| scholarly article | Q13442814 |
| P2093 | author name string | J. Chung | |
| G. R. Crabtree | |||
| J. Blenis | |||
| C. J. Kuo | |||
| P433 | issue | 7 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | signal transduction | Q828130 |
| P304 | page(s) | 1227-36 | |
| P577 | publication date | 1992-06-26 | |
| P1433 | published in | Cell | Q655814 |
| P1476 | title | Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases | |
| P478 | volume | 69 |
| Q33889159 | 14-3-3tau associates with a translational control factor FKBP12-rapamycin-associated protein in T-cells after stimulation by pervanadate |
| Q37628904 | 4E-BP1 phosphorylation is mediated by the FRAP-p70s6k pathway and is independent of mitogen-activated protein kinase |
| Q29620730 | 4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway |
| Q35924056 | A Drosophila gene structurally and functionally homologous to the mammalian 70-kDa s6 kinase gene |
| Q29037561 | A Novel Mitogenic Signaling Pathway of Bradykinin in the Human Colon Carcinoma Cell Line SW-480 Involves Sequential Activation of a Gq/11 Protein, Phosphatidylinositol 3-Kinase , and Protein Kinase C |
| Q33419115 | A Phase I Study of Cixutumumab (IMC-A12) in Combination with Temsirolimus (CCI-779) in Children with Recurrent Solid Tumors: A Children's Oncology Group Phase I Consortium Report |
| Q40021572 | A dominant-negative mutant of mSOS1 inhibits insulin-induced Ras activation and reveals Ras-dependent and -independent insulin signaling pathways |
| Q33526484 | A genetic screen for modifiers of Drosophila caspase Dcp-1 reveals caspase involvement in autophagy and novel caspase-related genes |
| Q28243712 | A mammalian protein targeted by G1-arresting rapamycin-receptor complex |
| Q40771721 | A new role for the p85-phosphatidylinositol 3-kinase regulatory subunit linking FRAP to p70 S6 kinase activation. |
| Q34863186 | A novel pathway regulating the mammalian target of rapamycin (mTOR) signaling |
| Q73195828 | A phosphatidylinositol 3-Kinase/p70 ribosomal S6 protein kinase pathway is required for the regulation by insulin of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase gene expression in human muscle cells |
| Q40969113 | A phosphatidylinositol 3-kinase-dependent pathway that differentially regulates c-Raf and A-Raf |
| Q73515628 | A role for phosphoinositides in tyrosine phosphorylation of p125 focal adhesion kinase in rat pancreatic acini |
| Q34585873 | A role of the kinase mTOR in cellular transformation induced by the oncoproteins P3k and Akt. |
| Q42624833 | A unique herpesviral transcriptional program in KSHV-infected lymphatic endothelial cells leads to mTORC1 activation and rapamycin sensitivity |
| Q54523852 | ABCB1 haplotype influences the sirolimus dose requirements in Chinese renal transplant recipients. |
| Q35752700 | ATG1, an autophagy regulator, inhibits cell growth by negatively regulating S6 kinase |
| Q42804390 | ATP-dependent choline phosphate-induced mitogenesis in fibroblasts involves activation of pp70 S6 kinase and phosphatidylinositol 3'-kinase through an extracellular site. Synergistic mitogenic effects of choline phosphate and sphingosine 1-phosphate |
| Q38275627 | Aberrant mTOR activation in senescence and aging: A mitochondrial stress response? |
| Q24651443 | Abnormal growth of smooth muscle-like cells in lymphangioleiomyomatosis: Role for tumor suppressor TSC2 |
| Q48289134 | Abnormalities of protein kinases in neurodegenerative diseases. |
| Q42840914 | Activated phosphatidylinositol 3-kinase and Akt kinase promote survival of superior cervical neurons |
| Q24632768 | Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases |
| Q41431083 | Activation of 70-kDa S6 kinase, induced by the cytokines interleukin-3 and erythropoietin and inhibited by rapamycin, is not an absolute requirement for cell proliferation |
| Q55403111 | Activation of Calcium-Sensing Receptor increases intracellular calcium and decreases cAMP and mTOR in PKD1 deficient cells. |
| Q71602259 | Activation of MAP kinases, pp90rsk and pp70-S6 kinases in mouse mast cells by signaling through the c-kit receptor tyrosine kinase or Fc epsilon RI: rapamycin inhibits activation of pp70-S6 kinase and proliferation in mouse mast cells |
| Q37036270 | Activation of PI3K signaling prevents aminoglycoside-induced hair cell death in the murine cochlea |
| Q42159726 | Activation of mitogen-activated protein kinase and p70S6 kinase is not correlated with cerebellar granule cell survival. |
| Q41266089 | Activation of mitogen-activated protein kinase by heat shock treatment in Drosophila |
| Q42820812 | Activation of p70 S6 Kinase and erk-encoded Mitogen-activated Protein Kinases Is Resistant to High Cyclic Nucleotide Levels in Swiss 3T3 Fibroblasts |
| Q41441452 | Activation of p70/p85 S6 kinase by a pathway independent of p21ras |
| Q39576120 | Activation of phosphatidylinositol 3-kinase is sufficient for cell cycle entry and promotes cellular changes characteristic of oncogenic transformation |
| Q74037504 | Activation of phosphoinositide 3-OH kinase by the alpha6beta4 integrin promotes carcinoma invasion |
| Q24563004 | Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation |
| Q36566823 | Activation of pp70/85 S6 kinases in interleukin-2-responsive lymphoid cells is mediated by phosphatidylinositol 3-kinase and inhibited by cyclic AMP. |
| Q34339010 | Activation of the MEK-S6 pathway in high-grade ovarian cancers |
| Q34626081 | Activation of the mTOR signaling pathway in breast cancer MCF‑7 cells by a peptide derived from Porphyra yezoensis |
| Q40646200 | Activation of the p70 S6 kinase and phosphorylation of the 4E-BP1 repressor of mRNA translation by type I interferons |
| Q41398474 | Acute rejection of renal allografts: mechanistic insights and therapeutic options |
| Q40024191 | Adenovirus-mediated overexpression of IRS-1 interacting domains abolishes insulin-stimulated mitogenesis without affecting glucose transport in 3T3-L1 adipocytes |
| Q42824997 | Akt-1 expression level regulates CNS precursors. |
| Q24310812 | Alpha 4 associates with protein phosphatases 2A, 4, and 6 |
| Q33975117 | Altered extracellular signal-regulated kinase signaling and glycogen metabolism in skeletal muscle from p90 ribosomal S6 kinase 2 knockout mice |
| Q36283815 | Amino Acid Availability Modulates Vacuolar H+-ATPase Assembly |
| Q30453740 | Amino acid-induced translation of TOP mRNAs is fully dependent on phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylation |
| Q30483779 | An RNA interference screen identifies a novel regulator of target of rapamycin that mediates hypoxia suppression of translation in Drosophila S2 cells. |
| Q40493476 | An emerging family of dual specificity MAP kinase phosphatases |
| Q24629305 | An emerging role for TOR signaling in mammalian tissue and stem cell physiology |
| Q37305443 | An essential role for Bruton's [corrected] tyrosine kinase in the regulation of B-cell apoptosis |
| Q33943166 | An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice |
| Q40906577 | An update on new immunosuppressive drugs undergoing preclinical and clinical trials: potential applications in organ transplantation |
| Q41185163 | Analysis of the signaling pathway involved in the regulation of hexokinase II gene transcription by insulin |
| Q41489749 | Anisomycin and rapamycin define an area upstream of p70/85S6k containing a bifurcation to histone H3-HMG-like protein phosphorylation and c-fos-c-jun induction |
| Q39630957 | Anisomycin selectively desensitizes signalling components involved in stress kinase activation and fos and jun induction |
| Q41431597 | Anisomycin-activated protein kinases p45 and p55 but not mitogen-activated protein kinases ERK-1 and -2 are implicated in the induction of c-fos and c-jun |
