| scholarly article | Q13442814 |
| P356 | DOI | 10.1126/SCIENCE.1380182 |
| P698 | PubMed publication ID | 1380182 |
| P50 | author | Barbara Bierer | Q42698866 |
| P2093 | author name string | J. Avruch | |
| B. E. Bierer | |||
| V. Calvo | |||
| D. J. Price | |||
| J. R. Grove | |||
| P433 | issue | 5072 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 973-977 | |
| P577 | publication date | 1992-08-01 | |
| 1992-08-14 | |||
| P1433 | published in | Science | Q192864 |
| P1476 | title | Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase | |
| P478 | volume | 257 |
| Q33889159 | 14-3-3tau associates with a translational control factor FKBP12-rapamycin-associated protein in T-cells after stimulation by pervanadate |
| Q44000714 | 15-Deoxyspergualin inhibits Akt kinase activation and phosphatidylcholine synthesis |
| Q29620730 | 4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway |
| Q35752048 | A Phase I/II Study of the mTOR Inhibitor Everolimus in Combination with HyperCVAD Chemotherapy in Patients with Relapsed/Refractory Acute Lymphoblastic Leukemia |
| Q40021572 | A dominant-negative mutant of mSOS1 inhibits insulin-induced Ras activation and reveals Ras-dependent and -independent insulin signaling pathways |
| Q33526484 | A genetic screen for modifiers of Drosophila caspase Dcp-1 reveals caspase involvement in autophagy and novel caspase-related genes |
| Q36502058 | A genome-wide RNAi screen for polypeptides that alter rpS6 phosphorylation |
| Q28119143 | A genome-wide siRNA screen in mammalian cells for regulators of S6 phosphorylation |
| Q28243712 | A mammalian protein targeted by G1-arresting rapamycin-receptor complex |
| Q40771721 | A new role for the p85-phosphatidylinositol 3-kinase regulatory subunit linking FRAP to p70 S6 kinase activation. |
| Q27937787 | A novel FK506- and rapamycin-binding protein (FPR3 gene product) in the yeast Saccharomyces cerevisiae is a proline rotamase localized to the nucleolus |
| Q34123433 | A phosphatidylinositol 3-kinase/protein kinase B-independent activation of mammalian target of rapamycin signaling is sufficient to induce skeletal muscle hypertrophy |
| Q34585873 | A role of the kinase mTOR in cellular transformation induced by the oncoproteins P3k and Akt. |
| Q24323579 | A single ataxia telangiectasia gene with a product similar to PI-3 kinase |
| Q38275627 | Aberrant mTOR activation in senescence and aging: A mitochondrial stress response? |
| Q42840914 | Activated phosphatidylinositol 3-kinase and Akt kinase promote survival of superior cervical neurons |
| Q41431083 | Activation of 70-kDa S6 kinase, induced by the cytokines interleukin-3 and erythropoietin and inhibited by rapamycin, is not an absolute requirement for cell proliferation |
| Q71602259 | Activation of MAP kinases, pp90rsk and pp70-S6 kinases in mouse mast cells by signaling through the c-kit receptor tyrosine kinase or Fc epsilon RI: rapamycin inhibits activation of pp70-S6 kinase and proliferation in mouse mast cells |
| Q37036270 | Activation of PI3K signaling prevents aminoglycoside-induced hair cell death in the murine cochlea |
| Q42014257 | Activation of S6 kinase in human neutrophils by calcium pyrophosphate dihydrate crystals: protein kinase C-dependent and phosphatidylinositol-3-kinase-independent pathways |
| Q40690668 | Activation of S6K1 (p70 ribosomal protein S6 kinase 1) requires an initial calcium-dependent priming event involving formation of a high-molecular-mass signalling complex. |
| Q44133731 | Activation of multiple signaling modules is critical in angiotensin IV-induced lung endothelial cell proliferation |
| Q74037504 | Activation of phosphoinositide 3-OH kinase by the alpha6beta4 integrin promotes carcinoma invasion |
| Q36566823 | Activation of pp70/85 S6 kinases in interleukin-2-responsive lymphoid cells is mediated by phosphatidylinositol 3-kinase and inhibited by cyclic AMP. |
| Q41004320 | Activation of protein kinase B/Akt is sufficient to repress the glucocorticoid and cAMP induction of phosphoenolpyruvate carboxykinase gene. |
| Q35479067 | Activation of the mTOR pathway by low levels of xenoestrogens in breast epithelial cells from high-risk women. |
| Q35453508 | Activation of the pp90rsk and mitogen-activated serine/threonine protein kinases by ionizing radiation |
