Effects of serine/threonine protein phosphatases on ion channels in excitable membranes

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Effects of serine/threonine protein phosphatases on ion channels in excitable membranes is …
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P356DOI10.1152/PHYSREV.2000.80.1.173
P8608Fatcat IDrelease_ivf5usbsxzbmnlbwxsdxo6aybi
P698PubMed publication ID10617768

P2093author name stringHerzig S
Neumann J
P2860cites workDARPP-32: regulator of the efficacy of dopaminergic neurotransmissionQ23909380
The nucleotide sequence of the cDNA encoding the human lung protein phosphatase 2A alpha catalytic subunitQ24293240
The nucleotide sequence of the cDNA encoding the human lung protein phosphatase 2A beta catalytic subunitQ24293256
Molecular cloning of NIPP-1, a nuclear inhibitor of protein phosphatase-1, reveals homology with polypeptides involved in RNA processingQ24304305
The myeloid leukemia-associated protein SET is a potent inhibitor of protein phosphatase 2AQ24310186
Amino acid sequence of a novel protein phosphatase 1 binding protein (R5) which is related to the liver- and muscle-specific glycogen binding subunits of protein phosphatase 1Q24310762
Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complexQ24310797
Cloning of human calcineurin A: evidence for two isozymes and identification of a polyproline structural domainQ24312973
Purification and characterization of two putative HLA class II associated proteins: PHAPI and PHAPIIQ24315134
Structure of the 55-kDa regulatory subunit of protein phosphatase 2A: evidence for a neuronal-specific isoformQ24315744
Identification of a new family of protein phosphatase 2A regulatory subunitsQ24315781
Replication factor encoded by a putative oncogene, set, associated with myeloid leukemogenesisQ24318273
Multiple structural elements define the specificity of recombinant human inhibitor-1 as a protein phosphatase-1 inhibitorQ24324682
Molecular cloning, expression, and characterization of a novel human serine/threonine protein phosphatase, PP7, that is homologous to Drosophila retinal degeneration C gene product (rdgC)Q28610016
Regulation of protein serine-threonine phosphatase type-2A by tyrosine phosphorylationQ28638545
The structure and regulation of protein phosphatasesQ29618929
Molecular cloning of rat type 2C (IA) protein phosphatase mRNAQ30450849
Modulation of a calcium-sensitive nonspecific cation channel by closely associated protein kinase and phosphatase activitiesQ30454273
Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II.Q30460881
Molecular cloning of a calmodulin-dependent phosphatase from murine testis: identification of a developmentally expressed nonneural isoenzymeQ30734801
CDC55, a Saccharomyces cerevisiae gene involved in cellular morphogenesis: identification, characterization, and homology to the B subunit of mammalian type 2A protein phosphataseQ33237530
Rat DARPP-32: cloning, sequencing, and characterization of the cDNA.Q33507917
Okadaic acid: an additional non-phorbol-12-tetradecanoate-13-acetate-type tumor promoterQ33559371
Serine-1321-independent regulation of the mu 1 adult skeletal muscle Na+ channel by protein kinase CQ33638979
Identification of members of the protein phosphatase 1 gene family in the rat and enhanced expression of protein phosphatase 1 alpha gene in rat hepatocellular carcinomasQ33966428
Wanderlust kinetics and variable Ca(2+)-sensitivity of Drosophila, a large conductance Ca(2+)-activated K+ channel, expressed in oocytesQ34017889
Mechanisms of beta-adrenergic stimulation of cardiac Ca2+ channels revealed by discrete-time Markov analysis of slow gatingQ34019850
Presynaptic modulation of cortical synaptic activity by calcineurin.Q34111952
Intramolecular and intermolecular enzymatic modulation of ion channels in excised membrane patchesQ34115432
Cyanobacterial microcystin-LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plantsQ34188529
Crystal structure of the catalytic subunit of human protein phosphatase 1 and its complex with tungstateQ34290366
