Acute treatment with TNF-alpha attenuates insulin-stimulated protein synthesis in cultures of C2C12 myotubes through a MEK1-sensitive mechanism.

scientific article published on 8 February 2005

Acute treatment with TNF-alpha attenuates insulin-stimulated protein synthesis in cultures of C2C12 myotubes through a MEK1-sensitive mechanism. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1152/AJPENDO.00397.2004
P698PubMed publication ID15701678
P5875ResearchGate publication ID8030582

P2093author name stringLeonard S Jefferson
Scot R Kimball
David L Williamson
P2860cites workMitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2Q24532154
Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivoQ24554527
Extracellular signal-regulated kinase 2 interacts with and is negatively regulated by the LIM-only protein FHL2 in cardiomyocytesQ24629352
RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1Q24682697
Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanismsQ28586863
IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistanceQ29619774
PHAS/4E-BPs as regulators of mRNA translation and cell proliferationQ30471012
eIF4E expression in tumors: its possible role in progression of malignanciesQ33601639
Physiologic hyperinsulinemia stimulates protein synthesis and enhances transport of selected amino acids in human skeletal muscleQ34202761
Phosphorylation of eukaryotic translation initiation factor 4E is critical for growthQ34323752
Phosphorylation of eukaryotic initiation factor 4E (eIF4E) at Ser209 is not required for protein synthesis in vitro and in vivoQ34518466
Serum-stimulated, rapamycin-sensitive phosphorylation sites in the eukaryotic translation initiation factor 4GI.Q34662460
Does phosphorylation of the cap-binding protein eIF4E play a role in translation initiation?Q34992458
Alterations in mitogen-activated protein kinase kinase and extracellular regulated kinase signaling in theca cells contribute to excessive androgen production in polycystic ovary syndromeQ40498593
Phosphorylation of eukaryotic initiation factor 4E markedly reduces its affinity for capped mRNA.Q40766564
Initiation of protein synthesis in eukaryotic cellsQ41006460
Effect of tumor necrosis factor-alpha on insulin action in cultured rat skeletal muscle cellsQ41196884
Mechanisms of muscle wasting. The role of the ubiquitin-proteasome pathwayQ41249327
Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinaseQ41608842
Effects of tumor necrosis factor-alpha on insulin action in cultured human muscle cellsQ42503776
Orally administered leucine enhances protein synthesis in skeletal muscle of diabetic rats in the absence of increases in 4E-BP1 or S6K1 phosphorylationQ43935389
Tumor necrosis factor-alpha stimulates lipolysis in differentiated human adipocytes through activation of extracellular signal-related kinase and elevation of intracellular cAMP.Q44155489
Endotoxin induces differential regulation of mTOR-dependent signaling in skeletal muscle and liver of neonatal pigsQ44457694
Differential signalling mechanisms predisposing primary human skeletal muscle cells to altered proliferation and differentiation: roles of IGF-I and TNFalphaQ44774249
Molecular cross-talk between MEK1/2 and mTOR signaling during recovery of 293 cells from hypertonic stressQ45005978
Insulin fails to stimulate muscle protein synthesis in sepsis despite unimpaired signaling to 4E-BP1 and S6K1.Q53991546
P433issue1
P304page(s)E95-104
P577publication date2005-02-08
P1433published inAmerican Journal of Physiology - Endocrinology and MetabolismQ15765671
P1476titleAcute treatment with TNF-alpha attenuates insulin-stimulated protein synthesis in cultures of C2C12 myotubes through a MEK1-sensitive mechanism.
P478volume289

Reverse relations

cites work (P2860)
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Q41847452Down-regulation of Sprouty2 via p38 MAPK plays a key role in the induction of cellular apoptosis by tumor necrosis factor-alpha
Q39503456Endotoxin transiently inhibits protein synthesis through Akt and MAPK mediating pathways in C2C12 myotubes
Q36846742Exercise but not diet-induced weight loss decreases skeletal muscle inflammatory gene expression in frail obese elderly persons
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Q33988273Role of IGF-I and the TNFα/NF-κB pathway in the induction of muscle atrogenes by acute inflammation
Q36683918Sarcopenic obesity and the pathogenesis of exercise intolerance in heart failure with preserved ejection fraction
Q40059831TNF-alpha increases protein content in C2C12 and primary myotubes by enhancing protein translation via the TNF-R1, PI3K, and MEK.
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Q36920587The molecular bases of training adaptation
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Q51164342Tumor necrosis factor-alpha promotes the accumulation of neutrophils and macrophages in skeletal muscle

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