reveals two alternative and functionally distinct protein quality control pathways: one for soluble Z variant of human alpha-1 proteinase inhibitor (A1PiZ) and another for aggregates of A1PiZ.Q24537406
Molecules and their functions in autophagyQ24622004
Regulation of the autophagy protein LC3 by phosphorylationQ24627351
Exome sequencing reveals VCP mutations as a cause of familial ALSQ24631513
Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairmentsQ24633947
The Atg16L complex specifies the site of LC3 lipidation for membrane biogenesis in autophagyQ24647053
Organization of the pre-autophagosomal structure responsible for autophagosome formationQ24647076
Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathyQ33670282
Cargo recognition failure is responsible for inefficient autophagy in Huntington's diseaseQ33814719
Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's diseaseQ33832866
The coordinate regulation of the p53 and mTOR pathways in cellsQ33840457
Inhibiting the ubiquitin-proteasome system leads to preferential accumulation of toxic N-terminal mutant huntingtin fragmentsQ33878287
Autophagy Promotes Oligodendrocyte Survival and Function following Dysmyelination in a Long-Lived Myelin MutantQ34027494
Inducing Autophagy by Rapamycin Before, but Not After, the Formation of Plaques and Tangles Ameliorates Cognitive DeficitsQ34043165
Induction of autophagy contributes to the neuroprotection of nicotinamide phosphoribosyltransferase in cerebral ischemiaQ34082412
A small-molecule scaffold induces autophagy in primary neurons and protects against toxicity in a Huntington disease model.Q34165508
Autophagosome Precursor Maturation Requires Homotypic FusionQ34203070
Peptide sequences that target cytosolic proteins for lysosomal proteolysisQ34229121
Propofol Prevents Autophagic Cell Death following Oxygen and Glucose Deprivation in PC12 Cells and Cerebral Ischemia-Reperfusion Injury in RatsQ34235629
Macroautophagy is not directly involved in the metabolism of amyloid precursor proteinQ34333621
Autophagic cell death and its execution by lysosomal cathepsinsQ34383536
Inhibition of Autophagy Contributes to Ischemic Postconditioning-Induced Neuroprotection against Focal Cerebral Ischemia in RatsQ34430798
IGF-I stimulates Rab7-RILP interaction during neuronal autophagyQ34522743
Autophagy and its possible roles in nervous system diseases, damage and repairQ34552018
JNK regulates FoxO-dependent autophagy in neuronsQ34588421
Consequences of the selective blockage of chaperone-mediated autophagyQ34596028
Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinaseQ34601234
Discovery of Atg5/Atg7-independent alternative macroautophagyQ34612369
The mitochondrial-lysosomal axis theory of aging: accumulation of damaged mitochondria as a result of imperfect autophagocytosisQ34621569
Small molecules enhance autophagy and reduce toxicity in Huntington's disease models.Q34626231
HDAC6 at the intersection of autophagy, the ubiquitin-proteasome system and neurodegenerationQ34697419
A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagyQ34962715
α-Synuclein impairs macroautophagy: implications for Parkinson's disease.Q35005567
An Atg9-containing compartment that functions in the early steps of autophagosome biogenesisQ35005592
Mutant fibrinogen cleared from the endoplasmic reticulum via endoplasmic reticulum-associated protein degradation and autophagy: an explanation for liver diseaseQ35088205
Ischemic tolerance and endogenous neuroprotectionQ35126696
Accumulation of p62 in degenerated spinal cord under chronic mechanical compression: functional analysis of p62 and autophagy in hypoxic neuronal cellsQ35782367
Neuronal Functions of ESCRTsQ35803312
Two ubiquitin-like conjugation systems essential for autophagyQ35812443
Autophagy, proteasomes, lipofuscin, and oxidative stress in the aging brain.Q35869366
Methods for monitoring autophagyQ35869399
α-Synuclein Is Degraded by Both Autophagy and the ProteasomeQ44420467
The influence of age on apoptotic and other mechanisms of cell death after cerebral hypoxia-ischemia.Q45183594
HspB8 participates in protein quality control by a non-chaperone-like mechanism that requires eIF2{alpha} phosphorylationQ45292128
