Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication Interferes with mTORC1 Regulation of Autophagy and Viral Protein Synthesis

scientific article published on 15 October 2019

Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication Interferes with mTORC1 Regulation of Autophagy and Viral Protein Synthesis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/JVI.00854-19
P932PMC publication ID6803247
P698PubMed publication ID31375594

P50authorCraig McCormickQ42370548
P2093author name stringEric S Pringle
Carolyn-Ann Robinson
P2860cites workBeclin-1-interacting autophagy protein Atg14L targets the SNARE-associated protein Snapin to coordinate endocytic traffickingQ24293411
Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagyQ24310301
ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machineryQ24649645
ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagyQ24654787
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Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagyQ28131727
Defining the role of mTOR in cancerQ28235431
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Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomasQ28299069
Kaposi's sarcoma associated herpes virus (KSHV) induced COX-2: a key factor in latency, inflammation, angiogenesis, cell survival and invasionQ28472867
Rapamycin blocks production of KSHV/HHV8: insights into the anti-tumor activity of an immunosuppressant drugQ28476740
Viral activation of MK2-hsp27-p115RhoGEF-RhoA signaling axis causes cytoskeletal rearrangements, p-body disruption and ARE-mRNA stabilizationQ28543000
An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1Q29614563
Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's diseaseQ29619158
Termination of autophagy and reformation of lysosomes regulated by mTORQ29619817
Activation of p90 ribosomal S6 kinase by ORF45 of Kaposi's sarcoma-associated herpesvirus and its role in viral lytic replicationQ30441657
Histone deacetylase classes I and II regulate Kaposi's sarcoma-associated herpesvirus reactivationQ30570559
Activation of host translational control pathways by a viral developmental switchQ33419826
A viral gene that activates lytic cycle expression of Kaposi's sarcoma-associated herpesvirusQ33559699
Viral latency and its regulation: lessons from the gamma-herpesvirusesQ34039189
Viral profiling identifies multiple subtypes of Kaposi's sarcoma.Q34237734
Sirolimus for Kaposi's sarcoma in renal-transplant recipientsQ34556363
ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase.Q34728044
Global changes in Kaposi's sarcoma-associated virus gene expression patterns following expression of a tetracycline-inducible Rta transactivatorQ34782463
A unifying model for mTORC1-mediated regulation of mRNA translation.Q35945036
Non-autophagic roles of autophagy-related proteinsQ36594175
mTOR inhibitors block Kaposi sarcoma growth by inhibiting essential autocrine growth factors and tumor angiogenesisQ36745445
Constitutive Activation of mTORC1 in Endothelial Cells Leads to the Development and Progression of Lymphangiosarcoma through VEGF Autocrine SignalingQ36788733
A viral kinase mimics S6 kinase to enhance cell proliferationQ37102331
mTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycinQ37166913
Kaposi's sarcoma-associated herpesvirus K7 modulates Rubicon-mediated inhibition of autophagosome maturation.Q37254378
Differential role for host translation factors in host and viral protein synthesis during human cytomegalovirus infectionQ37547266
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AKTivation of PI3K/AKT/mTOR signaling pathway by KSHV.Q38073761
The scanning mechanism of eukaryotic translation initiationQ38185457
Human cytomegalovirus infection maintains mTOR activity and its perinuclear localization during amino acid deprivationQ38286086
Kaposi's Sarcoma-Associated Herpesvirus Utilizes and Manipulates RNA N6-Adenosine Methylation To Promote Lytic ReplicationQ38700916
The K1 Protein of Kaposi's Sarcoma-Associated Herpesvirus Augments Viral Lytic ReplicationQ38764215
