Kaposi's sarcoma associated herpes virus (KSHV) induced COX-2: a key factor in latency, inflammation, angiogenesis, cell survival and invasion

scientific article

Kaposi's sarcoma associated herpes virus (KSHV) induced COX-2: a key factor in latency, inflammation, angiogenesis, cell survival and invasion is …
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scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PPAT.1000777
P3181OpenCitations bibliographic resource ID4475472
P932PMC publication ID2820536
P698PubMed publication ID20169190
P5875ResearchGate publication ID41487824

P2093author name stringArun George Paul
Bala Chandran
Neelam Sharma-Walia
Virginie Bottero
Nagaraj Kerur
Mohanan Valiya Veettil
Sathish Sadagopan
P2860cites workProstaglandin E2 activates Ca2+ channels in bovine adrenal chromaffin cellsQ67912317
Selective expression of stromal-derived factor-1 in the capillary vascular endothelium plays a role in Kaposi sarcoma pathogenesisQ73784002
Anti-inflammatory drugs and their mechanism of actionQ77609041
IL-3 induces expression of lymphatic markers Prox-1 and podoplanin in human endothelial cellsQ81111357
Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8)Q24650427
Gene expression profile of AIDS-related Kaposi's sarcomaQ24797857
Angiogenesis in cancer and other diseasesQ27861015
Cyclooxygenase-2 expression in chronic hepatitis C and the effect of interferon alpha treatmentQ28221273
Kaposi's sarcoma associated herpesvirus G-protein coupled receptor activation of cyclooxygenase-2 in vascular endothelial cellsQ28221605
Establishing a KSHV+ cell line (BCP-1) from peripheral blood and characterizing its growth in Nod/SCID miceQ28262487
Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomasQ28299069
Tissue inhibitor of metalloproteinases 4 (TIMP4) is involved in inflammatory processes of human cardiovascular pathologyQ28300693
Molecular virology of Kaposi's sarcoma-associated herpesvirusQ28363323
Cyclooxygenase-2 pathway correlates with VEGF expression in head and neck cancer. Implications for tumor angiogenesis and metastasisQ28363910
Prostaglandin E2 activates Stat3 in neonatal rat ventricular cardiomyocytes: A role in cardiac hypertrophyQ28577167
Rho and Rac take center stageQ28645748
Cyclooxygenases: structural, cellular, and molecular biologyQ29616510
Rho GTPases and cell migrationQ29616714
Evidence of COX-1 and COX-2 expression in Kaposi's sarcoma tissues.Q53334041
Kaposi's sarcoma-associated herpesvirus.Q53947567
Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma–associated herpesvirusQ56794246
Comparative Evaluation of FGF-2–, VEGF-A–, and VEGF-C–Induced Angiogenesis, Lymphangiogenesis, Vascular Fenestrations, and PermeabilityQ57382107
Prostaglandin E2Induction of Binding Activity to CRE and AP-2 Elements in Human T LymphocytesQ58052224
Pirated genes in Kaposi's sarcomaQ60085824
Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistryQ29618605
Prostaglandin E2 activates HPK1 kinase activity via a PKA-dependent pathwayQ30157749
Kaposi's sarcoma-associated herpesvirus-encoded interleukin-6 and G-protein-coupled receptor regulate angiopoietin-2 expression in lymphatic endothelial cells.Q33283844
Cox-2-selective inhibitors: the new super aspirinsQ33547609
Kaposi's sarcoma-associated herpesvirus reactivation is regulated by interaction of latency-associated nuclear antigen with recombination signal sequence-binding protein Jkappa, the major downstream effector of the Notch signaling pathwayQ33737793
A cluster of latently expressed genes in Kaposi's sarcoma-associated herpesvirusQ33784966
Matrix metalloproteinase 9 expression is induced by Epstein-Barr virus latent membrane protein 1 C-terminal activation regions 1 and 2.Q33815241