| Q40460377 | Acute treatment with TNF-alpha attenuates insulin-stimulated protein synthesis in cultures of C2C12 myotubes through a MEK1-sensitive mechanism. |
| Q29614737 | Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism |
| Q30453740 | Amino acid-induced translation of TOP mRNAs is fully dependent on phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylation |
| Q30483779 | An RNA interference screen identifies a novel regulator of target of rapamycin that mediates hypoxia suppression of translation in Drosophila S2 cells. |
| Q37305443 | An essential role for Bruton's [corrected] tyrosine kinase in the regulation of B-cell apoptosis |
| Q33943166 | An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice |
| Q47780582 | Analogous conformations of both binding and effector regions in cyclosporin A, FK506 and rapamycin |
| Q41185163 | Analysis of the signaling pathway involved in the regulation of hexokinase II gene transcription by insulin |
| Q41489749 | Anisomycin and rapamycin define an area upstream of p70/85S6k containing a bifurcation to histone H3-HMG-like protein phosphorylation and c-fos-c-jun induction |
| Q28343624 | Antifungal activities of antineoplastic agents: Saccharomyces cerevisiae as a model system to study drug action |
| Q46868178 | Arabidopsis TARGET OF RAPAMYCIN interacts with RAPTOR, which regulates the activity of S6 kinase in response to osmotic stress signals |
| Q37488759 | Association of sirolimus adverse effects with m-TOR, p70S6K or Raptor polymorphisms in kidney transplant recipients |
| Q42827313 | Atypical lambda/iota PKC conveys 5-lipoxygenase/leukotriene B4-mediated cross-talk between phospholipase A2s regulating NF-kappa B activation in response to tumor necrosis factor-alpha and interleukin-1beta |
| Q42141390 | Atypical protein kinase Clambda binds and regulates p70 S6 kinase |
| Q37376649 | B lymphocytes from patients with chronic lymphocytic leukemia contain signal transducer and activator of transcription (STAT) 1 and STAT3 constitutively phosphorylated on serine residues. |
| Q59102114 | BCR signals target p27Kip1 and cyclin D2 via the PI3-K signalling pathway to mediate cell cycle arrest and apoptosis of WEHI 231 B cells |
| Q45113910 | Biology of the interleukin-2 receptor |
| Q38832326 | CCR5-Dependent Activation of mTORC1 Regulates Translation of Inducible NO Synthase and COX-2 during Encephalomyocarditis Virus Infection |
| Q44814347 | Calcineurin is required for translational control of protein synthesis in rat pancreatic acini |
| Q28145271 | Carboxyl-terminal region conserved among phosphoinositide-kinase-related kinases is indispensable for mTOR function in vivo and in vitro |
| Q52650762 | Cell biology: regulated self-cannibalism. |
| Q42817515 | Cell cycle regulation of p70 S6 kinase and p42/p44 mitogen-activated protein kinases in Swiss mouse 3T3 fibroblasts |
| Q40812896 | Cellular insulin action and insulin resistance |
| Q28144592 | Characterization of S6K2, a novel kinase homologous to S6K1 |
| Q37891553 | Chlamydia trachomatis Mip‐like protein has peptidylprolyl cis/trans isomerase activity that is inhibited by FK506 and rapamycin and is implicated in initiation of chlamydial infection |
| Q24620236 | Cholesterol trafficking is required for mTOR activation in endothelial cells |
| Q91892015 | Clinical Implications of Sub-grouping HER2 Positive Tumors by Amplicon Structure and Co-amplified Genes |
| Q22008607 | Cloning and characterization of RLPK, a novel RSK-related protein kinase |
| Q41753614 | Cloning and characterization of Xenopus Rsk2, the predominant p90 Rsk isozyme in oocytes and eggs |
| Q51088160 | Commitment of neutrophilic differentiation and proliferation of HL-60 cells coincides with expression of transferrin receptor. Effect of granulocyte colony stimulating factor on differentiation and proliferation. |
| Q41553984 | Communication between the extracellular environment, cytoplasmic signalling cascades and the nuclear cell-cycle machinery |
| Q48502049 | Comparative effects of FK-506, rapamycin and cyclosporin A, on the in vitro differentiation of dorsal root ganglia explants and septal cholinergic neurons |
| Q28586467 | Control of PHAS-I by insulin in 3T3-L1 adipocytes. Synthesis, degradation, and phosphorylation by a rapamycin-sensitive and mitogen-activated protein kinase-independent pathway |
| Q41284168 | Control of p70 s6 kinase by kinase activity of FRAP in vivo |