Nitric oxide and cGMP cause vasorelaxation by activation of a charybdotoxin-sensitive K channel by cGMP-dependent protein kinaseQ34292233
The cyanobacterial toxin microcystin binds covalently to cysteine-273 on protein phosphatase 1.Q34295150
Dopamine- and cAMP-regulated phosphoprotein (DARPP-32) and dopamine DA1 agonist-sensitive Na+,K+-ATPase in renal tubule cellsQ34313695
Molecular cloning and chromosomal localization of a human skeletal muscle PP-1 gamma 1 cDNA.Q34335931
The interaction of SV40 small tumor antigen with protein phosphatase 2A stimulates the map kinase pathway and induces cell proliferation.Q34345750
Protein serine/threonine phosphatases: structure, regulation, and functions in cell growthQ34358877
Molecular identification of I1PP2A, a novel potent heat-stable inhibitor protein of protein phosphatase 2A.Q34386589
A novel protein phosphatase-1 inhibitory protein potentiated by protein kinase C. Isolation from porcine aorta media and characterizationQ34389858
Molecular cloning of a novel phosphorylation-dependent inhibitory protein of protein phosphatase-1 (CPI17) in smooth muscle: its specific localization in smooth muscleQ34433763
Novel protein serine/threonine phosphatases: variety is the spice of lifeQ34435200
Regulation of protein phosphatase-1G from rabbit skeletal muscle. 1. Phosphorylation by cAMP-dependent protein kinase at site 2 releases catalytic subunit from the glycogen-bound holoenzymeQ34457676
Dopamine- and cAMP-regulated phosphoprotein DARPP-32: phosphorylation of Ser-137 by casein kinase I inhibits dephosphorylation of Thr-34 by calcineurinQ34492149
Hepatocyte deformation induced by cyanobacterial toxins reflects inhibition of protein phosphatasesQ34631024
Molecular cloning and sequence analysis of the catalytic subunit of bovine type 2A protein phosphataseQ34638898
Effects of chronic growth hormone treatment in aged rats on the biophysical and pharmacological properties of skeletal muscle chloride channelsQ35026185
Okadaic acid-induced decrease in the magnitude and efficacy of the Ca2+ signal in pancreatic beta cells and inhibition of insulin secretion.Q35027061
Modulation of cardiac Na+ channels expressed in a mammalian cell line and in ventricular myocytes by protein kinase CQ35167168
PP1 gamma 2, a testis-specific protein-serine/threonine-phosphatase type 1 catalytic subunit, is associated with a protein having high sequence homology with the 78-kDa glucose-regulated protein, a member of the 70-kDa heat shock protein familyQ35169014
Is the inhibition of protein phosphatase 1 and 2A activities a general mechanism of tumor promotion in human cancer development?Q35226651
Activation of protein kinases and inhibition of protein phosphatases play a central role in the regulation of exocytosis in mouse pancreatic beta cells.Q35228526
Phosphorylation and inactivation of protein phosphatase 1 by cyclin-dependent kinasesQ35573568
Regulation of ROMK1 K+ channel activity involves phosphorylation processesQ35680860
Phosphatase inhibitors activate normal and defective CFTR chloride channelsQ35767286
Electrical effects of okadaic acid extracted from black sponge on rabbit sinus nodeQ35888302
Targeting of a distinctive protein-serine phosphatase to the protein kinase-like domain of the atrial natriuretic peptide receptorQ35894619
Activation of calcium-dependent potassium channels in mouse [correction of rat] brain neurons by neurotrophin-3 and nerve growth factorQ35967608
The absence of a major Ca2+ signaling pathway in GABAergic neurons of the hippocampusQ35985080
Cell cycle-dependent phosphorylation of mammalian protein phosphatase 1 by cdc2 kinaseQ36033312
Regulation of cell cycle progression and nuclear affinity of the retinoblastoma protein by protein phosphatases.Q36050995
Immunosuppressants implicate protein phosphatase regulation of K+ channels in guard cellsQ36160975
Autophosphorylation-activated protein kinase phosphorylates and inactivates protein phosphatase 2AQ36178824
Isolation and sequence analysis of a cDNA clone encoding a type-1 protein phosphatase catalytic subunit: homology with protein phosphatase 2A.Q36287193
A second catalytic subunit of type-2A protein phosphatase from rabbit skeletal muscleQ36297896
