review article | Q7318358 |
scholarly article | Q13442814 |
P50 | author | Maiken Lise Marcker | Q55602480 |
Claus Desler | Q58295137 | ||
Lene Juel Rasmussen | Q42427537 | ||
P2093 | author name string | Keshav K Singh | |
P2860 | cites work | The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis | Q22009936 |
Oxidative damage of mitochondria induced by Fe(II)citrate or t-butyl hydroperoxide in the presence of Ca2+: effect of coenzyme Q redox state | Q72644255 | ||
Aging decreases electron transport complex III activity in heart interfibrillar mitochondria by alteration of the cytochrome c binding site | Q73334971 | ||
Mitochondrial DNA rearrangements in aging human brain and in situ PCR of mtDNA | Q73362977 | ||
Dihydroorotat-ubiquinone oxidoreductase links mitochondria in the biosynthesis of pyrimidine nucleotides | Q73729841 | ||
Mitochondrial DNA abnormalities in skeletal muscle of patients with sporadic amyotrophic lateral sclerosis | Q73929287 | ||
Ageing muscle: clonal expansions of mitochondrial DNA point mutations and deletions cause focal impairment of mitochondrial function | Q74180066 | ||
Oxidative damage elicited by imbalance of free radical scavenging enzymes is associated with large-scale mtDNA deletions in aging human skin | Q74463073 | ||
Mitochondrial electron transport complex I is a potential source of oxygen free radicals in the failing myocardium | Q78151171 | ||
Mitochondrial dysfunction in cancer | Q81110774 | ||
Mitochondrial DNA mutations activate programmed cell survival in the mouse heart | Q81667251 | ||
Reduction of age-associated pathology in old mice by overexpression of catalase in mitochondria | Q81932010 | ||
Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases | Q69368213 | ||
Relative importance of intracellular glutathione peroxidase and catalase in vivo for prevention of peroxidation to the heart | Q69425389 | ||
Age-dependent increase in deleted mitochondrial DNA in the human heart: possible contributory factor to presbycardia | Q70160150 | ||
In vivo formation of single-strand breaks in DNA by hydrogen peroxide is mediated by the Haber-Weiss reaction | Q70189815 | ||
Effects of leflunomide and other immunosuppressive agents on T cell proliferation in vitro | Q70897704 | ||
Fragile sites in chromosomes: possible model for the study of spontaneous chromosome breakage | Q71673015 | ||
Leflunomide inhibits pyrimidine de novo synthesis in mitogen-stimulated T-lymphocytes from healthy humans | Q47682285 | ||
Positive contribution of pathogenic mutations in the mitochondrial genome to the promotion of cancer by prevention from apoptosis | Q47836751 | ||
Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age | Q48403808 | ||
Inactivation of glutathione peroxidase by benzaldehyde | Q48848275 | ||
Ultrastructural changes accompanying the aging of human diploid cells in culture | Q52992355 | ||
Mitochondrial phospholipid hydroperoxide glutathione peroxidase plays a major role in preventing oxidative injury to cells. | Q54105326 | ||
On auxotrophy for pyrimidines of respiration-deficient chick embryo cells. | Q54471555 | ||
Role of mitochondria in oxidative stress and ageing | Q57014212 | ||
Mitochondria as determinant of nucleotide pools and chromosomal stability | Q57742400 | ||
Control of nucleolar RNA synthesis by the intracellular pool sizes of ATP and GTP | Q67773504 | ||
Detection of catalase in rat heart mitochondria | Q68261224 | ||
Premature ageing in mice expressing defective mitochondrial DNA polymerase | Q24294365 | ||
Normal oxidative damage to mitochondrial and nuclear DNA is extensive | Q24649831 | ||
Structures of human dihydroorotate dehydrogenase in complex with antiproliferative agents | Q27621351 | ||
Aging: a theory based on free radical and radiation chemistry | Q27860549 | ||
On the Origin of Cancer Cells | Q27861025 | ||
Oxidants, oxidative stress and the biology of ageing | Q28131725 | ||
Role of oxidants in NF-kappa B activation and TNF-alpha gene transcription induced by hypoxia and endotoxin | Q28139739 | ||
The biologic clock: the mitochondria? | Q28249363 | ||
Modulation of mutagenesis by deoxyribonucleotide levels | Q28262307 | ||
Age-associated mitochondrial DNA mutations lead to small but significant changes in cell proliferation and apoptosis in human colonic crypts | Q28263194 | ||
Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis | Q28279053 | ||
Inhibition of synthesis of pyrimidine nucleotides by 2-hydroxy-3-(3,3-dichloroallyl)-1,4-naphthoquinone | Q28322882 | ||