| Q43237438 | Conversion from cyclosporin A to sirolimus retards the progression of chronic allograft nephropathy in the long term in a rat kidney transplantation model |
| Q78177544 | Coordinate regulation of the alpha(2)-macroglobulin signaling receptor and the low density lipoprotein receptor-related protein/alpha(2)-macroglobulin receptor by insulin |
| Q57245411 | Cross-linking CD28 leads to activation of 70-kDa S6 kinase |
| Q33687017 | Crosstalk between protein kinase A and growth factor receptor signaling pathways in arterial smooth muscle |
| Q37953476 | Current development of the second generation of mTOR inhibitors as anticancer agents |
| Q57589068 | Cyclin D Expression Is Controlled Post-transcriptionally via a Phosphatidylinositol 3-Kinase/Akt-dependent Pathway |
| Q42826838 | Cyclin D1 and cyclin D3 show divergent responses to distinct mitogenic stimulation |
| Q39610954 | Cyclin D1 expression mediated by phosphatidylinositol 3-kinase through mTOR-p70(S6K)-independent signaling in growth factor-stimulated NIH 3T3 fibroblasts |
| Q35801388 | Deconvoluting mTOR biology |
| Q49970895 | Dendrite Growth and the Effect of Ectopic Rheb Expression on Cortical Neurons |
| Q73328429 | Density-dependent proliferation of adult rat hepatocytes in primary culture induced by epidermal growth factor is potentiated by cAMP-elevating agents |
| Q74191553 | Dexamethasone stimulates the expression of GLUT1 and GLUT4 proteins via different signalling pathways in L6 skeletal muscle cells |
| Q32023669 | Differential activation of p70 and p85 S6 kinase isoforms during cardiac hypertrophy in the adult mammal |
| Q42805086 | Differential control of the NIMA-related kinases, Nek6 and Nek7, by serum stimulation |
| Q45193067 | Differential effects of rapamycin, cyclosporine A, and FK506 on human coronary artery smooth muscle cell proliferation and signalling. |
| Q35909879 | Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002. |
| Q33890035 | Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase |
| Q89697546 | Distinct Roles of mTOR Targets S6K1 and S6K2 in Breast Cancer |
| Q28208587 | Distinct regulatory mechanism for p70 S6 kinase beta from that for p70 S6 kinase alpha |
| Q34358570 | Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity |
| Q24644595 | Dual requirement for a newly identified phosphorylation site in p70s6k |
| Q99711697 | EGFR/c-Met and mTOR signaling are predictors of survival in non-small cell lung cancer |
| Q77354743 | Effects of insulin-like growth factor I and II on DNA synthesis and proliferation in primary cultures of adult rat hepatocytes |
| Q33807200 | Effects of serine/threonine protein phosphatases on ion channels in excitable membranes |
| Q41038061 | Effects of wortmannin and rapamycin on CSF-1-mediated responses in macrophages |
| Q24537557 | Elucidating TOR signaling and rapamycin action: lessons from Saccharomyces cerevisiae |
| Q31454913 | Endothelin-1 as a protective factor against beta-adrenergic agonist-induced apoptosis in cardiac myocytes |
| Q43800246 | ErbB2-overexpressing human mammary carcinoma cells display an increased requirement for the phosphatidylinositol 3-kinase signaling pathway in anchorage-independent growth |
| Q44886651 | Evidence for cyclin D3 as a novel target of rapamycin in human T lymphocytes. |
| Q47858013 | Exocytosis of insulin promotes insulin gene transcription via the insulin receptor/PI-3 kinase/p70 s6 kinase and CaM kinase pathways |
| Q42800851 | Extracellular zinc activates p70 S6 kinase through the phosphatidylinositol 3-kinase signaling pathway |
| Q24562050 | FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2 |
| Q41377918 | FK506 binding protein 12 mediates sensitivity to both FK506 and rapamycin in murine mast cells |
| Q73740432 | FK506-binding proteins regulate smooth muscle contractility by altering neurotransmitter release |
| Q27931304 | FKBP12-rapamycin target TOR2 is a vacuolar protein with an associated phosphatidylinositol-4 kinase activity. |
| Q51552999 | Feeding stimulates protein synthesis in muscle and liver of neonatal pigs through an mTOR-dependent process. |
| Q24600427 | Functional interaction between RAFT1/FRAP/mTOR and protein kinase cdelta in the regulation of cap-dependent initiation of translation |
| Q30336194 | Genetic Analysis of TOR Signaling in Drosophila |
