Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins

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Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins is …
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scholarly articleQ13442814

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P356DOI10.1016/0014-5793(92)81216-9
P698PubMed publication ID1332886
P5875ResearchGate publication ID21822596

P50authorMatthias GaestelQ23057692
P2093author name stringCohen P
Campbell DG
Engel K
Stokoe D
P2860cites workHuman muscle glycogen synthase cDNA sequence: a negatively charged protein with an asymmetric charge distributionQ24623698
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Recent progress in characterization of protein kinase cascades for phosphorylation of ribosomal protein S6.Q30439463
Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II.Q30460881
Effect of proteases on the structure and activity of rabbit skeletal muscle glycogen synthetaseQ39654785
Heat shock resistance conferred by expression of the human HSP27 gene in rodent cellsQ41571711
Phosphorylation of the small heat-shock protein is regulated by interleukin 1, tumour necrosis factor, growth factors, bradykinin and ATP.Q41671415
Molecular cloning, sequencing and expression in Escherichia coli of the 25-kDa growth-related protein of Ehrlich ascites tumor and its homology to mammalian stress proteinsQ44454104
Over-expression of the small heat-shock protein, hsp25, inhibits growth of Ehrlich ascites tumor cellsQ45090745
Purification and characterisation of the insulin-stimulated protein kinase from rabbit skeletal muscle; close similarity to S6 kinase II.Q50798730
Enhanced constitutive expression of the 27-kDa heat shock proteins in heat-resistant variants from Chinese hamster cells.Q54375768
The molecular mechanism by which insulin stimulates glycogen synthesis in mammalian skeletal muscleQ59069709
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
P304page(s)307-313
P577publication date1992-11-01
P1433published inFEBS LettersQ1388051
P1476titleIdentification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins
P478volume313