Molecular cloning of cDNAs encoding two isoforms of the catalytic subunit of protein phosphatase 2A.Q36302019
Identification of a novel protein phosphatase 2A regulatory subunit highly expressed in muscleQ24336379
Serine/threonine protein phosphatasesQ24528215
Structural basis for the recognition of regulatory subunits by the catalytic subunit of protein phosphatase 1Q24532150
Molecular cloning and sequence of cDNA encoding polyoma medium tumor antigen-associated 61-kDa proteinQ24603540
The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNAQ24606378
A specific protein carboxyl methylesterase that demethylates phosphoprotein phosphatase 2A in bovine brainQ24607382
Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3' half to different genes: characterization of the set geneQ24629998
Human liver phosphatase 2A: cDNA and amino acid sequence of two catalytic subunit isotypesQ24648347
Differential methylation and altered conformation of cytoplasmic and nuclear forms of protein phosphatase 2A during cell cycle progressionQ24651574
X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complexQ27729433
Three-dimensional structure of the catalytic subunit of protein serine/threonine phosphatase-1Q27729832
Solution structure of nodularin. An inhibitor of serine/threonine-specific protein phosphatasesQ27732840
The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunitQ27860669
Mammalian protein serine/threonine phosphatase 2C: cDNA cloning and comparative analysis of amino acid sequencesQ28115219
Regulation of protein phosphatase 2A by direct interaction with casein kinase 2alphaQ28237230
alpha- and beta-forms of the 65-kDa subunit of protein phosphatase 2A have a similar 39 amino acid repeating structureQ28238073
cAMP-dependent regulation of cardiac L-type Ca2+ channels requires membrane targeting of PKA and phosphorylation of channel subunitsQ28245619
Identification of in vivo phosphorylation sites of SET, a nuclear phosphoprotein encoded by the translocation breakpoint in acute undifferentiated leukemiaQ28250694
Properties and phosphorylation sites of baculovirus-expressed nuclear inhibitor of protein phosphatase-1 (NIPP-1)Q28257320
The toxins of cyanobacteriaQ28258403
DARPP-32, a dopamine-regulated neuronal phosphoprotein, is a potent inhibitor of protein phosphatase-1Q28259380
A calcineurin-dependent transcriptional pathway for cardiac hypertrophyQ28269300
Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexesQ28277749
Association of protein kinase A and protein phosphatase 2B with a common anchoring proteinQ28287251
Postsynaptic cAMP pathway gates early LTP in hippocampal CA1 regionQ28292471
Cyanobacteria secondary metabolites-the cyanotoxinsQ28294662
Interaction of the ribosomal protein, L5, with protein phosphatase type 1Q28295878
Cloning and expression of an inwardly rectifying ATP-regulated potassium channelQ28297778
Chromosomal mapping of the human genes for the calmodulin-dependent protein phosphatase (calcineurin) catalytic subunitQ28306034
Structure and expression of two isoforms of the murine calmodulin-dependent protein phosphatase regulatory subunit (calcineurin B)Q28513944
Cain, a novel physiologic protein inhibitor of calcineurinQ28570296
Amino acid sequence and expression of the hepatic glycogen-binding (GL)-subunit of protein phosphatase-1Q28579025
Beta-adrenergic and cholinergic modulation of inward rectifier K+ channel function and phosphorylation in guinea-pig ventricleQ46305956
Regulation of NMDA channel function by endogenous Ca(2+)-dependent phosphataseQ46364713
In vivo and in vitro binding of microcystin to protein phosphatases 1 and 2A.Q46447942
Suppression of GABAA receptor responses by NMDA application in hippocampal neurones acutely isolated from the adult guinea-pigQ46457724
On the mechanism of muscarinic inhibition of the cardiac Ca currentQ46469304
Effects of a protein phosphatase inhibitor, okadaic acid, on membrane currents of isolated guinea-pig cardiac myocytesQ46473208
Mg2+-dependent phosphatase as an inhibitory mediator of the nonselective cation current induced by aluminum fluoride in guinea-pig chromaffin cellsQ46492977
