Rapamycin is efficacious against primary effusion lymphoma (PEL) cell lines in vivo by inhibiting autocrine signaling

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Rapamycin is efficacious against primary effusion lymphoma (PEL) cell lines in vivo by inhibiting autocrine signaling is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1182/BLOOD-2006-06-028092
P3181OpenCitations bibliographic resource ID2106152
P932PMC publication ID1801055
P698PubMed publication ID17082322
P5875ResearchGate publication ID6715081

P50authorMichelle R StaudtQ64539062
Dirk DittmerQ71109132
Sang-Hoon SinQ79326292
P2093author name stringDavid Henry
Ling Wang
Dhavalkumar D Patel
Farnaz D Fakhari
William J Harrington
Debasmita Roy
Blossom A Damania
P2860cites workHuman interleukin-6 is in vivo an autocrine growth factor for human herpesvirus-8-infected malignant B lymphocytesQ40913931
Constitutive cytokine production by primary effusion (body cavity-based) lymphoma-derived cell linesQ40958887
Detection of Kaposi sarcoma associated herpesvirus in peripheral blood of HIV-infected individuals and progression to Kaposi's sarcomaQ40972068
Establishment and characterization of a primary effusion (body cavity-based) lymphoma cell line (BC-3) harboring kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) in the absence of Epstein-Barr virus.Q41164451
The natural history and molecular heterogeneity of HIV-associated primary malignant lymphomatous effusionsQ41193978
Real-time quantitative PCR analysis of viral transcription.Q42639044
Expression of p53 and human herpesvirus-8 (HHV-8)-encoded latency-associated nuclear antigen with inhibition of apoptosis in HHV-8-associated malignanciesQ42665921
Angiogenesis and hematopoiesis induced by Kaposi's sarcoma-associated herpesvirus-encoded interleukin-6.Q42814766
Biochemical correlates of mTOR inhibition by the rapamycin ester CCI-779 and tumor growth inhibitionQ43643471
Viral IL-6-induced cell proliferation and immune evasion of interferon activityQ44218062
Inhibition of the mammalian target of rapamycin sensitizes U87 xenografts to fractionated radiation therapy.Q44260426
Detection of human herpesvirus-8 DNA in kidney allografts prior to the development of Kaposi's sarcomaQ44309430
Prevalence, incidence and correlates of HHV-8/KSHV infection and Kaposi's sarcoma in renal and liver transplant recipients.Q44448784
Involvement of interleukin-10 (IL-10) and viral IL-6 in the spontaneous growth of Kaposi's sarcoma herpesvirus-associated infected primary effusion lymphoma cellsQ44761629
mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathwaysQ44905183
Immunosuppression, timing of human herpesvirus 8 infection, and risk of Kaposi's sarcoma among human immunodeficiency virus type 1-infected persons and transplant recipientsQ45739846
Human herpes virus-8 and other risk factors for Kaposi's sarcoma in kidney transplant recipients. Groupe Cooperatif de Transplantation d' Ile de France (GCIF).Q45749285
Mechanisms of growth control of Kaposi's sarcoma-associated herpes virus-associated primary effusion lymphoma cells.Q45757235
Gene expression profile analysis of AIDS-related primary effusion lymphoma (PEL) suggests a plasmablastic derivation and identifies PEL-specific transcripts.Q52008432
Immortalization of primary endothelial cells by the K1 protein of Kaposi's sarcoma-associated herpesvirus.Q53347753
Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma–associated herpesvirusQ56794246
Posttransplantation Plasmacytic Proliferations Related to Kaposi's Sarcoma–Associated HerpesvirusQ56999785
Primary-Effusion Lymphoma and Kaposi's Sarcoma in a Cardiac-Transplant RecipientQ60178452
Kaposi's sarcoma-associated herpesvirus infects endothelial and spindle cellsQ71563744
Transcription profile of Kaposi's sarcoma-associated herpesvirus in primary Kaposi's sarcoma lesions as determined by real-time PCR arraysQ73344152
Relationship of HHV8 replication and Kaposi's sarcoma after solid organ transplantationQ77415508
Transmission of human herpesvirus 8 infection from renal-transplant donors to recipientsQ77509015