Rapamycin alleviates toxicity of different aggregate-prone proteinsQ45299514
Studies on brain biopsies of patients with Huntington's choreaQ45300907
Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein.Q45303665
A stress sensitive ER membrane-association domain in Huntingtin protein defines a potential role for Huntingtin in the regulation of autophagyQ45306898
In search of an "autophagomometer".Q46027342
The pharmacology of mTOR inhibitionQ46041824
Protective role of autophagy in neonatal hypoxia-ischemia induced brain injuryQ46400463
Autophagy activation is associated with neuroprotection in a rat model of focal cerebral ischemic preconditioningQ48232821
Huntington diseaseQ48465200
Glia-specific activation of all pathways of the unfolded protein response in vanishing white matter diseaseQ48476941
The neuronal endoplasmic reticulum: Its cytochemistry and contribution to the endomembrane system. II. Axons and terminalsQ48597620
Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease.Q48806014
Dual role of Atg1 in regulation of autophagy-specific PAS assembly in Saccharomyces cerevisiaeQ51954164
How shall I eat thee?Q51983235
Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy studyQ53369656
“Phagocytic” Lysosomes in Chromatolytic NeuronesQ59054498
A light and electron microscopic study of the cellular response to axonal injury in the superior cervical ganglion of the ratQ68765067
Inhibition of protein synthesis separates autophagic sequestration from the delivery of lysosomal enzymesQ70501367
Retention of mutant alpha(1)-antitrypsin Z in endoplasmic reticulum is associated with an autophagic responseQ73127387
Altered macroautophagy in the spinal cord of SOD1 mutant miceQ80496792
Increased autophagy in transgenic mice with a G93A mutant SOD1 geneQ80774356
Microautophagy in the yeast Saccharomyces cerevisiaeQ81121792
Intracellular inclusions containing mutant alpha1-antitrypsin Z are propagated in the absence of autophagic activityQ81645189
Severe Global Cerebral Ischemia-Induced Programmed Necrosis of Hippocampal CA1 Neurons in Rat Is Prevented by 3-Methyladenine: A Widely Used Inhibitor of AutophagyQ83632609
Huntington's DiseaseQ83728053
Autophagy in Spinal Cord Motor Neurons in Sporadic Amyotrophic Lateral SclerosisQ83843572
Autophagosome formation in mammalian cellsQ84807096
HMGB1: A novel Beclin 1-binding protein active in autophagyQ85176562
ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machineryQ24649645
Regulation of autophagy by cytoplasmic p53Q24651258
ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagyQ24654787
XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagyQ24655821
Tau fragmentation, aggregation and clearance: the dual role of lysosomal processingQ24656204
Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4Q24670840
Regulation of autophagy by extracellular signal-regulated protein kinases during 1-methyl-4-phenylpyridinium-induced cell deathQ24676936
Tor-mediated induction of autophagy via an Apg1 protein kinase complexQ24685670
Autophagy modulation as a potential therapeutic target for diverse diseasesQ27010076
TOR signaling in growth and metabolismQ27860757
Autophagy fights disease through cellular self-digestionQ27860902
Hierarchy of Atg proteins in pre-autophagosomal structure organizationQ27931408
Atg9 cycles between mitochondria and the pre-autophagosomal structure in yeastsQ27931774
Retromer function in endosome-to-Golgi retrograde transport is regulated by the yeast Vps34 PtdIns 3-kinaseQ27932803
The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagyQ27933717
Apg9p/Cvt7p is an integral membrane protein required for transport vesicle formation in the Cvt and autophagy pathwaysQ27935410
Cdk5-mediated phosphorylation of endophilin B1 is required for induced autophagy in models of Parkinson's diseaseQ28115581
ESCRT-III dysfunction causes autophagosome accumulation and neurodegenerationQ28117494
Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagyQ28131727
Suppression of basal autophagy in neural cells causes neurodegenerative disease in miceQ28131756