Protein phosphatase 2A and its [3H]cantharidin/[3H]endothall thioanhydride binding site. Inhibitor specificity of cantharidin and ATP analoguesQ46504347
Modulation of slow gating process of calcium channels by isoprenaline in guinea-pig ventricular cellsQ46557610
Specific inhibition of calcineurin by type II synthetic pyrethroid insecticidesQ46563590
Two distinct functional effects of protein phosphatase inhibitors on guinea-pig cardiac L-type Ca2+ channelsQ46589173
Effects of the phosphatase inhibitor calyculin A on the phosphorylation of C-protein in mammalian ventricular cardiomyocytesQ46614801
Ca(2+)-dependent inactivation of Ca2+ current in Aplysia neurons: kinetic studies using photolabile Ca2+ chelatorsQ46846275
Phosphatase-mediated enhancement of cardiac cAMP-activated Cl-conductance by a Cl- channel blocker, anthracene-9-carboxylateQ46879938
Calcineurin involvement in the regulation of high-threshold Ca2+ channels in NG108-15 (rodent neuroblastoma x glioma hybrid) cells.Q47679197
Glomerular mesangial cells: electrophysiology and regulation of contractionQ47802001
Molecular cloning of cDNA encoding the 110 kDa and 21 kDa regulatory subunits of smooth muscle protein phosphatase 1M.Q48077108
Diversity in the regulatory B-subunits of protein phosphatase 2A: identification of a novel isoform highly expressed in brainQ48078489
GABAA receptors in mouse cortical homogenates are phosphorylated by endogenous protein kinase A.Q48096920
Regulation of NMDA receptors in cultured hippocampal neurons by protein phosphatases 1 and 2A.Q48122032
Molecular cloning and primary structure of a protein phosphatase 2C isoformQ48186458
Identification of PP1 catalytic subunit isotypes PP1 gamma 1, PP1 delta and PP1 alpha in various rat tissuesQ48285422
Molecular cloning of rat phosphoprotein phosphatase 2A beta cDNA and increased expressions of phosphatase 2A alpha and 2A beta in rat liver tumorsQ48309034
Modulation of the voltage-gated sodium current in rat striatal neurons by DARPP-32, an inhibitor of protein phosphataseQ48388865
Single-channel activity of the Ca2+-dependent K+ channel is modulated by FK506 and rapamycinQ48445229
Effects of 2,3-butanedione monoxime (BDM) on calcium channels expressed in Xenopus oocytesQ48456618
Facilitation of L-type calcium current in thalamic neuronsQ48531100
Fostriecin, an antitumor antibiotic with inhibitory activity against serine/threonine protein phosphatases types 1 (PP1) and 2A (PP2A), is highly selective for PP2A.Q48579088
Calmodulin antagonists and protein phosphatase inhibitor okadaic acid fasten the ‘run-up’ of high-voltage activated calcium current in rat hippocampal neuronesQ48611125
Depolarization of rat brain synaptosomes increases phosphorylation of voltage-sensitive sodium channelsQ48660580
Protein Kinase Activity Closely Associated with a Reconstituted Calcium-Activated Potassium ChannelQ48675187
Ethanol activates maxi Ca2+-activated K+ channels of clonal pituitary (GH3) cells.Q48699165
Evidence for colocalization of calcineurin and calcium channels in dorsal root ganglion neurons.Q48702622
Somatostatin stimulates Ca2+-activated K+ channels through protein dephosphorylationQ48707748
Apomorphine is a potent inhibitor of type 2A protein phosphatase in rat brainQ48737418
Differential modulation of cortical synaptic activity by calcineurin (phosphatase 2B) versus phosphatases 1 and 2A.Q48796980
A dual mechanism for impairment of GABAA receptor activity by NMDA receptor activation in rat cerebellum granule cellsQ48809067
The discovery of protein phosphatases: from chaos and confusion to an understanding of their role in cell regulation and human diseaseQ48917424
A role for calcineurin in the desensitization of the P2X3 receptorQ48960566
Osmosensitivity of the hyperpolarization-activated chloride current in human intestinal T84 cellsQ48961666
Complexity of the regulation of Kir2.1 K+ channelsQ49023982
Beta-adrenergic regulation of synaptic NMDA receptors by cAMP-dependent protein kinaseQ49133448
