Inhibition of HSP27 phosphorylation by a cell-permeant MAPKAP Kinase 2 inhibitor

scientific article published on 14 March 2009

Inhibition of HSP27 phosphorylation by a cell-permeant MAPKAP Kinase 2 inhibitor is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.BBRC.2009.03.056
P932PMC publication ID2745729
P698PubMed publication ID19289101

P50authorCharles Robert FlynnQ42550013
P2093author name stringAlyssa Panitch
Colleen M Brophy
Padmini Komalavilas
Luciana B Lopes
Brandon L Seal
P2860cites workTGF-beta signal transductionQ22003891
The substrate specificity and structure of mitogen-activated protein (MAP) kinase-activated protein kinase-2Q24528645
Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAsQ24539187
Modulation of cellular thermoresistance and actin filament stability accompanies phosphorylation-induced changes in the oligomeric structure of heat shock protein 27Q24646796
Transforming growth factor beta in tissue fibrosisQ28239292
MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesisQ28593865
A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteinsQ29617438
Modulation of the expression of connective tissue growth factor by alterations of the cytoskeletonQ34227149
Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteinsQ34239042
From scarless fetal wounds to keloids: Molecular studies in wound healingQ35583617
p38 MAP kinase inhibitors: many are made, but few are chosen.Q36196226
Protein kinases as small molecule inhibitor targets in inflammation.Q36952165
Smooth muscle alpha-actin expression and myofibroblast differentiation by TGFbeta are dependent upon MK2.Q36982849
Regulation of cyclooxygenase 2 mRNA stability by the mitogen-activated protein kinase p38 signaling cascadeQ39453587
Actin-dependent regulation of connective tissue growth factorQ40184484
MAPKAPK2 and HSP27 are downstream effectors of p38 MAP kinase-mediated matrix metalloproteinase type 2 activation and cell invasion in human prostate cancerQ40330923
In vivo evaluation of hsp27 as an inhibitor of actin polymerization: hsp27 limits actin stress fiber and focal adhesion formation after heat shockQ40965092
Modulation of actin dynamics during stress and physiological stimulation by a signaling pathway involving p38 MAP kinase and heat-shock protein 27.Q41037943
Regulation of actin filament dynamics by p38 map kinase-mediated phosphorylation of heat shock protein 27.Q41130163
Modulation of actin microfilament dynamics and fluid phase pinocytosis by phosphorylation of heat shock protein 27.Q41514183
Smad3 signalling plays an important role in keloid pathogenesis via epithelial-mesenchymal interactionsQ42481896
Cellular stress inhibits vascular smooth muscle relaxationQ42483348
Small heat shock proteins are molecular chaperones.Q42812560
Enhanced skin penetration of P20 phosphopeptide using protein transduction domainsQ42920354
The effect of TGF-beta on keloid fibroblast proliferation and collagen synthesisQ45099624
P38 MAP kinase mediates transforming growth factor-beta2 transcription in human keloid fibroblasts.Q45977949
Hypertrophic scar fibroblasts have increased connective tissue growth factor expression after transforming growth factor-beta stimulationQ46816473
Small stress proteins as novel regulators of apoptosis. Heat shock protein 27 blocks Fas/APO-1- and staurosporine-induced cell death.Q52548229
Heat shock protein 27 functions in inflammatory gene expression and transforming growth factor-beta-activated kinase-1 (TAK1)-mediated signaling.Q53579649
A Role for p38MAPK/HSP27 Pathway in Smooth Muscle Cell MigrationQ54964221
HSP27 phosphorylation-mediated resistance against actin fragmentation and cell death induced by oxidative stressQ70840030
Connective tissue growth factor mediates transforming growth factor beta-induced collagen synthesis: down-regulation by cAMPQ73042158
Effect of protein kinase inhibitors on activity of mammalian small heat-shock protein (HSP25) kinaseQ73492415
Involvement of the p38 mitogen-activated protein kinase pathway in transforming growth factor-beta-induced gene expressionQ78239880
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
P304page(s)535-539
P577publication date2009-03-14
P1433published inBiochemical and Biophysical Research CommunicationsQ864228
P1476titleInhibition of HSP27 phosphorylation by a cell-permeant MAPKAP Kinase 2 inhibitor
P478volume382

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cites work (P2860)
Q34424178A novel cell permeant peptide inhibitor of MAPKAP kinase II inhibits intimal hyperplasia in a human saphenous vein organ culture model
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Q24302534Distinct roles of MK2 and MK5 in cAMP/PKA- and stress/p38MAPK-induced heat shock protein 27 phosphorylation
Q34292270Heat shock protein 27 phosphorylation state is associated with cancer progression
Q37548226Heat shock protein 27 phosphorylation: kinases, phosphatases, functions and pathology
Q34911441Heat shock proteins modulate keloid formation
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Q35713452Inhibition of Mitogen Activated Protein Kinase Activated Protein Kinase II with MMI-0100 reduces intimal hyperplasia ex vivo and in vivo
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Q27302407MMI-0100 inhibits cardiac fibrosis in myocardial infarction by direct actions on cardiomyocytes and fibroblasts via MK2 inhibition
Q38385016Mechanism of Enhanced Cellular Uptake and Cytosolic Retention of MK2 Inhibitory Peptide Nano-polyplexes
Q54643471Mitogen-activated protein kinase-activated protein kinase 2 (MK2) contributes to secondary damage after spinal cord injury.
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Q41887469The Role of Mitogen-Activated Protein Kinase-Activated Protein Kinases (MAPKAPKs) in Inflammation

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