A Cap-to-Tail Guide to mRNA Translation Strategies in Virus-Infected CellsQ38921764
KSHV microRNAs: Tricks of the Devil.Q39161558
Kaposi's sarcoma-derived cell line SLK is not of endothelial origin, but is a contaminant from a known renal carcinoma cell lineQ39276602
An oxygen-regulated switch in the protein synthesis machineryQ39335083
Generation of a doxycycline-inducible KSHV producer cell line of endothelial origin: maintenance of tight latency with efficient reactivation upon inductionQ39573744
Transcriptional activation by the product of open reading frame 50 of Kaposi's sarcoma-associated herpesvirus is required for lytic viral reactivation in B cellsQ39596534
Host Range of Kaposi's Sarcoma-Associated Herpesvirus in Cultured CellsQ39752549
HSV-1 ICP34.5 confers neurovirulence by targeting the Beclin 1 autophagy proteinQ40051258
The TSC2/mTOR pathway drives endothelial cell transformation induced by the Kaposi's sarcoma-associated herpesvirus G protein-coupled receptorQ40244438
Inefficient establishment of KSHV latency suggests an additional role for continued lytic replication in Kaposi sarcoma pathogenesis.Q40364647
Use of the red fluorescent protein as a marker of Kaposi's sarcoma-associated herpesvirus lytic gene expressionQ40537413
Lytic KSHV infection inhibits host gene expression by accelerating global mRNA turnoverQ40578287
In vivo-restricted and reversible malignancy induced by human herpesvirus-8 KSHV: a cell and animal model of virally induced Kaposi's sarcoma.Q41839438
A molecular network for de novo generation of the apical surface and lumenQ42116509
A unique herpesviral transcriptional program in KSHV-infected lymphatic endothelial cells leads to mTORC1 activation and rapamycin sensitivityQ42624833
FLIP-mediated autophagy regulation in cell death controlQ42832950
Centrifugal enhancement of Kaposi's sarcoma-associated virus infection of human endothelial cells in vitro.Q43405163
Accumulation of dephosphorylated 4EBP after mTOR inhibition with rapamycin is sufficient to disrupt paracrine transformation by the KSHV vGPCR oncogene.Q45746573
Viral and cellular N(6)-methyladenosine and N(6),2'-O-dimethyladenosine epitranscriptomes in the KSHV life cycle.Q45965685
m6A Facilitates eIF4F-Independent mRNA TranslationQ47436391
TORC1 and TORC2 converge to regulate the SAGA co-activator in response to nutrient availability.Q48111731
SUnSET, a nonradioactive method to monitor protein synthesis.Q51755635
N6-methyladenosine modification and the YTHDF2 reader protein play cell type specific roles in lytic viral gene expression during Kaposi's sarcoma-associated herpesvirus infection.Q54235221
Remodeling mTORC1 responsiveness to amino acids by the herpes simplex virus UL46 and Us3 gene products supports replication during nutrient insufficiencyQ57038993
Transcriptional and Epigenetic Regulation by the Mechanistic Target of Rapamycin Complex 1 PathwayQ57803942
Chromatin remodeling controls Kaposi's sarcoma-associated herpesvirus reactivation from latencyQ58744047
Differential and convergent utilization of autophagy components by positive-strand RNA virusesQ61053716
Targeting mTOR with MLN0128 Overcomes Rapamycin and Chemoresistant Primary Effusion LymphomaQ64258880
mTOR as a central hub of nutrient signalling and cell growthQ90854370
Kaposi sarcoma-associated herpesvirus miRNAs suppress CASTOR1-mediated mTORC1 inhibition to promote tumorigenesisQ91876872
Autophagy-Independent Functions of the Autophagy MachineryQ92752249
P433issue21
P921main subjectautophagyQ288322
P577publication date2019-10-15
P1433published inJournal of VirologyQ1251128
P1476titleKaposi's Sarcoma-Associated Herpesvirus Lytic Replication Interferes with mTORC1 Regulation of Autophagy and Viral Protein Synthesis
P478volume93

Reverse relations

Q104795052Targeting XPO1 enhances innate immune response and inhibits KSHV lytic replication during primary infection by nuclear stabilization of the p62 autophagy adaptor proteincites workP2860

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