Critical determinants of neoplastic angiogenesis.Q33955072
Targeting cyclooxygenase-2 in human neoplasia: rationale and promiseQ34287766
Cyclooxygenase-2: a novel target for cancer chemotherapy?Q34317347
A novel viral mechanism for dysregulation of beta-catenin in Kaposi's sarcoma-associated herpesvirus latency.Q34531461
Cyclooxygenase-2: a novel molecular target for the prevention and treatment of head and neck cancerQ34804039
Initiation of angiogenic Kaposi's sarcoma lesionsQ35057045
Prostaglandin E2 induces fibroblast growth factor 9 via EP3-dependent protein kinase Cdelta and Elk-1 signalingQ35131505
Distribution of human herpesvirus-8 latently infected cells in Kaposi's sarcoma, multicentric Castleman's disease, and primary effusion lymphomaQ35131811
Kaposi's sarcoma-associated herpesvirus LANA-1 interacts with the short variant of BRD4 and releases cells from a BRD4- and BRD2/RING3-induced G1 cell cycle arrestQ35139294
The possible role of matrix metalloproteinase (MMP)-2 and MMP-9 in cancer, e.g. acute leukemiaQ35780951
Human herpesvirus 8 encodes a homolog of interleukin-6.Q35876140
Kaposi's sarcoma-associated herpesvirus infection promotes invasion of primary human umbilical vein endothelial cells by inducing matrix metalloproteinasesQ35914351
The role of prostaglandins and other eicosanoids in the gastrointestinal tractQ36123763
Towards third generation matrix metalloproteinase inhibitors for cancer therapyQ36421691
Novel functions of TIMPs in cell signalingQ36471132
Kaposi's sarcoma-associated herpesvirus latent gene vFLIP inhibits viral lytic replication through NF-kappaB-mediated suppression of the AP-1 pathway: a novel mechanism of virus control of latencyQ36540187
KSHV LANA inhibits TGF-beta signaling through epigenetic silencing of the TGF-beta type II receptorQ36591375
Matrix metalloproteinase dysregulation in HIV infection: implications for therapeutic strategiesQ37009325
Concurrent expression of latent and a limited number of lytic genes with immune modulation and antiapoptotic function by Kaposi's sarcoma-associated herpesvirus early during infection of primary endothelial and fibroblast cells and subsequent declinQ37010247
KSHV infection and the pathogenesis of Kaposi's sarcomaQ37014777
Prostaglandin E2 promotes integrin alpha Vbeta 3-dependent endothelial cell adhesion, rac-activation, and spreading through cAMP/PKA-dependent signalingQ38362857
COX-2 and survivin are overexpressed and positively correlated in endometrial carcinomaQ38435775
Enhanced expression of matrix metalloproteinase-9 by hepatitis B virus infection in liver cellsQ38521564
RhoA-GTPase facilitates entry of Kaposi's sarcoma-associated herpesvirus into adherent target cells in a Src-dependent mannerQ39321282
Kaposi's sarcoma-associated herpesvirus gene expression in endothelial (spindle) tumor cellsQ39877852
Kaposi's sarcoma-associated herpesvirus upregulates angiogenin during infection of human dermal microvascular endothelial cells, which induces 45S rRNA synthesis, antiapoptosis, cell proliferation, migration, and angiogenesisQ39892759
Rapamycin suppresses TLR4-triggered IL-6 and PGE(2) production of colon cancer cells by inhibiting TLR4 expression and NF-kappaB activationQ40002083
Kaposi's sarcoma herpes virus taps into a host microRNA regulatory networkQ40025792
Kaposi's sarcoma-associated herpesvirus induces sustained levels of vascular endothelial growth factors A and C early during in vitro infection of human microvascular dermal endothelial cells: biological implicationsQ40040603
Celecoxib and a novel COX-2 inhibitor ON09310 upregulate death receptor 5 expression via GADD153/CHOP.Q40060479
Prostanoids induce egr1 gene expression in cementoblastic OCCM cellsQ40087300