Mitochondrial DNA mutations induce mitochondrial dysfunction, apoptosis and sarcopenia in skeletal muscle of mitochondrial DNA mutator mice | Q28474793 | ||
Expression, purification, and characterization of histidine-tagged rat and human flavoenzyme dihydroorotate dehydrogenase | Q28578020 | ||
MAPKs: new JNK expands the group | Q28611010 | ||
Mitochondrial reactive oxygen species trigger hypoxia-induced transcription | Q29614203 | ||
Mitochondrial respiratory-chain diseases | Q29614474 | ||
Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation | Q29614475 | ||
Extension of murine life span by overexpression of catalase targeted to mitochondria | Q29614546 | ||
Mitochondrial diseases in man and mouse | Q29614555 | ||
Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging | Q29616056 | ||
High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease | Q29619113 | ||
Proteomic analysis of mitochondria-to-nucleus retrograde response in human cancer | Q33246819 | ||
Ectopic catalase expression in mitochondria by adeno-associated virus enhances exercise performance in mice. | Q33494824 | ||
Activation of mitochondrial ERK protects cancer cells from death through inhibition of the permeability transition | Q33640002 | ||
Frameshift errors initiated by nucleotide misincorporation | Q33653503 | ||
mtDNA mutations increase tumorigenicity in prostate cancer | Q33757050 | ||
Role of redox potential and reactive oxygen species in stress signaling | Q33771754 | ||
Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication | Q33877846 | ||
Oxidative damage to mitochondrial DNA is inversely related to maximum life span in the heart and brain of mammals | Q33888725 | ||
Control of dTTP pool size by anaphase promoting complex/cyclosome is essential for the maintenance of genetic stability | Q33917704 | ||
Decline in skeletal muscle mitochondrial function with aging in humans | Q33936772 | ||
Mitochondrial glutathione and oxidative stress: implications for pulmonary oxygen toxicity in premature infants | Q34043177 | ||
Mitochondrial DNA in human malignancy. | Q34245551 | ||
Mitochondrial DNA and aging | Q34336524 | ||
Decline with age of the respiratory chain activity in human skeletal muscle. | Q34339368 | ||
p38 MAPK in development and cancer | Q34515854 | ||
A proposed refinement of the mitochondrial free radical theory of aging | Q34738272 | ||
Mitochondrial metabolism and cancer | Q35008848 | ||
HIF1alpha delays premature senescence through the activation of MIF. | Q35221154 | ||
Mitochondria as targets for detection and treatment of cancer. | Q35677132 | ||
Detection of a specific mitochondrial DNA deletion in tissues of older humans | Q35891834 | ||
Mitochondria damage checkpoint in apoptosis and genome stability | Q35920545 | ||
Radical medicine: treating ageing to cure disease | Q36287875 | ||
Targeting the ERK signaling pathway in cancer therapy | Q36486780 | ||
Free radical theory of aging: an update: increasing the functional life span | Q36520928 | ||
Mitochondrial DNA mutations in human colonic crypt stem cells | Q36524727 | ||
A novel role for mitochondria in regulating epigenetic modification in the nucleus | Q37091272 | ||
Supercomplexes of the mitochondrial electron transport chain decline in the aging rat heart. | Q37388302 | ||
Mitochondria and aging in the vascular system. | Q37780470 | ||
Reduced rate of DNA replication fork movement in megaloblastic anemia | Q38524907 | ||
Mitochondrial respiration is required for activation of ERK1/2 and caspase-3 in human eosinophils stimulated with hydrogen peroxide | Q39167644 | ||
Random intracellular drift explains the clonal expansion of mitochondrial DNA mutations with age. | Q39413342 | ||
Interactions between deoxyribonucleotide and DNA synthesis | Q39532113 | ||
A heteroplasmic, not homoplasmic, mitochondrial DNA mutation promotes tumorigenesis via alteration in reactive oxygen species generation and apoptosis | Q39885131 | ||
The Effect of Age on Mitochondrial Ultrastructure and Enzymes | Q39922671 | ||
Mutation of succinate dehydrogenase subunit C results in increased O2.-, oxidative stress, and genomic instability | Q40248526 | ||
Inter-genomic cross talk between mitochondria and the nucleus plays an important role in tumorigenesis | Q40404693 | ||
Mechanism of somatic mitochondrial DNA mutations associated with age and diseases | Q40437270 | ||
The mitochondrial production of reactive oxygen species in relation to aging and pathology | Q40559296 | ||