| Q73481688 | Glutamine and regulation of gene expression in mammmalian cells. Special reference to phosphoenolpyruvate carboxykinase (PEPCK) |
| Q43812180 | Glycyrrhizin and some analogues induce growth of primary cultured adult rat hepatocytes via epidermal growth factor receptors |
| Q37586668 | Growth inhibition by bupivacaine is associated with inactivation of ribosomal protein S6 kinase 1. |
| Q42983387 | Growth-condition-dependent regulation of insulin-like growth factor II mRNA stability |
| Q59080908 | Growth-dependent translation of IGF-II mRNA by a rapamycin-sensitive pathway |
| Q41352566 | Heat shock protein 27 (HSPB1) suppresses the PDGF-BB-induced migration of osteoblasts |
| Q78951906 | Herpetic stromal keratitis in the absence of viral antigen recognition |
| Q42049383 | Host mTORC1 signaling regulates andes virus replication |
| Q40919286 | Hydrogen peroxide activates p70(S6k) signaling pathway |
| Q42468950 | Hydrogen peroxide mediates Rac1 activation of S6K1. |
| Q41221120 | Hypersensitivity to rapamycin of BJAB B lymphoblastoid cells |
| Q36439371 | Hypoxia induces autophagy in primary human trophoblasts |
| Q28367688 | Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue |
| Q35631134 | Identification of immunosuppressant-induced apoptosis in a murine B-cell line and its prevention by bcl-x but not bcl-2. |
| Q28307131 | Identification of phosphorylation sites in the translational regulator, PHAS-I, that are controlled by insulin and rapamycin in rat adipocytes |
| Q77328523 | Ikaros sets thresholds for T cell activation and regulates chromosome propagation |
| Q41094924 | Immunopathogenesis and immunotherapy of psoriasis. |
| Q40429841 | Immunophilins and nervous system |
| Q28138191 | Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitro |
| Q35160653 | Immunosuppressant FK506 promotes neurite outgrowth in cultures of PC12 cells and sensory ganglia |
| Q43745071 | Immunosuppressant rapamycin inhibits protein kinase C alpha and p38 mitogen-activated protein kinase leading to the inhibition of chondrogenesis. |
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| Q74686279 | Immunosuppressive agents: recent developments in molecular action and clinical application |
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| Q35301892 | Increase of microRNA-210, decrease of raptor gene expression and alteration of mammalian target of rapamycin regulated proteins following mithramycin treatment of human erythroid cells |
| Q43619915 | Induction of differentiation of human myeloid leukemia cells by immunosuppressant macrolides (rapamycin and FK506) and calcium/calmodulin-dependent kinase inhibitors |
| Q40673162 | Inhibition of amino acid-mTOR signaling by a leucine derivative induces G1 arrest in Jurkat cells |
| Q37456176 | Inhibition of mammalian target of rapamycin is required for optimal antitumor effect of HER2 inhibitors against HER2-overexpressing cancer cells |
| Q34337364 | Inhibition of primary human T cell proliferation by Helicobacter pylori vacuolating toxin (VacA) is independent of VacA effects on IL-2 secretion |
| Q30470683 | Insulin activates a PD 098059-sensitive kinase that is involved in the regulation of p70S6K and PHAS-I. |
| Q36623662 | Insulin and amino-acid regulation of mTOR signaling and kinase activity through the Rheb GTPase |
| Q33195730 | Insulin promotes rat retinal neuronal cell survival in a p70S6K-dependent manner |
| Q39887874 | Insulin receptor substrate-2 mediated insulin-like growth factor-I receptor overexpression in pancreatic adenocarcinoma through protein kinase Cdelta |
| Q28574617 | Insulin regulation of insulin-like growth factor-binding protein-1 gene expression is dependent on the mammalian target of rapamycin, but independent of ribosomal S6 kinase activity |
| Q48021735 | Insulin signal transduction through protein kinase cascades |
| Q40019067 | Insulin signalling and insulin actions in the muscles and livers of insulin-resistant, insulin receptor substrate 1-deficient mice |
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| Q24309311 | Insulin stimulates the kinase activity of RAC-PK, a pleckstrin homology domain containing ser/thr kinase |
| Q24530813 | Insulin-stimulated phosphorylation of lipin mediated by the mammalian target of rapamycin |
| Q30469708 | Integrin-dependent activation of the p70 ribosomal S6 kinase signaling pathway |