Prostaglandin E2 induces vascular endothelial growth factor secretion in prostate cancer cells through EP2 receptor-mediated cAMP pathwayQ40146956
Kaposi's sarcoma-associated herpesvirus induces sustained NF-kappaB activation during de novo infection of primary human dermal microvascular endothelial cells that is essential for viral gene expressionQ40173444
Modulation of host gene expression by the K15 protein of Kaposi's sarcoma-associated herpesvirusQ40218296
Cyclooxygenase 2 induced by Kaposi's sarcoma-associated herpesvirus early during in vitro infection of target cells plays a role in the maintenance of latent viral gene expressionQ40267788
Long-term-infected telomerase-immortalized endothelial cells: a model for Kaposi's sarcoma-associated herpesvirus latency in vitro and in vivoQ40287215
Connecting COX-2 and Wnt in cancerQ40329613
Prostaglandin E2 activates mitogen-activated protein kinase/Erk pathway signaling and cell proliferation in non-small cell lung cancer cells in an epidermal growth factor receptor-independent manner.Q40396797
Coexpression of cyclooxygenases (COX-1, COX-2) and vascular endothelial growth factors (VEGF-A, VEGF-C) in esophageal adenocarcinomaQ40409082
The kaposin B protein of KSHV activates the p38/MK2 pathway and stabilizes cytokine mRNAs.Q40461940
Prostaglandin E2 enhances pancreatic cancer invasiveness through an Ets-1-dependent induction of matrix metalloproteinase-2.Q40502651
Cyclooxygenase-2 inhibitor nimesulide suppresses telomerase activity by blocking Akt/PKB activation in gastric cancer cell lineQ40525674
Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 envelope glycoprotein gB induces the integrin-dependent focal adhesion kinase-Src-phosphatidylinositol 3-kinase-rho GTPase signal pathways and cytoskeletal rearrangementsQ40572745
Inflammatory cytokines inhibit Kaposi's sarcoma-associated herpesvirus lytic gene transcription in in vitro-infected endothelial cellsQ40589924
Host gene induction and transcriptional reprogramming in Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8)-infected endothelial, fibroblast, and B cells: insights into modulation events early during infectionQ40598301
Kaposi sarcoma-associated herpesvirus (KSHV) induces heme oxygenase-1 expression and activity in KSHV-infected endothelial cellsQ40598941
Novel target for induction of apoptosis by cyclo-oxygenase-2 inhibitor SC-236 through a protein kinase C-beta(1)-dependent pathwayQ40636925
Prostaglandin E2 induces hypoxia-inducible factor-1alpha stabilization and nuclear localization in a human prostate cancer cell lineQ40694101
The restricted cellular host range of human herpesvirus 8.Q40868542
Aetiology of Kaposi's sarcoma: current understanding and implications for therapyQ41682881
Regulation by PGE2 of the production of interleukin-6, macrophage colony stimulating factor, and vascular endothelial growth factor in human synovial fibroblastsQ41910302
EP4 mediates PGE2 dependent cell survival through the PI3 kinase/AKT pathwayQ41949634
Kaposi's sarcoma-associated herpesvirus latent protein LANA interacts with HIF-1 alpha to upregulate RTA expression during hypoxia: Latency control under low oxygen conditionsQ42049779
Inhibitors of prostaglandin synthesis inhibit human prostate tumor cell invasiveness and reduce the release of matrix metalloproteinasesQ42797828
ERK1/2 and MEK1/2 induced by Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) early during infection of target cells are essential for expression of viral genes and for establishment of infectionQ42931199
Inhibitors of cyclooxygenase-2 (COX-2) suppressed the proliferation and differentiation of human leukaemia cell linesQ43708447
Increased prostaglandin E2 and cAMP phosphodiesterase levels in Kaposi's sarcoma--a virus against host defense mechanismQ43804595
