Cyclooxygenase-2 inhibitor nimesulide suppresses telomerase activity by blocking Akt/PKB activation in gastric cancer cell line

scientific article published on June 2004

Cyclooxygenase-2 inhibitor nimesulide suppresses telomerase activity by blocking Akt/PKB activation in gastric cancer cell line is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1030455670
P356DOI10.1023/B:DDAS.0000034553.58554.AB
P698PubMed publication ID15309882

P2093author name stringLuo Hesheng
Hu Guoyong
Ran Zongxue
Yu Baoping
Yu Jieping
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Prostaglandin endoperoxide H synthases (cyclooxygenases)-1 and -2Q28299729
Increased cyclooxygenase-2 expression in human pancreatic carcinomas and cell lines: growth inhibition by nonsteroidal anti-inflammatory drugsQ28372797
The cyclooxygenase-2 inhibitor celecoxib induces apoptosis by blocking Akt activation in human prostate cancer cells independently of Bcl-2Q28375904
Decrease in nucleophosmin/B23 mRNA and telomerase activity during indomethacin-induced apoptosis of gastric KATO-III cancer cellsQ28378332
A survey of telomerase activity in human cancerQ29614858
The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposisQ29616121
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Celecoxib inhibits proliferation and induces apoptosis via prostaglandin E2 pathway in human cholangiocarcinoma cell linesQ36179852
Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitorsQ37549774
Selective cyclooxygenase (COX)-1 or COX-2 inhibitors control metastatic disease in a murine model of breast cancer.Q40737945
A selective cyclooxygenase-2 inhibitor suppresses tumor growth in nude mouse xenografted with human head and neck squamous carcinoma cellsQ40912553
Telomerase activity is restored in human cells by ectopic expression of hTERT (hEST2), the catalytic subunit of telomeraseQ41053498
Induction of cytosolic phospholipase A2 by oncogenic Ras in human non-small cell lung cancerQ41105606
Nonsteroidal anti-inflammatory drugs and colorectal cancer: evolving concepts of their chemopreventive actionsQ41658552
Non-steroidal anti-inflammatory drug-induced apoptosis in gastric cancer cells is blocked by protein kinase C activation through inhibition of c-mycQ42205510
COX-2 independent induction of cell cycle arrest and apoptosis in colon cancer cells by the selective COX-2 inhibitor celecoxibQ43770432
Non-steroidal anti-inflammatory drugs inhibit telomerase activity in head and neck squamous carcinoma cell linesQ43844202
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A selective cyclooxygenase 2 inhibitor suppresses the growth of H-ras-transformed rat intestinal epithelial cells.Q53438992
Aspirin and the Risk of Colorectal Cancer in WomenQ57751820
Enhancement of chemotherapeutic drug toxicity to human tumour cells in vitro by a subset of non-steroidal anti-inflammatory drugs (NSAIDs)Q58838535
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Telomerase activity in gastric cancerQ71887258
The cyclooxygenase-2 inhibitor celecoxib is a potent preventive and therapeutic agent in the min mouse model of adenomatous polyposisQ73034117
Chemopreventive efficacies of aspirin and sulindac against lung tumorigenesis in A/J miceQ73367388
Induction of apoptosis by JTE-522, a specific cyclooxygenase-2 inhibitor, in human gastric cancer cell linesQ73505426
Non-small cell lung cancer cycloxygenase activity and proliferation are inhibited by non-steroidal antiinflammatory drugsQ74619460
Cyclooxygenase-2 inhibitors suppress the growth of gastric cancer xenografts via induction of apoptosis in nude miceQ77060828
Akt protein kinase enhances human telomerase activity through phosphorylation of telomerase reverse transcriptase subunitQ77388144
Effects of NSAIDs on proliferation of gastric cancer cells in vitro: possible implication of cyclooxygenase-2 in cancer developmentQ77746617
Induced apoptosis in the prevention of colorectal cancer by non-steroidal anti-inflammatory drugsQ79317711
P433issue6
P921main subjectnimesulideQ20994
cancer cell lineQ23058136
P304page(s)948-953
P577publication date2004-06-01
P1433published inDigestive Diseases and SciencesQ15716711
P1476titleCyclooxygenase-2 inhibitor nimesulide suppresses telomerase activity by blocking Akt/PKB activation in gastric cancer cell line
P478volume49

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cites work (P2860)
Q28393278A multi-targeted approach to suppress tumor-promoting inflammation
Q39540555Activation of telomerase by seminal plasma in malignant and normal cervical epithelial cells
Q27692701COX-2 Inhibitors and Gastric Cancer
Q39980869Effects of a selective cyclooxygenase-2 inhibitor, nimesulide, on the growth of ovarian carcinoma in vivo
Q39772800Expression of p-Akt and COX-2 in gastric adenocarcinomas and adenovirus mediated Akt1 and COX-2 ShRNA suppresses SGC-7901 gastric adenocarcinoma and U251 glioma cell growth in vitro and in vivo
Q82907101Inhibition of human neuroblastoma in SCID mice by low-dose of selective Cox-2 inhibitor nimesulide
Q28472867Kaposi's sarcoma associated herpes virus (KSHV) induced COX-2: a key factor in latency, inflammation, angiogenesis, cell survival and invasion
Q28303196Role of cyclooxygenase-2 in the carcinogenesis of gastrointestinal tract cancers: a review and report of personal experience
Q26741736Therapeutic Targeting of Telomerase

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