Human cytomegalovirus infection maintains mTOR activity and its perinuclear localization during amino acid deprivation

scientific article published on 06 July 2011

Human cytomegalovirus infection maintains mTOR activity and its perinuclear localization during amino acid deprivation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/JVI.05102-11
P932PMC publication ID3165763
P698PubMed publication ID21734039

P2093author name stringJames C Alwine
Tobi G Maguire
Amy J Clippinger
P2860cites workNovel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag BQ24290501
Bicaudal D1-dependent trafficking of human cytomegalovirus tegument protein pp150 in virus-infected cellsQ24296677
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinaseQ24300915
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Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acidsQ24306330
RagA is a functional homologue of S. cerevisiae Gtr1p involved in the Ran/Gsp1-GTPase pathwayQ24311946
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1Q24315566
rheb, a growth factor- and synaptic activity-regulated gene, encodes a novel Ras-related proteinQ24316714
Insulin-stimulated kinase from rat fat cells that phosphorylates initiation factor 4E-binding protein 1 on the rapamycin-insensitive site (serine-111)Q24531289
The C terminus of initiation factor 4E-binding protein 1 contains multiple regulatory features that influence its function and phosphorylationQ24554323
Regulation of 4E-BP1 phosphorylation: a novel two-step mechanismQ24603034
Human cytomegalovirus infection alters the substrate specificities and rapamycin sensitivities of raptor- and rictor-containing complexesQ24676817
Human cytomegalovirus infection activates and regulates the unfolded protein responseQ27469611
Two motifs in the translational repressor PHAS-I required for efficient phosphorylation by mammalian target of rapamycin and for recognition by raptorQ28187391
The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stressesQ28240102
Identification of phosphorylation sites in the translational regulator, PHAS-I, that are controlled by insulin and rapamycin in rat adipocytesQ28307131
Regulation of TORC1 by Rag GTPases in nutrient responseQ29614478
Three-dimensional structure of the human cytomegalovirus cytoplasmic virion assembly complex includes a reoriented secretory apparatus.Q30480949
Spatial relationships between markers for secretory and endosomal machinery in human cytomegalovirus-infected cells versus those in uninfected cellsQ30501722
Evasion of cellular antiviral responses by human cytomegalovirus TRS1 and IRS1Q33195896
Regulation of host translational machinery by African swine fever virusQ33497920
Phosphorylation of the human cytomegalovirus 86-kilodalton immediate-early protein IE2.Q33784945
Replication of wild-type and mutant human cytomegalovirus in life-extended human diploid fibroblastsQ33787378
Accumulation of virion tegument and envelope proteins in a stable cytoplasmic compartment during human cytomegalovirus replication: characterization of a potential site of virus assemblyQ33796667
Human cytomegalovirus pp28 (UL99) localizes to a cytoplasmic compartment which overlaps the endoplasmic reticulum-golgi-intermediate compartmentQ33802787
Rapamycin-resistant mTORC1 kinase activity is required for herpesvirus replicationQ33826815
Regulation of the translation initiation factor eIF4F by multiple mechanisms in human cytomegalovirus-infected cellsQ33843314
Production of infectious human cytomegalovirus virions is inhibited by drugs that disrupt calcium homeostasis in the endoplasmic reticulumQ34228644
Coding potential of laboratory and clinical strains of human cytomegalovirusQ34388908
Human cytomegalovirus activates glucose transporter 4 expression to increase glucose uptake during infectionQ34529843
Modulation of host cell stress responses by human cytomegalovirusQ34797780
AMPK-mediated inhibition of mTOR kinase is circumvented during immediate-early times of human cytomegalovirus infectionQ35785196
Phosphorylation and dephosphorylation events that regulate viral mRNA translationQ36321340
Human cytomegalovirus specifically controls the levels of the endoplasmic reticulum chaperone BiP/GRP78, which is required for virion assemblyQ36423955
Interaction between simian virus 40 large T antigen and insulin receptor substrate 1 is disrupted by the K1 mutation, resulting in the loss of large T antigen-mediated phosphorylation of Akt.Q36540107
Eukaryotic translation initiation factor 4F architectural alterations accompany translation initiation factor redistribution in poxvirus-infected cellsQ36540315
hvps34, an ancient player, enters a growing game: mTOR Complex1/S6K1 signalingQ36744736
The TORrid affairs of viruses: effects of mammalian DNA viruses on the PI3K-Akt-mTOR signalling pathwayQ37003173
Reevaluation of human cytomegalovirus coding potential.Q37089601
Akt-dependent and -independent mechanisms of mTOR regulation in cancerQ37114404
Human cytomegalovirus protein pUL38 induces ATF4 expression, inhibits persistent JNK phosphorylation, and suppresses endoplasmic reticulum stress-induced cell deathQ37145200
Human cytomegalovirus protein UL38 inhibits host cell stress responses by antagonizing the tuberous sclerosis protein complexQ37380692
The endoplasmic reticulum chaperone BiP/GRP78 is important in the structure and function of the human cytomegalovirus assembly compartmentQ37410651
Human cytomegalovirus infection induces rapamycin-insensitive phosphorylation of downstream effectors of mTOR kinaseQ37567926
Binding and nuclear relocalization of protein kinase R by human cytomegalovirus TRS1.Q39321563
Distinct glycoprotein O complexes arise in a post-Golgi compartment of cytomegalovirus-infected cellsQ39682836
Role of the endoplasmic reticulum chaperone BiP, SUN domain proteins, and dynein in altering nuclear morphology during human cytomegalovirus infectionQ42113026
The changing role of mTOR kinase in the maintenance of protein synthesis during human cytomegalovirus infectionQ42779515
FKBP12-Rapamycin-associated Protein or Mammalian Target of Rapamycin (FRAP/mTOR) Localization in the Endoplasmic Reticulum and the Golgi ApparatusQ44631928
P433issue18
P407language of work or nameEnglishQ1860
P921main subjectCytomegalovirusQ6946
cytomegaloviral diseaseQ2076966
P304page(s)9369-9376
P577publication date2011-07-06
P1433published inJournal of VirologyQ1251128
P1476titleHuman cytomegalovirus infection maintains mTOR activity and its perinuclear localization during amino acid deprivation
P478volume85

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cites work (P2860)
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