Morning hypercoagulability and hypofibrinolysis. Diurnal variations in circulating activated factor VII, prothrombin fragment F1+2, and plasmin-plasmin inhibitor complex.Q51574692
Developmental changes in the actions of phosphatase inhibitors on calcium current of rabbit heart cells.Q52215869
Regulation of murine cystic fibrosis transmembrane conductance regulator Cl- channels expressed in Chinese hamster ovary cells.Q52234805
Stimulation of phosphorylase phosphatase activity of protein phosphatase 2A1 by protamine is ionic strength dependent and involves interaction of protamine with both substrate and enzyme.Q52288209
Activation of Cl- channels by extracellular Ca2+ in freshly isolated rabbit osteoclasts.Q52296008
Protein kinase C-induced changes in the stoichiometry of ATP binding activate cardiac ATP-sensitive K+ channels. A possible mechanistic link to ischemic preconditioning.Q52298670
Protein phosphatase 1 gamma 2 is associated with nuclei of meiotic cells in rat testis.Q53479236
Permeability of a non-TPA-type tumor promoter, okadaic acid, through lipid bilayer membrane.Q53506577
Calyculin A increases voltage-dependent inward current in smooth muscle cells isolated from guinea pig taenia coli.Q53855808
Functionally distinct phospho-forms underlie incremental activation of protein kinase-regulated Cl- conductance in mammalian heartQ36411397
Phosphatase is responsible for run down, and probably G protein-mediated inhibition of inwardly rectifying K+ currents in guinea pig chromaffin cellsQ36411624
Actions of genistein on cystic fibrosis transmembrane conductance regulator channel gating. Evidence for two binding sites with opposite effectsQ36411954
A serine residue in ClC-3 links phosphorylation-dephosphorylation to chloride channel regulation by cell volumeQ36420549
Isolation and sequence analysis of a cDNA clone encoding the entire catalytic subunit of a type-2A protein phosphataseQ36427347
Two components of cardiac delayed rectifier K+ current. Differential sensitivity to block by class III antiarrhythmic agentsQ36434545
Intracellular Ca2+ inhibits smooth muscle L-type Ca2+ channels by activation of protein phosphatase type 2B and by direct interaction with the channelQ36435991
Voltage-dependent potentiation of the activity of cardiac L-type calcium channel alpha 1 subunits due to phosphorylation by cAMP-dependent protein kinaseQ36635566
cDNA cloning of an alternatively spliced isoform of the regulatory subunit of Ca2+/calmodulin-dependent protein phosphatase (calcineurin B alpha 2).Q36742506
Molecular cloning of a novel isotype of Mg(2+)-dependent protein phosphatase beta (type 2C beta) enriched in brain and heartQ36759105
High complexity in the expression of the B' subunit of protein phosphatase 2A0. Evidence for the existence of at least seven novel isoformsQ36792704
Interaction of protein phosphatase type 1 with a splicing factor.Q36814895
Compensatory mechanisms associated with the hyperdynamic function of phospholamban-deficient mouse heartsQ36835427
Chromostatin inhibits catecholamine secretion in adrenal chromaffin cells by activating a protein phosphataseQ37148501
Cantharidin-binding protein: identification as protein phosphatase 2AQ37342231
Okadaic acid: a new probe for the study of cellular regulationQ37876246
Elevated Chlamydia pneumoniae antibodies, cardiovascular events, and azithromycin in male survivors of myocardial infarctionQ37882420
Mechanism of inhibition of protein phosphatase 1 by DARPP-32: studies with recombinant DARPP-32 and synthetic peptidesQ38299723
Identification of protein-phosphatase-1-binding domains on the glycogen and myofibrillar targetting subunitsQ38355365
Interactions and properties of smooth muscle myosin phosphatase.Q38357666
Mutational analysis of the catalytic subunit of muscle protein phosphatase-1.Q38357671
Cantharidin, another natural toxin that inhibits the activity of serine/threonine protein phosphatases types 1 and 2A.Q38566443
A second heat-stable protein inhibitor of phosphorylase phosphatase from rabbit muscleQ39995361
Separation and Characterization of Two Phosphorylase Phosphatase Inhibitors from Rabbit Skeletal MuscleQ40038892