Loss of autophagy in the central nervous system causes neurodegeneration in miceQ28131804
A novel protein complex linking the delta 2 glutamate receptor and autophagy: implications for neurodegeneration in lurcher miceQ28206164
Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington diseaseQ28261987
Inositol trisphosphate and calcium signallingQ28262867
Roles of LAMP-1 and LAMP-2 in lysosome biogenesis and autophagyQ28263676
The roles of intracellular protein-degradation pathways in neurodegenerationQ28269322
The Beclin 1-VPS34 complex--at the crossroads of autophagy and beyondQ28278349
Autophagy and signaling: their role in cell survival and cell deathQ28278893
Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1Q28300820
The ubiquitin-proteasome systemQ28305844
Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1Q28505561
Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutationsQ28506710
Microautophagy of cytosolic proteins by late endosomesQ28509224
Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degenerationQ28509904
Neuronal injury in rat model of permanent focal cerebral ischemia is associated with activation of autophagic and lysosomal pathwaysQ28573254
The pancreatitis-induced vacuole membrane protein 1 triggers autophagy in mammalian cellsQ28579032
Induction of autophagy in axonal dystrophy and degenerationQ28589924
The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in miceQ28591283
Involvement of Beclin 1 in engulfment of apoptotic cellsQ28592745
Autophagy: Renovation of Cells and TissuesQ29547206
p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell deathQ29547297
Regulation mechanisms and signaling pathways of autophagyQ29547416
Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagyQ29614178
Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAGQ29614477
JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagyQ29614479
FoxO3 controls autophagy in skeletal muscle in vivoQ29614483
Mitochondria supply membranes for autophagosome biogenesis during starvationQ29614495
A role for ubiquitin in selective autophagyQ29614499
Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulumQ29614500
Impairment of the ubiquitin-proteasome system by protein aggregationQ29614556
An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1Q29614563
DRAM, a p53-induced modulator of autophagy, is critical for apoptosisQ29616308
Isolation of autophagocytosis mutants of Saccharomyces cerevisiaeQ29617037
A Unified Nomenclature for Yeast Autophagy-Related GenesQ29618950
Termination of autophagy and reformation of lysosomes regulated by mTORQ29619817
Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8Q29620200
PINK1-dependent recruitment of Parkin to mitochondria in mitophagyQ29620567
HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagyQ30014829
Autophagosomes initiate distally and mature during transport toward the cell soma in primary neuronsQ30425491
Deletion of the huntingtin polyglutamine stretch enhances neuronal autophagy and longevity in mice.Q30437121
A common mechanism of PLP/DM20 misfolding causes cysteine-mediated endoplasmic reticulum retention in oligodendrocytes and Pelizaeus-Merzbacher diseaseQ30480632
Starving neurons show sex difference in autophagy.Q30485524
The LC3 recruitment mechanism is separate from Atg9L1-dependent membrane formation in the autophagic response against SalmonellaQ30502008
Characterization of autophagosome formation site by a hierarchical analysis of mammalian Atg proteinsQ30512856
Atg9 vesicles are an important membrane source during early steps of autophagosome formationQ30523963
Small molecule regulators of autophagy identified by an image-based high-throughput screenQ33306309
Abberant alpha-synuclein confers toxicity to neurons in part through inhibition of chaperone-mediated autophagyQ33444800
Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP diseaseQ33589965
Regulation of amyloid precursor protein processing by the Beclin 1 complexQ33608732
Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseasesQ33613123
Autophagy and caspases: a new cell death program.Q35869843
Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viabilityQ35916071