| Q42831127 | Involvement of p70 S6 kinase in bone morphogenetic protein signaling: vascular endothelial growth factor synthesis by bone morphogenetic protein-4 in osteoblasts |
| Q42500306 | Involvement of phosphoinositide-3-kinase and p70 S6 kinase in regulation of proliferation of rat lactotrophs in culture |
| Q42278342 | Involvement of the Ras/extracellular signal-regulated kinase signalling pathway in the regulation of ERCC-1 mRNA levels by insulin |
| Q33709769 | Itraconazole exerts its anti-melanoma effect by suppressing Hedgehog, Wnt, and PI3K/mTOR signaling pathways |
| Q35560391 | Kinase Activities Associated with mTOR |
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| Q41102257 | Mitogenic signalling by delta opioid receptors expressed in rat-1 fibroblasts involves activation of the p70s6k/p85s6k S6 kinase |
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| Q36844992 | Molecular cloning, developmental expression, and phosphorylation of ribosomal protein S6 in the endocrine gland responsible for insect molting |
| Q38295925 | Multiple independent inputs are required for activation of the p70 S6 kinase |
| Q41592332 | Multiple signaling pathways involved in the metabolic effects of insulin |
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| Q42101485 | Muscarinic receptor-mediated activation of p70 S6 kinase 1 (S6K1) in 1321N1 astrocytoma cells: permissive role of phosphoinositide 3-kinase |
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| Q42801822 | PHAS-I phosphorylation in response to foetal bovine serum (FBS) is regulated by an ERK1/ERK2-independent and rapamycin-sensitive pathway in 3T3-L1 adipocytes |
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| Q44294939 | Paclitaxel induces inactivation of p70 S6 kinase and phosphorylation of Thr421 and Ser424 via multiple signaling pathways in mitosis |
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| Q58450061 | Phosphatidylinositol 3-Kinase, but Not p70/p85 Ribosomal S6 Protein Kinase, Is Required for the Regulation of Phosphoenolpyruvate Carboxykinase (PEPCK) Gene Expression by Insulin |
| Q41102950 | Phosphatidylinositol 3-kinase related kinases |
| Q37463310 | Phosphoinositide 3-kinase signaling in the vertebrate retina |
| Q36346828 | Phosphoinositide 3-kinase: from viral oncoprotein to drug target |
| Q37275199 | Phosphorylation of eukaryotic translation initiation factor 2alpha coordinates rRNA transcription and translation inhibition during endoplasmic reticulum stress |
| Q42526875 | Phosphorylation of the eIF4E-binding protein PHAS-I after exposure of PC12 cells to EGF and NGF. |
| Q40919242 | Phosphorylation of tumor necrosis factor receptor CD120a (p55) by p42(mapk/erk2) induces changes in its subcellular localization |
| Q42809872 | Platelet-derived growth factor stimulation of monocyte chemoattractant protein-1 gene expression is mediated by transient activation of the phosphoinositide 3-kinase signal transduction pathway |
| Q24533977 | Platelet-derived growth factor-BB-mediated glycosaminoglycan synthesis is transduced through Akt |
| Q73293616 | Population pharmacokinetics of sirolimus in kidney transplant patients |
| Q37461622 | Possible dual regulatory circuits involving AtS6K1 in the regulation of plant cell cycle and growth |
| Q73421149 | Proliferation of adult rat hepatocytes in primary culture induced by insulin is potentiated by cAMP-elevating agents |
| Q39551585 | Protein kinase B localization and activation differentially affect S6 kinase 1 activity and eukaryotic translation initiation factor 4E-binding protein 1 phosphorylation |
| Q24604987 | Protein kinases and phosphatases in the control of cell fate |
| Q30307769 | Protein kinases: getting NEKed for S6K activation |
| Q23918164 | Protein phosphorylation cascades associated with methamphetamine-induced glial activation |
| Q28368227 | RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex |
| Q24320064 | RSK3 encodes a novel pp90rsk isoform with a unique N-terminal sequence: growth factor-stimulated kinase function and nuclear translocation |
| Q57362835 | Rapamune® (RAPA, rapamycin, sirolimus): mechanism of action immunosuppressive effect results from blockade of signal transduction and inhibition of cell cycle progression |
