PTEN contributes to profound PI3K/Akt signaling pathway deregulation in dystrophin-deficient dog muscle

scientific article published on 05 March 2009

PTEN contributes to profound PI3K/Akt signaling pathway deregulation in dystrophin-deficient dog muscle is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.2353/AJPATH.2009.080460
P932PMC publication ID2671376
P698PubMed publication ID19264909
P5875ResearchGate publication ID24180753

P50authorVehary SakanyanQ55965493
P2093author name stringLynn A Megeney
Laurence Dubreil
Karl Rouger
Mireille Ledevin
Yan Cherel
Marie-Claire Arnaud
Laetitia Guevel
Marie Feron
P2860cites workCaveolin-3 directly interacts with the C-terminal tail of beta -dystroglycan. Identification of a central WW-like domain within caveolin family membersQ24290252
Some protein tyrosine phosphatases target in part to lipid rafts and interact with caveolin-1Q24304322
Nitric oxide synthase complexed with dystrophin and absent from skeletal muscle sarcolemma in Duchenne muscular dystrophyQ24307833
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphateQ24317714
Signaling by target of rapamycin proteins in cell growth controlQ24522447
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase BQ27860731
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signallingQ28131740
Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinasesQ28187456
Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivoQ28206290
Skeletal muscle hypertrophy and atrophy signaling pathwaysQ28266345
Caveolin-3 in muscular dystrophyQ28267179
Mutations in the caveolin-3 gene cause autosomal dominant limb-girdle muscular dystrophyQ28267252
Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphateQ28280837
Glycoprotein complex anchoring dystrophin to sarcolemmaQ28292439
Primary structure of dystrophin-associated glycoproteins linking dystrophin to the extracellular matrixQ28296676
SH3 domain-mediated interaction of dystroglycan and Grb2Q28301162
Expression of caveolin-3 in skeletal, cardiac, and smooth muscle cells. Caveolin-3 is a component of the sarcolemma and co-fractionates with dystrophin and dystrophin-associated glycoproteinsQ28585091
X chromosome-linked muscular dystrophy (mdx) in the mouseQ28589078
Loss of dystrophin causes aberrant mechanotransduction in skeletal muscle fibersQ28593090
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase BalphaQ28616168
Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndromeQ29615538
Dystrophin: the protein product of the Duchenne muscular dystrophy locusQ29618077
Complete cloning of the duchenne muscular dystrophy (DMD) cDNA and preliminary genomic organization of the DMD gene in normal and affected individualsQ30050310
Regulation of protein kinase cascades by protein phosphatase 2A.Q33632946
Caveolae and caveolin-3 in muscular dystrophyQ33845396
Isolation of candidate cDNAs for portions of the Duchenne muscular dystrophy geneQ34190227
Tumor suppressor PTEN acts through dynamic interaction with the plasma membraneQ34574432
Regulation of PTEN function as a PIP3 gatekeeper through membrane interactionQ36544446
PTEN: a new guardian of the genome.Q37270432
Conditional activation of akt in adult skeletal muscle induces rapid hypertrophyQ37574344
Association of the polymorphisms in the 5′‐untranslated region of PTEN gene with type 2 diabetes in a Japanese populationQ40615998
GSK-3beta negatively regulates skeletal myotube hypertrophyQ40719828
Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways.Q40767544
Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinaseQ41608842
Freeze-fracture studies of muscle caveolae in human muscular dystrophy.Q41879930
Dystrophin-associated proteins are greatly reduced in skeletal muscle from mdx miceQ42052137
Hypertrophic response of Duchenne and limb-girdle muscular dystrophies is associated with activation of Akt pathwayQ44610584
Altered activity of signaling pathways in diaphragm and tibialis anterior muscle of dystrophic mice.Q44915435
Glucocorticoid treatment alleviates dystrophic myofiber pathology by activation of the calcineurin/NF-AT pathway.Q45084815
Regulation of phosphatidylinositol 3-kinase (PI3K)/Akt and nuclear factor-kappa B signaling pathways in dystrophin-deficient skeletal muscle in response to mechanical stretch.Q46452445
Caveolin-3 is not an integral component of the dystrophin glycoprotein complexQ48025640
Association of the dystroglycan complex isolated from bovine brain synaptosomes with proteins involved in signal transductionQ48251106
Canine X-linked muscular dystrophy. An animal model of Duchenne muscular dystrophy: clinical studies.Q50892927
Muscular dystrophy in the mdx mouse: histopathology of the soleus and extensor digitorum longus muscles.Q52255659
Association of dystrophin and an integral membrane glycoprotein.Q52485843
The homologue of the Duchenne locus is defective in X-linked muscular dystrophy of dogsQ59051983
Deficiency of a glycoprotein component of the dystrophin complex in dystrophic muscleQ59089242
An error in dystrophin mRNA processing in golden retriever muscular dystrophy, an animal homologue of Duchenne muscular dystrophyQ59416437
Activation of JNK1 contributes to dystrophic muscle pathogenesisQ64379561
Calmodulin specifically binds three proteins of the dystrophin-glycoprotein complexQ68164364
The mutant mdx: inherited myopathy in the mouse. Morphological studies of nerves, muscles and end-platesQ68984568
The mdx mouse skeletal muscle myopathy: I. A histological, morphometric and biochemical investigationQ70054992
Increased number of caveolae and caveolin-3 overexpression in Duchenne muscular dystrophyQ78109530
Up-regulation of mitogen activated protein kinases in mdx skeletal muscle following chronic treadmill exerciseQ81837319
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)1459-1470
P577publication date2009-03-05
P1433published inThe American Journal of PathologyQ4744259
P1476titlePTEN contributes to profound PI3K/Akt signaling pathway deregulation in dystrophin-deficient dog muscle
P478volume174