| Q28343624 | Antifungal activities of antineoplastic agents: Saccharomyces cerevisiae as a model system to study drug action |
| Q46868178 | Arabidopsis TARGET OF RAPAMYCIN interacts with RAPTOR, which regulates the activity of S6 kinase in response to osmotic stress signals |
| Q37270861 | Assessment of mitochondrial biogenesis and mTORC1 signaling during chronic rapamycin feeding in male and female mice |
| Q42141390 | Atypical protein kinase Clambda binds and regulates p70 S6 kinase |
| Q56593448 | Augmenter of liver regeneration: Its place in the universe of hepatic growth factors |
| Q37376649 | B lymphocytes from patients with chronic lymphocytic leukemia contain signal transducer and activator of transcription (STAT) 1 and STAT3 constitutively phosphorylated on serine residues. |
| Q59102114 | BCR signals target p27Kip1 and cyclin D2 via the PI3-K signalling pathway to mediate cell cycle arrest and apoptosis of WEHI 231 B cells |
| Q40220439 | BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo |
| Q37340200 | BK Polyomavirus Replication in Renal Tubular Epithelial Cells Is Inhibited by Sirolimus, but Activated by Tacrolimus Through a Pathway Involving FKBP-12. |
| Q43559806 | Basic fibroblast growth factor-induced activation of novel CREB kinase during the differentiation of immortalized hippocampal cells |
| Q34100177 | Binding of the La autoantigen to the 5' untranslated region of a chimeric human translation elongation factor 1A reporter mRNA inhibits translation in vitro |
| Q45113910 | Biology of the interleukin-2 receptor |
| Q38979235 | Biosynthesis, regulation, and engineering of a linear polyketide tautomycetin: a novel immunosuppressant in Streptomyces sp. CK4412. |
| Q42522078 | Biphasic regulation of extracellular-signal-regulated protein kinase by leptin in macrophages: role in regulating STAT3 Ser727 phosphorylation and DNA binding |
| Q42834917 | Bombesin and zinc enhance the synergistic mitogenic effects of insulin and phosphocholine by a MAP kinase-dependent mechanism in Swiss 3T3 cells |
| Q24672058 | CCI-779 inhibits rhabdomyosarcoma xenograft growth by an antiangiogenic mechanism linked to the targeting of mTOR/Hif-1alpha/VEGF signaling |
| Q38832326 | CCR5-Dependent Activation of mTORC1 Regulates Translation of Inducible NO Synthase and COX-2 during Encephalomyocarditis Virus Infection |
| Q35616131 | CDK1 substitutes for mTOR kinase to activate mitotic cap-dependent protein translation |
| Q34075083 | CTLA4-Ig: a novel immunosuppressive agent |
| Q35740051 | Caffeic acid phenethyl ester induced cell cycle arrest and growth inhibition in androgen-independent prostate cancer cells via regulation of Skp2, p53, p21Cip1 and p27Kip1. |
| Q34578721 | Calcineurin inhibitors and rapamycin: cancer protection or promotion? |
| Q36563908 | Calcium-dependent immediate-early gene induction in lymphocytes is negatively regulated by p21Ha-ras |
| Q40493211 | Calcium-dependent regulation of protein synthesis. |
| Q28145271 | Carboxyl-terminal region conserved among phosphoinositide-kinase-related kinases is indispensable for mTOR function in vivo and in vitro |
| Q38312046 | Catalytic and ligand binding properties of the FK506 binding protein FKBP12: effects of the single amino acid substitution of Tyr82 to Leu |
| Q52650762 | Cell biology: regulated self-cannibalism. |
| Q42817515 | Cell cycle regulation of p70 S6 kinase and p42/p44 mitogen-activated protein kinases in Swiss mouse 3T3 fibroblasts |
| Q42252132 | Cellular and molecular mechanisms of intestinal fibrosis |
| Q40812896 | Cellular insulin action and insulin resistance |
| Q28144592 | Characterization of S6K2, a novel kinase homologous to S6K1 |
| Q38615106 | Characterization of Saccharomyces cerevisiae dna2 mutants suggests a role for the helicase late in S phase |
| Q47548862 | Characterization of female germline stem cells from adult mouse ovaries and the role of rapamycin on them |
| Q43251932 | Characterization of p70 S6 kinase 1 in early development of mouse embryos |
| Q34508481 | Chemical genomics in the global study of protein functions |
| Q24620236 | Cholesterol trafficking is required for mTOR activation in endothelial cells |
| Q52730249 | Chronic Akt blockade aggravates pathological hypertrophy and inhibits physiological hypertrophy. |
| Q36347738 | Clonal selection and in vivo quantitation of protein interactions with protein-fragment complementation assays |
| Q22008607 | Cloning and characterization of RLPK, a novel RSK-related protein kinase |
| Q41753614 | Cloning and characterization of Xenopus Rsk2, the predominant p90 Rsk isozyme in oocytes and eggs |
| Q28144601 | Cloning and characterization of a nuclear S6 kinase, S6 kinase-related kinase (SRK); a novel nuclear target of Akt |
| Q22008628 | Cloning and characterization of p70(S6K beta) defines a novel family of p70 S6 kinases |
| Q22010764 | Cloning, characterization, and chromosome mapping of RPS6KC1, a novel putative member of the ribosome protein S6 kinase family, to chromosome 12q12-q13.1 |
| Q36214162 | Co-targeting of Akt and Myc inhibits viability of lymphoma cells from Lck-Dlx5 mice |
| Q46694715 | Combination of immunosuppressive agents in treatment of steroid-resistant minimal change disease and primary focal segmental glomerulosclerosis |
| Q101216806 | Combined treatment of mitoxantrone sensitizes breast cancer cells to rapalogs through blocking eEF-2K-mediated activation of Akt and autophagy |
| Q51088160 | Commitment of neutrophilic differentiation and proliferation of HL-60 cells coincides with expression of transferrin receptor. Effect of granulocyte colony stimulating factor on differentiation and proliferation. |
| Q41553984 | Communication between the extracellular environment, cytoplasmic signalling cascades and the nuclear cell-cycle machinery |
| Q46681664 | Compensatory PI3-kinase/Akt/mTor activation regulates imatinib resistance development |
| Q40018101 | Constitutive activation of S6 kinase by deletion of amino-terminal autoinhibitory and rapamycin sensitivity domains |
| Q42371922 | Context-Specific Function of S6K2 in Th Cell Differentiation. |
| Q37339231 | Contraction mode itself does not determine the level of mTORC1 activity in rat skeletal muscle |
| Q28586467 | Control of PHAS-I by insulin in 3T3-L1 adipocytes. Synthesis, degradation, and phosphorylation by a rapamycin-sensitive and mitogen-activated protein kinase-independent pathway |
| Q41284168 | Control of p70 s6 kinase by kinase activity of FRAP in vivo |
| Q43237438 | Conversion from cyclosporin A to sirolimus retards the progression of chronic allograft nephropathy in the long term in a rat kidney transplantation model |
| Q34956044 | Coordinate regulation of translation by the PI 3-kinase and mTOR pathways |
| Q39967749 | Coordination of mitochondrial bioenergetics with G1 phase cell cycle progression |
| Q57245411 | Cross-linking CD28 leads to activation of 70-kDa S6 kinase |
| Q33687017 | Crosstalk between protein kinase A and growth factor receptor signaling pathways in arterial smooth muscle |
| Q27684745 | Crystal structures of S6K1 provide insights into the regulation mechanism of S6K1 by the hydrophobic motif |
| Q57589068 | Cyclin D Expression Is Controlled Post-transcriptionally via a Phosphatidylinositol 3-Kinase/Akt-dependent Pathway |
| Q39096402 | Cyproheptadine-induced myeloma cell apoptosis is associated with inhibition of the PI3K/AKT signaling |
| Q35801388 | Deconvoluting mTOR biology |
| Q73253201 | Decrease in kidney calbindin-D 28kDa as a possible mechanism mediating cyclosporine A- and FK-506-induced calciuria and tubular mineralization |