Matrix metalloproteinases in the progression and regression of Kaposi's sarcomaQ44053161
Kaposi's sarcoma associated herpesvirus G protein-coupled receptor immortalizes human endothelial cells by activation of the VEGF receptor-2/ KDR.Q44277985
Cyclooxygenase-2 inhibition improves macrophage function in melanoma and increases the antineoplastic activity of interferon gammaQ44392696
Prostaglandin E2 activates Src signaling in lung adenocarcinoma cell via EP3.Q45032023
Induction of matrix metalloproteinases by Epstein-Barr virus latent membrane protein 1 isolated from nasopharyngeal carcinoma.Q45399853
Regulation of matrix metalloproteinase-1 by Epstein-Barr virus proteins.Q45729612
Design and cloning of lentiviral vectors expressing small interfering RNAsQ46412641
Vascular endothelial growth factor induction by prostaglandin E2 in human airway smooth muscle cells is mediated by E prostanoid EP2/EP4 receptors and SP-1 transcription factor binding sites.Q46560423
Cyclooxygenase-2-derived prostaglandin E2 activates beta-catenin in human cholangiocarcinoma cells: evidence for inhibition of these signaling pathways by omega 3 polyunsaturated fatty acidsQ46805111
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectangiogenesisQ539568
Kaposi's sarcomaQ725345
inflammationQ101991
P304page(s)e1000777
P577publication date2010-02-12
P1433published inPLOS PathogensQ283209
P1476titleKaposi's sarcoma associated herpes virus (KSHV) induced COX-2: a key factor in latency, inflammation, angiogenesis, cell survival and invasion
P478volume6

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cites work (P2860)
Q36415707A role for virally induced reactive oxygen species in Kaposi's sarcoma herpesvirus tumorigenesis
Q38073761AKTivation of PI3K/AKT/mTOR signaling pathway by KSHV.
Q35861265Activated Nrf2 Interacts with Kaposi's Sarcoma-Associated Herpesvirus Latency Protein LANA-1 and Host Protein KAP1 To Mediate Global Lytic Gene Repression.
Q34541350Altering the Anti-inflammatory Lipoxin Microenvironment: a New Insight into Kaposi's Sarcoma-Associated Herpesvirus Pathogenesis
Q36336086An APE1 inhibitor reveals critical roles of the redox function of APE1 in KSHV replication and pathogenic phenotypes
Q64102452Arachidonic Acid Derived Lipid Mediators Influence Kaposi's Sarcoma-Associated Herpesvirus Infection and Pathogenesis
Q41840182COX-2/PGE2: molecular ambassadors of Kaposi's sarcoma-associated herpes virus oncoprotein-v-FLIP.
Q35675995Celecoxib Inhibits the Lytic Activation of Kaposi's Sarcoma-Associated Herpesvirus through Down-Regulation of RTA Expression by Inhibiting the Activation of p38 MAPK.
Q39327821Classical swine fever virus NS5A protein localizes to endoplasmic reticulum and induces oxidative stress in vascular endothelial cells
Q39176686Concurrent targeting of eicosanoid receptor 1/eicosanoid receptor 4 receptors and COX-2 induces synergistic apoptosis in Kaposi's sarcoma-associated herpesvirus and Epstein-Barr virus associated non-Hodgkin lymphoma cell lines
Q42123554Constitutive interferon-inducible protein 16-inflammasome activation during Epstein-Barr virus latency I, II, and III in B and epithelial cells
Q88037600Correlation study of chronic nonbacterial prostatitis with the levels of COX-2 and PGE2 in prostatic secretion
Q37644800Crosstalk between osteoprotegerin (OPG), fatty acid synthase (FASN) and, cycloxygenase-2 (COX-2) in breast cancer: implications in carcinogenesis
Q38097263Cyclooxygenase-2-prostaglandin E2-eicosanoid receptor inflammatory axis: a key player in Kaposi's sarcoma-associated herpes virus associated malignancies
Q37057685Emmprin and KSHV: new partners in viral cancer pathogenesis.