Reverse relations

cites work (P2860)
Q33523810A duchenne muscular dystrophy gene hot spot mutation in dystrophin-deficient cavalier king charles spaniels is amenable to exon 51 skipping
Q40746398A quantum leap in the reproducibility, precision, and sensitivity of gene expression profile analysis even when sample size is extremely small
Q42639922Activation of AKT signaling promotes cell growth and survival in α7β1 integrin-mediated alleviation of muscular dystrophy
Q56770399Altered mitogen-activated protein kinase signaling in dystrophic (mdx) muscle
Q49846340Deregulation of Nrf2/ARE signaling pathway causes susceptibility of dystrophin-deficient myotubes to menadione-induced oxidative stress
Q34222153Dietary blue pigments derived from genipin, attenuate inflammation by inhibiting LPS-induced iNOS and COX-2 expression via the NF-κB inactivation.
Q27309883Differential Gene Expression Profiling of Dystrophic Dog Muscle after MuStem Cell Transplantation
Q30512833Enhancing muscle membrane repair by gene delivery of MG53 ameliorates muscular dystrophy and heart failure in δ-Sarcoglycan-deficient hamsters.
Q98166029GSK3 inhibition with low dose lithium supplementation augments murine muscle fatigue resistance and specific force production
Q42493873Insulin-like growth factor-binding protein-1 (IGFBP-1) regulates human schwannoma proliferation, adhesion and survival.
Q33685967MicroRNA-486-dependent modulation of DOCK3/PTEN/AKT signaling pathways improves muscular dystrophy-associated symptoms
Q38444259NF-κB inhibition reveals a novel role for HGF during skeletal muscle repair
Q100696231PTEN Inhibition Ameliorates Muscle Degeneration and Improves Muscle Function in a Mouse Model of Duchenne Muscular Dystrophy
Q34152280Pharmacologic management of Duchenne muscular dystrophy: target identification and preclinical trials
Q30557792Reduced IGF signaling prevents muscle cell death in a Caenorhabditis elegans model of muscular dystrophy
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