Multiple forms of protein phosphatase inhibitors in mammalian tissuesQ40104226
The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signalingQ40751632
Regulation of Ca2+-dependent Cl- conductance in a human colonic epithelial cell line (T84): cross-talk between Ins(3,4,5,6)P4 and protein phosphatasesQ41026182
Glucocorticoid regulation of calcium-activated potassium channels mediated by serine/threonine protein phosphatase.Q41037626
Protein phosphatase 2B-dependent pathway of insulin action on single Cl- channel conductance in renal epitheliumQ41061131
Differential inhibition and posttranslational modification of protein phosphatase 1 and 2A in MCF7 cells treated with calyculin-A, okadaic acid, and tautomycinQ41109535
Mechanism of Ca(2+)-dependent inactivation of L-type Ca2+ channels in GH3 cells: direct evidence against dephosphorylation by calcineurinQ41124497
The protein phosphatase inhibitor okadaic acid induces morphological changes typical of apoptosis in mammalian cellsQ41129663
Evidence for isoproterenol-induced phosphorylation of phosphatase inhibitor-1 in the intact heartQ41131436
Inhibition of cloned human L-type cardiac calcium channels by 2,3-butanedione monoxime does not require PKA-dependent phosphorylation sitesQ41133419
Modulation of CFTR chloride channels by calyculin A and genisteinQ41141435
Regulation of the phosphorylation state and microtubule-binding activity of Tau by protein phosphatase 2A.Q41147532
The phosphatase inhibitor okadaic acid blocks KCl-depolarization-induced rise of cytosolic calcium of rat insulinoma cells (RINm5F).Q41186953
Activation of K+ channels and suppression of neuronal activity by secreted beta-amyloid-precursor protein.Q41240734
The actin filament disrupter cytochalasin D activates the recombinant cystic fibrosis transmembrane conductance regulator Cl- channel in mouse 3T3 fibroblastsQ41258928
Isotype-specific activation of cystic fibrosis transmembrane conductance regulator-chloride channels by cGMP-dependent protein kinase II.Q41272464
A non-selective cation current activated via the multifunctional Ca(2+)-calmodulin-dependent protein kinase in human epithelial cellsQ41287371
Thyrsiferyl 23-acetate is a novel specific inhibitor of protein phosphatase PP2A.Q41409229
Regulation of the cloned L-type cardiac calcium channel by cyclic-AMP-dependent protein kinaseQ41474868
Protein kinase A anchoringQ41505004
Protein phosphatase 2A reverses inhibition of inward rectifying K+ currents by thyrotropin-releasing hormone in GH3 pituitary cellsQ41508004
Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinaseQ41608842
Stimulation of protein phosphatases as a mechanism of the muscarinic-receptor-mediated inhibition of cardiac L-type Ca2+ channelsQ41676737
Rapid histone H3 phosphorylation in response to growth factors, phorbol esters, okadaic acid, and protein synthesis inhibitorsQ41683430
Regulation of progesterone receptor-mediated transcription by phosphorylationQ41710148
Hepatocellular uptake of 3H-dihydromicrocystin-LR, a cyclic peptide toxinQ41731167
The effect of the protein phosphatases inhibitor cantharidin on beta-adrenoceptor-mediated vasorelaxationQ41777285
Control of protein phosphatase 2A by simian virus 40 small-t antigenQ41814391
Phosphorylation‐ and voltage‐dependent inhibition of neuronal calcium currents by activation of human D2(short) dopamine receptorsQ41903993
Effects of protein phosphatase and kinase inhibitors on the cardiac L-type Ca current suggest two sites are phosphorylated by protein kinase A and another protein kinaseQ41937502
Modulation by calcineurin of 5-HT3 receptor function in NG108-15 neuroblastoma x glioma cellsQ41963525
Effects of okadaic acid and ATP gamma S on cell length and Ca(2+)-channel currents recorded in single smooth muscle cells of the guinea-pig taenia caeciQ41986753
Inactivation of glycogen synthase kinase-3 beta by phosphorylation: new kinase connections in insulin and growth-factor signallingQ42032355
Effects of cantharidin on force of contraction and phosphatase activity in nonfailing and failing human heartsQ42074948