| Q35126646 | Deletion of ribosomal S6 kinases does not attenuate pathological, physiological, or insulin-like growth factor 1 receptor-phosphoinositide 3-kinase-induced cardiac hypertrophy |
| Q49970895 | Dendrite Growth and the Effect of Ectopic Rheb Expression on Cortical Neurons |
| Q73328429 | Density-dependent proliferation of adult rat hepatocytes in primary culture induced by epidermal growth factor is potentiated by cAMP-elevating agents |
| Q35549436 | Destination 'lysosome': a target organelle for tumour cell killing? |
| Q30960829 | Detection of protein-protein interactions by protein fragment complementation strategies |
| Q38889267 | Differential Role of Rapamycin and Torin/KU63794 in Inflammatory Response of 264.7 RAW Macrophages Stimulated by CA-MRSA. |
| Q32023669 | Differential activation of p70 and p85 S6 kinase isoforms during cardiac hypertrophy in the adult mammal |
| Q35919826 | Differential effects of tautomycetin and its derivatives on protein phosphatase inhibition, immunosuppressive function and antitumor activity |
| Q22253167 | Differential regulation of the phosphatidylinositol 3-kinase/Akt and p70 S6 kinase pathways by the alpha(1A)-adrenergic receptor in rat-1 fibroblasts |
| Q40839150 | Differential requirements of the MAP kinase and PI3 kinase signaling pathways in Src- versus insulin and IGF-1 receptors-induced growth and transformation of rat intestinal epithelial cells |
| Q35909879 | Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002. |
| Q38911598 | Direct small-molecule inhibitors of KRAS: from structural insights to mechanism-based design |
| Q42468133 | Discordant effects of rapamycin on proliferation and p70S6 kinase phosphorylation in normal and neoplastic rat chromaffin cells |
| Q40816988 | Disruption of 3-phosphoinositide-dependent kinase 1 (PDK1) signaling by the anti-tumorigenic and anti-proliferative agent n-alpha-tosyl-l-phenylalanyl chloromethyl ketone |
| Q52528321 | Disruption of the gene encoding the mitogen-regulated translational modulator PHAS-I in mice. |
| Q33890035 | Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase |
| Q71475504 | Dissection of protein kinase cascades that mediate cellular response to cytokines and cellular stress |
| Q42824461 | Dissociation of cAMP-stimulated Mitogenesis from Activation of the Mitogen-activated Protein Kinase Cascade in Swiss 3T3 Cells |
| Q42811924 | Dissociation of pp70 ribosomal protein S6 kinase from insulin-stimulated glucose transport in 3T3-L1 adipocytes |
| Q28254826 | Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function |
| Q89697546 | Distinct Roles of mTOR Targets S6K1 and S6K2 in Breast Cancer |
| Q28208587 | Distinct regulatory mechanism for p70 S6 kinase beta from that for p70 S6 kinase alpha |
| Q40831704 | Distinct signalling pathways mediate insulin and phorbol ester-stimulated eukaryotic initiation factor 4F assembly and protein synthesis in HEK 293 cells. |
| Q44496547 | Divergence in signaling pathways involved in promotion of cell viability mediated by bFGF, NGF, and EGF in PC12 cells |
| Q40600008 | Does mitogen-activated-protein kinase have a role in insulin action? The cases for and against |
| Q34358570 | Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity |
| Q24644595 | Dual requirement for a newly identified phosphorylation site in p70s6k |
| Q29615216 | ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions |
| Q104064617 | Effect of immunosuppressants on a mouse model of osteogenesis imperfecta type V harboring a heterozygous Ifitm5 c.-14C > T mutation |
| Q51977964 | Effect of protein kinase inhibitors on protein phosphorylation and germination of aerial spores from Streptomyces coelicolor. |
| Q73793440 | Effect of rapamycin on prolactin-stimulated S6 kinase activity and milk product formation in mouse mammary explants |
| Q79864248 | Effect of sirolimus treatment on gene expression in renal transplant patients |
| Q42484622 | Effects of bis(maltolato) oxovanadium (IV) on protein serine kinases in skeletal muscle of streptozotocin-diabetic rats |
| Q77354743 | Effects of insulin-like growth factor I and II on DNA synthesis and proliferation in primary cultures of adult rat hepatocytes |
| Q24537557 | Elucidating TOR signaling and rapamycin action: lessons from Saccharomyces cerevisiae |
| Q31454913 | Endothelin-1 as a protective factor against beta-adrenergic agonist-induced apoptosis in cardiac myocytes |
| Q37692576 | Environmental signaling through the mechanistic target of rapamycin complex 1: mTORC1 goes nuclear. |
| Q24522441 | Epidermal growth factor receptor and the adaptor protein p52Shc are specific substrates of T-cell protein tyrosine phosphatase |
| Q43800246 | ErbB2-overexpressing human mammary carcinoma cells display an increased requirement for the phosphatidylinositol 3-kinase signaling pathway in anchorage-independent growth |
| Q30304286 | Essential roles of c-JUN and c-JUN N-terminal kinase (JNK) in neuregulin-increased expression of the acetylcholine receptor epsilon-subunit |
| Q35928654 | Estrogenic regulation of S6K1 expression creates a positive regulatory loop in control of breast cancer cell proliferation |
| Q41828672 | Ethanol potentiates the stimulatory effects of insulin and phosphocholine on mitogenesis by a zinc-dependent and rapamycin-sensitive mechanism in fibroblasts and JB6 cells |
| Q47299406 | Eukaryotic elongation factor 2 kinase upregulates the expression of proteins implicated in cell migration and cancer cell metastasis |
| Q38442560 | Everolimus and sirolimus in transplantation-related but different. |
| Q84712603 | Everolimus vs. rapamycin for treating diabetic nephropathy in diabetic mouse model |
| Q40018405 | Evidence for two catalytically active kinase domains in pp90rsk |
| Q58450348 | Evidence that Thrombin-stimulated DNA Synthesis in Pulmonary Arterial Fibroblasts Involves Phosphatidylinositol 3-kinase-dependent p70 Ribosomal S6 Kinase Activation |
| Q41377222 | Evidence that protein kinase C and mitogen activated protein kinase are not involved in the mechanism by which insulin stimulates translation in L6 myoblasts |
| Q92238007 | Exploration of Multiple Signaling Pathways Through Which Sodium Tanshinone IIA Sulfonate Attenuates Pathologic Remodeling Experimental Infarction |
| Q42801685 | Expression of human choline kinase in NIH 3T3 fibroblasts increases the mitogenic potential of insulin and insulin-like growth factor I. |
| Q28114782 | Expression of human mitochondrial NADP-dependent isocitrate dehydrogenase during lymphocyte activation |
| Q40914407 | Extracellular calcium stimulates DNA synthesis in synergism with zinc, insulin and insulin-like growth factor I in fibroblasts |
| Q42800851 | Extracellular zinc activates p70 S6 kinase through the phosphatidylinositol 3-kinase signaling pathway |
| Q24562050 | FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2 |
| Q41377918 | FK506 binding protein 12 mediates sensitivity to both FK506 and rapamycin in murine mast cells |
| Q27931304 | FKBP12-rapamycin target TOR2 is a vacuolar protein with an associated phosphatidylinositol-4 kinase activity. |
| Q36564552 | Fas activation of the p38 mitogen-activated protein kinase signalling pathway requires ICE/CED-3 family proteases |
| Q51552999 | Feeding stimulates protein synthesis in muscle and liver of neonatal pigs through an mTOR-dependent process. |
| Q71934600 | Fibrillar collagen inhibits arterial smooth muscle proliferation through regulation of Cdk2 inhibitors |
| Q36509759 | Forkhead box protein O1 negatively regulates skeletal myocyte differentiation through degradation of mammalian target of rapamycin pathway components |