| Q28378927 | Rapamycin (sirolimus) inhibits proliferating cell nuclear antigen expression and blocks cell cycle in the G1 phase in human keratinocyte stem cells |
| Q46905208 | Rapamycin antagonizes NF-kappaB nuclear translocation activated by TNF-alpha in primary vascular smooth muscle cells and enhances apoptosis |
| Q41069325 | Rapamycin antagonizes interleukin-6 mediated growth arrest and differentiation of myeloblastic M1 cells |
| Q83864077 | Rapamycin attenuates unilateral ureteral obstruction-induced renal fibrosis |
| Q28476740 | Rapamycin blocks production of KSHV/HHV8: insights into the anti-tumor activity of an immunosuppressant drug |
| Q28378802 | Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation |
| Q44920860 | Rapamycin confers preconditioning-like protection against ischemia-reperfusion injury in isolated mouse heart and cardiomyocytes |
| Q40022362 | Rapamycin destabilizes interleukin-3 mRNA in autocrine tumor cells by a mechanism requiring an intact 3' untranslated region |
| Q42804494 | Rapamycin dissociates p70(S6K) activation from DNA synthesis stimulated by bombesin and insulin in Swiss 3T3 cells |
| Q43735102 | Rapamycin impairs recovery from acute renal failure: role of cell-cycle arrest and apoptosis of tubular cells |
| Q42569903 | Rapamycin inhibition of baculovirus recombinant (BVr) ribosomal protein S6 kinase (S6K1) is mediated by an event other than phosphorylation |
| Q57348273 | Rapamycin inhibits aldolase A expression during human lymphocyte activation |
| Q33755192 | Rapamycin inhibits clonal expansion and adipogenic differentiation of 3T3-L1 cells |
| Q40459006 | Rapamycin inhibits fibronectin-induced migration of the human arterial smooth muscle line (E47) through the mammalian target of rapamycin. |
| Q34736691 | Rapamycin inhibits vascular smooth muscle cell migration |
| Q40887263 | Rapamycin protects against neuron death in in vitro and in vivo models of Parkinson's disease |
| Q36564073 | Rapamycin resistance tied to defective regulation of p27Kip1. |
| Q35917778 | Rapamycin selectively inhibits translation of mRNAs encoding elongation factors and ribosomal proteins |
| Q35234179 | Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family |
| Q39847519 | Rapamycin specifically interferes with the developmental response of fission yeast to starvation |
| Q41666761 | Rapamycin, wortmannin, and the methylxanthine SQ20006 inactivate p70s6k by inducing dephosphorylation of the same subset of sites |
| Q34271784 | Rapamycin-resistant proliferation of CD8+ T cells correlates with p27kip1 down-regulation and bcl-xL induction, and is prevented by an inhibitor of phosphoinositide 3-kinase activity |
| Q37679469 | Rapamycin: one drug, many effects |
| Q24302566 | Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action |
| Q33681499 | Recent advances in immunosuppressants. |
| Q57245409 | Recent advances in immunosuppression |
| Q39454861 | Receptor isoforms mediate opposing proliferative effects through gbetagamma-activated p38 or Akt pathways |
| Q28273915 | Redox regulation of the nutrient-sensitive raptor-mTOR pathway and complex |
| Q57903792 | Regulating 56 kinase |
| Q41087062 | Regulation of eIF-4E BP1 phosphorylation by mTOR. |
| Q37409739 | Regulation of mTORC1 by lysosomal calcium and calmodulin. |
| Q74263760 | Regulation of mitogen-activated protein kinase activation by the cytoplasmic domain of the alpha6 integrin subunit |
| Q36301436 | Regulation of p21(cip1) expression by growth factors and the extracellular matrix reveals a role for transient ERK activity in G1 phase |
| Q77164943 | Regulation of protein synthesis by cholecystokinin in rat pancreatic acini involves PHAS-I and the p70 S6 kinase pathway |
| Q41061932 | Regulation of protein synthesis in ventricular myocytes by vasopressin. The role of sarcoplasmic/endoplasmic reticulum Ca2+ stores |
| Q42450297 | Regulation of system A amino acid transport in 3T3-L1 adipocytes by insulin |
| Q47954202 | Regulation of the p70 S6 kinase by phosphorylation in vivo. Analysis using site-specific anti-phosphopeptide antibodies |
| Q41064925 | Regulation of translation elongation factor-2 by insulin via a rapamycin-sensitive signalling pathway |
| Q54073234 | Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance. |
| Q28577282 | Requirement for activation of the serine-threonine kinase Akt (protein kinase B) in insulin stimulation of protein synthesis but not of glucose transport |