Can autophagy protect against neurodegeneration caused by aggregate-prone proteins?Q35945776
Lysosomal Proteolysis Inhibition Selectively Disrupts Axonal Transport of Degradative Organelles and Causes an Alzheimer's-Like Axonal DystrophyQ35955959
Protein kinase A and Sch9 cooperatively regulate induction of autophagy in Saccharomyces cerevisiaeQ36017028
Stimulation of autophagy reduces neurodegeneration in a mouse model of human tauopathyQ36054214
Autophagy-mediated clearance of huntingtin aggregates triggered by the insulin-signaling pathwayQ36117201
Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative diseaseQ36119653
The pleiotropic role of autophagy: from protein metabolism to bactericide.Q36296171
Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's diseaseQ36320351
Dissection of autophagosome biogenesis into distinct nucleation and expansion stepsQ36326435
ATP-dependent conjugation of reticulocyte proteins with the polypeptide required for protein degradationQ36359536
Products of endocytosis and autophagy are retrieved from axons by regulated retrograde organelle transportQ36383118
The Atg1 kinase complex is involved in the regulation of protein recruitment to initiate sequestering vesicle formation for nonspecific autophagy in Saccharomyces cerevisiaeQ36438806
Autophagy and protein aggregation after brain ischemiaQ36455967
Maturation of autophagic vacuoles in Mammalian cellsQ36549471
Inhibition of autophagy prevents hippocampal pyramidal neuron death after hypoxic-ischemic injuryQ36559658
Autophagic vacuolar myopathy.Q36617474
Constitutive activation of chaperone-mediated autophagy in cells with impaired macroautophagyQ36631143
Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturationQ36835194
Autophagy in neuroprotection and neurodegeneration: A question of balance.Q36893822
A picky eater: exploring the mechanisms of selective autophagy in human pathologiesQ36995558
Autophagic neuron death in neonatal brain ischemia/hypoxiaQ37062794
Rab5 modulates aggregation and toxicity of mutant huntingtin through macroautophagy in cell and fly models of Huntington diseaseQ37083085
The selectivity of autophagy and its role in cell death and survivalQ37117371
Lost to translation: when autophagy targets mature ribosomesQ37174976
Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's diseaseQ37178375
Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathiesQ37219529
Huntington's disease: degradation of mutant huntingtin by autophagyQ37220135
Neuronal autophagy and neurodevelopmental disordersQ37251865
Liaisons dangereuses: autophagy, neuronal survival and neurodegenerationQ37289011
The cellular pathways of neuronal autophagy and their implication in neurodegenerative diseasesQ37336182
TOR-mediated autophagy regulates cell death in Drosophila neurodegenerative diseaseQ37342465
ESCRT, autophagy, and frontotemporal dementiaQ37362455
Nutrient-dependent regulation of autophagy through the target of rapamycin pathway.Q37368307
Intermittent fasting alleviates the neuropathic phenotype in a mouse model of Charcot-Marie-Tooth diseaseQ37377545
Selective types of autophagy in yeast.Q37407404
Regulation of the autophagic bcl-2/beclin 1 interaction.Q37512209
Autophagy in neurodegeneration: two sides of the same coinQ37532752
The role of autophagy on the survival of dopamine neuronsQ37597273
Macroautophagy signaling and regulationQ37608022
The life span-prolonging effect of sirtuin-1 is mediated by autophagyQ37659692
Mechanisms of cross-talk between the ubiquitin-proteasome and autophagy-lysosome systemsQ37664227
The role of autophagy: what can be learned from the genetic forms of amyotrophic lateral sclerosis.Q37734513
Beclin 1 complex in autophagy and Alzheimer diseaseQ37799464
Chaperone-mediated autophagy: machinery, regulation and biological consequencesQ37803152
Amyloid Precursor Protein Processing and Alzheimer's DiseaseQ37860317
Autophagy: for better or for worseQ37930982
Clinical genetics of amyotrophic lateral sclerosis: what do we really know?Q37944428
Clinical diagnosis and management of amyotrophic lateral sclerosisQ37944429
Mechanisms of Autophagosome BiogenesisQ37975364
Membrane trafficking pathways in Alzheimer's diseaseQ37978006