| Q28237393 | From polyploidy to aneuploidy, genome instability and cancer |
| Q39014611 | Functional Proteomics Identifies Acinus L as a Direct Insulin- and Amino Acid-Dependent Mammalian Target of Rapamycin Complex 1 (mTORC1) Substrate. |
| Q24600427 | Functional interaction between RAFT1/FRAP/mTOR and protein kinase cdelta in the regulation of cap-dependent initiation of translation |
| Q35093120 | Functional modulation of dendritic cells to suppress adaptive immune responses |
| Q36127901 | GIMAP5 Deficiency Is Associated with Increased AKT Activity in T Lymphocytes |
| Q36170215 | GRP78/BiP is a novel downstream target of IGF-1 receptor mediated signaling |
| Q33967129 | Gas6 induces growth, beta-catenin stabilization, and T-cell factor transcriptional activation in contact-inhibited C57 mammary cells |
| Q30336194 | Genetic Analysis of TOR Signaling in Drosophila |
| Q52723495 | Genetic defects in SAPK signalling, chromatin regulation, vesicle transport and CoA-related lipid metabolism are rescued by rapamycin in fission yeast. |
| Q38290355 | Global and specific translational control by rapamycin in T cells uncovered by microarrays and proteomics |
| Q40868631 | Glucocorticoids abate p70(S6k) and eIF4E function in L6 skeletal myoblasts |
| Q90709538 | Glucose-dependent trans-plasma membrane electron transport and p70S6k phosphorylation in skeletal muscle cells |
| Q43812180 | Glycyrrhizin and some analogues induce growth of primary cultured adult rat hepatocytes via epidermal growth factor receptors |
| Q33831975 | Growth controls connect: interactions between c-myc and the tuberous sclerosis complex-mTOR pathway |
| Q40894398 | Growth factor-like effects of placental alkaline phosphatase in human fetus and mouse embryo fibroblasts |
| Q42983387 | Growth-condition-dependent regulation of insulin-like growth factor II mRNA stability |
| Q59080908 | Growth-dependent translation of IGF-II mRNA by a rapamycin-sensitive pathway |
| Q73735545 | HMG-I(Y) phosphorylation status as a nuclear target regulated through insulin receptor substrate-1 and the I4R motif of the interleukin-4 receptor |
| Q33796676 | Hepatitis B virus lacks immune activating capacity, but actively inhibits plasmacytoid dendritic cell function |
| Q33886118 | Heregulin-stimulated acetylcholine receptor gene expression in muscle: requirement for MAP kinase and evidence for a parallel inhibitory pathway independent of electrical activity |
| Q37692030 | How to Train a Cell-Cutting-Edge Molecular Tools |
| Q33842473 | Human cytomegalovirus up-regulates the phosphatidylinositol 3-kinase (PI3-K) pathway: inhibition of PI3-K activity inhibits viral replication and virus-induced signaling |
| Q40919286 | Hydrogen peroxide activates p70(S6k) signaling pathway |
| Q42468950 | Hydrogen peroxide mediates Rac1 activation of S6K1. |
| Q41221120 | Hypersensitivity to rapamycin of BJAB B lymphoblastoid cells |
| Q47791849 | Hypoxia induces phosphorylation of the cyclic AMP response element-binding protein by a novel signaling mechanism |
| Q34489670 | IL-3 Maintains Activation of the p90S6K/RPS6 Pathway and Increases Translation in Human Eosinophils |
| Q34239042 | Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins |
| Q40736711 | Identification of a conserved motif required for mTOR signaling |
| Q37583378 | Identification of a promising PI3K inhibitor for the treatment of multiple myeloma through the structural optimization |
| Q28367688 | Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue |
| Q35631134 | Identification of immunosuppressant-induced apoptosis in a murine B-cell line and its prevention by bcl-x but not bcl-2. |
| Q28307131 | Identification of phosphorylation sites in the translational regulator, PHAS-I, that are controlled by insulin and rapamycin in rat adipocytes |
| Q28646919 | Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway |
| Q24532221 | Ikappa Balpha is a target for the mitogen-activated 90kDa ribosomal S6 kinase |
| Q40434142 | Immunobiology and immunopharmacology of organ allograft rejection |
| Q40429841 | Immunophilins and nervous system |
| Q77206295 | Immunophilins in the nervous system |
| Q28138191 | Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitro |
| Q35160653 | Immunosuppressant FK506 promotes neurite outgrowth in cultures of PC12 cells and sensory ganglia |
| Q41080817 | Immunosuppressants: cellular and molecular mechanisms of action |
| Q74686279 | Immunosuppressive agents: recent developments in molecular action and clinical application |
| Q34075304 | Immunosuppressive effects of tautomycetin in vivo and in vitro via T cell-specific apoptosis induction |
| Q26751433 | Immunosuppressive potency of mechanistic target of rapamycin inhibitors in solid-organ transplantation |
| Q40979448 | Improved antitumor effect of ionizing radiation in combination with rapamycin for treating nasopharyngeal carcinoma |
| Q28567218 | Inactivation of eIF2B and phosphorylation of PHAS-I in heat-shocked rat hepatoma cells |
| Q35301892 | Increase of microRNA-210, decrease of raptor gene expression and alteration of mammalian target of rapamycin regulated proteins following mithramycin treatment of human erythroid cells |
| Q30468691 | Induction of acetylcholine receptor gene expression by ARIA requires activation of mitogen-activated protein kinase |
| Q45969585 | Infarct size is increased in female post-MI rats treated with rapamycin. |
| Q38618654 | Inhibiting the PI3K signaling pathway: buparlisib as a new targeted option in breast carcinoma |
| Q40673162 | Inhibition of amino acid-mTOR signaling by a leucine derivative induces G1 arrest in Jurkat cells |
| Q37456176 | Inhibition of mammalian target of rapamycin is required for optimal antitumor effect of HER2 inhibitors against HER2-overexpressing cancer cells |
| Q34337364 | Inhibition of primary human T cell proliferation by Helicobacter pylori vacuolating toxin (VacA) is independent of VacA effects on IL-2 secretion |
| Q50514761 | Inhibition of protein synthesis by TOR inactivation revealed a conserved regulatory mechanism of the BiP chaperone in Chlamydomonas. |
| Q33642375 | Inhibition of the mammalian target of rapamycin signaling pathway suppresses dentate granule cell axon sprouting in a rodent model of temporal lobe epilepsy |
| Q41302794 | Inhibitors of signalling identify differential control processes responsible for selective effects of insulin on the expression of phosphoenolpyruvate carboxykinase and gene 33 in rat H4 hepatoma cells |
| Q33780195 | Inhibitory effects of rapamycin on the different stages of hepatic fibrosis |
| Q42156574 | Insulin action in cultured human myoblasts: contribution of different signalling pathways to regulation of glycogen synthesis. |
| Q30470683 | Insulin activates a PD 098059-sensitive kinase that is involved in the regulation of p70S6K and PHAS-I. |
| Q28566035 | Insulin activates a p21-activated kinase in muscle cells via phosphatidylinositol 3-kinase |
| Q41128395 | Insulin and insulin-like growth factor-I responsiveness and signalling mechanisms in C2C12 satellite cells: effect of differentiation and fusion |
| Q41043761 | Insulin enhances macrophage scavenger receptor-mediated endocytic uptake of advanced glycation end products |
| Q51219752 | Insulin increases gelatinase activity in rat glomerular mesangial cells via ERK- and PI-3 kinase-dependent signalling. |
| Q33195730 | Insulin promotes rat retinal neuronal cell survival in a p70S6K-dependent manner |
| Q74561854 | Insulin regulates lipoprotein lipase activity in rat adipose cells via wortmannin- and rapamycin-sensitive pathways |
| Q28574617 | Insulin regulation of insulin-like growth factor-binding protein-1 gene expression is dependent on the mammalian target of rapamycin, but independent of ribosomal S6 kinase activity |