Oxidative stress-induced apoptosis is mediated by ERK1/2 phosphorylation | Q40620283 | ||
Mitochondrial membrane potential regulates matrix configuration and cytochrome c release during apoptosis | Q40645786 | ||
The rate of cell growth is regulated by purine biosynthesis via ATP production and G(1) to S phase transition | Q40870453 | ||
Inhibition of dihydroorotate dehydrogenase by the immunosuppressive agent leflunomide | Q41296886 | ||
Leflunomide interferes with pyrimidine nucleotide biosynthesis | Q41314211 | ||
Production of reactive oxygen species by mitochondria: central role of complex III. | Q42163292 | ||
The Genes for and Regulation of the Enzyme Activities of two Multifunctional Proteins Required for the De Novo Pathway for UMP Biosynthesis in Mammals | Q42241011 | ||
The effect of mitochondrial dysfunction on cytosolic nucleotide metabolism | Q42427505 | ||
Mitochondrial ROS initiate phosphorylation of p38 MAP kinase during hypoxia in cardiomyocytes | Q43988501 | ||
Mitochondrial complex I inhibitor rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production | Q44258988 | ||
A Morphometric Study of Age-Dependent Changes in Mitochondrial Populations of Mouse Liver and Heart | Q44278282 | ||
Differential Control of Cell Cycle, Proliferation, and Survival of Primary T Lymphocytes by Purine and Pyrimidine Nucleotides | Q44432122 | ||
A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage. | Q45985375 | ||
Family patterns of coronary heart disease mortality: the Framingham Longevity Study | Q46368322 | ||
P275 | copyright license | Creative Commons Attribution 3.0 Unported | Q14947546 |
P6216 | copyright status | copyrighted | Q50423863 |
P921 | main subject | mitochondrial DNA | Q27075 |
P304 | page(s) | 407536 | |
P577 | publication date | 2011-03-30 | |
P1433 | published in | Journal of Aging Research | Q26841941 |
P1476 | title | The importance of mitochondrial DNA in aging and cancer | |
P478 | volume | 2011 |
Q58762661 | Age-Dependent Loss of Mitochondrial Function in Epithelial Tissue Can Be Reversed by Coenzyme Q |
Q35723527 | Borrowing nuclear DNA helicases to protect mitochondrial DNA. |
Q51740578 | Differing Effects of Younger and Older Human Plasma on C2C12 Myocytes in Vitro. |
Q37074991 | Effects of Antioxidant N-acetylcysteine Against Paraquat-Induced Oxidative Stress in Vital Tissues of Mice |
Q91982186 | From Powerhouse to Perpetrator-Mitochondria in Health and Disease |
Q36031463 | Is There a Link between Mitochondrial Reserve Respiratory Capacity and Aging? |
Q36129109 | MaGelLAn 1.0: a software to facilitate quantitative and population genetic analysis of maternal inheritance by combination of molecular and pedigree information. |
Q36652725 | Microarray analysis of ageing-related signatures and their expression in tumors based on a computational biology approach |
Q41808812 | Mitochondria and aging |
Q36077249 | Mitochondria and the aging heart |
Q53721421 | Mitochondrial Diseases as Model of Neurodegeneration. |
Q36839391 | Mitochondrial common deletion is elevated in blood of breast cancer patients mediated by oxidative stress. |
Q39294200 | Mitochondrial determinants of cancer health disparities |
Q102141808 | Mitochondrial oxidative phosphorylation in cutaneous melanoma |
Q37320456 | Mitochondrial retrograde signaling at the crossroads of tumor bioenergetics, genetics and epigenetics |
Q38866763 | Molecular mechanisms of mTOR regulation by stress |
Q38817808 | Oxidative stress and ageing |
Q38635015 | Oxidative stress--a key emerging impact factor in health, ageing, lifestyle and aesthetics |
Q35234072 | Pathways to aging: the mitochondrion at the intersection of biological and psychosocial sciences. |
Q39474417 | Premature and accelerated aging: HIV or HAART? |
Q47712203 | Present Status and Future Challenges of New Therapeutic Targets in Preclinical Models of Stroke in Aged Animals with/without Comorbidities |
Q40043672 | Reduced serum IGF-1 associated with hepatic osteodystrophy is a main determinant of low cortical but not trabecular bone mass |
Q37298565 | Role of antioxidant enzymes and small molecular weight antioxidants in the pathogenesis of age-related macular degeneration (AMD) |
Q41662751 | The Ability of Exercise-Associated Oxidative Stress to Trigger Redox-Sensitive Signalling Responses |
Q37617228 | The mitochondrial ATPase6 gene is more susceptible to mutation than the ATPase8 gene in breast cancer patients. |
Q38153364 | The role of extracellular vesicles in phenotypic cancer transformation. |
Search more.