The crosstalk between autophagy and apoptosis: where does this lead?Q37982296
Selective autophagy in budding yeastQ38019315
Defective autophagy in Parkinson's disease: role of oxidative stress.Q38035191
Lysosome-dependent pathways as a unifying theme in Parkinson's disease.Q38038561
Autophagy and apoptosis dysfunction in neurodegenerative disordersQ38161278
A genome-wide siRNA screen reveals multiple mTORC1 independent signaling pathways regulating autophagy under normal nutritional conditionsQ39680852
Amyloid-beta1-42 induces reactive oxygen species-mediated autophagic cell death in U87 and SH-SY5Y cellsQ39689297
The small heat shock protein B8 (HspB8) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS).Q39689378
Inhibition of mammalian S6 kinase by resveratrol suppresses autophagyQ39739155
The cellular response to aggregated proteins associated with human diseaseQ39740034
The Parkinson-associated protein PINK1 interacts with Beclin1 and promotes autophagyQ39754547
A novel mTOR activating protein protects dopamine neurons against oxidative stress by repressing autophagy related cell deathQ39781400
Endoplasmic reticulum stress response as a potential therapeutic target in multiple sclerosisQ39848302
The inositol 1,4,5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1.Q39867616
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectautophagyQ288322
P304page(s)1190-1209
P577publication date2014-10-15
P13046publication type of scholarly workreview articleQ7318358
P1433published inMolecular NeurobiologyQ15716645
P1476titleMechanism and Regulation of Autophagy and Its Role in Neuronal Diseases
P478volume52

Reverse relations

cites work (P2860)
Q483631006-OHDA Induces Oxidation of F-box Protein Fbw7β by Chaperone-Mediated Autophagy in Parkinson's Model.
Q38883495Activation of Autophagy Contributes to the Angiotensin II-Triggered Apoptosis in a Dopaminergic Neuronal Cell Line
Q91970445Applications of genome editing technology in the targeted therapy of human diseases: mechanisms, advances and prospects
Q36294163Autophagy biomarkers in CSF correlates with infarct size, clinical severity and neurological outcome in AIS patients
Q38932738Autophagy core machinery: overcoming spatial barriers in neurons
Q30821147Clearance of autophagy-associated dying retinal pigment epithelial cells - a possible source for inflammation in age-related macular degeneration
Q39120563Deficiency in the Ubiquitin Conjugating Enzyme UBE2A in Alzheimer's Disease (AD) is Linked to Deficits in a Natural Circular miRNA-7 Sponge (circRNA; ciRS-7)
Q33875245Dexmedetomidine Protects Mouse Brain from Ischemia-Reperfusion Injury via Inhibiting Neuronal Autophagy through Up-Regulating HIF-1α
Q92698941Dual Role of Autophagy in Diseases of the Central Nervous System
Q51762070Filamentous Aggregation of Sequestosome-1/p62 in Brain Neurons and Neuroepithelial Cells upon Tyr-Cre-Mediated Deletion of the Autophagy Gene Atg7.
Q39992984Gadd45b prevents autophagy and apoptosis against rat cerebral neuron oxygen-glucose deprivation/reperfusion injury
Q88689463P2X7 Receptor-Associated Programmed Cell Death in the Pathophysiology of Hemorrhagic Stroke
Q40947659Poloxamer 188 Attenuates Cerebral Hypoxia/Ischemia Injury in Parallel with Preventing Mitochondrial Membrane Permeabilization and Autophagic Activation
Q55034943Protective Effects of Gastrodin Against Autophagy-Mediated Astrocyte Death.
Q58700287Rapamycin and fasting sustain autophagy response activated by ischemia/reperfusion injury and promote retinal ganglion cell survival
Q41621554Silibinin Prevents Autophagic Cell Death upon Oxidative Stress in Cortical Neurons and Cerebral Ischemia-Reperfusion Injury
Q41248721Tanshinone IIA Protects Hippocampal Neuronal Cells from Reactive Oxygen Species Through Changes in Autophagy and Activation of Phosphatidylinositol 3-Kinase, Protein Kinas B, and Mechanistic Target of Rapamycin Pathways
Q39223884The Role of Autophagy in Subarachnoid Hemorrhage: An Update.
Q92154033The activation of Mucolipin TRP channel 1 (TRPML1) protects motor neurons from L-BMAA neurotoxicity by promoting autophagic clearance

Search more.