IL-3 Maintains Activation of the p90S6K/RPS6 Pathway and Increases Translation in Human Eosinophils

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IL-3 Maintains Activation of the p90S6K/RPS6 Pathway and Increases Translation in Human Eosinophils is …
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scholarly articleQ13442814

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P356DOI10.4049/JIMMUNOL.1500871
P932PMC publication ID4561194
P698PubMed publication ID26276876
P5875ResearchGate publication ID281054854

P50authorMats W. JohanssonQ55094089
Nizar N JarjourQ88330675
Stephane EsnaultQ42777061
P2093author name stringJames S Malter
Zhong-Jian Shen
Elizabeth A B Kelly
P2860cites workPlexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebratesQ22010646
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Ribosomal protein S6 kinase activity controls the ribosome biogenesis transcriptional program.Q54457299
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Distinctive Blood Eosinophilic Phenotypes and Cytokine Patterns in Eosinophilic Esophagitis, Inflammatory Bowel Disease and Airway AllergyQ58848601
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CD48 is an allergen and IL-3-induced activation molecule on eosinophilsQ79754943
Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinasesQ28187456
Decreased expression of membrane IL-5 receptor alpha on human eosinophils: I. Loss of membrane IL-5 receptor alpha on airway eosinophils and increased soluble IL-5 receptor alpha in the airway after allergen challengeQ28215560
Transcriptional and translational control of cytoplasmic proteins after serum stimulation of quiescent Swiss 3T3 cellsQ28275892
mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation eventsQ28281590
Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasisQ28585415
The MAPK-activated kinase Rsk controls an acute Toll-like receptor signaling response in dendritic cells and is activated through two distinct pathwaysQ28594395
Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolinQ28910229
Protein phosphatase 2A activates the proapoptotic function of BAD in interleukin- 3-dependent lymphoid cells by a mechanism requiring 14-3-3 dissociationQ32061766
Role and regulation of 90 kDa ribosomal S6 kinase (RSK) in signal transduction.Q33690319
An encore for ribosome biogenesis in the control of cell proliferationQ33915837
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Regulation of ribosomal protein S6 phosphorylation by casein kinase 1 and protein phosphatase 1Q34624565
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Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA familyQ35234179
Semaphorin 7A plays a critical role in TGF-beta1-induced pulmonary fibrosisQ36229334
Detection of immunological biomarkers correlated with asthma control and quality of life measurements in sera from chronic asthmatic patientsQ36288054
Pin1 regulates TGF-beta1 production by activated human and murine eosinophils and contributes to allergic lung fibrosisQ36330861
Anti-IL-5 attenuates activation and surface density of β(2) -integrins on circulating eosinophils after segmental antigen challenge.Q36630280
RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translationQ36745240
Metabotropic glutamate receptor-initiated translocation of protein kinase p90rsk to polyribosomes: a possible factor regulating synaptic protein synthesisQ36760241
Up-regulation and activation of eosinophil integrins in blood and airway after segmental lung antigen challengeQ36980346
Physiological roles of ribosomal protein S6: one of its kindQ37243586
Human basophils secrete IL-3: evidence of autocrine priming for phenotypic and functional responses in allergic diseaseQ37245942
Semaphorin 7A is expressed on airway eosinophils and upregulated by IL-5 family cytokinesQ37625993
A protein kinase from Xenopus eggs specific for ribosomal protein S6.Q37676559
Mepolizumab and exacerbations of refractory eosinophilic asthmaQ37711391
The p90 RSK family members: common functions and isoform specificityQ38130898
Eosinophils in mucosal immune responsesQ38390424
Evidence for the efficacy and safety of anti-interleukin-5 treatment in the management of refractory eosinophilic asthmaQ38434820
Human eosinophils release IL-1ß and increase expression of IL-17A in activated CD4+ T lymphocytesQ39464920
The cytokine interleukin-5 (IL-5) effects cotransport of its receptor subunits to the nucleus in vitroQ41103584
Identification by RNA-protein cross-linking of ribosomal proteins located at the interface between the small and the large subunits of mammalian ribosomesQ41300449
Potent synergistic effect of IL-3 and TNF on matrix metalloproteinase 9 generation by human eosinophilsQ41909413
Identification of 40 S ribosomal protein S6 phosphorylation sites in Swiss mouse 3T3 fibroblasts stimulated with serum.Q42811658
P4510describes a project that usesImageJQ1659584
P433issue6
P407language of work or nameEnglishQ1860
P921main subjecthuman eosinophilQ101405048
P304page(s)2529-2539
P577publication date2015-08-14
P1433published inJournal of ImmunologyQ3521441
P1476titleIL-3 Maintains Activation of the p90S6K/RPS6 Pathway and Increases Translation in Human Eosinophils
P478volume195

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Q33621816Understanding Interleukin 33 and Its Roles in Eosinophil Development

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