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complexQ24295120
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitiveQ24306328
Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.Q27824772
Post-transplant Kaposi sarcoma originates from the seeding of donor-derived progenitorsQ28190673
Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcomaQ28242984
The tumor microenvironment controls primary effusion lymphoma growth in vivoQ28272290
Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's diseaseQ29619158
A cluster of latently expressed genes in Kaposi's sarcoma-associated herpesvirusQ33784966
p53 inhibition by the LANA protein of KSHV protects against cell deathQ33885642
Spectrum of Kaposi's sarcoma-associated herpesvirus, or human herpesvirus 8, diseasesQ33906970
An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- miceQ33943166
4E-binding proteins, the suppressors of eukaryotic initiation factor 4E, are down-regulated in cells with acquired or intrinsic resistance to rapamycinQ34114303
Charting latency transcripts in Kaposi's sarcoma-associated herpesvirus by whole-genome real-time quantitative PCRQ34340317
Rapamycin inhibits the interleukin 10 signal transduction pathway and the growth of Epstein Barr virus B-cell lymphomasQ34536060
Kaposi sarcoma herpesvirus-induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma.Q34548882
Sirolimus for Kaposi's sarcoma in renal-transplant recipientsQ34556363
A role of the kinase mTOR in cellular transformation induced by the oncoproteins P3k and Akt.Q34585873
Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assayQ34661407
Human herpesvirus 8-encoded vGPCR activates nuclear factor of activated T cells and collaborates with human immunodeficiency virus type 1 Tat.Q34976938
Distribution of human herpesvirus-8 latently infected cells in Kaposi's sarcoma, multicentric Castleman's disease, and primary effusion lymphomaQ35131811
Will mTOR inhibitors make it as cancer drugs?Q35604822
Oncogenic gamma-herpesviruses: comparison of viral proteins involved in tumorigenesisQ35841060
Kaposi's sarcoma-associated herpesvirus-infected primary effusion lymphoma has a plasma cell gene expression profileQ35918316
Restraining PI3K: mTOR signalling goes back to the membrane.Q36011048
Kaposi's sarcoma in the era of HAART-an update on mechanisms, diagnostics and treatment.Q36117364
The Akt-mTOR tango and its relevance to cancerQ36260264
Human herpesvirus-8/Kaposi's sarcoma-associated herpesvirus is a new transmissible virus that infects B cellsQ36366617
Human interferon-gamma-inducible protein 10 (IP-10) inhibits constitutive signaling of Kaposi's sarcoma-associated herpesvirus G protein-coupled receptorQ36401443
Akt plays a central role in sarcomagenesis induced by Kaposi's sarcoma herpesvirus-encoded G protein-coupled receptorQ37415110
Identification of human herpesvirus 8-specific cytotoxic T-cell responses.Q39594967
Kaposi's sarcoma-associated herpesvirus gene expression in endothelial (spindle) tumor cellsQ39877852
The Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor as a therapeutic target for the treatment of Kaposi's sarcoma.Q40333151
Activation of mammalian target of rapamycin in transformed B lymphocytes is nutrient dependent but independent of Akt, mitogen-activated protein kinase/extracellular signal-regulated kinase kinase, insulin growth factor-I, and serum.Q40377835
Inhibition of phosphatidylinositol 3'-kinase/AKT signaling promotes apoptosis of primary effusion lymphoma cells.Q40433643
The K1 protein of Kaposi's sarcoma-associated herpesvirus activates the Akt signaling pathwayQ40594961
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectcell biologyQ7141
sirolimusQ32089
primary effusion lymphomaQ3832899
P304page(s)2165-2173
P577publication date2006-11-02
P1433published inBloodQ885070
P1476titleRapamycin is efficacious against primary effusion lymphoma (PEL) cell lines in vivo by inhibiting autocrine signaling
P478volume109

Reverse relations

cites work (P2860)
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