Inhibition of specific binding of okadaic acid to protein phosphatase 2A by microcystin-LR, calyculin-A and tautomycin: method of analysis of interactions of tight-binding ligands with target proteinQ42092485
Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kineticsQ42163759
Phosphorylation and IGF-1-mediated dephosphorylation pathways control the activity and the pharmacological properties of skeletal muscle chloride channelsQ42234720
Regulation of large calcium-activated potassium channels by protein phosphatase 2A.Q42436569
Control of Ca2+ channel current and exocytosis in rat lactotrophs by basally active protein kinase C and calcineurinQ42438231
Protein kinase A phosphorylation enhances sodium channel currents in Xenopus oocytesQ42452102
Genistein increases the sensitivity of cardiac ion channels to beta-adrenergic receptor stimulation.Q42458432
Effects of Mg2+ on basal and beta-adrenergic-stimulated delayed rectifier potassium current in frog atrial myocytesQ42464987
Regulation of the L-type Ca2+ channel current in rat pinealocytes: role of basal phosphorylationQ42466439
The effect of a chemical phosphatase on single calcium channels and the inactivation of whole-cell calcium current from isolated guinea-pig ventricular myocytesQ42478052
Basal dephosphorylation controls slow gating of L-type Ca2+ channels in human vascular smooth muscle.Q42479545
Regulation of the cardiac calcium channel by protein phosphatasesQ42488016
Opposite effects of phosphatase inhibitors on L-type calcium and delayed rectifier currents in frog cardiac myocytesQ42499455
Phosphorylation enhances inactivation of N-type calcium channel current in bullfrog sympathetic neuronsQ42503381
cAMP- and Ca2+-independent activation of cystic fibrosis transmembrane conductance regulator channels by phenylimidazothiazole drugsQ42518833
Protein phosphatase 2A is essential for the activation of Ca2+-activated K+ currents by cGMP-dependent protein kinase in tracheal smooth muscle and Chinese hamster ovary cellsQ42519822
CFTR chloride channel activation by genistein: the role of serine/threonine protein phosphatasesQ42521984
Dynamic modulation of excitation-contraction coupling by protein phosphatases in rat ventricular myocytesQ42523030
Translocation of PKC, protein phosphatase inhibition and preconditioning of rabbit cardiomyocytesQ42524447
Reconstitution and regulation of an epithelial chloride channelQ42600733
Regulation of Ca(2+)-activated K+ channels by protein kinase A and phosphatase inhibitorsQ42613456
Involvement of phosphatase activities in the run-down of GABA(A) receptor function in rat cerebellar granule cells in cultureQ42675554
Block of ATP-sensitive K+ channels in isolated mouse pancreatic beta-cells by 2,3-butanedione monoximeQ42701075
Genistein activates CFTR Cl- channels via a tyrosine kinase- and protein phosphatase-independent mechanismQ42798090
Molecular cloning and analysis of the 5'-flanking region of the rat PP1 alpha geneQ42806219
Regulation of CFTR by protein phosphatase 2B and protein kinase C.Q42828996
Calyculin-A increases the level of protein phosphorylation and changes the shape of 3T3 fibroblastsQ42829835
Inhibition of serine/threonine protein phosphatases promotes opening of voltage-activated L-type Ca2+ channels in insulin-secreting cellsQ42833251
Identification of the ATP + Mg-dependent and polycation-stimulated protein phosphatases in the germinal vesicle of the Xenopus oocyteQ42836195
Okadaic acid identifies a phosphorylation/dephosphorylation cycle controlling the inhibitory guanine-nucleotide-binding regulatory protein Gi2Q42860144
The mechanism of action of cantharidin in smooth muscleQ43103502
Deactivation of CFTR-Cl conductance by endogenous phosphatases in the native sweat ductQ43439840
The molecular mechanism by which adrenalin inhibits glycogen synthesisQ43480704
Remarkable similarities between yeast and mammalian protein phosphatasesQ43482559
Separation of rabbit liver latent and spontaneously active phosphorylase phosphatases by chromatography on heparin-sepharoseQ43520906
Regulation of protein phosphatase-1G from rabbit skeletal muscle. 2. Catalytic subunit translocation is a mechanism for reversible inhibition of activity toward glycogen-bound substratesQ43551845