| Q48021735 | Insulin signal transduction through protein kinase cascades |
| Q40019067 | Insulin signalling and insulin actions in the muscles and livers of insulin-resistant, insulin receptor substrate 1-deficient mice |
| Q55514148 | Insulin signalling promotes dendrite and synapse regeneration and restores circuit function after axonal injury. |
| Q73893945 | Insulin stimulated glycogen synthesis in isolated rat hepatocytes: effect of protein kinase inhibitors |
| Q42823635 | Insulin stimulation of glycogen synthesis and glycogen synthase activity is blocked by wortmannin and rapamycin in 3T3-L1 adipocytes: evidence for the involvement of phosphoinositide 3-kinase and p70 ribosomal protein-S6 kinase |
| Q24802469 | Insulin utilizes the PI 3-kinase pathway to inhibit SP-A gene expression in lung epithelial cells |
| Q40854166 | Insulin-like growth factor-1-induced phosphorylation of the forkhead family transcription factor FKHRL1 is mediated by Akt kinase in PC12 cells |
| Q30469708 | Integrin-dependent activation of the p70 ribosomal S6 kinase signaling pathway |
| Q42058448 | Interaction of Ras with phosphoinositide 3-kinase gamma |
| Q38291149 | Interleukin 4-inducible phosphorylation of HMG-I(Y) is inhibited by rapamycin |
| Q40933624 | Interleukin-10 stimulation of phosphatidylinositol 3-kinase and p70 S6 kinase is required for the proliferative but not the antiinflammatory effects of the cytokine |
| Q36551314 | Interleukin-2 triggers a novel phosphatidylinositol 3-kinase-dependent MEK activation pathway |
| Q40905578 | Intracellular signaling molecules involved in an inhibitory factor-induced decrease in fetal-type AChR expression |
| Q30306742 | Intracellular signals that control cell proliferation in mammalian balance epithelia: key roles for phosphatidylinositol-3 kinase, mammalian target of rapamycin, and S6 kinases in preference to calcium, protein kinase C, and mitogen-activated [...] |
| Q53478295 | Intracellular sirolimus concentration is reduced by tacrolimus in human pancreatic islets in vitro. |
| Q38260264 | Investigation of phosphoproteome in RAGE signaling |
| Q57364041 | Involvement of Phosphatidylinositol 3-Kinase in the Mediation of Erythropoietin-Induced Activation of p70S6k |
| Q42278342 | Involvement of the Ras/extracellular signal-regulated kinase signalling pathway in the regulation of ERCC-1 mRNA levels by insulin |
| Q28305483 | Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells |
| Q33709769 | Itraconazole exerts its anti-melanoma effect by suppressing Hedgehog, Wnt, and PI3K/mTOR signaling pathways |
| Q36765791 | Jun NH2-terminal kinase is constitutively activated in T cells transformed by the intracellular parasite Theileria parva |
| Q37330681 | Ketamine: synaptogenesis, immunomodulation and glycogen synthase kinase-3 as underlying mechanisms of its antidepressant properties |
| Q35560391 | Kinase Activities Associated with mTOR |
| Q83278057 | Kinetoplastida: model organisms for simple autophagic pathways? |
| Q35757977 | L-type amino acid transport and cancer: targeting the mTORC1 pathway to inhibit neoplasia |
| Q86406164 | Long-term effects of conversion from cyclosporine to rapamycin on testicular function and morphology in a rat transplantation model |
| Q37384485 | Lysophosphatidic acid is a major serum noncytokine survival factor for murine macrophages which acts via the phosphatidylinositol 3-kinase signaling pathway |
| Q42829930 | MAP kinase phosphatase-1 mRNA is expressed in embryonic sympathetic neurons and is upregulated after NGF stimulation |
| Q40675146 | MAP kinases ERK1 and ERK2: pleiotropic enzymes in a ubiquitous signaling network |
| Q41461105 | MAP kinases in mitogenesis and development |
| Q41539247 | MAPKAP kinase-2; a novel protein kinase activated by mitogen-activated protein kinase |
| Q51134156 | MAb 18D3 Triggering of Integrin β1 Will Prevent but Not Terminate Proliferation of Human T Cells |
| Q36546300 | MCL-1-independent mechanisms of synergy between dual PI3K/mTOR and BCL-2 inhibition in diffuse large B cell lymphoma |
| Q39277137 | Maintenance pharmacological immunosuppressive strategies in renal transplantation |
| Q54943035 | Mammalian EAK-7 activates alternative mTOR signaling to regulate cell proliferation and migration. |
| Q34498303 | Mammalian target of rapamycin (mTOR) inhibition as a potential antiepileptogenic therapy: From tuberous sclerosis to common acquired epilepsies |
| Q37074284 | Mammalian target of rapamycin (mTOR) pathway signalling in lymphomas |
| Q42995176 | Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation. |
| Q24562735 | Mapping of residues forming the voltage sensor of the voltage-dependent anion-selective channel |
| Q41732739 | Mechanism of activation and function of protein kinase B. |
| Q41734033 | Mechanisms and management of acute renal allograft rejection |
| Q40958970 | Mechanistic Target of Rapamycin Complex 1/S6 Kinase 1 Signals Influence T Cell Activation Independently of Ribosomal Protein S6 Phosphorylation |
| Q38354870 | Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways |
| Q35145340 | Membrane protein CNNM4-dependent Mg2+ efflux suppresses tumor progression |
| Q39318607 | Metabolic Alterations at the Crossroad of Aging and Oncogenesis |
| Q40888793 | Metabolic regulation of Na(+)/P(i)-cotransporter-1 gene expression in H4IIE cells |
| Q36760241 | Metabotropic glutamate receptor-initiated translocation of protein kinase p90rsk to polyribosomes: a possible factor regulating synaptic protein synthesis |
| Q34357983 | Metformin in cancer prevention and therapy |
| Q41102257 | Mitogenic signalling by delta opioid receptors expressed in rat-1 fibroblasts involves activation of the p70s6k/p85s6k S6 kinase |
| Q44315431 | Mitotic regulation of ribosomal S6 kinase 1 involves Ser/Thr, Pro phosphorylation of consensus and non-consensus sites by Cdc2. |
| Q34170300 | Modern immunosuppression |
| Q42042015 | Molecular Characterization and Expression Analysis of S6K1 in Cashmere Goats (Capra hircus). |
| Q42122598 | Molecular characterization and functional analysis of Cashmere goat mammalian target of rapamycin. |
| Q38866763 | Molecular mechanisms of mTOR regulation by stress |
| Q38295925 | Multiple independent inputs are required for activation of the p70 S6 kinase |
| Q41592332 | Multiple signaling pathways involved in the metabolic effects of insulin |
| Q42822243 | Multiple signalling pathways involved in the stimulation of fatty acid and glycogen synthesis by insulin in rat epididymal fat cells. |
| Q42101485 | Muscarinic receptor-mediated activation of p70 S6 kinase 1 (S6K1) in 1321N1 astrocytoma cells: permissive role of phosphoinositide 3-kinase |
| Q24530079 | Mutational analysis of ribosomal S6 kinase 2 shows differential regulation of its kinase activity from that of ribosomal S6 kinase 1 |
| Q38710386 | Mycophenolate Mofetil and Rapamycin Induce Apoptosis in the Human Monocytic U937 Cell Line Through Two Different Pathways |
| Q52537021 | NRG-1-induced cardiomyocyte hypertrophy. Role of PI-3-kinase, p70(S6K), and MEK-MAPK-RSK. |
| Q39631004 | Nerve growth factor activates extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways to stimulate CREB serine 133 phosphorylation |
| Q43746975 | Nerve growth factor uses Ras/ERK and phosphatidylinositol 3-kinase cascades to up-regulate the N-methyl-D-aspartate receptor 1 promoter |
| Q40637218 | Networking with mitogen-activated protein kinases. |
| Q24685127 | Neurabin is a synaptic protein linking p70 S6 kinase and the neuronal cytoskeleton |
| Q41659803 | Neural roles of immunophilins and their ligands |