| Q36725003 | Reversing the Warburg effect as a treatment for glioblastoma |
| Q34857314 | Ribosomal p70S6K basal activity increases upon induction of differentiation of myelomonocytic leukemic cell lines HL60, AML14 and MPD |
| Q27331645 | Rictor/TORC2 regulates Caenorhabditis elegans fat storage, body size, and development through sgk-1 |
| Q55478123 | Ro31-8220 inhibits protein kinase C to block the phorbol ester-stimulated release of choline- and ethanolamine-metabolites from C6 glioma cells: p70 S6 kinase and MAPKAP kinase-1beta do not function downstream of PKC in activating PLD. |
| Q40963711 | Role of ERK1/ERK2 and p70S6K pathway in insulin signalling of protein synthesis |
| Q34047808 | Role of S6 phosphorylation and S6 kinase in cell growth |
| Q37824477 | Role of mTOR signaling in tumor cell motility, invasion and metastasis |
| Q40499781 | S6 phosphorylation and the p70s6k/p85s6k |
| Q42069149 | S6 phosphorylation results from prothoracicotropic hormone stimulation of insect prothoracic glands: a role for S6 kinase |
| Q39777490 | Schizosaccharomyces pombe AGC family kinase Gad8p forms a conserved signaling module with TOR and PDK1-like kinases |
| Q42827298 | Selective Inhibition of p70 S6 Kinase Activation by Phosphatidylinositol 3‐Kinase Inhibitors |
| Q33818655 | Serine/threonine phosphorylation in cytokine signal transduction |
| Q41440046 | Signal transduction pathways in macroautophagy. |
| Q40816145 | Signal transduction pathways involved in phosphorylation and activation of p70S6K following exposure to UVA irradiation. |
| Q24522447 | Signaling by target of rapamycin proteins in cell growth control |
| Q47836867 | Signalling events regulating the retrograde axonal transport of 125I-beta nerve growth factor in vivo |
| Q70865353 | Sirolimus (rapamycin) inhibits mitogen-induced stimulation of protein synthesis in primary lymphocytes |
| Q36847294 | Sirolimus and liver transplantation: clinical implications for hepatocellular carcinoma |
| Q40446087 | Sirolimus inhibits growth of human hepatoma cells alone or combined with tacrolimus, while tacrolimus promotes cell growth |
| Q44101184 | Sirolimus inhibits growth of human hepatoma cells in contrast to tacrolimus which promotes cell growth |
| Q33986353 | Sirt1 overexpression in neurons promotes neurite outgrowth and cell survival through inhibition of the mTOR signaling. |
| Q36564768 | Specific activation of p85-p110 phosphatidylinositol 3'-kinase stimulates DNA synthesis by ras- and p70 S6 kinase-dependent pathways |
| Q74341850 | Stimulation of DNA synthesis and proliferation by prostaglandins in primary cultures of adult rat hepatocytes |
| Q74453080 | Stimulation of MAP kinase and S6 kinase by vanadium and selenium in rat adipocytes |
| Q57348290 | Stimulation of glycogen synthesis by insulin requires S6 kinase and phosphatidylinositol-3-kinase in HTC-IR cells |
| Q36553215 | Stimulatory effect of insulin on theca-interstitial cell proliferation and cell cycle regulatory proteins through MTORC1 dependent pathway |
| Q33716466 | Structural and functional analysis of pp70S6k |
| Q28243447 | Structure of S6 kinase 1 determines whether raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site |
| Q35730744 | Suppression or induction of apoptosis by opposing pathways downstream from calcium-activated calcineurin |
| Q28243344 | Syk Is Required for BCR-mediated Activation of p90Rsk, but Not p70S6k, via a Mitogen-activated Protein Kinase-independent Pathway in B Cells |
| Q35560369 | TOR Action in Mammalian Cells and in Caenorhabditis elegans |
| Q35714532 | TOR complex 2 (TORC2) in Dictyostelium suppresses phagocytic nutrient capture independently of TORC1-mediated nutrient sensing |
| Q27931425 | TOR controls translation initiation and early G1 progression in yeast |
| Q38289137 | TOR mutations confer rapamycin resistance by preventing interaction with FKBP12-rapamycin. |
| Q30312086 | TOR signaling |
| Q36063511 | Targeted disruption of p70(s6k) defines its role in protein synthesis and rapamycin sensitivity |
| Q35125788 | Ten years of sirolimus therapy in orthotopic liver transplant recipients |
| Q24561774 | The 25-kDa FK506-binding protein is localized in the nucleus and associates with casein kinase II and nucleolin |
| Q42812980 | The 70 kDa S6 kinase complexes with and is activated by the Rho family G proteins Cdc42 and Rac1. |
