Interaction between simian virus 40 large T antigen and insulin receptor substrate 1 is disrupted by the K1 mutation, resulting in the loss of large T antigen-mediated phosphorylation of Akt.

scientific article published on 27 February 2008

Interaction between simian virus 40 large T antigen and insulin receptor substrate 1 is disrupted by the K1 mutation, resulting in the loss of large T antigen-mediated phosphorylation of Akt. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/JVI.02365-07
P932PMC publication ID2293033
P698PubMed publication ID18305032

P2093author name stringJames C Alwine
Yongjun Yu
P2860cites workTyr(612) and Tyr(632) in human insulin receptor substrate-1 are important for full activation of insulin-stimulated phosphatidylinositol 3-kinase activity and translocation of GLUT4 in adipose cellsQ24291346
Phosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulationQ24293143
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complexQ24295120
Definition of the minimal simian virus 40 large T antigen- and adenovirus E1A-binding domain in the retinoblastoma gene productQ24304934
Association of insulin receptor substrate 1 with simian virus 40 large T antigenQ24307564
Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factorQ24648537
Structural basis of 3-phosphoinositide recognition by pleckstrin homology domainsQ27627006
Identification of a region of simian virus 40 large T antigen required for cell transformationQ28238857
SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility geneQ28281071
New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathwayQ28608965
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase BalphaQ28616168
Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase BQ28646131
Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretionQ29547317
Cellular survival: a play in three AktsQ29547806
Effects of simian virus 40 large and small tumor antigens on mammalian target of rapamycin signaling: small tumor antigen mediates hypophosphorylation of eIF4E-binding protein 1 late in infectionQ33788939
Antigenic and immunogenic characteristics of nuclear and membrane-associated simian virus 40 tumor antigen.Q33915246
SV40 large T antigen functions in DNA replication and transformationQ34070113
Human cytomegalovirus major immediate-early proteins and simian virus 40 large T antigen can inhibit apoptosis through activation of the phosphatidylinositide 3'-OH kinase pathway and the cellular kinase Akt.Q34336521
Simian virus 40 small tumor antigen activates AKT and telomerase and induces anchorage-independent growth of human epithelial cellsQ34349115
T antigens of simian virus 40: molecular chaperones for viral replication and tumorigenesisQ34662543
The pivotal role of phosphatidylinositol 3-kinase-Akt signal transduction in virus survivalQ35754596
Advances in protein kinase B signalling: AKTion on multiple frontsQ35766370
PI 3-kinase, Akt and cell survivalQ35812415
Critical role for scaffolding adapter Gab2 in Fc gamma R-mediated phagocytosisQ36323583
Role of pRb-related proteins in simian virus 40 large-T-antigen-mediated transformationQ36555544
Transcriptional activation by simian virus 40 large T antigen: requirements for simple promoter structures containing either TATA or initiator elements with variable upstream factor binding sitesQ36654471
Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene productQ37016112
IRS-1 activates phosphatidylinositol 3'-kinase by associating with src homology 2 domains of p85Q37276745
Protein phosphatase 2A negatively regulates insulin's metabolic signaling pathway by inhibiting Akt (protein kinase B) activity in 3T3-L1 adipocytesQ37515921
A complex between E2F and the pRb-related protein p130 is specifically targeted by the simian virus 40 large T antigen during cell transformationQ38294569
Cellular proteins reactive with monoclonal antibodies directed against simian virus 40 T-antigenQ40145588
Simian virus 40 T-antigen-related cell surface antigen: serological demonstration on simian virus 40-transformed monolayer cells in situQ40307810
Transformation by the simian virus 40 T antigen is regulated by IGF-I receptor and IRS-1 signalingQ40371756
Transcriptional regulation of AKT activation by E2F.Q40485951
Biochemical and biological responses induced by coupling of Gab1 to phosphatidylinositol 3-kinase in RET-expressing cellsQ40518438
Nuclear translocation of insulin receptor substrate-1 by the simian virus 40 T antigen and the activated type 1 insulin-like growth factor receptorQ40725478
mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytesQ42809294
SV40-transformed cells express SV40 T antigen-related antigens on the cell surfaceQ43749432
Nuclear translocation of insulin receptor substrate-1 by oncogenes and Igf-I. Effect on ribosomal RNA synthesisQ44119094
Cell and molecular biology of simian virus 40: implications for human infections and diseaseQ44314704
The cellular 107K protein that binds to adenovirus E1A also associates with the large T antigens of SV40 and JC virusQ45845654
Production and purification of lentiviral vectorsQ46172190
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
SV40Q734305
P304page(s)4521-4526
P577publication date2008-02-27
P1433published inJournal of VirologyQ1251128
P1476titleInteraction between simian virus 40 large T antigen and insulin receptor substrate 1 is disrupted by the K1 mutation, resulting in the loss of large T antigen-mediated phosphorylation of Akt.
P478volume82

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