| Q42528881 | Neurotransmitter- and growth factor-induced cAMP response element binding protein phosphorylation in glial cell progenitors: role of calcium ions, protein kinase C, and mitogen-activated protein kinase/ribosomal S6 kinase pathway. |
| Q41334079 | New immunosuppressive drugs in organ transplantation |
| Q34275358 | New immunosuppressive drugs: mechanistic insights and potential therapeutic advances |
| Q34507177 | New targets for rapid antidepressant action |
| Q92340915 | Nitrogen-dependent coordination of cell cycle, quiescence and TAG accumulation in Chlamydomonas |
| Q30418844 | Novel 5'TOPmRNAs regulated by ribosomal S6 kinase are important for cardiomyocyte development: S6 kinase suppression limits cardiac differentiation and promotes pluripotent cells toward a neural lineage. |
| Q28213233 | Novel cross talk between MEK and S6K2 in FGF-2 induced proliferation of SCLC cells |
| Q40791371 | Nuclear localization of p85s6k: functional requirement for entry into S phase. |
| Q40047969 | Octreotide and the mTOR inhibitor RAD001 (everolimus) block proliferation and interact with the Akt-mTOR-p70S6K pathway in a neuro-endocrine tumour cell Line |
| Q72109739 | Okadaic acid potentiates heat-induced activation of erk2 |
| Q47232136 | Oncogenic Signalling through Mechanistic Target of Rapamycin (mTOR): A Driver of Metabolic Transformation and Cancer Progression |
| Q42809068 | Opposite translational control of GLUT1 and GLUT4 glucose transporter mRNAs in response to insulin. Role of mammalian target of rapamycin, protein kinase b, and phosphatidylinositol 3-kinase in GLUT1 mRNA translation |
| Q40934280 | Osmotic stress inhibits p70/85 S6 kinase through activation of a protein phosphatase |
| Q24815638 | Overcoming cisplatin resistance by mTOR inhibitor in lung cancer |
| Q41392993 | Overexpression of initiation factor eIF-4E does not relieve the translational repression of ribosomal protein mRNAs in quiescent cells |
| Q47867724 | Overexpression of mTOR and p(240-244)S6 in IDH1 Wild-Type Human Glioblastomas Is Predictive of Low Survival |
| Q36100039 | PAK2 is an effector of TSC1/2 signaling independent of mTOR and a potential therapeutic target for Tuberous Sclerosis Complex |
| Q28244045 | PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase |
| Q41553975 | PDK1, one of the missing links in insulin signal transduction? |
| Q33341346 | PDK2: the missing piece in the receptor tyrosine kinase signaling pathway puzzle |
| Q30471333 | PHAS proteins as mediators of the actions of insulin, growth factors and cAMP on protein synthesis and cell proliferation |
| Q42801822 | PHAS-I phosphorylation in response to foetal bovine serum (FBS) is regulated by an ERK1/ERK2-independent and rapamycin-sensitive pathway in 3T3-L1 adipocytes |
| Q73816410 | PI-3-kinase is an essential anti-apoptotic effector in the proliferative response of primary human epithelial cells to mutant RAS |
| Q36422120 | PKCδ Regulates Translation Initiation through PKR and eIF2α in Response to Retinoic Acid in Acute Myeloid Leukemia Cells |
| Q37164566 | PTEN contributes to profound PI3K/Akt signaling pathway deregulation in dystrophin-deficient dog muscle |
| Q44294939 | Paclitaxel induces inactivation of p70 S6 kinase and phosphorylation of Thr421 and Ser424 via multiple signaling pathways in mitosis |
| Q33739184 | Patient-derived xenografts of triple-negative breast cancer reproduce molecular features of patient tumors and respond to mTOR inhibition |
| Q28588541 | Pdk1 activity controls proliferation, survival, and growth of developing pancreatic cells |
| Q38127844 | Perifosine--a new option in treatment of acute myeloid leukemia? |
| Q41038906 | Perspective: The Potential Role of Essential Amino Acids and the Mechanistic Target of Rapamycin Complex 1 (mTORC1) Pathway in the Pathogenesis of Child Stunting |
| Q60955118 | Perspectives of RAS and RHEB GTPase Signaling Pathways in Regenerating Brain Neurons |
| Q30440938 | Phorbol 12-myristate 13-acetate and serum synergize to promote rapamycin-insensitive cell proliferation via protein kinase C-eta |
| Q34316184 | Phosphatidylinositol 3' kinase signaling in mammary tumorigenesis. |
| Q42528754 | Phosphatidylinositol 3'-kinase and p70s6k are required for insulin but not bisperoxovanadium 1,10-phenanthroline (bpV(phen)) inhibition of insulin-like growth factor binding protein gene expression. Evidence for MEK-independent activation of mitogen |
| Q48630214 | Phosphatidylinositol 3'-kinase-independent p70 S6 kinase activation by fibroblast growth factor receptor-1 is important for proliferation but not differentiation of endothelial cells |
| Q58450061 | Phosphatidylinositol 3-Kinase, but Not p70/p85 Ribosomal S6 Protein Kinase, Is Required for the Regulation of Phosphoenolpyruvate Carboxykinase (PEPCK) Gene Expression by Insulin |
| Q42796185 | Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation |
| Q41102950 | Phosphatidylinositol 3-kinase related kinases |
| Q29620177 | Phosphatidylinositol-3-OH kinase as a direct target of Ras |
| Q37554503 | Phospho-p70S6K and cdc2/cdk1 as therapeutic targets for diffuse large B-cell lymphoma |
| Q42802805 | Phosphoinositide 3-kinase activation regulates cell division time by coordinated control of cell mass and cell cycle progression rate |
| Q37463310 | Phosphoinositide 3-kinase signaling in the vertebrate retina |
| Q36346828 | Phosphoinositide 3-kinase: from viral oncoprotein to drug target |
| Q34268347 | Phospholipase D signaling pathways and phosphatidic acid as therapeutic targets in cancer |
| Q24599204 | Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases |
| Q37275199 | Phosphorylation of eukaryotic translation initiation factor 2alpha coordinates rRNA transcription and translation inhibition during endoplasmic reticulum stress |
| Q24564046 | Phosphorylation of the c-Fos transrepression domain by mitogen-activated protein kinase and 90-kDa ribosomal S6 kinase |
| Q42526875 | Phosphorylation of the eIF4E-binding protein PHAS-I after exposure of PC12 cells to EGF and NGF. |
| Q28211693 | Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth |
| Q54310511 | Phosphorylation of the ribosomal protein S6, a marker of mTOR (mammalian target of rapamycin) pathway activation, is strongly increased in hypertrophic scars and keloids. |
| Q48787316 | Phosphorylation pattern of the p90rsk and mitogen-activated protein kinase (MAPK) molecule: comparison of in vitro and in vivo matured porcine oocytes |
| Q41289644 | Phosphorylation state of the RNA polymerase II C-terminal domain (CTD) in heat-shocked cells. Possible involvement of the stress-activated mitogen-activated protein (MAP) kinases |
| Q37243586 | Physiological roles of ribosomal protein S6: one of its kind |
| Q27930976 | Pkh1 and Pkh2 differentially phosphorylate and activate Ypk1 and Ykr2 and define protein kinase modules required for maintenance of cell wall integrity |
| Q35763264 | Pleckstrin homology domain leucine-rich repeat protein phosphatase (PHLPP): a new player in cell signaling. |
| Q37461622 | Possible dual regulatory circuits involving AtS6K1 in the regulation of plant cell cycle and growth |
| Q35024097 | Poxviral regulation of the host NF-kappaB response: the vaccinia virus M2L protein inhibits induction of NF-kappaB activation via an ERK2 pathway in virus-infected human embryonic kidney cells. |
| Q40733083 | Predominant nuclear localization of mammalian target of rapamycin in normal and malignant cells in culture |
| Q73421149 | Proliferation of adult rat hepatocytes in primary culture induced by insulin is potentiated by cAMP-elevating agents |
| Q42362534 | Protein Translation and Signaling in Human Eosinophils |