Q34845606EphrinA2 regulates clathrin mediated KSHV endocytosis in fibroblast cells by coordinating integrin-associated signaling and c-Cbl directed polyubiquitination
Q38611188Expression and Subcellular Localization of the Kaposi's Sarcoma-Associated Herpesvirus K15P Protein during Latency and Lytic Reactivation in Primary Effusion Lymphoma Cells
Q35315503Glutamate secretion and metabotropic glutamate receptor 1 expression during Kaposi's sarcoma-associated herpesvirus infection promotes cell proliferation
Q91760713HACE1, an E3 Ubiquitin Protein Ligase, Mitigates Kaposi's Sarcoma-Associated Herpesvirus Infection-Induced Oxidative Stress by Promoting Nrf2 Activity
Q28545016Herpesviral G protein-coupled receptors activate NFAT to induce tumor formation via inhibiting the SERCA calcium ATPase
Q30406863Herpesvirus Genome Recognition Induced Acetylation of Nuclear IFI16 Is Essential for Its Cytoplasmic Translocation, Inflammasome and IFN-β Responses
Q38802773Hijacking GPCRs by viral pathogens and tumor
Q37867038Horizontal gene transfers with or without cell fusions in all categories of the living matter
Q34130226Human Herpesvirus 8 (HHV8) sequentially shapes the NK cell repertoire during the course of asymptomatic infection and Kaposi sarcoma
Q90308027Human Herpesvirus 8 and Host-Cell Interaction: Long-Lasting Physiological Modifications, Inflammation and Related Chronic Diseases
Q24302985IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection
Q37085828Implications of a peroxisome proliferator-activated receptor alpha (PPARα) ligand clofibrate in breast cancer
Q37378867Inflammatory stress and sarcomagenesis: a vicious interplay
Q34615002Interplay between Kaposi's sarcoma-associated herpesvirus and the innate immune system
Q39126546Involvement of unfolded protein response, p53 and Akt in modulation of porcine reproductive and respiratory syndrome virus-mediated JNK activation
Q42562294KSHV Induction of Angiogenic and Lymphangiogenic Phenotypes
Q49363063KSHV LANA upregulates the expression of epidermal growth factor like domain 7 to promote angiogenesis.
Q26742030KSHV-Mediated Angiogenesis in Tumor Progression
Q34644229Kaposi Sarcoma Pathogenesis: A Triad of Viral Infection, Oncogenesis and Chronic Inflammation.
Q40046587Kaposi sarcoma herpesvirus pathogenesis.
Q92376588Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication Interferes with mTORC1 Regulation of Autophagy and Viral Protein Synthesis
Q36487309Kaposi's sarcoma and its associated herpesvirus
Q34426472Kaposi's sarcoma herpesvirus K15 protein contributes to virus-induced angiogenesis by recruiting PLCγ1 and activating NFAT1-dependent RCAN1 expression
Q28388436Kaposi's sarcoma-associated herpesvirus induces Nrf2 activation in latently infected endothelial cells through SQSTM1 phosphorylation and interaction with polyubiquitinated Keap1
Q28396451Kaposi's sarcoma-associated herpesvirus induces Nrf2 during de novo infection of endothelial cells to create a microenvironment conducive to infection
Q24629364Kaposi's sarcoma-associated herpesvirus induces rapid release of angiopoietin-2 from endothelial cells
Q39792755Kaposi's sarcoma-associated herpesvirus latency in endothelial and B cells activates gamma interferon-inducible protein 16-mediated inflammasomes.
Q36023151Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen interacts with multifunctional angiogenin to utilize its antiapoptotic functions.