| Q36227198 | The Akt-mTOR axis is a pivotal regulator of eccentric hypertrophy during volume overload |
| Q37296142 | The Drosophila p70s6k homolog exhibits conserved regulatory elements and rapamycin sensitivity |
| Q27930631 | The FKB2 gene of Saccharomyces cerevisiae, encoding the immunosuppressant-binding protein FKBP-13, is regulated in response to accumulation of unfolded proteins in the endoplasmic reticulum |
| Q40637233 | The MAP kinase cascade. Discovery of a new signal transduction pathway |
| Q74098911 | The MDR1 (P-glycoprotein) and MRP (P-190) transporters do not play a major role in the intrinsic multiple drug resistance of Jurkat T lymphocytes |
| Q73901921 | The MRD1 (P-glycoprotein) and MRP (P-190) transporters do not play a major role in the intrinsic multiple drug resistance of Jurkat T lymphocytes |
| Q29620801 | The TOR signaling cascade regulates gene expression in response to nutrients |
| Q34116818 | The complexes of mammalian target of rapamycin. |
| Q37956712 | The emerging role of large immunophilin FK506 binding protein 51 in cancer |
| Q36572099 | The insulin-induced signalling pathway leading to S6 and initiation factor 4E binding protein 1 phosphorylation bifurcates at a rapamycin-sensitive point immediately upstream of p70s6k |
| Q34434557 | The modular phosphorylation and activation of p70s6k. |
| Q28567964 | The oligodendrocyte precursor mitogen PDGF stimulates proliferation by activation of alpha(v)beta3 integrins |
| Q40020238 | The principal rapamycin-sensitive p70(s6k) phosphorylation sites, T-229 and T-389, are differentially regulated by rapamycin-insensitive kinase kinases |
| Q40789796 | The principal target of rapamycin-induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain. |
| Q24634783 | The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1 |
| Q30310107 | The rapamycin-binding domain governs substrate selectivity by the mammalian target of rapamycin |
| Q44061979 | The role of cAMP-dependent signaling in receptor-recognized forms of alpha 2-macroglobulin-induced cellular proliferation |
| Q38179978 | The role of mTORC1 in regulating protein synthesis and skeletal muscle mass in response to various mechanical stimuli. |
| Q41166269 | The serine protease inhibitors, tosylphenylalanine chloromethyl ketone and tosyllysine chloromethyl ketone, potently inhibit pp70s6k activation |
| Q41235235 | The volume-activated chloride current in endothelial cells from bovine pulmonary artery is not modulated by phosphorylation |
| Q94564366 | Transcription and Translation Inhibitors in Cancer Treatment |
| Q34286691 | Transduction of growth or mitogenic signals into translational activation of TOP mRNAs is fully reliant on the phosphatidylinositol 3-kinase-mediated pathway but requires neither S6K1 nor rpS6 phosphorylation |
| Q35143191 | Tumour suppressors hamartin and tuberin: intracellular signalling |
| Q41076877 | Wingless inactivates glycogen synthase kinase-3 via an intracellular signalling pathway which involves a protein kinase C. |
| Q41437655 | Wortmannin inhibits the effects of insulin and serum on the activities of glycogen synthase kinase-3 and mitogen-activated protein kinase |
| Q36350264 | Y box-binding protein 1 induces resistance to oncogenic transformation by the phosphatidylinositol 3-kinase pathway |
| Q34038049 | cAMP- and rapamycin-sensitive regulation of the association of eukaryotic initiation factor 4E and the translational regulator PHAS-I in aortic smooth muscle cells |
| Q33706924 | mTOR Ser-2481 autophosphorylation monitors mTORC-specific catalytic activity and clarifies rapamycin mechanism of action |
| Q91105968 | mTOR and autophagy pathways are dysregulated in murine and human models of Schaaf-Yang syndrome |
| Q53559277 | mTOR as a potential therapeutic target for treatment of keloids and excessive scars. |
| Q37086022 | mTOR pathway in renal cell carcinoma |
| Q38141246 | mTOR: more targets of resveratrol? |
| Q37166913 | mTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin |
| Q40664065 | p38 MAP kinase regulates BMP-4-stimulated VEGF synthesis via p70 S6 kinase in osteoblasts |
| Q38007160 | p70 S6 kinase and actin dynamics: A perspective |
| Q57364262 | p70 S6 kinase: an enigma with variations |
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