The protein phosphatases involved in cellular regulation. Purification and characterisation of the glycogen-bound form of protein phosphatase-1 from rabbit skeletal muscleQ43553490
Effects of okadaic acid on isometric tension and myosin phosphorylation of chemically skinned guinea-pig taenia coliQ43602268
Modulation of a cloned mouse brain potassium channel.Q43766036
A role for protein kinases and phosphatases in the Ca(2+)-induced enhancement of hippocampal AMPA receptor-mediated synaptic responses.Q45983926
Smooth muscle myosin phosphatase inhibition and force enhancement by black sponge toxinQ46175060
Impairment of GABAA receptor function by N-methyl-D-aspartate-mediated calcium influx in isolated CA1 pyramidal cellsQ46295526
A novel protein phosphatase inhibitor, tautomycin. Effect on smooth muscle.Q53858292
An enzymatic mechanism for calcium current inactivation in dialysed Helix neurones.Q53887123
Control of CFTR channel gating by phosphorylation and nucleotide hydrolysis.Q53938455
Regulation of stably expressed and native BK channels from human myometrium by cGMP- and cAMP-dependent protein kinase.Q53947289
Mechanism of activation by cGMP-dependent protein kinase of large Ca(2+)-activated K+ channels in mesangial cells.Q53980153
Regulation of adenosine triphosphate-sensitive potassium channels from rabbit ventricular myocytes by protein kinase C and type 2A protein phosphatase.Q54009492
Mechanism of rapid desensitization of muscarinic K+ current in adult rat and guinea pig atrial cellsQ54046470
Phosphorylation restores activity of L-type calcium channels after rundown in inside-out patches from rabbit cardiac cellsQ54061625
Regulation of an epithelial chloride channel by direct phosphorylation and dephosphorylationQ54062766
Modulation of Ca(2+)-channel currents by protein kinase C in adult rat sympathetic neurons.Q54194414
Modulation of the hyperpolarization-activated current (Ih) by cyclic nucleotides in guinea-pig primary afferent neurons.Q54430697
Identification of the regions on the M110 subunit of protein phosphatase 1M that interact with the M21 subunit and with myosin.Q54569086
Inhibitor-2 functions like a chaperone to fold three expressed isoforms of mammalian protein phosphatase-1 into a conformation with the specificity and regulatory properties of the native enzyme.Q54658108
Dual effect of phosphatase inhibitors on calcium channels in intestinal smooth muscle cells.Q54662859
Modulation of calcium currents by a D1 dopaminergic protein kinase/phosphatase cascade in rat neostriatal neuronsQ56568483
Specificity of the polycation-stimulated (type-2A) and ATP, Mg-dependent (type-1) protein phosphatases toward substrates phosphorylated by P34cdc2 kinaseQ57082915
Calcium-induced inactivation of NMDA receptor-channels evolves independently of run-down in cultured rat brain neuronesQ57253342
Inhibition of protein phosphatases-1 and -2A with acanthifolicinQ57310222
Prevention of Cardiac Hypertrophy in Mice by Calcineurin InhibitionQ57396540
The α1-Subunit of Skeletal Muscle L-Type Ca Channels Is the Key Target for Regulation by A-Kinase and Protein Phosphatase-1CQ58009301
A Role for Calcineurin (Protein Phosphatase-2B) in the Regulation of Glutamate ReleaseQ58112677
Phosphorylation of DARPP-32, a Dopamine- and cAMP-regulated Phosphoprotein, by Casein Kinase Iin Vitroandin VivoQ58112703
Rundown of N-methyl-D-aspartate channels during whole-cell recording in rat hippocampal neurons: role of Ca2+ and ATPQ58191310
Potassium channel stimulation by natriuretic peptides through cGMP-dependent dephosphorylationQ59063032
The molecular mechanism by which insulin stimulates glycogen synthesis in mammalian skeletal muscleQ59069709
Voltage-dependent potentiation of L-type Ca2+ channels due to phosphorylation by cAMP-dependent protein kinaseQ59095106
P433issue1
P304page(s)173-210
P577publication date2000-01-01
P1433published inPhysiological ReviewsQ1091827
P1476titleEffects of serine/threonine protein phosphatases on ion channels in excitable membranes
P478volume80