Q39611761Kaposi's sarcoma-associated herpesvirus-induced angiogenin plays roles in latency via the phospholipase C gamma pathway: blocking angiogenin inhibits latent gene expression and induces the lytic cycle
Q34102739Latent KSHV infection of endothelial cells induces integrin beta3 to activate angiogenic phenotypes
Q33852054Life without double-headed non-muscle myosin II motor proteins
Q38894472Lipoxins exert antiangiogenic and anti-inflammatory effects on Kaposi's sarcoma cells
Q26784376Lipoxins: nature's way to resolve inflammation
Q57462211Mast Cell Activation and KSHV Infection in Kaposi Sarcoma
Q54229820Micro RNAs from DNA Viruses are Found Widely in Plasma in a Large Observational Human Population.
Q92238951Modulation of Angiogenic Processes by the Human Gammaherpesviruses, Epstein-Barr Virus and Kaposi's Sarcoma-Associated Herpesvirus
Q35158385Modulation of cellular signaling by herpesvirus-encoded G protein-coupled receptors
Q33624377Modulation of chemokine activity by viruses.
Q35124404Molecular Biology of Kaposi's Sarcoma-associated Herpesvirus and Related Oncogenesis
Q34013830Molecular biology of human herpesvirus 8: novel functions and virus-host interactions implicated in viral pathogenesis and replication
Q33718186NFAT and CREB Regulate Kaposi's Sarcoma-Associated Herpesvirus-Induced Cyclooxygenase 2 (COX-2)
Q34311582Opposing regulation of PROX1 by interleukin-3 receptor and NOTCH directs differential host cell fate reprogramming by Kaposi sarcoma herpes virus.
Q35853271Osteoprotegerin secreted by inflammatory and invasive breast cancer cells induces aneuploidy, cell proliferation and angiogenesis
Q42045465Phosphorylation and polyubiquitination of transforming growth factor beta-activated kinase 1 are necessary for activation of NF-kappaB by the Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor
Q33820704Piracy of prostaglandin E2/EP receptor-mediated signaling by Kaposi's sarcoma-associated herpes virus (HHV-8) for latency gene expression: strategy of a successful pathogen
Q39240333Reactive oxygen species are induced by Kaposi's sarcoma-associated herpesvirus early during primary infection of endothelial cells to promote virus entry.
Q38201237Rho'ing in and out of cells: viral interactions with Rho GTPase signaling
Q39236102Role of Modulator of Inflammation Cyclooxygenase-2 in Gammaherpesvirus Mediated Tumorigenesis
Q21135231Targeting KSHV/HHV-8 latency with COX-2 selective inhibitor nimesulide: a potential chemotherapeutic modality for primary effusion lymphoma
Q35066362The Kaposi's sarcoma-associated herpesvirus (KSHV)-induced 5-lipoxygenase-leukotriene B4 cascade plays key roles in KSHV latency, monocyte recruitment, and lipogenesis
Q26767186The Role of Gammaherpesviruses in Cancer Pathogenesis
Q37288834The inflammatory kinase MAP4K4 promotes reactivation of Kaposi's sarcoma herpesvirus and enhances the invasiveness of infected endothelial cells
Q26995410The modulation of apoptosis by oncogenic viruses
Q38248404The role of Kaposi sarcoma-associated herpesvirus in the pathogenesis of Kaposi sarcoma
Q38211082The role of inflammation in sarcoma
Q64247511Towards Better Understanding of KSHV Life Cycle: from Transcription and Posttranscriptional Regulations to Pathogenesis
Q58796905Virus and tumor microenvironment induced ER stress and unfolded protein response: from complexity to therapeutics
Q37871527Viruses as key regulators of angiogenesis
Q34569859Widespread evidence of viral miRNAs targeting host pathways
Q34027122c-Cbl-mediated selective virus-receptor translocations into lipid rafts regulate productive Kaposi's sarcoma-associated herpesvirus infection in endothelial cells.

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