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cites work (P2860)
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Q35038021Peptide inhibitors of MK2 show promise for inhibition of abdominal adhesions
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Q73177301Phosphorylation of A 27-kDa protein correlates with survival of protein-synthesis-inhibited MCF-7 cells
Q97540868Phosphorylation of steroid receptor coactivator-3 (SRC-3) at serine 857 is regulated by the p38MAPK-MK2 axis and affects NF-κB-mediated transcription
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Q47896902Phosphorylations of alpha A- and alpha B-crystallin
Q28115858Pituitary adenylate cyclase-activating polypeptide 38-mediated Rin activation requires Src and contributes to the regulation of HSP27 signaling during neuronal differentiation
Q40922000Possible involvement of heat shock protein 25 in the angiotensin II-induced glomerular mesangial cell contraction via p38 MAP kinase
Q35844484Promoter methylation of heat shock protein B2 in human esophageal squamous cell carcinoma
Q33624625Protective effect of phosphorylated Hsp27 in coronary arteries through actin stabilization
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Q28346924Protein kinase inhibitors can suppress stress-induced dissociation of Hsp27
Q56929345Proteomic Analysis of Calcium/Calmodulin-dependent Protein Kinase I and IVin VitroSubstrates Reveals Distinct Catalytic Preferences
Q35122194Proteomic alterations in heat shock protein 27 and identification of phosphoproteins in ascending aortic aneurysm associated with bicuspid and tricuspid aortic valve
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Q33536101Proteomic analysis reveals virus-specific Hsp25 modulation in cardiac myocytes
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Q64166670Purification of the stress protein αB-crystallin and its differentially phosphorylated forms
Q36237663Reactive Oxygen Species, SUMOylation, and Endothelial Inflammation
Q37739212Reactive oxygen species in early and delayed cardiac adaptation
Q37218406Regulated structural transitions unleash the chaperone activity of αB-crystallin
Q50337024Regulation of MAPK-activated protein kinase 5 activity and subcellular localization by the atypical MAPK ERK4/MAPK4.
Q39453587Regulation of cyclooxygenase 2 mRNA stability by the mitogen-activated protein kinase p38 signaling cascade
Q77376158Regulation of mitogen-activated protein kinase cascades in the heart
Q30660477Restricted access chromatographic sample preparation of low mass proteins expressed in human fibroblast cells for proteomics analysis
Q35764321Role of heat shock proteins during polyglutamine neurodegeneration: mechanisms and hypothesis
Q47764569Role of p38 MAPK and MAPKAPK-2 in angiotensin II-induced Akt activation in vascular smooth muscle cells
Q36571858Role of the human heat shock protein hsp70 in protection against stress-induced apoptosis
Q43941680S-thiolation of HSP27 regulates its multimeric aggregate size independently of phosphorylation
Q28587317Scaffolding by ERK3 regulates MK5 in development
Q24562305Selection of a subset of mRNAs from combinatorial 3' untranslated region libraries using neuronal RNA-binding protein Hel-N1
Q35801033Sequence, structure, and dynamic determinants of Hsp27 (HspB1) equilibrium dissociation are encoded by the N-terminal domain
Q41750250Signal transduction through MAP kinase cascades
Q42324125Simultaneous measurement of ERK, p38, and JNK MAP kinase cascades in vascular smooth muscle cells
Q54198162Skin equivalent tensional force alters keloid fibroblast behavior and phenotype.
Q27934278Small heat shock protein suppression of Vpr-induced cytoskeletal defects in budding yeast
Q58585311Small heat shock proteins: Simplicity meets complexity
Q38263437Small heat-shock proteins: important players in regulating cellular proteostasis
Q37577461Small molecule sensitization to TRAIL is mediated via nuclear localization, phosphorylation and inhibition of chaperone activity of Hsp27.
Q41106742Sounding the alarm: protein kinase cascades activated by stress and inflammation
Q41774306Specific activation of beta-casein kinase by the inflammatory cytokines interleukin 1 and tumour necrosis factor
Q41954007Stimulation of multiple mitogen-activated protein kinase sub-families by oxidative stress and phosphorylation of the small heat shock protein, HSP25/27, in neonatal ventricular myocytes
Q28237559Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398
Q41820861Stress induced gene expression: a direct role for MAPKAP kinases in transcriptional activation of immediate early genes
Q24597068Stress- and mitogen-induced phosphorylation of the small heat shock protein Hsp25 by MAPKAP kinase 2 is not essential for chaperone properties and cellular thermoresistance
Q34124131Stress-activated protein kinases are involved in coxsackievirus B3 viral progeny release
Q24534710Stress-induced regulation of eukaryotic elongation factor 2 kinase by SB 203580-sensitive and -insensitive pathways
Q28611349Stress-induced stimulation of early growth response gene-1 by p38/stress-activated protein kinase 2 is mediated by a cAMP-responsive promoter element in a MAPKAP kinase 2-independent manner
Q40691314Stress-mediated signaling in PC12 cells - the role of the small heat shock protein, Hsp27, and Akt in protecting cells from heat stress and nerve growth factor withdrawal
Q34323303Structure and modifications of the junior chaperone alpha-crystallin. From lens transparency to molecular pathology
Q34285116Sulforaphane Activates Heat Shock Response and Enhances Proteasome Activity through Up-regulation of Hsp27
Q34415685TRAIL-induced caspase/p38 activation is responsible for the increased catalytic and invasive activities of Akt
Q37802388Targeting RSK2 in human malignancies
Q97519821The Global Phosphorylation Landscape of SARS-CoV-2 Infection
Q30194632The MAP kinase-activated protein kinase 2 contains a proline-rich SH3-binding domain.
Q41887469The Role of Mitogen-Activated Protein Kinase-Activated Protein Kinases (MAPKAPKs) in Inflammation
Q38026044The Role of p38 MAPK and Its Substrates in Neuronal Plasticity and Neurodegenerative Disease
Q42822304The activation of distinct mitogen-activated protein kinase cascades is required for the stimulation of 2-deoxyglucose uptake by interleukin-1 and insulin-like growth factor-1 in KB cells
Q46222902The in vitro phosphorylation of the co-chaperone mSTI1 by cell cycle kinases substantiates a predicted casein kinase II-p34cdc2-NLS (CcN) motif
Q72770992The interleukin-1-stimulated protein kinase that phosphorylates heat shock protein hsp27 is activated by MAP kinase
Q33838955The p38 signal transduction pathway: activation and function
Q24300649The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ
Q41041404The phosphorylation of eukaryotic initiation factor eIF4E in response to phorbol esters, cell stresses, and cytokines is mediated by distinct MAP kinase pathways
Q45230728The respiratory syncytial virus small hydrophobic protein is phosphorylated via a mitogen-activated protein kinase p38-dependent tyrosine kinase activity during virus infection
Q30489583The role of Hsp27 and actin in the regulation of movement in human cancer cells responding to heat shock
Q43131932The role of the cysteine residue in the chaperone and anti-apoptotic functions of human Hsp27.
Q24528645The substrate specificity and structure of mitogen-activated protein (MAP) kinase-activated protein kinase-2
Q33838914Thiolutin inhibits endothelial cell adhesion by perturbing Hsp27 interactions with components of the actin and intermediate filament cytoskeleton
Q47994357Thrombin activates MAPKAP2 kinase in vascular smooth muscle
Q44746410Tropomyosin interacts with phosphorylated HSP27 in agonist-induced contraction of smooth muscle
Q35754884Twitchin kinase interacts with MAPKAP kinase 2 in Caenorhabditis elegans striated muscle
Q40947866Use of a drug-resistant mutant of stress-activated protein kinase 2a/p38 to validate the in vivo specificity of SB 203580.
Q24336073Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase
Q48009625beta-Amyloid fibrils activate parallel mitogen-activated protein kinase pathways in microglia and THP1 monocytes.
Q28141837p38 Kinase-dependent MAPKAPK-2 activation functions as 3-phosphoinositide-dependent kinase-2 for Akt in human neutrophils
Q34483284p38 MAP kinase: molecular target for the inhibition of pro-inflammatory cytokines.
Q38791188p38 MAPK regulates the Wnt inhibitor Dickkopf-1 in osteotropic prostate cancer cells
Q47925827p38 MAPK signaling during murine preimplantation development.
Q37716475p38 mitogen-activated protein kinase and mitogen-activated protein kinase-activated protein kinase 2 (MK2) signaling in atrophic and hypertrophic denervated mouse skeletal muscle
Q35113634p38MAPK/MK2-mediated phosphorylation of RBM7 regulates the human nuclear exosome targeting complex

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