| Q39551585 | Protein kinase B localization and activation differentially affect S6 kinase 1 activity and eukaryotic translation initiation factor 4E-binding protein 1 phosphorylation |
| Q24675387 | Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycinassociated protein |
| Q55066840 | Protein phosphorylation profiling identifies potential mechanisms for direct immunotoxicity. |
| Q50066488 | Protein translation in the nucleus accumbens is dysregulated during cocaine withdrawal and required for expression of incubation of cocaine craving. |
| Q59805552 | Quantitative Phosphoproteomic and System-Level Analysis of TOR Inhibition Unravel Distinct Organellar Acclimation in |
| Q24682697 | RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1 |
| Q36745240 | RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation |
| Q36067739 | REDD2-mediated inhibition of mTOR promotes dendrite retraction induced by axonal injury |
| Q34662354 | ROS inhibit autophagy by downregulating ULK1 mediated by the phosphorylation of p53 in selenite-treated NB4 cells. |
| Q24320064 | RSK3 encodes a novel pp90rsk isoform with a unique N-terminal sequence: growth factor-stimulated kinase function and nuclear translocation |
| Q57362835 | Rapamune® (RAPA, rapamycin, sirolimus): mechanism of action immunosuppressive effect results from blockade of signal transduction and inhibition of cell cycle progression |
| Q42415993 | Rapamycin Augments the NMDA-Mediated TNF Suppression of MRSA-Stimulated RAW264.7 Murine Macrophages |
| Q46135983 | Rapamycin administration in humans blocks the contraction-induced increase in skeletal muscle protein synthesis |
| Q34325486 | Rapamycin and mTOR: a serendipitous discovery and implications for breast cancer |
| Q28476740 | Rapamycin blocks production of KSHV/HHV8: insights into the anti-tumor activity of an immunosuppressant drug |
| Q28378802 | Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation |
| Q44920860 | Rapamycin confers preconditioning-like protection against ischemia-reperfusion injury in isolated mouse heart and cardiomyocytes |
| Q40022362 | Rapamycin destabilizes interleukin-3 mRNA in autocrine tumor cells by a mechanism requiring an intact 3' untranslated region |
| Q36971030 | Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation |
| Q42804494 | Rapamycin dissociates p70(S6K) activation from DNA synthesis stimulated by bombesin and insulin in Swiss 3T3 cells |
| Q43735102 | Rapamycin impairs recovery from acute renal failure: role of cell-cycle arrest and apoptosis of tubular cells |
| Q40443941 | Rapamycin induces apoptosis of JN-DSRCT-1 cells by increasing the Bax : Bcl-xL ratio through concurrent mechanisms dependent and independent of its mTOR inhibitory activity |
| Q34781893 | Rapamycin inhibits GM-CSF-induced neutrophil migration |
| Q57348273 | Rapamycin inhibits aldolase A expression during human lymphocyte activation |
| Q33755192 | Rapamycin inhibits clonal expansion and adipogenic differentiation of 3T3-L1 cells |
| Q28377538 | Rapamycin inhibits didemnin B-induced apoptosis in human HL-60 cells: evidence for the possible involvement of FK506-binding protein 25 |
| Q28375219 | Rapamycin inhibits hepatic stellate cell proliferation in vitro and limits fibrogenesis in an in vivo model of liver fibrosis |
| Q45071043 | Rapamycin inhibits proliferation and differentiation of human endothelial progenitor cells in vitro |
| Q40887263 | Rapamycin protects against neuron death in in vitro and in vivo models of Parkinson's disease |
| Q36564073 | Rapamycin resistance tied to defective regulation of p27Kip1. |
| Q35917778 | Rapamycin selectively inhibits translation of mRNAs encoding elongation factors and ribosomal proteins |
| Q35234179 | Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family |
| Q39847519 | Rapamycin specifically interferes with the developmental response of fission yeast to starvation |
| Q41106936 | Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k. |
| Q79919091 | Rapamycin, not cyclosporine, permits thymic generation and peripheral preservation of CD4+ CD25+ FoxP3+ T cells |
| Q41666761 | Rapamycin, wortmannin, and the methylxanthine SQ20006 inactivate p70s6k by inducing dephosphorylation of the same subset of sites |
| Q39438481 | Rapamycin-resistant phosphorylation of the initiation factor-4E-binding protein (4E-BP1) in v-SRC-transformed hamster fibroblasts |
| Q37679469 | Rapamycin: one drug, many effects |
| Q40584303 | Rapid isolation of viral integration site reveals frequent integration of HTLV-1 into expressed loci |
| Q35593768 | Rapid mitogenic regulation of the mTORC1 inhibitor, DEPTOR, by phosphatidic acid |
| Q35560388 | Raptor and mTOR: Subunits of a Nutrient-Sensitive Complex |
| Q24302566 | Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action |
| Q38174585 | Rationale of personalized immunosuppressive medication for hepatocellular carcinoma patients after liver transplantation |
| Q35358625 | Reassessment of the role of TSC, mTORC1 and microRNAs in amino acids-meditated translational control of TOP mRNAs. |
| Q33681499 | Recent advances in immunosuppressants. |
| Q57245409 | Recent advances in immunosuppression |
| Q28273915 | Redox regulation of the nutrient-sensitive raptor-mTOR pathway and complex |
| Q30307977 | Regeneration in avian hair cell epithelia: identification of intracellular signals required for S-phase entry |
| Q57903792 | Regulating 56 kinase |
| Q28255399 | Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks |
| Q40910700 | Regulation of BAD phosphorylation at serine 112 by the Ras-mitogen-activated protein kinase pathway |
| Q37603072 | Regulation of cell death and epileptogenesis by the mammalian target of rapamycin (mTOR): a double-edged sword? |
| Q35206467 | Regulation of cellular growth by the Drosophila target of rapamycin dTOR |
| Q31442597 | Regulation of glycogen synthesis by amino acids in cultured human muscle cells. |
| Q38034202 | Regulation of mRNA translation by signaling pathways |
| Q37409739 | Regulation of mTORC1 by lysosomal calcium and calmodulin. |
| Q74263760 | Regulation of mitogen-activated protein kinase activation by the cytoplasmic domain of the alpha6 integrin subunit |
| Q77164943 | Regulation of protein synthesis by cholecystokinin in rat pancreatic acini involves PHAS-I and the p70 S6 kinase pathway |
| Q28139573 | Regulation of ribosomal S6 kinase 2 by effectors of the phosphoinositide 3-kinase pathway |
| Q34624565 | Regulation of ribosomal protein S6 phosphorylation by casein kinase 1 and protein phosphatase 1 |
| Q53577692 | Regulation of s6 kinase 1 activation by phosphorylation at ser-411. |
| Q47954202 | Regulation of the p70 S6 kinase by phosphorylation in vivo. Analysis using site-specific anti-phosphopeptide antibodies |
| Q34284892 | Regulation of the polarization of T cells toward antigen-presenting cells by Ras-related GTPase CDC42 |
| Q41064925 | Regulation of translation elongation factor-2 by insulin via a rapamycin-sensitive signalling pathway |
| Q40022933 | Requirement of phosphatidylinositol 3-kinase-dependent pathway and Src for Gas6-Axl mitogenic and survival activities in NIH 3T3 fibroblasts |
| Q40023254 | Requirement of protein kinase C zeta for stimulation of protein synthesis by insulin |
| Q36725003 | Reversing the Warburg effect as a treatment for glioblastoma |
| Q48508173 | Rheb activation of mTOR and S6K1 signaling |
| Q39413456 | Ribosomal protein S6 is hyperactivated and differentially phosphorylated in epidermal lesions of patients with psoriasis and atopic dermatitis |
| Q37726439 | Ribosomal protein S6 kinase from TOP mRNAs to cell size |
| Q28585415 | Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis |
| Q24299873 | Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton |
| Q27331645 | Rictor/TORC2 regulates Caenorhabditis elegans fat storage, body size, and development through sgk-1 |
| Q55478123 | Ro31-8220 inhibits protein kinase C to block the phorbol ester-stimulated release of choline- and ethanolamine-metabolites from C6 glioma cells: p70 S6 kinase and MAPKAP kinase-1beta do not function downstream of PKC in activating PLD. |
| Q33690319 | Role and regulation of 90 kDa ribosomal S6 kinase (RSK) in signal transduction. |
| Q34047808 | Role of S6 phosphorylation and S6 kinase in cell growth |
| Q41244385 | Role of p70 S6 kinase in cytokine-regulated hemopoietic cell survival |
| Q90230822 | Roles of mTOR Signaling in Tissue Regeneration |
| Q40499781 | S6 phosphorylation and the p70s6k/p85s6k |
| Q73556163 | S6 ribosomal protein phosphorylation and translation of stored mRNA in maize |
| Q34554631 | SHP2 is a target of the immunosuppressant tautomycetin |
| Q36202378 | SOX2 and PI3K Cooperate to Induce and Stabilize a Squamous-Committed Stem Cell Injury State during Lung Squamous Cell Carcinoma Pathogenesis. |
| Q24644334 | STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation |
| Q39777490 | Schizosaccharomyces pombe AGC family kinase Gad8p forms a conserved signaling module with TOR and PDK1-like kinases |
| Q42827298 | Selective Inhibition of p70 S6 Kinase Activation by Phosphatidylinositol 3‐Kinase Inhibitors |
| Q36317333 | Sevoflurane inhibits the phosphorylation of ribosomal protein S6 in neonatal rat brain |
| Q72827475 | Signal transduction mechanisms in the regulation of protein synthesis |
| Q41440046 | Signal transduction pathways in macroautophagy. |
| Q40816145 | Signal transduction pathways involved in phosphorylation and activation of p70S6K following exposure to UVA irradiation. |
| Q41750250 | Signal transduction through MAP kinase cascades |
| Q36381460 | Signal transduction via the MAP kinases: proceed at your own RSK. |
| Q24522447 | Signaling by target of rapamycin proteins in cell growth control |
| Q38700659 | Signaling crosstalk between the mTOR complexes |
| Q54118148 | Signaling pathways involved in the regulation of mRNA translation. |
| Q40866821 | Signalling pathways regulating protein turnover in skeletal muscle |
| Q40015717 | Single-chain antibody-mediated intracellular retention of ErbB-2 impairs Neu differentiation factor and epidermal growth factor signaling |
| Q70865353 | Sirolimus (rapamycin) inhibits mitogen-induced stimulation of protein synthesis in primary lymphocytes |
| Q35130521 | Sirolimus pharmacokinetics in pediatric renal transplant recipients receiving calcineurin inhibitor co-therapy |
| Q45276341 | Sirolimus rescue of renal failure in children after combined liver-kidney transplantation |
| Q33986353 | Sirt1 overexpression in neurons promotes neurite outgrowth and cell survival through inhibition of the mTOR signaling. |
| Q37257403 | Six1 is down-regulated in end-stage human dilated cardiomyopathy independently of Ezh2. |
| Q24633679 | Skeletal muscle protein balance in mTOR heterozygous mice in response to inflammation and leucine |
| Q40916836 | Sphingomyelinase treatment of rat hepatocytes inhibits cell-swelling-stimulated glycogen synthesis by causing cell shrinkage |
| Q41042885 | Stimulation of DNA synthesis in untransformed cells by the antiviral and antitumoral compound tricyclodecan-9-yl-xanthogenate (D609). |
| Q74453080 | Stimulation of MAP kinase and S6 kinase by vanadium and selenium in rat adipocytes |
| Q41055633 | Stimulation of glucose and amino acid transport and activation of the insulin signaling pathways by insulin lispro in L6 skeletal muscle cells |
| Q57348290 | Stimulation of glycogen synthesis by insulin requires S6 kinase and phosphatidylinositol-3-kinase in HTC-IR cells |
| Q40018987 | Stimulation of protein synthesis, eukaryotic translation initiation factor 4E phosphorylation, and PHAS-I phosphorylation by insulin requires insulin receptor substrate 1 and phosphatidylinositol 3-kinase |
| Q42804613 | Stress-inducible, murine protein mSTI1. Characterization of binding domains for heat shock proteins and in vitro phosphorylation by different kinases |
| Q33716466 | Structural and functional analysis of pp70S6k |
| Q34323303 | Structure and modifications of the junior chaperone alpha-crystallin. From lens transparency to molecular pathology |
| Q28243447 | Structure of S6 kinase 1 determines whether raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site |
| Q36560034 | Studies of partially transforming polyomavirus mutants establish a role for phosphatidylinositol 3-kinase in activation of pp70 S6 kinase |
| Q41128352 | Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB. |
| Q28181392 | Sustained activation of the JNK cascade and rapamycin-induced apoptosis are suppressed by p53/p21(Cip1) |
| Q38259308 | TBC1D14 regulates autophagy via the TRAPP complex and ATG9 traffic |
| Q40718865 | TNF-alpha inhibits SP-A gene expression in lung epithelial cells via p38 MAPK. |
| Q64910864 | TOFA induces cell cycle arrest and apoptosis in ACHN and 786-O cells through inhibiting PI3K/Akt/mTOR pathway. |
| Q35560369 | TOR Action in Mammalian Cells and in Caenorhabditis elegans |
| Q27931425 | TOR controls translation initiation and early G1 progression in yeast |
| Q33784149 | TOR kinase homologs function in a signal transduction pathway that is conserved from yeast to mammals |
| Q38289137 | TOR mutations confer rapamycin resistance by preventing interaction with FKBP12-rapamycin. |
| Q30312086 | TOR signaling |
| Q27929939 | Target of rapamycin proteins and their kinase activities are required for meiosis |
| Q36063511 | Targeted disruption of p70(s6k) defines its role in protein synthesis and rapamycin sensitivity |
| Q37047669 | Targeting the PI3K/Akt/mTOR pathway for breast cancer therapy |
| Q43651300 | The 12th Annual Report of the North American Pediatric Renal Transplant Cooperative Study: renal transplantation from 1987 through 1998. |
| Q24561774 | The 25-kDa FK506-binding protein is localized in the nucleus and associates with casein kinase II and nucleolin |
| Q42812980 | The 70 kDa S6 kinase complexes with and is activated by the Rho family G proteins Cdc42 and Rac1. |
| Q36227198 | The Akt-mTOR axis is a pivotal regulator of eccentric hypertrophy during volume overload |
| Q42628853 | The C-terminal extension that characterizes mosquito (Diptera: Culicidae) ribosomal protein S6 is widespread among the Culicomorpha |
| Q35956694 | The C-terminal kinase and ERK-binding domains of Drosophila S6KII (RSK) are required for phosphorylation of the protein and modulation of circadian behavior |
| Q28284128 | The COOH-terminal tyrosine phosphorylation sites on IRS-1 bind SHP-2 and negatively regulate insulin signaling |
| Q33599031 | The Croonian Lecture 1998. Identification of a protein kinase cascade of major importance in insulin signal transduction |
| Q36559748 | The Drosophila insulin receptor activates multiple signaling pathways but requires insulin receptor substrate proteins for DNA synthesis |
| Q37296142 | The Drosophila p70s6k homolog exhibits conserved regulatory elements and rapamycin sensitivity |
| Q27930631 | The FKB2 gene of Saccharomyces cerevisiae, encoding the immunosuppressant-binding protein FKBP-13, is regulated in response to accumulation of unfolded proteins in the endoplasmic reticulum |
| Q40637233 | The MAP kinase cascade. Discovery of a new signal transduction pathway |
| Q33632328 | The PIK-related kinases intercept conventional signaling pathways |
| Q24315679 | The RSK family of kinases: emerging roles in cellular signalling |
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